{"id":973,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2025-12-19T20:03:35","modified_gmt":"2025-12-19T20:03:35","slug":"klinicke-studie-hypertermie-wira-onkologi","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/cs\/klinicke-studie-hypertermie-wira-onkologi\/","title":{"rendered":"Klinick\u00e9 studie"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"973\" class=\"elementor elementor-973 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Celot\u011blov\u00e1 Hypertermie (WBH) v Onkologii a Jin\u00fdch Patologi\u00edch: Konsolidovan\u00e1 Synergie, Imunomodulace a Klinick\u00e9 studie<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header><p><strong>Zve\u0159ejn\u011bno:\u00a0<time datetime=\"2025-10-13\">2025-10-13<\/time>\u00a0| Posledn\u00ed Revize:\u00a0<time datetime=\"2025-10-13\">2025-10-13<\/time><\/strong><\/p><\/header><div class=\"authors\"><p>Auto\u0159i:<br \/><a href=\"https:\/\/ardenneiratherm.com\/cs\/our-team\/veronica-iatan\/\">Veronica Iatan, M.D.<\/a>,<br \/><a href=\"https:\/\/ardenneiratherm.com\/cs\/our-team\/cristian-gologan\/\">Cristian Gologan, M.Sc.<\/a><\/p><\/div><section class=\"ai-summary\"><p><strong>Celot\u011blov\u00e1 Hypertermie (WBH)<\/strong> je syst\u00e9mov\u00e1 onkologick\u00e1 strategie zahrnuj\u00edc\u00ed \u0159\u00edzen\u00e9 zv\u00fd\u0161en\u00ed centr\u00e1ln\u00ed t\u011blesn\u00e9 teploty, \u010dasto prov\u00e1d\u011bn\u00e9 pomoc\u00ed technologie <strong>Vodou filtrovan\u00e9ho Infra\u010derven\u00e9ho-A (wIRA)<\/strong>. WBH je z\u00e1sadn\u011b <strong>chemo\/radio-senzibiliz\u00e1tor<\/strong>, kter\u00fd v\u00fdznamn\u011b zlep\u0161uje prokrven\u00ed tumoru a okysli\u010den\u00ed, aby se zes\u00edlila \u00fa\u010dinnost tradi\u010dn\u00edch terapi\u00ed. Kl\u00ed\u010dov\u011b p\u016fsob\u00ed tak\u00e9 jako siln\u00fd <strong>syst\u00e9mov\u00fd imunomodul\u00e1tor<\/strong>, mobilizuj\u00edc\u00ed Proteiny Teplotn\u00edho \u0160oku (HSP) a T-lymfocyty. Tato akce vytv\u00e1\u0159\u00ed esenci\u00e1ln\u00ed synergie s pokro\u010dilou *<strong>Imunoterapi\u00ed (ICI)<\/strong>* a nab\u00edz\u00ed dramatickou, rychlou \u00falevu od bolesti a v\u00fdrazn\u00e9 zlep\u0161en\u00ed Kvality \u017divota (K\u017d) u r\u016fzn\u00fdch typ\u016f rakoviny a chronick\u00fdch stav\u016f, jako je Fibromyalgie.<\/p><\/section><section class=\"disclaimer\"><strong>* L\u00e9ka\u0159sk\u00e9 Upozorn\u011bn\u00ed: Tento \u010dl\u00e1nek slou\u017e\u00ed pouze k informa\u010dn\u00edm \u00fa\u010del\u016fm a v \u017e\u00e1dn\u00e9m p\u0159\u00edpad\u011b nenahrazuje individu\u00e1ln\u00ed l\u00e9ka\u0159skou konzultaci, diagnostiku nebo l\u00e9\u010dbu poskytnutou licencovan\u00fdm l\u00e9ka\u0159em.*<\/strong><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. Definice Celot\u011blov\u00e9 Hypertermie (WBH) a Terapeutick\u00e1 Technologie<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"text-align: center;\"><div><div><div><div><header><div style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\"><strong>Celot\u011blov\u00e1 Hypertermie (WBH)<\/strong>, neboli \u201esyst\u00e9mov\u00e1 hypertermie\u201c, je definov\u00e1na jako \u0159\u00edzen\u00e9 zv\u00fd\u0161en\u00ed centr\u00e1ln\u00ed t\u011blesn\u00e9 teploty pro terapeutick\u00e9 \u00fa\u010dely. Na z\u00e1klad\u011b spektra <strong>\u00fa\u010dink\u016f p\u0159irozen\u00e9 hore\u010dky p\u0159i r\u016fzn\u00fdch teplot\u00e1ch<\/strong>, se postupy WBH rozli\u0161uj\u00ed takto:<\/p><ul style=\"text-align: left;\"><li><strong>M\u00edrn\u00e1 WBH:<\/strong> &lt; 38,5\u00b0C<\/li><li><strong>St\u0159edn\u00ed WBH:<\/strong> 38,5\u00b0C \u2013 40,5 \u00b0C<\/li><li><strong>Extr\u00e9mn\u00ed WBH:<\/strong> &gt; 40,5\u00b0C<\/li><\/ul><p style=\"text-align: left;\">Zejm\u00e9na m\u00edrn\u00e1 a st\u0159edn\u00ed WBH <strong>zvy\u0161uje prokrven\u00ed (perfuzi)<\/strong>, stimuluje metabolismus, sni\u017euje svalov\u00fd tonus a <strong>stimuluje imunitn\u00ed syst\u00e9m.<\/strong><\/p><p style=\"text-align: left;\"><a title=\"Technick\u00e9 detaily za\u0159\u00edzen\u00ed von Ardenne IRATHERM\u00ae 1000M WBH wIRA\" href=\"https:\/\/ardenneiratherm.com\/cs\/ardenne-iratherm-hypertermicky-pristroj\/\">Za\u0159\u00edzen\u00ed hypertermie von Ardenne IRATHERM\u00ae 1000M WBH wIRA<\/a> k tomuto \u00fa\u010delu pou\u017e\u00edv\u00e1 v\u00fdhradn\u011b <strong>hluboce pronikaj\u00edc\u00ed, k poko\u017ece \u0161etrn\u00e9, vodou filtrovan\u00e9 Infra\u010derven\u00e9-A (wIRA) tepeln\u00e9 z\u00e1\u0159en\u00ed<\/strong>\u00a0(bez IR-B \/ IR-C). Jeho otev\u0159en\u00e1, ne-klaustrofobick\u00e1 konstrukce zaji\u0161\u0165uje rovnom\u011brnou intenzitu z\u00e1\u0159en\u00ed po cel\u00e9 plo\u0161e pacienta (z\u00e1da) a nab\u00edz\u00ed u\u017eivateli optim\u00e1ln\u00ed, pacientsky specifick\u00fd p\u0159\u00edsun tepla co do lokalizace a intenzity.<\/p><p style=\"text-align: left;\">Vodou filtrovan\u00e9 Infra\u010derven\u00e9-A z\u00e1\u0159en\u00ed odpov\u00edd\u00e1 p\u0159irozen\u00e9mu tepeln\u00e9mu z\u00e1\u0159en\u00ed slunce a poskytuje technologick\u00fd z\u00e1klad pro rovnom\u011brnou a \u0161etrnou aplikaci tepla\u00a0[1, 5, 7, 8].<\/p><p style=\"text-align: left;\">Pou\u017eit\u00edm principu von Ardenne IRATHERM<sup>\u00ae<\/sup>\u00a01000, kter\u00fd byl vyv\u00edjen a ov\u011b\u0159ov\u00e1n po v\u00edce ne\u017e 30 let, se\u00a0<a title=\"Prof. Manfred von Ardenne - P\u0159\u00edsp\u011bvky\" href=\"https:\/\/ardenneiratherm.com\/cs\/our-team\/manfred-von-ardenne-2\/\">Prof. Manfred von Ardenne<\/a>\u00a0poda\u0159ilo toto tepeln\u00e9 z\u00e1\u0159en\u00ed fyzik\u00e1ln\u011b a technicky reprodukovat a zp\u0159\u00edstupnit jej pr\u016fmyslov\u011b pro trval\u00e9 l\u00e9ka\u0159sk\u00e9 pou\u017eit\u00ed prost\u0159ednictv\u00edm celot\u011blov\u00e9 hypertermie.