{"id":977,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2026-01-16T11:45:32","modified_gmt":"2026-01-16T11:45:32","slug":"essais-cliniques-hyperthermie-oncologie","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/fr\/essais-cliniques-hyperthermie-oncologie\/","title":{"rendered":"Essais cliniques"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"977\" class=\"elementor elementor-977 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Hyperthermie Corps Entier (HCE\/WBH) en Oncologie : Synergie Th\u00e9rapeutique, Immunomodulation et \u00c9vidence Clinique<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header><p><strong>Publi\u00e9:\u00a0<time datetime=\"2025-10-13\">2025-10-13<\/time>\u00a0| Derni\u00e8re R\u00e9vision:\u00a0<time datetime=\"2025-10-13\">2025-10-13<\/time><\/strong><\/p><\/header><div class=\"authors\"><p>Par<br \/><a href=\"https:\/\/ardenneiratherm.com\/fr\/our-team\/veronica-iatan\/\">Veronica Iatan, MD<\/a>,<br \/><a href=\"https:\/\/ardenneiratherm.com\/fr\/our-team\/cristian-gologan\/\">Cristian Gologan, M.Sc.<\/a><\/p><\/div><section class=\"ai-summary\"><p>L\u2019Hyperthermie du Corps Entier ( HCE\/WBH) est une strat\u00e9gie oncologique syst\u00e9mique impliquant une \u00e9l\u00e9vation contr\u00f4l\u00e9e de la temp\u00e9rature corporelle centrale, souvent r\u00e9alis\u00e9e par la technologie d\u2019<strong>Infrarouge-A filtr\u00e9 par l\u2019eau (wIRA)<\/strong>. L\u2019HCE est fondamentalement un <strong>ch\u00e9mio\/radio-sensibilisateur<\/strong>,<strong> am\u00e9liorant significativement la perfusion tumorale et l\u2019oxyg\u00e9nation pour amplifier l\u2019efficacit\u00e9 des traitements traditionnels<\/strong>. Elle fonctionne \u00e9galement comme un puissant <strong>immunomodulateur syst\u00e9mique, mobilisant les Prot\u00e9ines de Choc Thermique (HSP) et les lymphocytes T<\/strong>. Cette action cr\u00e9e une synergie essentielle avec l\u2019<strong>Immunoth\u00e9rapie (ICI)<\/strong> de pointe et offre un soulagement rapide et spectaculaire de la douleur, ainsi qu\u2019une am\u00e9lioration notable de la Qualit\u00e9 de Vie dans divers cancers et pathologies chroniques comme la Fibromyalgie.<\/p><\/section><section class=\"disclaimer\">* <strong>Avertissement M\u00e9dical: Cet article est destin\u00e9 \u00e0 des fins d\u2019information uniquement et ne remplace en aucun cas une consultation m\u00e9dicale individualis\u00e9e, un diagnostic ou un traitement fourni par un m\u00e9decin agr\u00e9\u00e9.<\/strong>*<\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. D\u00e9finition de l\u2019Hyperthermie du Corps Entier (WBH) et Technologie Th\u00e9rapeutique<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">L\u2019<strong>Hyperthermie du Corps Entier (WBH)<\/strong>, ou \u00ab hyperthermie syst\u00e9mique \u00bb, est d\u00e9finie comme l\u2019augmentation contr\u00f4l\u00e9e de la temp\u00e9rature corporelle centrale \u00e0 des fins th\u00e9rapeutiques. Sur la base du spectre des <strong>effets de la fi\u00e8vre naturelle \u00e0 diff\u00e9rentes temp\u00e9ratures<\/strong>, les proc\u00e9dures d\u2019WBH sont diff\u00e9renci\u00e9es comme suit :<\/p><ul style=\"text-align: left;\"><li><strong>WBH \/ HCE L\u00e9g\u00e8re<\/strong> : &lt; 38,5\u00b0C<\/li><li><strong>WBH \/HCE Mod\u00e9r\u00e9e<\/strong> : 38,5\u00b0C \u2013 40,5 \u00b0C<\/li><li><strong>WBH\/HCE Extr\u00eame<\/strong> : &gt; 40,5\u00b0C<\/li><\/ul><p style=\"text-align: left;\">L\u2019WBH l\u00e9g\u00e8re et mod\u00e9r\u00e9e en particulier <strong>augmente la perfusion<\/strong>,<strong> stimule le m\u00e9tabolisme, r\u00e9duit le tonus musculaire<\/strong> et <strong class=\"key-term\">stimule le syst\u00e8me immunitaire.