{"id":974,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2025-12-19T07:58:17","modified_gmt":"2025-12-19T07:58:17","slug":"kliniske-forsoeg-hypertermi-wbh-wira-onkologi","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/da\/kliniske-forsoeg-hypertermi-wbh-wira-onkologi\/","title":{"rendered":"Kliniske fors\u00f8g"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"974\" class=\"elementor elementor-974 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Helkrops Hypertermi (WBH) i Onkologi og Andre Patologier: Konsolideret Synergi, Immunmodulering og Kliniske fors\u00f8g\n\u200b<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header><p><strong>Udgivet:\u00a0<time datetime=\"2025-10-13\">2025-10-13<\/time>\u00a0| Seneste Revision:\u00a0<time datetime=\"2025-10-13\">2025-10-13<\/time><\/strong><\/p><\/header><div class=\"authors\"><p>Forfattere:<br \/><a href=\"https:\/\/ardenneiratherm.com\/da\/our-team\/veronica-iatan\/\">Veronica Iatan, M.D.<\/a>,<br \/><a href=\"https:\/\/ardenneiratherm.com\/da\/our-team\/cristian-gologan\/\">Cristian Gologan, M.Sc.<\/a><\/p><\/div><section class=\"ai-summary\"><p><b>Helkrops Hypertermi (WBH)<\/b> er en systemisk onkologisk strategi, der involverer kontrolleret h\u00e6vning af den centrale kropstemperatur, ofte ved hj\u00e6lp af <b>Vandfiltreret Infrar\u00f8d-A (wIRA)-teknologi<\/b>. WBH er prim\u00e6rt en <b>Kemo\/Radio-sensibilisator<\/b>, der signifikant forbedrer tumorperfusion og iltning for at \u00f8ge effektiviteten af traditionelle behandlinger. Vigtigst er, at den fungerer som en st\u00e6rk <b>Systemisk Immunmodulator<\/b>, der mobiliserer Varmestoksproteiner (HSP) og T-celler. Denne handling skaber essentiel synergi med avanceret <b>Immuno-terapi (ICI)<\/b>\u00a0og giver dramatisk, hurtig smertelindring og forbedret Livskvalitet (LK) ved forskellige kr\u00e6ftformer og kroniske tilstande som Fibromyalgi.<\/p><\/section><section class=\"disclaimer\"><b>\u00a0Medicinsk Ansvarsfraskrivelse: Denne artikel er udelukkende beregnet til informationsform\u00e5l og er ikke en erstatning for individuel medicinsk konsultation, diagnose eller behandling fra en autoriseret l\u00e6ge.<\/b><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. Definition af Helkrops Hypertermi (WBH) og Terapeutisk Teknologi<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"text-align: center;\"><div><div><div><div><header><div style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\"><b>Helkrops Hypertermi (WBH)<\/b>, eller <b>systemisk hypertermi<\/b>, defineres som en kontrolleret forh\u00f8jelse af den centrale kropstemperatur til terapeutiske form\u00e5l. Baseret p\u00e5 spektret af <b>effekter af naturlig feber ved forskellige temperaturer<\/b>, differentieres WBH-procedurerne s\u00e5ledes:<\/p><ul style=\"text-align: left;\"><li>*<b>Mild WBH<\/b>:* &lt; 38,5\u00b0C<\/li><li>*<b>Moderat WBH<\/b>:* 38,5\u00b0C \u2013 40,5 \u00b0C<\/li><li>*<b>Ekstrem WBH<\/b>:* &gt; 40,5\u00b0C<\/li><\/ul><p style=\"text-align: left;\">Is\u00e6r mild og moderat WBH <b>\u00f8ger blodgennemstr\u00f8mningen (perfusionen)<\/b>, stimulerer stofskiftet, reducerer muskeltonus og\u00a0<strong>stimulerer immunsystemet.<\/strong><\/p><p style=\"text-align: left;\"><a title=\"Tekniske detaljer for von Ardenne IRATHERM\u00ae 1000M WBH wIRA-apparatet\" href=\"https:\/\/ardenneiratherm.com\/da\/ardenne-iratherm-hyperthermia-apparat-wira\/\"><b>von Ardenne IRATHERM\u00ae 1000M WBH wIRA-hypertermi apparatet<\/b><\/a>\u00a0anvender til dette form\u00e5l udelukkende <b>dybt gennemtr\u00e6ngende, vandfiltreret Infrar\u00f8d-A (wIRA) varmestr\u00e5ling, som er sk\u00e5nsom mod huden (uden IR-B \/ IR-C)<\/b>. Systemets \u00e5bne, ikke-klaustrofobiske design sikrer en j\u00e6vn str\u00e5lingsintensitet over patientens hele overflade (ryg) og tilbyder brugeren en optimal, patientspecifik varmetilf\u00f8rsel i form af placering og intensitet.<\/p><p style=\"text-align: left;\">Vandfiltreret Infrar\u00f8d-A str\u00e5ling svarer til solens naturlige varmestr\u00e5ling og danner det teknologiske grundlag for en j\u00e6vn og sk\u00e5nsom varmep\u00e5f\u00f8ring.[1, 5, 7, 8].<\/p><p style=\"text-align: left;\">Ved at anvende von Ardenne IRATHERM<sup>\u00ae<\/sup>\u00a01000-princippet, som er blevet udviklet og bevist i over 30 \u00e5r, lykkedes det\u00a0<a title=\"Prof. Manfred von Ardenne - Bidrag\" href=\"https:\/\/ardenneiratherm.com\/da\/our-team\/manfred-von-ardenne\/\">Prof. Manfred von Ardenne<\/a>\u00a0fysisk og teknisk at reproducere denne varmestr\u00e5ling og g\u00f8re den industrielt tilg\u00e6ngelig til varig medicinsk brug gennem helkrops hypertermi.