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. V\u011bdeck\u00e9 Z\u00e1klady a Syst\u00e9mov\u00e9 \u00da\u010dinky<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">WBH se vyvinula ve strategii zalo\u017eenou na pevn\u00fdch biofyzik\u00e1ln\u00edch a fyziologick\u00fdch principech. V onkologii je kladen d\u016fraz na <b>St\u0159edn\u00ed<\/b> a <b>Hypertermii v Rozmez\u00ed Hore\u010dky (HRV-WBH)<\/b>, uzn\u00e1van\u00e9 jako l\u00e9\u010dby s mnoha terapeutick\u00fdmi indikacemi[1,3].<\/p><p style=\"text-align: left;\">Technologick\u00fd z\u00e1klad pro rovnom\u011brnou a \u0161etrnou aplikaci tepla \u010dasto poskytuj\u00ed za\u0159\u00edzen\u00ed vyu\u017e\u00edvaj\u00edc\u00ed <b>Vodou filtrovan\u00e9 Infra\u010derven\u00e9-A (wIRA) z\u00e1\u0159en\u00ed<\/b>. Detailn\u00ed biofyzik\u00e1ln\u00ed studie potvrdily <b>schopnost t\u00e9to technologie zajistit hlubok\u00e9 a kontrolovan\u00e9 zah\u0159\u00edv\u00e1n\u00ed,<\/b>\u00a0s ohledem na optick\u00e9 vlastnosti k\u016f\u017ee a fotobiologick\u00fd z\u00e1klad pro d\u00e1vkov\u00e1n\u00ed[5,7,8].<\/p><p style=\"text-align: left;\">Detailn\u00ed biofyzik\u00e1ln\u00ed studie potvrdily\u00a0<strong class=\"key-term\">schopnost wIRA technologie<\/strong>\u00a0zajistit <b>hlubok\u00e9 a kontrolovan\u00e9 zah\u0159\u00edv\u00e1n\u00ed<\/b>.[5,7,8] Na fyziologick\u00e9 \u00farovni m\u00e1 WBH z\u00e1kladn\u00ed syst\u00e9mov\u00e9 \u00fa\u010dinky:<\/p><ol style=\"text-align: left;\"><li><strong>Zlep\u0161en\u00e1 Reologie Krve<\/strong>: Expozice IR-WBH p\u0159\u00edzniv\u011b ovliv\u0148uje <b>pr\u016ftokov\u00e9 vlastnosti krve a hemodynamiku[2],<\/b> podporuj\u00edc z\u00e1sadn\u00ed mechanismus <b>zlep\u0161en\u00e9ho prokrven\u00ed (perfuzi) tumoru<\/b> \u2014 kritick\u00fd p\u0159edpoklad pro \u00fasp\u011bch syst\u00e9mov\u00fdch l\u00e9\u010deb.<\/li><li><strong>Obecn\u00e1 Biologick\u00e1 Aktivace:<\/strong>\u00a0WBH indukuje reakci na tepeln\u00fd stres, kter\u00e1 spou\u0161t\u00ed kask\u00e1du biologick\u00fdch proces\u016f, v\u010detn\u011b *modulace hormon\u00e1ln\u00edho syst\u00e9mu* a <b>zrychlen\u00ed metabolismu[4,6]<\/b>.<\/li><\/ol><p style=\"text-align: left;\">Na z\u00e1klad\u011b t\u011bchto z\u00e1klad\u016f funguje WBH jako\u00a0<strong class=\"key-term\">syst\u00e9mov\u00fd imunomodul\u00e1tor<\/strong>, optimalizuj\u00edc\u00ed\u00a0<strong class=\"key-term\">mikroprost\u0159ed\u00ed tumoru (MPT)<\/strong>\u00a0a <b>zesiluj\u00edc\u00ed \u00fa\u010dinnost pokro\u010dil\u00fdch onkologick\u00fdch l\u00e9\u010deb<\/b>.[9]<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. Kl\u00ed\u010dov\u00e9 Mechanizmy \u00da\u010dinku (Molekul\u00e1rn\u00ed, Fyziologick\u00e9 a Imunologick\u00e9)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Terapeutick\u00e9 \u00fa\u010dinky WBH jsou komplexn\u00ed, zprost\u0159edkovan\u00e9 zm\u011bnami na bun\u011b\u010dn\u00e9, imunitn\u00ed a fyziologick\u00e9 \u00farovni:<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Synergie s Chemoterapi\u00ed a Radioterapi\u00ed (Chemo\/Radio-senzibiliz\u00e1tor)<\/h3><ul><li style=\"text-align: left;\"><strong>Optimalizace Mikroprost\u0159ed\u00ed Tumoru (MPT):<\/strong> WBH zlep\u0161uje <strong>prokrven\u00ed tumoru krv\u00ed<\/strong> a <strong>okysli\u010den\u00ed, \u010d\u00edm\u017e obrac\u00ed hypoxii tumoru.<\/strong> To je z\u00e1sadn\u00ed, proto\u017ee dob\u0159e okysli\u010den\u00e9 n\u00e1dorov\u00e9 bu\u0148ky jsou v\u00fdznamn\u011b citliv\u011bj\u0161\u00ed na destrukci <strong>Chemoterap\u00ed\u00ed<\/strong> (WBH) a <strong>Radioterapi\u00ed<\/strong> (RT).[9,41]<\/li><li style=\"text-align: left;\"><strong>Chemo\/Radio \u00da\u010dinnost:<\/strong>\u00a0Hypertermie p\u016fsob\u00ed jako\u00a0<strong class=\"key-term\">chemo &amp; radio senzibiliz\u00e1tor<\/strong>, zlep\u0161uj\u00edc\u00ed dod\u00e1vku kysl\u00edku do tumoru (radio-senzibilizuj\u00edc\u00ed \u00fa\u010dinek) a zvy\u0161uj\u00edc\u00ed \u00fa\u010dinnost l\u00e9k\u016f jako jsou Cisplatina, Gemcitabin a Karboplatina.[12,16,36]<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Indukce Robustn\u00ed Anti-Tumorov\u00e9 Imunitn\u00ed Odpov\u011bdi (Imunomodulace)<\/h3><p style=\"text-align: left;\">WBH je siln\u00fd aktiv\u00e1tor obrann\u00e9ho syst\u00e9mu t\u011bla:<\/p><ul><li style=\"text-align: left;\"><strong>Proteiny Teplotn\u00edho \u0160oku (HSP):<\/strong>\u00a0Tepeln\u00fd stres stimuluje synt\u00e9zu a uvol\u0148ov\u00e1n\u00ed *HSP70*. Tyto proteiny funguj\u00ed jako \u201asign\u00e1ly nebezpe\u010d\u00ed\u2018, kter\u00e9 ozna\u010duj\u00ed rakovinn\u00e9 bu\u0148ky pro zes\u00edlen\u00fd \u00fatok ze strany\u00a0<strong class=\"key-term\">Cytotoxick\u00fdch T-Lymfocyt\u016f (CTL)<\/strong>\u00a0imunitn\u00edho syst\u00e9mu.[9,10,29]<\/li><li style=\"text-align: left;\"><strong>Aktivace Kl\u00ed\u010dov\u00fdch Imunitn\u00edch Bun\u011bk<\/strong>: Teplotn\u00ed rozsah 39-43*\u00b0C zvy\u0161uje aktivitu <strong>P\u0159irozen\u00fdch Zab\u00edje\u010d\u016f (NK) bun\u011bk<\/strong> a podporuje aktivitu <strong>pomocn\u00fdch a cytotoxick\u00fdch T-lymfocyt\u016f<\/strong>, <strong>dendritick\u00fdch bun\u011bk<\/strong> a <strong>makrof\u00e1g\u016f<\/strong>, zat\u00edmco potenci\u00e1ln\u011b naru\u0161uje imunosupresivn\u00ed bu\u0148ky.<span class=\"citation\">[9, 10, 11, 25, 26]<\/span>.<\/li><li style=\"text-align: left;\"><strong>N\u00e1r\u016fst T-Lymfocyt\u016f:<\/strong> HRV-WBH m\u016f\u017ee <strong>v\u00fdznamn\u011b zv\u00fd\u0161it (nap\u0159. 3x)<\/strong>\u00a0populaci cytotoxick\u00fdch T-lymfocyt\u016f v lymfoidn\u00edch org\u00e1nech, <strong>\u010d\u00edm\u017e posiluje syst\u00e9mov\u00fd anti-tumorov\u00fd imunitn\u00ed \u00fatok<\/strong>.[10]<\/li><li style=\"text-align: left;\"><strong>Vakc\u00edny a APC<\/strong>: WBH m\u016f\u017ee regulovat funkci Antigen Prezentuj\u00edc\u00edch Bun\u011bk (APC) a zv\u00fd\u0161it \u00fa\u010dinnost vakc\u00edn proti rakovin\u011b, v\u010detn\u011b t\u011bch zalo\u017een\u00fdch na HSP110 a GRP170[28,37].