<\/strong><\/p><p style=\"text-align: left;\">Le <a title=\"D\u00e9tails techniques du dispositif von Ardenne IRATHERM\u00ae 1000M WBH wIRA\" href=\"https:\/\/ardenneiratherm.com\/fr\/von-ardenne-iratherm-1000-hyperthermia-device\/\"><strong>dispositif d&rsquo;hyperthermie corps entier von Ardenne IRATHERM\u00ae 1000M WBH wIRA<\/strong>\u00a0<\/a>utilise exclusivement un <strong>rayonnement thermique Infrarouge-A filtr\u00e9 par l\u2019eau (wIRA)<\/strong> <strong>compatible avec la peau et p\u00e9n\u00e9trant profond\u00e9ment<\/strong> (sans IR-B \/ IR-C) \u00e0 cette fin. Sa conception ouverte et non claustrophobe assure une intensit\u00e9 de rayonnement uniforme sur l\u2019ensemble du patient (dos) et offre \u00e0 l\u2019utilisateur un Transfert thermique optimal et sp\u00e9cifique au patient en termes de localisation et d\u2019intensit\u00e9.<\/p><p style=\"text-align: left;\">Le rayonnement Infrarouge-A filtr\u00e9 par l\u2019eau correspond au rayonnement thermique naturel du soleil, fournissant la base technologique pour une application uniforme et douce de la chaleur\u00a0<span class=\"citation\">[1, 5, 7, 8]<\/span>.<\/p><p style=\"text-align: left;\">En utilisant le principe von Ardenne IRATHERM<sup>\u00ae<\/sup>\u00a01000, qui a \u00e9t\u00e9 d\u00e9velopp\u00e9 et prouv\u00e9 depuis plus de 30 ans,\u00a0<a title=\"Prof. Manfred von Ardenne - Contributions\" href=\"https:\/\/ardenneiratherm.com\/fr\/our-team\/manfred-von-ardenne-2\/\">Prof. Manfred von Ardenne<\/a>\u00a0a r\u00e9ussi \u00e0 reproduire ce rayonnement thermique physiquement et techniquement et \u00e0 le rendre disponible industriellement pour une utilisation m\u00e9dicale durable par le biais de l\u2019hyperthermie du corps entier.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Fondements Scientifiques et Effets Syst\u00e9miques<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">L\u2019HCE est devenue une strat\u00e9gie bas\u00e9e sur des principes biophysiques et physiologiques solides. En oncologie, l\u2019accent est mis sur l\u2019<strong>Hyperthermie Mod\u00e9r\u00e9e<\/strong> et l\u2019<strong>Hyperthermie de l\u2019Ordre de la Fi\u00e8vre (WBH-OF)<\/strong>, reconnues comme des traitements avec de multiples indications th\u00e9rapeutiques <span class=\"citation\">[1, 3]<\/span>.<\/p><p>La base technologique pour l\u2019application uniforme et douce de la chaleur est souvent fournie par des dispositifs utilisant le <strong>rayonnement Infrarouge-A filtr\u00e9 par l\u2019eau (wIRA)<\/strong>. Des \u00e9tudes biophysiques d\u00e9taill\u00e9es ont valid\u00e9 la <strong>capacit\u00e9 de cette technologie \u00e0 assurer un chauffage profond et contr\u00f4l\u00e9<\/strong>, en tenant compte des propri\u00e9t\u00e9s optiques de la peau et de la base photobiologique de la dosim\u00e9trie [5,7,8].<\/p><p style=\"text-align: left;\">Des \u00e9tudes biophysiques d\u00e9taill\u00e9es ont valid\u00e9 la\u00a0<strong class=\"key-term\">capacit\u00e9 de la technologie wIRA<\/strong> \u00e0 assurer un <strong>chauffage profond et contr\u00f4l\u00e9<\/strong>\u00a0<span class=\"citation\">[5, 7, 8]<\/span>. Au niveau physiologique, l\u2019WBH a des effets syst\u00e9miques fondamentaux :<\/p><ol style=\"text-align: left;\"><li><strong>Am\u00e9lioration de la Rh\u00e9ologie Sanguine<\/strong> : L\u2019exposition \u00e0 l\u2019IR-WBH influence favorablement les <strong>propri\u00e9t\u00e9s d\u2019\u00e9coulement du sang et l\u2019h\u00e9modynamique<\/strong>\u00a0<span class=\"citation\">[2]<\/span>, soutenant le m\u00e9canisme essentiel de l\u2019<strong>am\u00e9lioration de la perfusion tumorale<\/strong>\u00a0\u2014 une condition pr\u00e9alable critique au succ\u00e8s des traitements syst\u00e9miques.