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Videnskabeligt Grundlag og Systemiske Effekter<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"text-align: center;\"><div><div><div><div><header><div style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">WBH har udviklet sig til en strategi baseret p\u00e5 solide biofysiske og fysiologiske principper. Inden for onkologien er der fokus p\u00e5 <b>Moderat<\/b>\u00a0og <b>Feber-range Hypertermi (HRV-WBH)<\/b>, anerkendt som behandlinger med multiple terapeutiske indikationer.[1,3[<\/p><p style=\"text-align: left;\">Det teknologiske grundlag for j\u00e6vn og sk\u00e5nsom varmep\u00e5f\u00f8ring leveres ofte af apparater, der anvender <b>Vandfiltreret Infrar\u00f8d-A (wIRA) str\u00e5ling<\/b>. Detaljerede biofysiske unders\u00f8gelser har bekr\u00e6ftet <b>denne teknologis evne til at sikre dyb og kontrolleret opvarmning<\/b>, under hensyntagen til hudens optiske egenskaber og det fotobiologiske grundlag for dosering.[5,7,8].<\/p><p style=\"text-align: left;\">Detaljerede biofysiske unders\u00f8gelser har bekr\u00e6ftet\u00a0<strong>wIRA-teknologiens evne<\/strong>\u00a0til at sikre <b>dyb og kontrolleret opvarmning<\/b>[5,7,8]. P\u00e5 et fysiologisk niveau har WBH fundamentale systemiske virkninger:<\/p><ol style=\"text-align: left;\"><li><strong>Forbedret Blodreologi:<\/strong>\u00a0Eksponering for IR-WBH p\u00e5virker gunstigt <b>blodets str\u00f8mningsegenskaber og h\u00e6modynamik[2]<\/b>, hvilket underst\u00f8tter den grundl\u00e6ggende mekanisme for <b>forbedret tumorperfusion<\/b>\u00a0\u2014 en kritisk foruds\u00e6tning for succes med systemiske behandlinger.<\/li><li><strong>Generel Biologisk Aktivering:<\/strong>\u00a0WBH inducerer en varmestressreaktion, der udl\u00f8ser en kaskade af biologiske processer, herunder <b>modulering af hormonsystemet<\/b>\u00a0og <b>acceleration af stofskiftet[4,6]<\/b>.<\/li><\/ol><p style=\"text-align: left;\">Baseret p\u00e5 disse fundamenter fungerer WBH som en\u00a0<strong>Systemisk Immunmodulator<\/strong>, der optimerer\u00a0<strong>Tumor-mikromilj\u00f8et (TMM)<\/strong>\u00a0og <b>forst\u00e6rker effektiviteten af avancerede onkologiske behandlinger<\/b>.[9]<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. N\u00f8glehandlingsmekanismer (Molekyl\u00e6re, Fysiologiske og Immunologiske)\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">De terapeutiske virkninger af WBH er komplekse, medieret af \u00e6ndringer p\u00e5 cellul\u00e6rt, immunologisk og fysiologisk niveau:<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Synergi med Kemoterapi og Str\u00e5lebehandling (Kemo\/Radio-sensibilisator)<\/h3><ul><li style=\"text-align: left;\"><strong>Optimering af Tumor-mikromilj\u00f8et (TMM):<\/strong>\u00a0WBH forbedrer <b>tumorens blodperfusion<\/b>\u00a0og <b>iltning, hvilket vender tumorhypoksi<\/b>. Dette er afg\u00f8rende, da veliltede tumorceller er signifikant mere f\u00f8lsomme over for destruktion ved <b>Kemoterapi<\/b>\u00a0(KT) og <b>Str\u00e5lebehandling<\/b>\u00a0(ST).[9,41]<\/li><li style=\"text-align: left;\"><strong>Kemo\/Radio-effektivitet:<\/strong>\u00a0Hypertermi fungerer som en\u00a0<strong class=\"key-term\">Kemo &amp; Radio Sensibilisator<\/strong>, der forbedrer ilttilf\u00f8rslen til tumoren (radio-sensibiliserende effekt) og \u00f8ger effektiviteten af l\u00e6gemidler som Cisplatin, Gemcitabin og Carboplatin.\u00a0<span class=\"citation\">[12, 16, 36]<\/span>.<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"text-align: center;\"><div><div><div><div><header><div style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Induktion af Robust Anti-Tumor Immunrespons (Immunmodulering)<\/h3><p style=\"text-align: left;\">WBH er en st\u00e6rk aktivator af kroppens forsvarssystem:<\/p><ul><li style=\"text-align: left;\"><strong>Varmestoksproteiner (HSP):<\/strong>\u00a0Varmestress stimulerer syntesen og frigivelsen af <b>HSP70<\/b>. Disse proteiner fungerer som \u2018fare-signaler\u2019, der markerer kr\u00e6ftceller for et forst\u00e6rket angreb af immunsystemets <b>Cytotoksiske T-Lymfocytter (CTL)<\/b>.[9, 10, 29].