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Klinick\u00e9 D\u016fkazy a Synergie v Multimod\u00e1ln\u00ed Terapii<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Synergie s Imunoterapi\u00ed (Inhibitory Imunitn\u00edch Kontroln\u00edch Bod\u016f \u2013 ICI)<\/h3><p style=\"text-align: left;\">Retrospektivn\u00ed s\u00e9rie p\u0159\u00edpad\u016f 131 pacient\u016f s pokro\u010dil\u00fdm (St\u00e1dium IV) karcinomem zkoumala multimod\u00e1ln\u00ed protokol zahrnuj\u00edc\u00ed <strong>celot\u011blovou hypertermii<\/strong>\u00a0nav\u00edc k inhibitor\u016fm kontroln\u00edch bod\u016f (Ipilimumab, Nivolumab) a IL-2.<\/p><p style=\"text-align: left;\"><strong>Kl\u00ed\u010dov\u00fd Z\u00e1v\u011br:<\/strong>\u00a0WBH wIRA byla ur\u010dena jako <strong>integr\u00e1ln\u00ed a esenci\u00e1ln\u00ed slo\u017eka, kter\u00e1 maximalizuje anti-tumorovou imunitn\u00ed odpov\u011b\u010f. WBH aktivuje a mobilizuje T-lymfocyty (indukc\u00ed HSP70 a uvol\u0148ov\u00e1n\u00edm tumorov\u00fdch antigen\u016f)<\/strong>; inhibitory kontroln\u00edch bod\u016f pot\u00e9 \u201euvoln\u00ed brzdu\u201c t\u011bchto p\u0159edem aktivovan\u00fdch T-lymfocyt\u016f, co\u017e vede k neobvykle vysok\u00fdm m\u00edr\u00e1m p\u0159\u00edzniv\u00e9 klinick\u00e9 odpov\u011bdi u pokro\u010dil\u00fdch onemocn\u011bn\u00ed.[18]<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Klinick\u00e9 Aplikace u R\u016fzn\u00fdch Rakovin<\/h3><ul><li style=\"text-align: left;\"><strong>Karcinom Pankreatu<\/strong>: Protokoly F\u00e1ze I-II pou\u017e\u00edvaj\u00edc\u00ed m\u00edrnou WBH (HRV-WBH) v kombinaci s chemoterapi\u00ed a Interferonem-alfa prok\u00e1zaly <strong>nejm\u00e9n\u011b 50% regresi tumoru u t\u00e9m\u011b\u0159 poloviny pacient\u016f rezistentn\u00edch na terapii<\/strong>.[4,22]<\/li><li style=\"text-align: left;\"><strong>Karcinom Prsu (Recidiva):<\/strong> WBH v kombinaci s re-oz\u00e1\u0159en\u00edm nebo radioterapi\u00ed prok\u00e1zala \u00fa\u010dinnost u lok\u00e1ln\u011b pokro\u010dil\u00e9ho karcinomu prsu a recidivy hrudn\u00ed st\u011bny, potvrzenou randomizovan\u00fdmi \u00fadaji[39,40].<\/li><li style=\"text-align: left;\"><strong>Karcinom Vaje\u010dn\u00edk\u016f:<\/strong> WBH v kombinaci s <strong>karboplatinou<\/strong> byla zkoum\u00e1na ve studii F\u00e1ze II pro rekurentn\u00ed karcinom vaje\u010dn\u00edk\u016f[16,20].<\/li><li style=\"text-align: left;\"><strong>Kolorekt\u00e1ln\u00ed Karcinom<\/strong>: WBH wIRA byla pou\u017eita v kontextu von Ardenneovy Syst\u00e9mov\u00e9 V\u00edcestup\u0148ov\u00e9 Terapie Rakoviny (sCMT) v kombinaci s chemoterapi\u00ed ve studii F\u00e1ze I\/II[15].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. Rychl\u00e1 \u00daleva od Boli a V\u00fdznamn\u00e9 Zlep\u0161en\u00ed Kvality \u017divota (K\u017d)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Pacienti mohou zaznamenat rychlou \u00falevu od bolesti a celkov\u00e9 zlep\u0161en\u00ed pohody, jak bylo pozorov\u00e1no ve studii Dr. Bulla a zejm\u00e9na v nov\u011bj\u0161\u00ed klinick\u00e9 studii F\u00e1ze III Sahinbase a kol.[14]<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div class=\"table-scroll-wrapper\"><h3 style=\"text-align: left;\">Klinick\u00e9 Hodnocen\u00ed F\u00e1ze III (2024) pro Kostn\u00ed Metast\u00e1zy<\/h3><div class=\"container\" style=\"text-align: left;\"><div class=\"section\"><section><span dir=\"auto\">V\u00a0<\/span><a title=\"Studie F\u00e1ze III Sahinbas 2024\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\">roce 2024 Sahinbas a kolegov\u00e9 publikovali studii F\u00e1ze III<\/span><\/a><span dir=\"auto\">\u00a0pro bolest kostn\u00edch metast\u00e1z, hlavn\u011b z karcinomu prsu a prostaty, pou\u017e\u00edvaj\u00edc\u00ed WBH wIRA Iratherm hypertermick\u00e1 za\u0159\u00edzen\u00ed jako dopln\u011bk k RT.<\/span><span dir=\"auto\">Na z\u00e1klad\u011b t\u00e9to studie, skupina pouze s RT p\u0159edstavovala nejintenzivn\u011bj\u0161\u00ed bolest. Studie byla dokon\u010dena po za\u0159azen\u00ed celkem 61 pacient\u016f, 5 let po prvn\u00edm z\u00e1pisu (duben 2016 \u2013 \u00fanor 2021). Nakonec, m\u00edra \u00dapln\u00e9 Odpov\u011bdi (\u00daO) ve skupin\u011b RT + WBH uk\u00e1zala nejv\u00fdznamn\u011bj\u0161\u00ed rozd\u00edl oproti samotn\u00e9 RT: <b>47,4 % vs. 5,3 %,<\/b> resp., <b>do 2 m\u011bs\u00edc\u016f po l\u00e9\u010db\u011b<\/b>\u00a0(P-hodnota &lt; 0,05). <b>Doba do \u00fapln\u00e9 \u00falevy od bolesti byla 10 dn\u00ed pro RT + WBH, zat\u00edmco u skupiny pouze s RT nebylo tohoto koncov\u00e9ho bodu dosa\u017eeno.<\/b>\u00a0Progrese bolesti nebo stabilita nemoci byla pozorov\u00e1na u poloviny pacient\u016f v RT skupin\u011b do 4 t\u00fddn\u016f po l\u00e9\u010db\u011b. Nicm\u00e9n\u011b, *toto sk\u00f3re bylo u pacient\u016f s RT + WBH do dvou m\u011bs\u00edc\u016f po l\u00e9\u010db\u011b bl\u00edzko nule*.<\/span><strong class=\"sub-title\"><span dir=\"auto\">Z\u00e1v\u011bry:\u00a0<\/span><\/strong><span dir=\"auto\">\u00a0WBH plus RT prok\u00e1zala v\u00fdznamn\u00e9 zv\u00fd\u0161en\u00ed \u00falevy od bolesti a krat\u0161\u00ed dobu odpov\u011bdi ve srovn\u00e1n\u00ed se samotnou RT u pacient\u016f s metastatick\u00fdmi kostn\u00edmi l\u00e9zemi.<\/span><\/section><\/div><\/div><div class=\"table-scroll-wrapper\"><table border=\"1\"><thead><tr><th><span dir=\"auto\">Indik\u00e1tor K\u017d\/Zlep\u0161en\u00ed Boli<\/span><\/th><th><span dir=\"auto\">RT monoterapie<\/span><\/th><th><span dir=\"auto\">RT + Hypertermie (WBH wIRA)<\/span><\/th><th><span dir=\"auto\">Dopad na K\u017d<\/span><\/th><\/tr><\/thead><tbody><tr><td><strong><span dir=\"auto\">M\u00edra \u00dapln\u00e9 Odpov\u011bdi (\u00daO) za 2 m\u011bs\u00edce<\/span><\/strong><span dir=\"auto\">\u00a0(nulov\u00e9 sk\u00f3re bolesti)<\/span><\/td><td>5,3 %<\/td><td><strong>47,4 %<\/strong><\/td><td><span dir=\"auto\">*\u00a0<\/span><strong><span dir=\"auto\">894% zv\u00fd\u0161en\u00ed<\/span><\/strong><span dir=\"auto\">\u00a0* \u0161ance na \u00fapln\u00e9 odstran\u011bn\u00ed bolesti.