<\/li><li><strong>Activation Biologique G\u00e9n\u00e9rale<\/strong> : L\u2019HCE induit une r\u00e9ponse au stress thermique qui d\u00e9clenche une cascade de processus biologiques, y compris la <strong>modulation du syst\u00e8me hormonal<\/strong> et l\u2019<strong>acc\u00e9l\u00e9ration du m\u00e9tabolisme<\/strong>\u00a0<span class=\"citation\">[6, 4]<\/span>.<\/li><\/ol><p style=\"text-align: left;\">En raison de ces fondements, l\u2019HCE fonctionne comme un <strong class=\"key-term\">immunomodulateur syst\u00e9mique<\/strong>, optimisant le\u00a0<strong class=\"key-term\">microenvironnement tumoral (MET)<\/strong> et <strong>amplifiant l\u2019efficacit\u00e9 des traitements oncologiques de pointe<\/strong>\u00a0<span class=\"citation\">[9]<\/span>.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">M\u00e9canismes d\u2019Action Cl\u00e9s (Mol\u00e9culaires, Physiologiques et Immunologiques)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Les effets th\u00e9rapeutiques de l\u2019HCE sont complexes, m\u00e9diatis\u00e9s par des changements aux niveaux cellulaire, immunitaire et physiologique :<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Synergie avec la Chimioth\u00e9rapie et la Radioth\u00e9rapie (Chimio\/Radio-sensibilisateur)<\/h3><ul><li style=\"text-align: left;\"><strong>Optimisation du Microenvironnement Tumoral (MET)<\/strong> : L\u2019HCE am\u00e9liore la <strong>perfusion sanguine tumorale<\/strong> et l\u2019<strong>oxyg\u00e9nation<\/strong>, inversant l\u2019hypoxie tumorale. Ceci est essentiel, car les cellules tumorales bien oxyg\u00e9n\u00e9es sont significativement plus sensibles \u00e0 la destruction par la Chimioth\u00e9rapie* (CT) et la Radioth\u00e9rapie (RT) <span class=\"citation\">[9, 41]<\/span>.<\/li><li style=\"text-align: left;\">*<strong>Efficacit\u00e9 Ch\u00e9mio\/Radio<\/strong> : L\u2019hyperthermie agit comme un\u00a0<strong class=\"key-term\">sensibilisateur<\/strong> <strong>ch\u00e9mio &amp; radio<\/strong>, am\u00e9liorant l\u2019apport en oxyg\u00e8ne de la tumeur (<em>\u00a0effet radio-sensibilisateur<\/em>\u00a0) &amp; augmentant l\u2019efficacit\u00e9 de m\u00e9dicaments comme le Cisplatine, la Gemcitabine et le Carboplatine\u00a0<span class=\"citation\">[12, 16, 36]<\/span>.<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Induction d\u2019une R\u00e9ponse Immunitaire Anti-Tumorale Robuste (Immunomodulation)<\/h3><p style=\"text-align: left;\">L\u2019HCE est un puissant activateur du syst\u00e8me de d\u00e9fense de l\u2019organisme <span class=\"citation\">[11]<\/span>\u00a0:<\/p><ul><li style=\"text-align: left;\"><strong>Prot\u00e9ines de Choc Thermique (HSP)<\/strong> : Le stress thermique stimule la synth\u00e8se et la lib\u00e9ration de l\u2019<strong>HSP70<\/strong>. Ces prot\u00e9ines agissent comme des \u2018signaux de danger\u2019 qui marquent les cellules canc\u00e9reuses pour une attaque renforc\u00e9e par les <strong class=\"key-term\">Lymphocytes T Cytotoxiques (LTC)<\/strong>\u00a0du syst\u00e8me immunitaire\u00a0<span class=\"citation\">[9, 10, 29]<\/span>.<\/li><li style=\"text-align: left;\"><strong>Activation des Cellules Immunitaires Cl\u00e9s<\/strong> : La plage de temp\u00e9rature de 39-43*\u00b0C augmente l\u2019activit\u00e9 des <strong>Cellules Tueuses Naturelles (NK)<\/strong> et <strong>favorise l\u2019activit\u00e9 des lymphocytes T auxiliaires et cytotoxiques, des cellules dendritiques<\/strong> et des <strong>macrophages<\/strong>, tout en compromettant potentiellement les cellules immunosuppressives <span class=\"citation\">[9, 10, 11, 25, 26]<\/span>.