<\/li><li style=\"text-align: left;\"><strong>Aktivering af N\u00f8gleimmunceller:<\/strong>\u00a0Temperaturintervallet 39-43\u00b0C \u00f8ger aktiviteten af <b>Naturlige Dr\u00e6ber (NK) celler<\/b>\u00a0og fremmer aktiviteten af <b>hj\u00e6lper- og cytotoksiske T-celler<\/b>, <b>dendritiske celler\u00a0<\/b>og <b>makrofager,<\/b> mens det\u00a0<u>potentielt kompromitterer immunsuppressive celler<\/u>.[9, 10, 11, 25, 26].<\/li><li style=\"text-align: left;\"><strong>For\u00f8gelse af T-Lymfocytter:<\/strong>\u00a0HRV-WBH kan <b>signifikant \u00f8ge (f.eks. 3 gange)<\/b>\u00a0populationen af cytotoksiske T-lymfocytter i lymfoide organer, <b>hvilket forst\u00e6rker det systemiske anti-tumor immunangreb<\/b>.[10]<\/li><li style=\"text-align: left;\"><strong>Vacciner og APC\u2019er:<\/strong>\u00a0WBH kan regulere funktionen af Antigen Pr\u00e6senterende Celler (APC\u2019er) og \u00f8ge effektiviteten af kr\u00e6ftvacciner, herunder dem baseret p\u00e5 HSP110 og GRP170.[28,37]<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Klinisk Evidens og Synergi i Multimodal Terapi<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Synergi med Immuno-terapi (Immune Checkpoint Inhibitors \u2013 ICI)<\/h3><p style=\"text-align: left;\">En retrospektiv sagsr\u00e6kke p\u00e5 131 patienter med fremskreden (Stadie IV) karcinom unders\u00f8gte en multimodal protokol, der inkluderede <b>helkrops hypertermi<\/b>\u00a0ud over checkpoint-h\u00e6mmere (Ipilimumab, Nivolumab) og IL-2.[18]<\/p><p style=\"text-align: left;\"><strong>Hovedkonklusion:<\/strong>\u00a0WBH wIRA blev fastsl\u00e5et som en <b>integreret og essentiel komponent,<\/b> der <b>maksimerer den anti-tumorale immunrespons<\/b>. <b>WBH aktiverer og mobiliserer T-celler (ved at inducere HSP70 og frigive tumorantigener);<\/b>\u00a0checkpoint-h\u00e6mmerne \u201cfjerner derefter bremsen\u201d fra disse tidligere aktiverede T-celler, hvilket resulterer i us\u00e6dvanligt h\u00f8je favorable kliniske responsrater for fremskreden sygdom.[18]<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Kliniske Anvendelser ved Forskellige Kr\u00e6ftformer<\/h3><ul><li style=\"text-align: left;\"><strong>Kr\u00e6ft i Bugspytkirtlen (Pancreas):<\/strong> Fase I-II-protokoller med mild WBH (HRV-WBH) i kombination med kemoterapi og Interferon-alfa har vist <strong>mindst 50% tumorregression hos n\u00e6sten halvdelen af de terapirefrakte patienter[4,22]<\/strong>.<\/li><li style=\"text-align: left;\"><strong>Brystkr\u00e6ft (Recidiv):<\/strong> WBH i kombination med re-bestr\u00e5ling eller str\u00e5lebehandling har vist effektivitet for lokalt fremskreden brystkr\u00e6ft og brystv\u00e6gsrecidiv, bekr\u00e6ftet af randomiserede data.[39,40]<\/li><li style=\"text-align: left;\"><strong>\u00c6ggestokkr\u00e6ft (Ovariecancer):<\/strong>\u00a0WBH i kombination med <b>carboplatin<\/b>\u00a0er blevet unders\u00f8gt i et Fase II-studie for recidiverende ovariecancer.[16,20]<\/li><li style=\"text-align: left;\"><strong>Kolorektal Kr\u00e6ft:<\/strong>\u00a0WBH wIRA er blevet anvendt i sammenh\u00e6ng med von Ardennes Systemiske Kr\u00e6ft-Multitrin Terapi (sCMT) i kombination med kemoterapi i et Fase I\/II-studie.[15]<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. Hurtig Smertelindring og Signifikant Forbedring af Livskvalitet (LK)\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Patienter kan opleve hurtig smertelindring og generel forbedring af velbefindende, som observeret i Dr. Bulls studie og is\u00e6r i et nyere Fase III klinisk fors\u00f8g udf\u00f8rt af Sahinbas et al.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><h3 style=\"text-align: left;\">Fase III Klinisk Fors\u00f8g (2024) for Knoglemetastaser<\/h3><div class=\"container\" style=\"text-align: left;\"><div class=\"section\"><section><span dir=\"auto\">I\u00a0<\/span><a title=\"Fase III-studie Sahinbas 2024\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\">2024 offentliggjorde Sahinbas og kolleger et Fase III-studie<\/span><\/a><span dir=\"auto\">\u00a0for smerter for\u00e5rsaget af knoglemetastaser, prim\u00e6rt fra bryst- og prostatakr\u00e6ft, ved hj\u00e6lp af WBH wIRA Iratherm hypertermiudstyr som supplement til ST.