<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Doba do \u00fapln\u00e9 \u00falevy od bolesti<\/span><\/strong><\/td><td><span dir=\"auto\">nedosa\u017eeno<\/span><\/td><td><strong><span dir=\"auto\">10 dn\u00ed<\/span><\/strong><\/td><td><span dir=\"auto\"><strong>\u201ev\u00fdznamn\u00fd a rychl\u00fd\u201c<\/strong>\u00a0\u00a0p\u0159\u00ednos<\/span><\/td><\/tr><tr><td style=\"text-align: left;\"><strong><span dir=\"auto\">Trv\u00e1n\u00ed \u00dalevy od Boli\u00a0<\/span><\/strong><\/td><td style=\"text-align: left;\"><span dir=\"auto\">Medi\u00e1n: 28 dn\u00ed\/4 t\u00fddny u poloviny pacient\u016f<\/span><\/td><td style=\"text-align: left;\"><span dir=\"auto\">Medi\u00e1n:\u00a0<strong>Nedosa\u017eeno za 24 t\u00fddn\u016f<\/strong><\/span><\/td><td style=\"text-align: left;\"><span dir=\"auto\">Doba trv\u00e1n\u00ed \u00falevy je *\u00a0<\/span><strong><span dir=\"auto\">\u0161estin\u00e1sobn\u00e1<\/span><\/strong><span dir=\"auto\">\u00a0*, sni\u017euj\u00edc\u00ed z\u00e1vislost na analgetic\u00edch.<\/span><\/td><\/tr><\/tbody><\/table><\/div><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Ve srovn\u00e1n\u00ed s podobnou\u00a0<a title=\"Studie F\u00e1ze III Chi MS et al. 2017\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5\" target=\"_blank\" rel=\"noopener\">\u00a0studi\u00ed F\u00e1ze III publikovanou Chi MS a kol<\/a><span dir=\"auto\">\u00a0. (2017) s RF lokoregion\u00e1ln\u00ed hypertermi\u00ed, byly p\u0159\u00ednosy (<em>co se t\u00fd\u010de K\u017d a redukce bolesti)<\/em>\u00a0dosa\u017een\u00e9 pou\u017eit\u00edm WBH wIRA hypertermie v\u00fdrazn\u011b lep\u0161\u00ed \u2013 v\u00fdsledky studie RF HT + RT:<\/span><\/p><div class=\"table-scroll-wrapper\" style=\"text-align: left;\"><table border=\"1\"><thead><tr><th><span dir=\"auto\">Indik\u00e1tor K\u017d\/Zlep\u0161en\u00ed Boli<\/span><\/th><th><span dir=\"auto\">RT monoterapie<\/span><\/th><th><span dir=\"auto\">RT + Hypertermie (HT)<\/span><\/th><th>Dopad na K\u017d<\/th><\/tr><\/thead><tbody><tr><td><strong><span dir=\"auto\">M\u00edra \u00dapln\u00e9 Odpov\u011bdi (\u00daO) za 3 M\u011bs\u00edce<\/span><\/strong><span dir=\"auto\">\u00a0(nulov\u00e9 sk\u00f3re bolesti)<\/span><\/td><td>7,1 %<\/td><td>37,9 %<\/td><td><span dir=\"auto\">533% zv\u00fd\u0161en\u00ed \u0161ance na \u00fapln\u00e9 zm\u00edrn\u011bn\u00ed bolesti.<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Trv\u00e1n\u00ed \u00dalevy od Boli<\/span><\/strong><\/td><td><span dir=\"auto\">Medi\u00e1n: 55 dn\u00ed\/7,9 t\u00fddn\u016f<\/span><\/td><td><span dir=\"auto\">Medi\u00e1n: Nedosa\u017eeno za 24 t\u00fddn\u016f<\/span><\/td><td><span dir=\"auto\">Doba trv\u00e1n\u00ed \u00falevy se ztrojn\u00e1sobuje, sni\u017euj\u00edc\u00ed z\u00e1vislost na analgetic\u00edch.<\/span><\/td><\/tr><\/tbody><\/table><\/div><p style=\"text-align: left;\">\u00a0<\/p><p style=\"text-align: left;\">Shrnuto, konsolidovan\u00e9 v\u011bdeck\u00e9 d\u016fkazy (od z\u00e1kladn\u00edch studi\u00ed o wIRA technologii po kl\u00ed\u010dov\u00e1 klinick\u00e1 hodnocen\u00ed F\u00e1ze III) potvrzuj\u00ed roli WBH jako adjuvantn\u00ed terapie s v\u00edcen\u00e1sobn\u00fdm dopadem v onkologii: <strong>zvy\u0161uje \u00fa\u010dinnost WBH\/RT, aktivuje syst\u00e9mov\u00fd imunitn\u00ed syst\u00e9m (v\u010detn\u011b synergie s imunoterapi\u00ed) a dramaticky zlep\u0161uje kontrolu bolesti a K\u017d<\/strong> u pacient\u016f s rakovinou.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Syst\u00e9mov\u00e9 Fyziologick\u00e9 P\u0159\u00ednosy a Terapeutick\u00fd Potenci\u00e1l u Jin\u00fdch Patologi\u00ed<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>M\u00edrn\u00e9, kontrolovan\u00e9 teplo dod\u00e1van\u00e9 WBH s wIRA z\u00e1\u0159en\u00edm spou\u0161t\u00ed komplexn\u00ed termoregula\u010dn\u00ed odpov\u011bdi, kter\u00e9 vytv\u00e1\u0159ej\u00ed \u0161irok\u00e9 syst\u00e9mov\u00e9 p\u0159\u00ednosy, roz\u0161i\u0159uj\u00edc\u00ed terapeutick\u00fd potenci\u00e1l i mimo onkologii:<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. L\u00e9\u010dba Muskuloskelet\u00e1ln\u00edch Stav\u016f a Boli<\/h3><p style=\"text-align: left;\">WBH je \u00fa\u010dinn\u00e1 p\u0159i zvl\u00e1d\u00e1n\u00ed chronick\u00fdch bolestiv\u00fdch syndrom\u016f, vyu\u017e\u00edvaj\u00edc\u00ed sv\u00fdch fyziologick\u00fdch \u00fa\u010dink\u016f na svalov\u00fd tonus a mikrocirkulaci:<\/p><ul><li style=\"text-align: left;\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\">Dorsalgie (chronick\u00e1 bolest zad):<\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0Studie ukazuj\u00ed, \u017ee m\u00edrn\u00e1 bolest doln\u00ed \u010d\u00e1sti zad v kombinaci se stacion\u00e1rn\u00ed multimod\u00e1ln\u00ed terapi\u00ed bolesti poskytuje v\u00fdznamn\u00fd p\u0159\u00ednos pacient\u016fm s chronickou nespecifickou bolest\u00ed doln\u00ed \u010d\u00e1sti zad (dorsalgi\u00ed)\u00a0<\/span><span class=\"citation\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[53, 54]<\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0.<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\">Fibromyalgick\u00fd syndrom (FMS):<\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0WBH je zdokumentovanou dopl\u0148kovou l\u00e9\u010dbou FMS. Randomizovan\u00e9 kontrolovan\u00e9 studie prok\u00e1zaly \u00fa\u010dinnost WBH s m\u00edrnou wIRA ve standardn\u00edm multimod\u00e1ln\u00edm rehabilita\u010dn\u00edm prost\u0159ed\u00ed a vykazovaly vliv na\u00a0<\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\">intenzitu bolesti<\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0a\u00a0<\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\">du\u0161evn\u00ed stav<\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0[\u00a0<\/span><span class=\"citation\"><span dir=\"auto\" style=\"vertical-align: inherit;\">17, 56, 57<\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0]. Tento p\u0159\u00ednos je \u010d\u00e1ste\u010dn\u011b spojen se zlep\u0161enou mikrocirkulac\u00ed, co\u017e je zn\u00e1m\u00fd probl\u00e9m u pacient\u016f s FMS [55].