<\/li><li style=\"text-align: left;\"><strong>Augmentation des Lymphocytes T<\/strong> : L\u2019<strong>HCE-OF<\/strong> peut <strong>augmenter significativement (par exemple, par 3)<\/strong>\u00a0<strong>la population de lymphocytes T cytotoxiques dans les organes lympho\u00efdes<\/strong>, renfor\u00e7ant ainsi l\u2019attaque immunitaire anti-tumorale syst\u00e9mique\u00a0<span class=\"citation\">[10]<\/span>.<\/li><li style=\"text-align: left;\"><strong>Vaccins et CPA<\/strong> : L\u2019<strong>HCE<\/strong> peut r\u00e9guler la fonction des Cellules Pr\u00e9sentatrices d\u2019Antig\u00e8nes (CPA) et augmenter l\u2019efficacit\u00e9 des vaccins anticanc\u00e9reux, y compris ceux bas\u00e9s sur HSP110 et GRP170 [37, 28].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Preuves Cliniques et Synergie dans la Th\u00e9rapie Multimodale<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Synergie avec l\u2019Immunoth\u00e9rapie (Inhibiteurs de Point de Contr\u00f4le \u2013 ICI)<\/h3><p style=\"text-align: left;\">Une s\u00e9rie de cas r\u00e9trospective de 131 patients atteints de cancer avanc\u00e9 (Stade IV) a \u00e9tudi\u00e9 un protocole multimodal comprenant l\u2019<strong>hyperthermie du corps entier<\/strong> en plus des inhibiteurs de point de contr\u00f4le (Ipilimumab, Nivolumab) et de l\u2019IL-2 <span class=\"citation\">[18]<\/span>.<\/p><p style=\"text-align: left;\"><strong>Conclusion Cl\u00e9 :<\/strong> L\u2019<strong>Hyperthermie du Corps Entier wIRA<\/strong> a \u00e9t\u00e9 d\u00e9termin\u00e9e comme \u00e9tant une <strong>composante int\u00e9grale et essentielle<\/strong> qui <strong>maximise la r\u00e9ponse immunitaire anti-tumorale<\/strong>. L\u2019<strong>HCE\/WBH active et mobilise les lymphocytes T (en induisant l\u2019HSP70 et en lib\u00e9rant des antig\u00e8nes tumoraux) ; <\/strong>les inhibiteurs de point de contr\u00f4le \u00ab l\u00e8vent ensuite le frein \u00bb sur ces lymphocytes T pr\u00e9-activ\u00e9s, ce qui entra\u00eene des taux de r\u00e9ponse clinique favorables inhabituellement \u00e9lev\u00e9s pour les maladies avanc\u00e9es <span class=\"citation\">[18]<\/span>.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><h3 style=\"text-align: left;\">B. Applications Cliniques dans Divers Cancers<\/h3><ul><li style=\"text-align: left;\"><strong>Cancer du Pancr\u00e9as<\/strong> : Les protocoles de Phase I-II utilisant l\u2019HCE l\u00e9g\u00e8re (WBH-OF) combin\u00e9e \u00e0 la chimioth\u00e9rapie et \u00e0 l\u2019Interf\u00e9ron-alpha ont montr\u00e9 <strong>au moins 50 % de r\u00e9gression tumorale chez pr\u00e8s de la moiti\u00e9 des patients r\u00e9sistants \u00e0 la th\u00e9rapie<\/strong>\u00a0<span class=\"citation\">[4, 22]<\/span>.<\/li><li style=\"text-align: left;\"><strong>Cancer du Sein (R\u00e9cidive)<\/strong> : L\u2019HCE combin\u00e9e \u00e0 la r\u00e9-irradiation ou \u00e0 la radioth\u00e9rapie a montr\u00e9 une efficacit\u00e9 pour le cancer du sein localement avanc\u00e9 et la r\u00e9cidive de la paroi thoracique, confirm\u00e9e par des donn\u00e9es randomis\u00e9es <span class=\"citation\">[39, 40]<\/span>.<\/li><li style=\"text-align: left;\"><strong>Cancer de l\u2019Ovaire<\/strong> : L\u2019HCE combin\u00e9e au *carboplatine* a \u00e9t\u00e9 \u00e9tudi\u00e9e dans une \u00e9tude de Phase II pour le cancer de l\u2019ovaire r\u00e9current <span class=\"citation\">[16, 20]<\/span>.<\/li><li style=\"text-align: left;\"><strong>Cancer Colorectal<\/strong> : L\u2019HCE wIRA a \u00e9t\u00e9 utilis\u00e9e dans le contexte de la Th\u00e9rapie Syst\u00e9mique Multistep du Cancer (sCMT) de Von Ardenne combin\u00e9e \u00e0 la chimioth\u00e9rapie dans une \u00e9tude de Phase I\/II [15].