<\/span><span dir=\"auto\">Baseret p\u00e5 dette studie udviste gruppen med kun ST den mest intense smerte. Unders\u00f8gelsen blev afsluttet efter inklusion af i alt 61 patienter, 5 \u00e5r efter f\u00f8rste registrering (april 2016 \u2013 februar 2021). Endelig viste raten for Fuldst\u00e6ndig Respons (FR) i ST + WBH-gruppen den mest signifikante forskel sammenlignet med ST alene: <b>47,4 % vs. 5,3 %<\/b>, henholdsvis, <b>inden for 2 m\u00e5neder efter behandlingen<\/b>\u00a0(P-v\u00e6rdi &lt; 0,05).<b> Tiden til fuld smertelindring var 10 dage for ST + WBH, mens slutpunktet ikke blev n\u00e5et i gruppen med kun ST<\/b>. Smerteprogression eller sygdomsstabilitet blev observeret hos halvdelen af patienterne i ST-gruppen inden for 4 uger efter behandlingen. Dette resultat var dog <b>t\u00e6t p\u00e5 nul hos patienter med ST + WBH inden for to m\u00e5neder efter behandlingen<\/b>.<\/span><strong class=\"sub-title\"><span dir=\"auto\">Konklusioner:\u00a0<\/span><\/strong><span dir=\"auto\">\u00a0WBH plus ST viste en signifikant stigning i smertelindring og kortere responstid sammenlignet med ST alene hos patienter med metastatiske knoglel\u00e6sioner.<\/span><\/section><\/div><\/div><div class=\"table-scroll-wrapper\" style=\"text-align: left;\"><table border=\"1\"><thead><tr><th><span dir=\"auto\">LK-indikator\/Smerteforbedring<\/span><\/th><th><span dir=\"auto\">ST Monoterapi<\/span><\/th><th><span dir=\"auto\">ST + Hypertermi (WBH wIRA)<\/span><\/th><th><span dir=\"auto\">Indvirkning p\u00e5 LK<\/span><\/th><\/tr><\/thead><tbody><tr><td><strong><span dir=\"auto\">Fuldst\u00e6ndig Respons (FR) efter 2 m\u00e5neder<\/span><\/strong><span dir=\"auto\">\u00a0(nul smertescore)<\/span><\/td><td>5,3 %<\/td><td><strong>47,4 %<\/strong><\/td><td><span dir=\"auto\">*\u00a0<\/span><strong><span dir=\"auto\">894 % stigning<\/span><\/strong><span dir=\"auto\">\u00a0* i chancen for fuld eliminering af smerte.<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Tid til fuld smertelindring<\/span><\/strong><\/td><td><span dir=\"auto\">ikke n\u00e5et<\/span><\/td><td><strong><span dir=\"auto\">10 dage<\/span><\/strong><\/td><td><span dir=\"auto\"><strong>\u201csignifikant og hurtig\u201d<\/strong>\u00a0\u00a0fordel<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Varighed af Smertelindring\u00a0<\/span><\/strong><\/td><td><span dir=\"auto\">Median: 28 dage\/4 uger hos halvdelen af patienterne<\/span><\/td><td><span dir=\"auto\">Median:\u00a0<strong>Ikke n\u00e5et efter 24 uger<\/strong><\/span><\/td><td><span dir=\"auto\">Varigheden af lindring er *\u00a0<\/span><strong><span dir=\"auto\">seks gange l\u00e6ngere<\/span><\/strong><span dir=\"auto\">\u00a0*, hvilket reducerer afh\u00e6ngigheden af smertestillende medicin.<\/span><\/td><\/tr><\/tbody><\/table><\/div><p style=\"text-align: left;\">\u00a0<\/p><\/section><section><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Sammenlignet med et lignende\u00a0<a title=\"Fase III-studie Chi MS et al. 2017\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5\" target=\"_blank\" rel=\"noopener\">\u00a0Fase III-studie offentliggjort af Chi MS et al<\/a><span dir=\"auto\">\u00a0. (2017) med RF lokoregional hypertermi, var fordelene (<em>med hensyn til LK og smertereduktion)<\/em>\u00a0opn\u00e5et ved brug af WBH wIRA hypertermi overlegne \u2013 resultater af RF HT + ST-studiet:<\/span><\/p><div class=\"table-scroll-wrapper\" style=\"text-align: left;\"><table border=\"1\"><thead><tr><th><span dir=\"auto\">LK-indikator\/Smerteforbedring<\/span><\/th><th><span dir=\"auto\">ST Monoterapi<\/span><\/th><th><span dir=\"auto\">ST + Hypertermi (HT)<\/span><\/th><th>Indvirkning p\u00e5 LK<\/th><\/tr><\/thead><tbody><tr><td><strong><span dir=\"auto\">Fuldst\u00e6ndig Respons (FR) efter 3 M\u00e5neder<\/span><\/strong><span dir=\"auto\">\u00a0(nul smertescore)<\/span><\/td><td>7,1 %<\/td><td>37,9 %<\/td><td><span dir=\"auto\">533 % stigning i chancen for fuld smertelindring.<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Varighed af Smertelindring<\/span><\/strong><\/td><td><span dir=\"auto\">Median: 55 dage\/7,9 uger<\/span><\/td><td><span dir=\"auto\">Median: Ikke n\u00e5et efter 24 uger<\/span><\/td><td><span dir=\"auto\">Varigheden af lindring tredobles, hvilket reducerer afh\u00e6ngigheden af smertestillende medicin.<\/span><\/td><\/tr><\/tbody><\/table><\/div><p style=\"text-align: left;\">\u00a0<\/p><p style=\"text-align: left;\">Sammenfattende bekr\u00e6fter den konsoliderede videnskabelige evidens (fra grundl\u00e6ggende studier af wIRA-teknologi til centrale Fase III kliniske fors\u00f8g) WBH\u2019s rolle som en adjuvant behandling med mangefacetteret virkning i onkologien: den \u00f8ger effektiviteten af KT\/ST, aktiverer det systemiske immunsystem (herunder synergi med immunterapi) og forbedrer dramatisk smertekontrol og LK hos kr\u00e6ftpatienter.