<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\">Ankylozuj\u00edc\u00ed spondylitida (AS):<\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0WBH prok\u00e1zal imunomodula\u010dn\u00ed \u00fa\u010dinky u pacient\u016f s AS. Studie uv\u00e1d\u011bj\u00ed schopnost WBH zvy\u0161ovat protiz\u00e1n\u011btliv\u00e9 medi\u00e1tory, jako je\u00a0<\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\">interleukin-10<\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0(IL-10), a modulovat proz\u00e1n\u011btliv\u00e9 cytokiny, jako je TNF-\u03b1, co\u017e nazna\u010duje prosp\u011b\u0161nou roli p\u0159i zvl\u00e1d\u00e1n\u00ed chronick\u00e9ho z\u00e1n\u011btu spojen\u00e9ho s t\u00edmto onemocn\u011bn\u00edm\u00a0<\/span><span class=\"citation\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[58, 59, 52]<\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0.<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\">Raynaud\u016fv fenom\u00e9n u syst\u00e9mov\u00e9 skler\u00f3zy:<\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0Bylo zji\u0161t\u011bno, \u017ee infra\u010derven\u00e1 hypertermie je \u00fa\u010dinn\u00e1 p\u0159i l\u00e9\u010db\u011b vazokonstrik\u010dn\u00edch symptom\u016f spojen\u00fdch s Raynaudov\u00fdm fenom\u00e9nem asociovan\u00fdm se sklerodermi\u00ed a prokazuje c\u00e9vn\u00ed p\u0159\u00ednosy [49].<\/span><\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\"><span dir=\"auto\">B. Kardiovaskul\u00e1rn\u00ed a ob\u011bhov\u00e9 zdrav\u00ed \u2764\ufe0f<\/span><\/h3><p style=\"text-align: left;\"><span dir=\"auto\">Krom\u011b zlep\u0161en\u00ed perfuze n\u00e1doru m\u00e1 WBH specifick\u00e9 \u00fa\u010dinky na ob\u011bhov\u00fd syst\u00e9m:<\/span><\/p><ul><li style=\"text-align: left;\"><strong><span dir=\"auto\">Esenci\u00e1ln\u00ed hypertenze:<\/span><\/strong><span dir=\"auto\">\u00a0S\u00e9rie studi\u00ed zkoumala pou\u017eit\u00ed m\u00edrn\u00e9 IR-A hypertermie u pacient\u016f s arteri\u00e1ln\u00ed hypertenz\u00ed (stadium WHO I a II). Zji\u0161t\u011bn\u00ed nazna\u010duj\u00ed, \u017ee s\u00e9riov\u00e1 l\u00e9\u010dba m\u016f\u017ee pozitivn\u011b ovlivnit\u00a0<\/span><strong><span dir=\"auto\">centr\u00e1ln\u00ed a perifern\u00ed pulzn\u00ed vlny<\/span><\/strong><span dir=\"auto\">\u00a0, krevn\u00ed tlak a\u00a0<\/span><strong><span dir=\"auto\">viskozitu krve<\/span><\/strong><span dir=\"auto\">\u00a0, co\u017e potvrzuje roli WBH jako nefarmakologick\u00e9 mo\u017enosti fyzioterapie [\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">44, 47<\/span><\/span><span dir=\"auto\">\u00a0].<\/span><\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \" style=\"text-align: left;\"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\"><span dir=\"auto\">C. Neuroendokrinn\u00ed a psychologick\u00e9 \u00fa\u010dinky<\/span><\/h3><p style=\"text-align: left;\"><span dir=\"auto\">WBH zapojuje neuroendokrinn\u00ed syst\u00e9my t\u011bla a ovliv\u0148uje n\u00e1ladu a metabolismus:<\/span><\/p><ul><li style=\"text-align: left;\"><strong><span dir=\"auto\">Velk\u00e1 depresivn\u00ed porucha (MDD):<\/span><\/strong><span dir=\"auto\">\u00a0Randomizovan\u00e1 klinick\u00e1 studie prok\u00e1zala, \u017ee jednor\u00e1zov\u00e1 terapie teplou vodou m\u016f\u017ee p\u016fsobit jako rychle p\u016fsob\u00edc\u00ed antidepresivum, co\u017e vede ke zm\u00edrn\u011bn\u00ed depresivn\u00edch symptom\u016f na n\u011bkolik t\u00fddn\u016f. Tento \u00fa\u010dinek je spojen s aktivac\u00ed imunitn\u00edch a z\u00e1n\u011btliv\u00fdch drah, kter\u00e9 ovliv\u0148uj\u00ed mozek, vyvolanou teplem [51].<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\">Hormon\u00e1ln\u00ed modulace (endokrinologie):<\/span><\/strong><span dir=\"auto\">\u00a0WBH stimuluje\u00a0<\/span><strong><span dir=\"auto\">osu hypotalamus-hypof\u00fdza-nadledviny (HPA)<\/span><\/strong><span dir=\"auto\">\u00a0a ovliv\u0148uje hladiny hormon\u016f. Studie dokumentovaly reakce\u00a0<\/span><strong><span dir=\"auto\">r\u016fstov\u00e9ho hormonu<\/span><\/strong><span dir=\"auto\">\u00a0a\u00a0<\/span><strong><span dir=\"auto\">prolaktinu<\/span><\/strong><span dir=\"auto\">\u00a0b\u011bhem celot\u011blov\u00e9 hypertermie, co\u017e zd\u016fraz\u0148uje jej\u00ed vliv na endokrinn\u00ed regulaci [\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">42, 43<\/span><\/span><span dir=\"auto\">\u00a0].<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\">Metabolismus a bun\u011b\u010dn\u00e1 reakce:<\/span><\/strong><span dir=\"auto\">\u00a0Teplo zrychluje baz\u00e1ln\u00ed metabolismus. Na bun\u011b\u010dn\u00e9 \u00farovni teplo ovliv\u0148uje kinetiku pO2 a je spojeno se synt\u00e9zou ochrann\u00fdch protein\u016f, jako je\u00a0<\/span><strong><span dir=\"auto\">feritin<\/span><\/strong><span dir=\"auto\">\u00a0, v k\u016f\u017ei, co\u017e podporuje opravu tk\u00e1n\u00ed [48; 46].<\/span><\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u010casto Kladen\u00e9 Ot\u00e1zky (FAQ) o Doporu\u010den\u00fdch WBH Sezen\u00edch a C\u00edlov\u00fdch Teplot\u00e1ch<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p><i>L\u00e9\u010dba\u00a0<\/i><i>sm\u00ed<\/i>\u00a0<i>b\u00fdt<\/i>\u00a0<i>prov\u00e1d\u011bna<\/i><i>\u00a0pouze po\u00a0<\/i><i>kone\u010dn\u00e9<\/i>\u00a0<i>konzultaci<\/i>\u00a0<i>s<\/i><i>\u00a0l\u00e9ka\u0159em<\/i><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div><h4>Jak\u00fd je doporu\u010den\u00fd protokol Celot\u011blov\u00e9 Hypertermie (WBH) pro Esenci\u00e1ln\u00ed Hypertenzi?<\/h4><div><p>Protokol pro Esenci\u00e1ln\u00ed Hypertenzi doporu\u010duje 12 sezen\u00ed s c\u00edlovou teplotou 38,3 \u00b0C. Ka\u017ed\u00e9 sezen\u00ed trv\u00e1 p\u0159ibli\u017en\u011b 45 minut, v\u010detn\u011b 30minutov\u00e9 f\u00e1ze zvy\u0161ov\u00e1n\u00ed teploty a 15minutov\u00e9 f\u00e1ze odpo\u010dinku (bez f\u00e1ze plata).