<\/li><\/ul><\/section><section><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. Soulagement Rapide de la Douleur et Am\u00e9lioration Significative de la Qualit\u00e9 de Vie (QdV)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Les patients peuvent ressentir un soulagement rapide de la douleur et une am\u00e9lioration g\u00e9n\u00e9rale du bien-\u00eatre, comme observ\u00e9 dans l\u2019\u00e9tude du Dr. Bull\u00a0<span class=\"citation\">[12]<\/span>\u00a0et surtout dans l\u2019\u00e9tude clinique de Phase III plus r\u00e9cente r\u00e9alis\u00e9e par Sahinbas et al.\u00a0<span class=\"citation\">[14]<\/span>.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">Essai Clinique de Phase III (2024) pour les M\u00e9tastases Osseuses<\/h3><div class=\"container\" style=\"text-align: left;\"><div class=\"section\"><section><span dir=\"auto\">En\u00a0<\/span><a title=\"\u00c9tude Phase III Sahinbas 2024\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\">2024, Sahinbas et ses coll\u00e8gues ont publi\u00e9 une \u00e9tude de phase III<\/span><\/a><span dir=\"auto\"> sur la douleur des m\u00e9tastases osseuses, principalement dues au cancer du sein et de la prostate, utilisant des dispositifs d\u2019hyperthermie HCE\/WBH wIRA Iratherm en compl\u00e9ment de la RT [14].<\/span><span dir=\"auto\">Sur la base de cette \u00e9tude, le groupe avec RT seule pr\u00e9sentait la douleur la plus intense. L\u2019\u00e9tude a \u00e9t\u00e9 achev\u00e9e apr\u00e8s l\u2019inclusion d\u2019un total de 61 patients, 5 ans apr\u00e8s la premi\u00e8re inscription (avril 2016 \u2013 f\u00e9vrier 2021). Finalement, le taux de R\u00e9ponse Compl\u00e8te (RC) dans le groupe RT + HCE a montr\u00e9 la diff\u00e9rence la plus significative avec la RT seule, soit <strong>47,4 % contre 5,3 %,<\/strong> respectivement, <strong>dans les 2 mois suivant le traitement<\/strong> (valeur P &lt; 0,05). <strong>Le temps pour un soulagement complet de la douleur \u00e9tait de 10 jours pour RT + HCE,<\/strong> tandis que le point final n\u2019a pas \u00e9t\u00e9 atteint dans le groupe avec RT seule.<strong> La progression de la douleur ou la stabilit\u00e9 de la maladie a \u00e9t\u00e9 observ\u00e9e chez la moiti\u00e9 des patients du groupe RT dans les 4 semaines suivant le traitement.<\/strong> Cependant, <strong>ce score \u00e9tait proche de z\u00e9ro chez les patients RT + HCE dans les deux mois suivant le traitement<\/strong>.<\/span><\/section><section><strong class=\"sub-title\"><span dir=\"auto\">Conclusions :\u00a0<\/span><\/strong><span dir=\"auto\"> L\u2019HCE plus RT a d\u00e9montr\u00e9 des augmentations significatives du soulagement de la douleur et un temps de r\u00e9ponse plus court par rapport \u00e0 la RT seule chez les patients atteints de l\u00e9sions osseuses m\u00e9tastatiques.<\/span><\/section><\/div><\/div><div class=\"table-scroll-wrapper\"><table border=\"1\"><thead><tr><th><span dir=\"auto\">Indicateur de QdV\/Am\u00e9lioration de la Douleur<\/span><\/th><th><span dir=\"auto\">RT monoth\u00e9rapie<\/span><\/th><th><span dir=\"auto\">RT + Hyperthermie (HCE wIRA)<\/span><\/th><th><span dir=\"auto\">Impact QdV<\/span><\/th><\/tr><\/thead><tbody><tr><td><strong><span dir=\"auto\">Taux de R\u00e9ponse Compl\u00e8te (RC) \u00e0 2 mois<\/span><\/strong><span dir=\"auto\">\u00a0(score de douleur z\u00e9ro)<\/span><\/td><td>5,3 %<\/td><td><strong>47,4 %<\/strong><\/td><td><span dir=\"auto\">* <strong>Accroissement de la probabilit\u00e9 de r\u00e9mission compl\u00e8te de la douleur de 894 %.<\/strong><\/span><span dir=\"auto\">* des chances d\u2019\u00e9limination totale de la douleur.