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Systemiske Fysiologiske Fordele og Terapeutisk Potentiale i Andre Patologier<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>Den milde, kontrollerede varme, der leveres af WBH med wIRA-str\u00e5ling, udl\u00f8ser komplekse termoregulerende reaktioner, der skaber brede systemiske fordele, hvilket udvider det terapeutiske potentiale ud over onkologi:<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"text-align: center;\"><div><div><div><div><header><div style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Muskuloskeletal- og Smertebehandling<\/h3><p style=\"text-align: left;\">WBH er effektiv til h\u00e5ndtering af kroniske smertesyndromer og udnytter dens fysiologiske virkninger p\u00e5 muskeltonus og mikrocirkulation:<\/p><ul><li style=\"text-align: left;\">*<strong>Dorsalgi (Kroniske Rygsmerter):<\/strong>* Studier viser, at mild WBH, i kombination med station\u00e6r multimodal smertebehandling, giver betydelige fordele for patienter med kroniske uspecifikke l\u00e6ndesmerter (dorsalgi).[53,54]<\/li><li style=\"text-align: left;\">*<strong>Fibromyalgi Syndrom (FMS):<\/strong>* WBH er en dokumenteret supplerende behandling for FMS. Randomiserede kontrollerede fors\u00f8g har vist effektiviteten af mild wIRA WBH i standard multimodale rehabiliteringsmilj\u00f8er, med virkninger p\u00e5 <b>smerteintensitet<\/b>\u00a0og <b>mental tilstand<\/b>[17, 56, 57]. Denne fordel er delvist forbundet med forbedret mikrocirkulation, et kendt problem hos FMS-patienter.[55]<\/li><li style=\"text-align: left;\">*<strong>Ankyloserende Spondylitis (Mb. Bechterew):<\/strong>* WBH har vist immunmodulerende virkninger hos patienter med AS, med studier, der rapporterer WBH\u2019s evne til at \u00f8ge antiinflammatoriske mediatorer som <b>Interleukin-10<\/b>\u00a0(IL-10) og modulere pro-inflammatoriske cytokiner som TNF-\u03b1, hvilket indikerer en gunstig rolle i behandlingen af den kroniske inflammation forbundet med tilstanden\u00a0[52, 58, 59].<\/li><li style=\"text-align: left;\">*<strong>Raynauds F\u00e6nomen ved Systemisk Sklerose:<\/strong>* Infrar\u00f8dbaseret hypertermi har vist sig at v\u00e6re effektiv til behandling af vasokonstriktive symptomer forbundet med sklerodermi-associeret Raynauds F\u00e6nomen, hvilket demonstrerer vaskul\u00e6re fordele.[49]<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Kardiovaskul\u00e6r og Cirkulatorisk Sundhed \u2764\ufe0f<\/h3><p style=\"text-align: left;\">Ud over at forbedre tumorperfusion har WBH specifikke virkninger p\u00e5 kredsl\u00f8bssystemet:<\/p><ul><li style=\"text-align: left;\">*<strong>Essentiel Hypertension:<\/strong>* En r\u00e6kke studier har unders\u00f8gt brugen af mild IR-A hypertermi hos patienter med arteriel hypertension (WHO Stadie I og II). Fund indikerer, at serielle behandlinger positivt kan p\u00e5virke <b>centrale og perifere pulsb\u00f8lger, blodtryk og blodviskositet<\/b>, hvilket bekr\u00e6fter WBH\u2019s rolle som en ikke-farmakologisk mulighed for fysioterapi.[<span class=\"citation\">44, 47<\/span>]<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \" style=\"text-align: left;\"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">C. Neuro-Endokrine og Psykologiske Effekter<\/h3><p style=\"text-align: left;\">WBH involverer kroppens neuro-endokrine systemer og p\u00e5virker hum\u00f8r og stofskifte:<\/p><ul><li style=\"text-align: left;\">*<strong>Sv\u00e6r Depressiv Lidelse (MDD)<\/strong>:* Et randomiseret klinisk fors\u00f8g viste, at en enkelt WBH-session kan fungere som et hurtigtvirkende antidepressivum, hvilket resulterer i en reduktion af depressive symptomer over flere uger. Denne effekt er forbundet med varmeinduceret aktivering af immun- og inflammationsveje, der p\u00e5virker hjernen.[51]<\/li><li style=\"text-align: left;\">*<strong>Hormonel Modulering (Endokrinologi):<\/strong>* WBH stimulerer <b>Hypothalamus-Hypofyse-Binyre (HPA) aksen<\/b> og p\u00e5virker hormonniveauer. Studier har dokumenteret reaktioner af <b>V\u00e6ksthormon<\/b> og <b>Prolaktin<\/b> under helkrops hypertermi, hvilket understreger dens indvirkning p\u00e5 endokrin regulering.