<\/p><\/div><\/div><div><h4>Jak\u00e9 jsou doporu\u010den\u00e9 WBH parametry pro Chronickou Bolest Zad (Dorsalgie)?<\/h4><div><p>Pro Dorsalgii se obvykle doporu\u010duje 6 sezen\u00ed, s c\u00edlem 38,4 \u00b0C. Celkov\u00e1 doba sezen\u00ed je p\u0159ibli\u017en\u011b 90 minut, se 45 minutami zvy\u0161ov\u00e1n\u00ed teploty, 15minutovou f\u00e1z\u00ed plata a 30 minutami odpo\u010dinku.<\/p><\/div><\/div><div><h4>Jak\u00fd je WBH protokol pro Fibromyalgii a Ankylozuj\u00edc\u00ed Spondylitidu?<\/h4><div><p>Fibromyalgie i Ankylozuj\u00edc\u00ed Spondylitida obvykle n\u00e1sleduj\u00ed protokol 6 sezen\u00ed, s c\u00edlem 38,5 \u00b0C. Celkov\u00e1 doba sezen\u00ed je p\u0159ibli\u017en\u011b 90 minut, v\u010detn\u011b 45 minut zvy\u0161ov\u00e1n\u00ed teploty, 15minutov\u00e9ho plata a 30 minut odpo\u010dinku.<\/p><\/div><\/div><div><h4>Jak\u00fd je doporu\u010den\u00fd protokol pro WBH jako Dopl\u0148kovou L\u00e9\u010dbu Rakoviny?<\/h4><div><p>Jako dopl\u0148kov\u00e1 l\u00e9\u010dba rakoviny vy\u017eaduje protokol 2 nebo v\u00edce sezen\u00ed s c\u00edlovou teplotou j\u00e1dra mezi 39,0 \u00b0C a 40,0 \u00b0C. Celkov\u00e1 doba sezen\u00ed je nejdel\u0161\u00ed, v rozmez\u00ed 3 a\u017e 4 hodiny, co\u017e zahrnuje 60-90 minut pro f\u00e1zi zvy\u0161ov\u00e1n\u00ed teploty, 60-90 minut pro f\u00e1zi plata a 60 minut pro f\u00e1zi odpo\u010dinku.<\/p><\/div><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div><div class=\"wpb_content_element \"><div><div><div><div class=\"wpb_content_element \"><div class=\"table-scroll-wrapper\"><table width=\"1151\"><tbody><tr><td width=\"278\">Indikace<\/td><td width=\"99\">Po\u010det sezen\u00ed<\/td><td width=\"135\">C\u00edlov\u00e1 teplota<\/td><td colspan=\"2\" width=\"309\">Doba terapie<br \/>F\u00e1ze zvy\u0161ov\u00e1n\u00ed\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 F\u00e1ze plata<\/td><td width=\"164\">Doba odpo\u010dinku<br \/>F\u00e1ze odpo\u010dinku<\/td><td width=\"164\"><b>Celkov\u00e1<\/b><br \/><b>Doba WBH sezen\u00ed<\/b><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Esenci\u00e1ln\u00ed Hypertenze<\/td><td rowspan=\"2\" width=\"99\">12<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Dorsalgie<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,4 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Fibromyalgie<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Ankylozuj\u00edc\u00ed Spondylitida<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Syst\u00e9mov\u00e1 Skler\u00f3za<\/td><td rowspan=\"2\" width=\"99\">15<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Velk\u00e1 Depresivn\u00ed Porucha<\/td><td rowspan=\"2\" width=\"99\">1+<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>105 -170 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 2-3\u00a0<\/b><b>hodiny<\/b><\/td><\/tr><tr><td width=\"155\">45-110 min<\/td><td width=\"155\">60 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Dopl\u0148kov\u00e1 L\u00e9\u010dba Rakoviny<\/td><td rowspan=\"2\" width=\"99\">2+<\/td><td rowspan=\"2\" width=\"135\">39,0-40,0 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>120-180 min<\/b><\/td><td rowspan=\"2\" width=\"164\">60 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 3-4\u00a0<\/b><b>hodiny<\/b><\/td><\/tr><tr><td width=\"155\">60-90 min<\/td><td width=\"155\">60-90 min<\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div><div id=\"ut-row-inner-68e7a7d03e7dd\" class=\"vc_row wpb_row vc_inner vc_row-fluid ut-row-inner-68e7a7d03e7ec\"><div class=\"wpb_column vc_column_container vc_col-sm-6\"><div id=\"ut-column-inner-68e7a7d03eb05\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"wpb_content_element\"><div id=\"ut_bi_68e7a7d03ebdb\" class=\"bklyn-big-icon-wrap\"><div class=\"bklyn-big-icon bklyn-big-icon-square\">\u00a0<\/div><p class=\"bklyn-big-icon-title\">\u00a0<\/p><\/div><\/div><\/div><\/div><\/div><\/div><p>\u00a0<\/p><\/div><\/div><\/div><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>POZN\u00c1MKA: tento \u010dl\u00e1nek nen\u00ed vy\u010derp\u00e1vaj\u00edc\u00edm seznamem studi\u00ed a \u00fa\u010dink\u016f WBH wIRA<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">References and Citations<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><ol><li style=\"text-align: left;\">Ardenne M. von. Moderate Hyperthermie als Behandlungsmethode mit vielen Indikationen. \u00c4rztzeitschr Naturheilverf 1994; 5:356-61.<\/li><li style=\"text-align: left;\">B\u00e4umler H., Scherf H.P., Aurisch R., et al. Einflu\u00df einer Serie von Infrarot-Ganzk\u00f6rperbestrahlungen auf Flie\u00dfeigenschaften des Blutes und die H\u00e4modynamik. Perfusion 1990: 138-43.<\/li><li style=\"text-align: left;\">Heckel M. Ganzk\u00f6rper-Hyperthermie und Fiebertherapie, Grundlagen und Praxis. Stuttgart: Hippokrates Verlag, 1990.<\/li><li style=\"text-align: left;\">Kosaka M., Sugahara T., Schmidt K.L., Simon E. Thermotherapy: Principles and Practice. Heidelberg: Springer Verlag, 2000.<\/li><li style=\"text-align: left;\">Meffert H., Hecht H.C., G\u00fcnther H., et al. Biophysikalische Ergebnisse des klinischen Tests der IRA-Therm-Hyperthermietechnik der 2. Generation. ThermoMed 1990; 6:71-78.<\/li><li style=\"text-align: left;\">Schmidt K.L. Hyperthermie und Fieber, Wirkungen bei Mensch und Tier. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1987.<\/li><li style=\"text-align: left;\">Vaupel P., Kr\u00fcger W. W\u00e4rmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsm\u00f6glichkeiten. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1995.<\/li><li style=\"text-align: left;\">Piazena H., Meffert H. Optische Eigenschaften der Haut und die photobiologischen Grundlagen zur Dosierung von IR-Hautbestrahlungen in vivo und in vitro. 6. Symposium Licht und Gesundheit 2008 13.-14.03. Berlin, 2008:162-178.