<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Temps pour un soulagement complet de la douleur<\/span><\/strong><\/td><td><span dir=\"auto\">non atteint<\/span><\/td><td><strong><span dir=\"auto\">10 jours<\/span><\/strong><\/td><td><span dir=\"auto\"><strong>\u00ab b\u00e9n\u00e9fice significatif et rapide \u00bb<\/strong><\/span><\/td><\/tr><tr><td style=\"text-align: left;\"><strong><span dir=\"auto\">Dur\u00e9e du Soulagement de la Douleur\u00a0<\/span><\/strong><\/td><td style=\"text-align: left;\"><span dir=\"auto\">M\u00e9diane : 28 jours\/4 semaines chez la moiti\u00e9 des patients<\/span><\/td><td style=\"text-align: left;\"><span dir=\"auto\">M\u00e9diane :<strong>\u00a0Non atteinte \u00e0 24 semaines<\/strong><\/span><\/td><td style=\"text-align: left;\"><span dir=\"auto\">La dur\u00e9e du soulagement *\u00a0<\/span><strong><span dir=\"auto\">multiplie par six<\/span><\/strong><span dir=\"auto\">\u00a0*, r\u00e9duisant la d\u00e9pendance aux analg\u00e9siques.<\/span><\/td><\/tr><\/tbody><\/table><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Comparativement \u00e0 l\u2019<a title=\"\u00c9tude Phase III Chi MS et al. 2017\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5\" target=\"_blank\" rel=\"noopener\">\u00a0\u00e9tude de Phase III similaire publi\u00e9e par Chi MS et al<\/a><span dir=\"auto\">\u00a0. (2017) avec l\u2019hyperthermie locor\u00e9gionale RF, les b\u00e9n\u00e9fices (<em>concernant la QdV et la r\u00e9duction de la douleur)<\/em> obtenus en utilisant l\u2019hyperthermie HCE wIRA \u00e9taient bien sup\u00e9rieurs \u2013 r\u00e9sultats de l\u2019\u00e9tude RF HT + RT :<\/span><\/p><div class=\"table-scroll-wrapper\" style=\"text-align: left;\"><table border=\"1\"><thead><tr><th><span dir=\"auto\">Indicateur de QdV\/Am\u00e9lioration de la Douleur<\/span><\/th><th><span dir=\"auto\">RT monoth\u00e9rapie<\/span><\/th><th><span dir=\"auto\">RT + Hyperthermie (HT)<\/span><\/th><th>Impact QdV<\/th><\/tr><\/thead><tbody><tr><td><strong><span dir=\"auto\">Taux de R\u00e9ponse Compl\u00e8te (RC) \u00e0 3 Mois<\/span><\/strong><span dir=\"auto\">\u00a0(score de douleur z\u00e9ro)<\/span><\/td><td>7,1 %<\/td><td><strong>37,9 %<\/strong><\/td><td><span dir=\"auto\">Augmentation de 533 % des chances de soulagement total de la douleur.<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Dur\u00e9e du Soulagement de la Douleur<\/span><\/strong><\/td><td><span dir=\"auto\">M\u00e9diane : 55 jours\/7,9 semaines<\/span><\/td><td><span dir=\"auto\">M\u00e9diane :\u00a0<strong>Non atteinte \u00e0 24 semaines<\/strong><\/span><\/td><td><span dir=\"auto\">La dur\u00e9e du soulagement triple, r\u00e9duisant la d\u00e9pendance aux analg\u00e9siques.<\/span><\/td><\/tr><\/tbody><\/table><\/div><p style=\"text-align: left;\">En r\u00e9sum\u00e9, les preuves scientifiques consolid\u00e9es (<em>des \u00e9tudes fondamentales sur la technologie wIRA aux essais cliniques cruciaux de Phase III<\/em>) confirment le r\u00f4le de l\u2019HCE comme th\u00e9rapie adjuvante \u00e0 impact multiple en oncologie : elle augmente l\u2019efficacit\u00e9 de la CT\/RT, active le syst\u00e8me immunitaire syst\u00e9mique (y compris la synergie avec l\u2019immunoth\u00e9rapie), et am\u00e9liore de mani\u00e8re spectaculaire le contr\u00f4le de la douleur et la QdV des patients atteints de cancer.