[42,43[<\/li><li style=\"text-align: left;\">*<strong>Stofskifte og Cellul\u00e6r Reaktion:<\/strong>* WBH accelererer den basale metaboliske oms\u00e6tning. P\u00e5 cellul\u00e6rt niveau p\u00e5virker varmen pO2-kinetikken og er forbundet med syntesen af beskyttende proteiner som <b>ferritin<\/b> i huden, hvilket underst\u00f8tter v\u00e6vsreparation.[46,48]<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Ofte Stillede Sp\u00f8rgsm\u00e5l (FAQ) om Anbefalede WBH-sessioner og M\u00e5ltemperaturer\n\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p><em>Behandlinger\u00a0m\u00e5\u00a0kun\u00a0udf\u00f8res\u00a0efter\u00a0endelig\u00a0konsultation\u00a0med\u00a0en l\u00e6ge<\/em><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" data-delay=\"0\"><p>\u00a0<\/p><\/div><\/header><div><h4>Hvad er den anbefalede Helkrops Hypertermi (WBH) protokol for Essentiel Hypertension?<\/h4><div><p>Protokollen for Essentiel Hypertension anbefaler 12 sessioner med en m\u00e5ltemperatur p\u00e5 38,3 \u00b0C. Hver session varer ca. 45 minutter, inklusive en 30-minutters stigningsfase og en 15-minutters restitutionsfase (uden plateau-fase).<\/p><\/div><\/div><div><h4>Hvad er de anbefalede WBH-parametre for Kroniske Rygsmerter (Dorsalgi)?<\/h4><div><p>For Dorsalgi anbefales typisk 6 sessioner, med m\u00e5l om 38,4 \u00b0C. Den samlede sessionstid er ca. 90 minutter, med 45 minutters stigning, en 15-minutters plateau-fase og 30 minutters restitution.<\/p><\/div><\/div><div><h4>Hvad er WBH-protokollen for Fibromyalgi og Ankyloserende Spondylitis?<\/h4><div><p>B\u00e5de Fibromyalgi og Ankyloserende Spondylitis f\u00f8lger typisk en protokol p\u00e5 6 sessioner, med m\u00e5l om 38,5 \u00b0C. Den samlede sessionstid er ca. 90 minutter, inklusive 45 minutters stigning, et 15-minutters plateau og 30 minutters restitution.<\/p><\/div><\/div><div><h4>Hvad er den anbefalede protokol for WBH som Supplerende Kr\u00e6ftbehandling?<\/h4><div><p>Som supplerende kr\u00e6ftbehandling kr\u00e6ver protokollen 2 eller flere sessioner med en m\u00e5l-kernetemperatur mellem 39,0 \u00b0C og 40,0 \u00b0C. Den samlede sessionstid er den l\u00e6ngste, varierende fra 3 til 4 timer, hvilket inkluderer 60-90 minutter til stigningsfasen, 60-90 minutter til plateau-fasen og 60 minutter til restitutionsfasen.<\/p><\/div><\/div><div class=\"table-scroll-wrapper\">\u00a0<\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ae031ee animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ae031ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><div><div class=\"wpb_content_element \"><div>\u00a0<\/div><div class=\"table-scroll-wrapper\"><table width=\"1151\"><tbody><tr><td width=\"278\">Indikation<\/td><td width=\"99\">Antal sessioner<\/td><td width=\"135\">M\u00e5ltemperatur<\/td><td colspan=\"2\" width=\"309\">Terapitid<br \/>Stigningsfase\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Plateau-fase<\/td><td width=\"164\">Restitutionstid<br \/>Restitutionsfase<\/td><td width=\"164\"><b>Total<\/b><br \/><b>WBH Sessionstid<\/b><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Essentiel Hypertension<\/td><td rowspan=\"2\" width=\"99\">12<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Dorsalgi<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,4 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Fibromyalgi<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Ankyloserende Spondylitis<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Systemisk Sklerose<\/td><td rowspan=\"2\" width=\"99\">15<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Sv\u00e6r Depressiv Lidelse<\/td><td rowspan=\"2\" width=\"99\">1+<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>105 -170 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 2-3\u00a0<\/b><b>timer<\/b><\/td><\/tr><tr><td width=\"155\">45-110 min<\/td><td width=\"155\">60 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Supplerende Kr\u00e6ftbehandling<\/td><td rowspan=\"2\" width=\"99\">2+<\/td><td rowspan=\"2\" width=\"135\">39,0-40,0 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>120-180 min<\/b><\/td><td rowspan=\"2\" width=\"164\">60 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 3-4\u00a0<\/b><b>timer<\/b><\/td><\/tr><tr><td width=\"155\">60-90 min<\/td><td width=\"155\">60-90 min<\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div><div