<\/li><li style=\"text-align: left;\">Zschaeck S. and Beck M. Chapter 8 Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?<\/li><li style=\"text-align: left;\">Zhang H, Wang W, Zhang S, Huang W. Comparison of the anti-tumor effects of various whole-body hyperthermia protocols&#8230; Immunol Invest. 2005;34(3):245-58.<\/li><li style=\"text-align: left;\">Abreu MM, Chocron AF, Smadja DM. From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. Front Immunol. 2025 Feb 28;16:1487296.<\/li><li style=\"text-align: left;\">Bull JMC. et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-\u03b1: A description of a phase I-II protocol. Journal of Hyperthermia. 2008; 24(8): 649-662.<\/li><li style=\"text-align: left;\">Weigelin B. Visualization of the immune effect of hyperthermia. ICHO 2021, Session: Hyperthermia and immunology.<\/li><li style=\"text-align: left;\">Faghihi Moghaddam F, Bakhshandeh M, Mofid B, et al. Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone&#8230; J Therm Biol. 2024 Feb;120:103804.<\/li><li style=\"text-align: left;\">Hildebrandt B, Dr\u00e4ger J, Kerner T. et al. Whole-body hyperthermia in the scope of von Ardenne\u2019s systemic cancer multistep therapy (sCMT)&#8230; International Journal of Hyperthermia. 2004;3:317\u2013333.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin in patients with recurrent ovarian cancer \u2013 a phase II study. Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Brockow T., Wagner A., Franke A., Offenb\u00e4cher M., Resch K.L. A Randomized Controlled Trial on the Effectiveness of Mild Water-filtered Near Infrared Whole-body Hyperthermia&#8230; Clin J Pain 2007; 1:67-75.<\/li><li style=\"text-align: left;\">Kleef R, Nagy R, Baierl A, et al. Low-dose Ipilimumab plus Nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series&#8230; Cancer Immunol Immunother. 2021;70:1393\u2013403.<\/li><li style=\"text-align: left;\">Adachi H., Katsuno M., Waza M., et al. Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications. Int J Hyperthermia 2009; 8:647-54.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin&#8230; Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Figueroa G., et al. An Update of a Phase II Clinical Trial Using Fever-Range Whole-Body Thermal Therapy (FR-WB-TT)&#8230; Soc for Thermal Med Joint Annual Meeting, 14.-17.5.2007.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Strebel F.R., et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine and daily interferon-\u03b1: A description of a phase I-II protocol. Int J Hyperthermia 2008; 8:649-62.<\/li><li style=\"text-align: left;\">Bull J.M., Nagle V.L., Scott G., et al. A phase-I-study of optimally-timed Gemcitabine + Cisplatin\/Interferon-a combined with long-duration, low-temperature whole-body hyperthermia. ESHO 2001, Verona\/ Italy, 30.05.-02.06.2001:67.<\/li><li style=\"text-align: left;\">Capitano M., Mace T., Nemeth M., et al. A novel strategy for improving neutrophil recovery following total body irradiation. Soc for Thermal Med Joint Annual Meeting, 24.-26.4.2010.<\/li><li style=\"text-align: left;\">Dayanc B.E., Ostberg J.R., Repasky E.A. Enhancement of NK Cell Cytotoxic Activity by Mild Thermal Stress. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Hajto T., Hostanska K. Effect of in vivo hyperthermia on human natural killer cells. Clin Trials J 1985; 6:514-20.<\/li><li style=\"text-align: left;\">Hattori T., Kokura S., Okuda T., et al. Antitumor effect of whole body hyperthermia with \u03b1-galactosylceramide in a subcutaneous tumor model of colon cancer. Int J Hyperthermia 2007; 7:591-98.<\/li><li style=\"text-align: left;\">Kisailus A., Pritchard M., Li Y., Ostberg J., Repasky E.A. Thermal Regulation of Antigen Presenting Cells: Use of Hyperthermia as an Adjuvant for Cancer Vaccines. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Multhoff G. Letter to Editor, Hyperthermia classic commentary: Activation of natural killer (NK) cells by heat shock protein 70&#8230; Int J Hyperthermia 2009; 3:176-79.<\/li><li style=\"text-align: left;\">Peer A.J., Grimm M.J., Zynda E.R., Repasky E.A. Diverse immune mechanisms may contribute to the survival benefit seen in cancer patients receiving hyperthermia. Immunol Res 2010; 1-3:137-154.<\/li><li style=\"text-align: left;\">Rowe R.W., Stebel F.R., Proett J.M., et al. Fever-range whole body thermotherapy combined with oxaliplatin: A curative regimen in a pre-clinical breast cancer model. Int J Hyperthermia 2010; 6:565-76.<\/li><li style=\"text-align: left;\">Schencking M., Frese T., Sandholzer H. Behandlung einer Radikulopathie bei oss\u00e4rer Metastasierung der Lendenwirbels\u00e4ule durch Infrarot-A-Ganzk\u00f6rperhyperthermie. Forsch Komplementmed 2008; 15:273-76.<\/li><li style=\"text-align: left;\">Scott G.L., Bull J.M.C., Kochn M. Management of Conscious Sedation&#8230; 9th Int Congress on Hyperthermic Oncology, 20.-24.4.2004.<\/li><li style=\"text-align: left;\">Shecterle L.M., Cyr J.A.S. Hyperthermia Aids Patients with Advanced Lung Cancer. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Skitzki J.J., Repasky E.A., Evans S.S. Hyperthermia as an immunotherapy strategy for cancer. Current Opnion in Investigational Drugs 2009; 6: 550-58.<\/li><li style=\"text-align: left;\">Toyota N., Strebel F.R., Stephens L.C., et al. Long-duration, mild whole body hyperthermia with cisplatin: tumour response and kinetics of apoptosis and necrosis&#8230; Int. J. Hyperthermia 1997; 5:497-506.<\/li><li style=\"text-align: left;\">Wang X.Y., Kazim L., Repasky E.A., Subjeck J.R. Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines&#8230; J of Immunology 2001; 165:490-97.<\/li><li style=\"text-align: left;\">VanderZee J., DeBruijne M., Mens J.W.M., et al. Reirradiation combined with hyperthermia in breast cancer recurrences&#8230; Int J Hyperthermia 2010; 7:638-48.<\/li><li style=\"text-align: left;\">Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia for locally advanced breast cancer. Int J Hyperthermia 2010; 7:618-24.