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Avantages Physiologiques Syst\u00e9miques et Potentiel Th\u00e9rapeutique dans d\u2019Autres Pathologies<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>La chaleur douce et contr\u00f4l\u00e9e fournie par l\u2019HCE avec le rayonnement wIRA d\u00e9clenche des r\u00e9ponses thermor\u00e9gulatrices complexes qui produisent de larges avantages syst\u00e9miques, \u00e9tendant le potentiel th\u00e9rapeutique au-del\u00e0 de l\u2019oncologie :<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Gestion Musculosquelettique et de la Douleur<\/h3><p style=\"text-align: left;\">L\u2019HCE est efficace dans la gestion des syndromes de douleur chronique, tirant parti de ses effets physiologiques sur le tonus musculaire et la microcirculation :<\/p><ul><li style=\"text-align: left;\"><strong>Dorsalgie (Douleur Chronique au Dos)<\/strong> : Des \u00e9tudes montrent que l\u2019WBH l\u00e9g\u00e8re, lorsqu\u2019elle est combin\u00e9e \u00e0 une th\u00e9rapie multimodale stationnaire de la douleur, apporte un b\u00e9n\u00e9fice significatif aux patients souffrant de lombalgie chronique non sp\u00e9cifique (dorsalgie)\u00a0<span class=\"citation\">[53, 54]<\/span>.<\/li><li style=\"text-align: left;\"><strong>Syndrome de Fibromyalgie (SFM)<\/strong> : L\u2019HCE est un traitement adjuvant document\u00e9 pour le SFM. Des essais contr\u00f4l\u00e9s randomis\u00e9s ont d\u00e9montr\u00e9 l\u2019efficacit\u00e9 de l\u2019WBH wIRA l\u00e9g\u00e8re dans un contexte de r\u00e9adaptation multimodale standard, montrant des effets sur l\u2019<strong>intensit\u00e9 de la douleur<\/strong> et l\u2019<strong>\u00e9tat mental<\/strong>\u00a0[<span class=\"citation\">17, 56, 57<\/span>]. Ce b\u00e9n\u00e9fice est en partie li\u00e9 \u00e0 l\u2019am\u00e9lioration de la microcirculation, un probl\u00e8me connu chez les patients atteints de SFM [55].<\/li><li style=\"text-align: left;\"><strong>Spondylarthrite Ankylosante (SA)<\/strong> : L\u2019HCE a montr\u00e9 des effets immunomodulateurs chez les patients atteints de SA, des \u00e9tudes signalant la capacit\u00e9 de l\u2019HCE \u00e0 augmenter les m\u00e9diateurs anti-inflammatoires comme l\u2019<strong>Interleukine-10<\/strong> (IL-10) et \u00e0 moduler les cytokines pro-inflammatoires comme le TNF-\u03b1, sugg\u00e9rant un r\u00f4le b\u00e9n\u00e9fique dans la gestion de l\u2019inflammation chronique associ\u00e9e \u00e0 la maladie <span class=\"citation\">[58, 59, 52]<\/span>.<\/li><li style=\"text-align: left;\"><strong>Ph\u00e9nom\u00e8ne de Raynaud dans la Scl\u00e9rose Syst\u00e9mique<\/strong> : L\u2019hyperthermie m\u00e9diatis\u00e9e par infrarouge s\u2019est av\u00e9r\u00e9e efficace dans le traitement des sympt\u00f4mes vasoconstricteurs associ\u00e9s au Ph\u00e9nom\u00e8ne de Raynaud li\u00e9 \u00e0 la Scl\u00e9rodermie, d\u00e9montrant des avantages vasculaires [49].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Sant\u00e9 Cardiovasculaire et Circulatoire \u2764\ufe0f<\/h3><p style=\"text-align: left;\">Au-del\u00e0 de l\u2019am\u00e9lioration de la perfusion tumorale, l\u2019HCE a des effets sp\u00e9cifiques sur le syst\u00e8me circulatoire :<\/p><ul><li style=\"text-align: left;\"><strong>Hypertension Essentielle<\/strong> : Une s\u00e9rie d\u2019\u00e9tudes a examin\u00e9 l\u2019utilisation de l\u2019hyperthermie wIR-A l\u00e9g\u00e8re chez des patients atteints d\u2019hypertension art\u00e9rielle (Stades I et II de l\u2019OMS). Les r\u00e9sultats indiquent que les traitements s\u00e9quentiels peuvent affecter positivement les <strong>ondes de pouls centrales et p\u00e9riph\u00e9riques, la pression art\u00e9rielle<\/strong> et la <strong>viscosit\u00e9 sanguine<\/strong>, confirmant le r\u00f4le de l\u2019HCE comme option de th\u00e9rapie physique non pharmacologique [<span class=\"citation\">44, 47<\/span>].