id=\"ut-row-inner-68e7a7d03e7dd\" class=\"vc_row wpb_row vc_inner vc_row-fluid ut-row-inner-68e7a7d03e7ec\"><div class=\"wpb_column vc_column_container vc_col-sm-6\"><div id=\"ut-column-inner-68e7a7d03eb05\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"wpb_content_element\"><div id=\"ut_bi_68e7a7d03ebdb\" class=\"bklyn-big-icon-wrap\"><div class=\"bklyn-big-icon bklyn-big-icon-square\">\u00a0<\/div><p class=\"bklyn-big-icon-title\">\u00a0<\/p><\/div><\/div><\/div><\/div><\/div><\/div><p>\u00a0<\/p><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>BEM\u00c6RK: denne artikel er ikke en udt\u00f8mmende liste over studier og virkninger af WBH wIRA<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Referencer og citater<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><ol><li style=\"text-align: left;\">Ardenne M. von. Moderate Hyperthermie als Behandlungsmethode mit vielen Indikationen. \u00c4rztzeitschr Naturheilverf 1994; 5:356-61.<\/li><li style=\"text-align: left;\">B\u00e4umler H., Scherf H.P., Aurisch R., et al. Einflu\u00df einer Serie von Infrarot-Ganzk\u00f6rperbestrahlungen auf Flie\u00dfeigenschaften des Blutes und die H\u00e4modynamik. Perfusion 1990: 138-43.<\/li><li style=\"text-align: left;\">Heckel M. Ganzk\u00f6rper-Hyperthermie und Fiebertherapie, Grundlagen und Praxis. Stuttgart: Hippokrates Verlag, 1990.<\/li><li style=\"text-align: left;\">Kosaka M., Sugahara T., Schmidt K.L., Simon E. Thermotherapy: Principles and Practice. Heidelberg: Springer Verlag, 2000.<\/li><li style=\"text-align: left;\">Meffert H., Hecht H.C., G\u00fcnther H., et al. Biophysikalische Ergebnisse des klinischen Tests der IRA-Therm-Hyperthermietechnik der 2. Generation. ThermoMed 1990; 6:71-78.<\/li><li style=\"text-align: left;\">Schmidt K.L. Hyperthermie und Fieber, Wirkungen bei Mensch und Tier. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1987.<\/li><li style=\"text-align: left;\">Vaupel P., Kr\u00fcger W. W\u00e4rmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsm\u00f6glichkeiten. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1995.<\/li><li style=\"text-align: left;\">Piazena H., Meffert H. Optische Eigenschaften der Haut und die photobiologischen Grundlagen zur Dosierung von IR-Hautbestrahlungen in vivo und in vitro. 6. Symposium Licht und Gesundheit 2008 13.-14.03. Berlin, 2008:162-178.<\/li><li style=\"text-align: left;\">Zschaeck S. and Beck M. Chapter 8 Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?<\/li><li style=\"text-align: left;\">Zhang H, Wang W, Zhang S, Huang W. Comparison of the anti-tumor effects of various whole-body hyperthermia protocols&#8230; Immunol Invest. 2005;34(3):245-58.<\/li><li style=\"text-align: left;\">Abreu MM, Chocron AF, Smadja DM. From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. Front Immunol. 2025 Feb 28;16:1487296.<\/li><li style=\"text-align: left;\">Bull JMC. et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-\u03b1: A description of a phase I-II protocol. Journal of Hyperthermia. 2008; 24(8): 649-662.<\/li><li style=\"text-align: left;\">Weigelin B. Visualization of the immune effect of hyperthermia. ICHO 2021, Session: Hyperthermia and immunology.<\/li><li style=\"text-align: left;\">Faghihi Moghaddam F, Bakhshandeh M, Mofid B, et al. Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone&#8230; J Therm Biol. 2024 Feb;120:103804.<\/li><li style=\"text-align: left;\">Hildebrandt B, Dr\u00e4ger J, Kerner T. et al. Whole-body hyperthermia in the scope of von Ardenne\u2019s systemic cancer multistep therapy (sCMT)&#8230; International Journal of Hyperthermia. 2004;3:317\u2013333.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin in patients with recurrent ovarian cancer \u2013 a phase II study. Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Brockow T., Wagner A., Franke A., Offenb\u00e4cher M., Resch K.L. A Randomized Controlled Trial on the Effectiveness of Mild Water-filtered Near Infrared Whole-body Hyperthermia&#8230; Clin J Pain 2007; 1:67-75.<\/li><li style=\"text-align: left;\">Kleef R, Nagy R, Baierl A, et al. Low-dose Ipilimumab plus Nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series&#8230; Cancer Immunol Immunother. 2021;70:1393\u2013403.<\/li><li style=\"text-align: left;\">Adachi H., Katsuno M., Waza M., et al. Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications. Int J Hyperthermia 2009; 8:647-54.