<\/li><li style=\"text-align: left;\">Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence&#8230; Int J Hyperthermia 2010; 7: 612\u201317.<\/li><li style=\"text-align: left;\">Sen A., Capitano M., Dommer M., et al. Thermoregulatory responses to mild systemic thermal stress increase tumor perfusion&#8230; Cancer Res. 2011; 71(11):3872-3880.<\/li><li style=\"text-align: left;\">Koska J., Rovensky J., Zimanova T., Vigas M. Growth hormone and prolactin responses during partial and whole body warm-water immersions. Acta Physiol Scand. 2003 May;178(1):19-23.<\/li><li style=\"text-align: left;\">Vigas M., Rovensky J., Zimanova T., Koska J. Responses of growth hormone and prolactin to local and whole-body application of Piestany mud. Acta Rheumatol et Balneol Pistiniana 2002:31-38.<\/li><li style=\"text-align: left;\">Meffert B., Hochmuth O., Steiner M. Effects of a multiple mild infrared a induced hyperthermia on central and peripheral pulse waves in hypertensive patients. North Sea Conference on Biomedical Engineering 1990.<\/li><li style=\"text-align: left;\">Meffert H., Scherf HP., Meffert B. Milde Infrarot-A-Hyperthermie. Auswirkungen von Serienbestrahlungen mit wassergefilterter Infrarotstrahlung&#8230; Akt Dermatol 1993; 19:142-48.<\/li><li style=\"text-align: left;\">Applegate L.A., Scaletta C., Panizzon R., et al. Induction of the putative protein ferritin by infrared radiation: Implications in skin repair. Int J of Molecular Med 2000; 5:247-51.<\/li><li style=\"text-align: left;\">Scherf H.P., Meffert H., B\u00e4umler H., et al. Wirkung einer einmaligen milden Infrarot-A-Hyperthermie auf K\u00f6rpertemperatur, Herzfrequenz, Blutdruck und Blutviskosit\u00e4t&#8230; Dermatol Monatsschr 1989; 175:733-40.<\/li><li style=\"text-align: left;\">Streffer C. Metabolic changes during and after hyperthermia. Int J Hyperthermia 1985; 4:305-319.<\/li><li style=\"text-align: left;\">F\u00f6rster J., Fleischanderl S., Wittstock S., et al. Infrared-Mediated Hyperthermia is Effective in the Treatment of Scleroderma-Associated Raynaud\u2019s Phenomenon. J of Investigative Dermatology 2005; 6:1313-16.<\/li><li style=\"text-align: left;\">Koska J., Rovensky J., Zimanova T., et al. Sympathoadrenal regulation of circulatory responses to whole-body hyperthermia&#8230; Acta Rheumatol et Balneol Pistiniana 2002:23-30.<\/li><li style=\"text-align: left;\">Janssen C.W., Lowry C.A., Mehl M.R., et al. Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder \u2013 A Randomized Clinical Trial. JAMA Psychiatry. 2016 May 12.<\/li><li style=\"text-align: left;\">Tarner I.H., Ladner U.M., Uhlemann C., Lange U. The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1 beta and IL-6 in patients with ankylosing spondylitis. Clin Rheumatol 2009; 4:397-402.<\/li><li style=\"text-align: left;\">Ettrich U., Konrad B., Prate K., et al. Milde Ganzk\u00f6rperhyperthermie in Kombination mit station\u00e4rer multimodal orientierter Schmerztherapie&#8230; Orthop\u00e4de 2014; 2:165-74.<\/li><li style=\"text-align: left;\">Weller E., Ullrich D. Infrarot-A-Hyperthermie-Anwendung bei Patienten mit Analgetica-Abusus wegen chronischer R\u00fcckenschmerzen. Vortrag auf dem 95. Kongre\u00df der Gesellschaft f\u00fcr Phys Med und Rehab 5.10.1990.<\/li><li style=\"text-align: left;\">Morf S., Vesti B.A., Forster A., et al. Microcirculation abnormalities in patients with fibromyalgia \u2013 measured by capillary and laser fluxmetry. Arthritis Res Ther 2005; 7:R209-16.<\/li><li style=\"text-align: left;\">Walz J., Hinzmann J., Haase I., Witte T. Ganzk\u00f6rperhyperthermie in der Schmerztherapie \u2013 eine kontrollierte Studie an Patienten mit Fibromyalgiesyndrom. Schmerz 2013; 27:38-45.<\/li><li style=\"text-align: left;\">Romeyke T., Stummer H. Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic whole-body hyperthermia&#8230; J Musculoskel Pain 2014; 4:341-55.<\/li><li style=\"text-align: left;\">Zauner D., Quehenberger F., Hermann J., et al. Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study. Int J Hyperthermia 2014; 6:393-401.<\/li><li style=\"text-align: left;\">Lange U., M\u00fcller-Ladner U., Dischereit G. Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis&#8230; Akt Rheumatol 2017; 2:122-128.<\/li><\/ol><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>\u00a0<\/p><\/section><footer>\u00a9 <time>2025<\/time> Romanian Society Oncologic Hyperthermia All rights reserved. Source: Analysis based on scientific literature.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Celot\u011blov\u00e1 Hypertermie (WBH) v Onkologii a Jin\u00fdch Patologi\u00edch: Konsolidovan\u00e1 Synergie, Imunomodulace a Klinick\u00e9 studie Zve\u0159ejn\u011bno:\u00a02025-10-13\u00a0| Posledn\u00ed Revize:\u00a02025-10-13 Auto\u0159i: Veronica Iatan, M.D., Cristian Gologan, M.Sc. Celot\u011blov\u00e1 Hypertermie (WBH) je syst\u00e9mov\u00e1 onkologick\u00e1 strategie zahrnuj\u00edc\u00ed \u0159\u00edzen\u00e9 zv\u00fd\u0161en\u00ed centr\u00e1ln\u00ed t\u011blesn\u00e9 teploty, \u010dasto prov\u00e1d\u011bn\u00e9 pomoc\u00ed technologie Vodou filtrovan\u00e9ho Infra\u010derven\u00e9ho-A (wIRA). WBH je z\u00e1sadn\u011b chemo\/radio-senzibiliz\u00e1tor, kter\u00fd v\u00fdznamn\u011b zlep\u0161uje prokrven\u00ed tumoru a<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/cs\/klinicke-studie-hypertermie-wira-onkologi\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-973","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/cs\/wp-json\/wp\/v2\/pages\/973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/cs\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/cs\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/cs\/wp-json\/wp\/v2\/comments?post=973"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/cs\/wp-json\/wp\/v2\/pages\/973\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/cs\/wp-json\/wp\/v2\/media?parent=973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}