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin&#8230; Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Figueroa G., et al. An Update of a Phase II Clinical Trial Using Fever-Range Whole-Body Thermal Therapy (FR-WB-TT)&#8230; Soc for Thermal Med Joint Annual Meeting, 14.-17.5.2007.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Strebel F.R., et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine and daily interferon-\u03b1: A description of a phase I-II protocol. Int J Hyperthermia 2008; 8:649-62.<\/li><li style=\"text-align: left;\">Bull J.M., Nagle V.L., Scott G., et al. A phase-I-study of optimally-timed Gemcitabine + Cisplatin\/Interferon-a combined with long-duration, low-temperature whole-body hyperthermia. ESHO 2001, Verona\/ Italy, 30.05.-02.06.2001:67.<\/li><li style=\"text-align: left;\">Capitano M., Mace T., Nemeth M., et al. A novel strategy for improving neutrophil recovery following total body irradiation. Soc for Thermal Med Joint Annual Meeting, 24.-26.4.2010.<\/li><li style=\"text-align: left;\">Dayanc B.E., Ostberg J.R., Repasky E.A. Enhancement of NK Cell Cytotoxic Activity by Mild Thermal Stress. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Hajto T., Hostanska K. Effect of in vivo hyperthermia on human natural killer cells. 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Immunol Res 2010; 1-3:137-154.<\/li><li style=\"text-align: left;\">Rowe R.W., Stebel F.R., Proett J.M., et al. Fever-range whole body thermotherapy combined with oxaliplatin: A curative regimen in a pre-clinical breast cancer model. Int J Hyperthermia 2010; 6:565-76.<\/li><li style=\"text-align: left;\">Schencking M., Frese T., Sandholzer H. Behandlung einer Radikulopathie bei oss\u00e4rer Metastasierung der Lendenwirbels\u00e4ule durch Infrarot-A-Ganzk\u00f6rperhyperthermie. Forsch Komplementmed 2008; 15:273-76.<\/li><li style=\"text-align: left;\">Scott G.L., Bull J.M.C., Kochn M. Management of Conscious Sedation&#8230; 9th Int Congress on Hyperthermic Oncology, 20.-24.4.2004.<\/li><li style=\"text-align: left;\">Shecterle L.M., Cyr J.A.S. Hyperthermia Aids Patients with Advanced Lung Cancer. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Skitzki J.J., Repasky E.A., Evans S.S. Hyperthermia as an immunotherapy strategy for cancer. 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Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic whole-body hyperthermia&#8230; J Musculoskel Pain 2014; 4:341-55.<\/li><li style=\"text-align: left;\">Zauner D., Quehenberger F., Hermann J., et al. Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study. Int J Hyperthermia 2014; 6:393-401.<\/li><li style=\"text-align: left;\">Lange U., M\u00fcller-Ladner U., Dischereit G. Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis&#8230; Akt Rheumatol 2017; 2:122-128.<\/li><\/ol><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>\u00a0<\/p><\/section><footer>\u00a9 <time>2025<\/time> Romanian Society Oncologic Hyperthermia All rights reserved. Source: Analysis based on scientific literature.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Helkrops Hypertermi (WBH) i Onkologi og Andre Patologier: Konsolideret Synergi, Immunmodulering og Kliniske fors\u00f8g \u200b Udgivet:\u00a02025-10-13\u00a0| Seneste Revision:\u00a02025-10-13 Forfattere: Veronica Iatan, M.D., Cristian Gologan, M.Sc. Helkrops Hypertermi (WBH) er en systemisk onkologisk strategi, der involverer kontrolleret h\u00e6vning af den centrale kropstemperatur, ofte ved hj\u00e6lp af Vandfiltreret Infrar\u00f8d-A (wIRA)-teknologi. WBH er prim\u00e6rt en Kemo\/Radio-sensibilisator, der signifikant<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/da\/kliniske-forsoeg-hypertermi-wbh-wira-onkologi\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-974","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/da\/wp-json\/wp\/v2\/pages\/974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/da\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/da\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/da\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/da\/wp-json\/wp\/v2\/comments?post=974"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/da\/wp-json\/wp\/v2\/pages\/974\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/da\/wp-json\/wp\/v2\/media?parent=974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}