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \" style=\"text-align: left;\"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">C. Effets Neuro-Endocriniens et Psychologiques<\/h3><p style=\"text-align: left;\">L\u2019HCE engage les syst\u00e8mes neuro-endocriniens du corps, influen\u00e7ant l\u2019humeur et le m\u00e9tabolisme :<\/p><ul><li style=\"text-align: left;\"><strong>Trouble D\u00e9pressif Majeur (TDM)<\/strong> : Un essai clinique randomis\u00e9 a d\u00e9montr\u00e9 qu\u2019une seule s\u00e9ance d\u2019HCE pouvait agir comme un antid\u00e9presseur \u00e0 action rapide, entra\u00eenant une r\u00e9duction des sympt\u00f4mes d\u00e9pressifs pendant plusieurs semaines. Cet effet est li\u00e9 \u00e0 l\u2019activation par la chaleur des voies immunitaires et inflammatoires qui influencent le cerveau [51].<\/li><li style=\"text-align: left;\"><strong>Modulation Hormonale (Endocrinologie)<\/strong> : L\u2019HCE stimule l\u2019*axe Hypothalamo-Hypophyso-Surr\u00e9nalien (HHS) et influence les niveaux d\u2019hormones. Des \u00e9tudes ont document\u00e9 les r\u00e9ponses de l\u2019<strong>Hormone de Croissance<\/strong> et de la <strong>Prolactine<\/strong> pendant l\u2019hyperthermie du corps entier, soulignant son impact sur la r\u00e9gulation endocrinienne [<span class=\"citation\">42, 43<\/span>].<\/li><li style=\"text-align: left;\"><strong>M\u00e9tabolisme et R\u00e9action Cellulaire<\/strong> : L\u2019HCE acc\u00e9l\u00e8re le taux m\u00e9tabolique de base. Au niveau cellulaire, la chaleur influence la cin\u00e9tique de la pO2 et est li\u00e9e \u00e0 la synth\u00e8se de prot\u00e9ines protectrices comme la <strong>ferritine<\/strong>\u00a0dans la peau, soutenant la r\u00e9paration tissulaire [48; 46].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Foire Aux Questions (FAQ) sur les S\u00e9ances WBH Recommand\u00e9es et les Temp\u00e9ratures Cibles<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p><i>Les traitements\u00a0<\/i><i>doivent<\/i>\u00a0<i>\u00eatre<\/i>\u00a0<i>effectu\u00e9s<\/i><i>\u00a0uniquement apr\u00e8s\u00a0<\/i><i>consultation<\/i>\u00a0<i>finale<\/i>\u00a0<i>avec<\/i><i>\u00a0un\u00a0<\/i><i>m\u00e9decin<\/i><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div><h4>Quel est le protocole d\u2019Hyperthermie du Corps Entier (HCE\/WBH) recommand\u00e9 pour l\u2019Hypertension Essentielle ?<\/h4><div><p>Le protocole pour l\u2019Hypertension Essentielle recommande 12 s\u00e9ances \u00e0 une temp\u00e9rature cible de 38,3 \u00b0C. Chaque s\u00e9ance dure environ 45 minutes, comprenant une phase d\u2019augmentation de 30 minutes et une phase de repos de 15 minutes (pas de phase de plateau).<\/p><\/div><\/div><div><h4>Quels sont les param\u00e8tres HCE recommand\u00e9s pour la Douleur Chronique au Dos (Dorsalgie) ?<\/h4><div><p>Pour la Dorsalgie, 6 s\u00e9ances sont g\u00e9n\u00e9ralement recommand\u00e9es, ciblant 38,4 \u00b0C. La dur\u00e9e totale de la s\u00e9ance est d\u2019environ 90 minutes, avec 45 minutes d\u2019augmentation, une phase de plateau de 15 minutes et 30 minutes de repos.<\/p><\/div><\/div><div><h4>Quel est le protocole HCE pour la Fibromyalgie et la Spondylarthrite Ankylosante ?<\/h4><div><p>La Fibromyalgie et la Spondylarthrite Ankylosante suivent g\u00e9n\u00e9ralement un protocole de 6 s\u00e9ances, ciblant 38,5 \u00b0C. La dur\u00e9e totale de la s\u00e9ance est d\u2019environ 90 minutes, comprenant 45 minutes d\u2019augmentation, un plateau de 15 minutes et 30 minutes de repos.<\/p><\/div><\/div><div><h4>Quel est le protocole recommand\u00e9 pour l\u2019HCE en tant que Traitement Compl\u00e9mentaire du Cancer ?<\/h4><div><p>En tant que traitement compl\u00e9mentaire du cancer, le protocole n\u00e9cessite 2 s\u00e9ances ou plus ciblant une temp\u00e9rature centrale comprise entre 39,0 \u00b0C et 40,0 \u00b0C. La dur\u00e9e totale de la s\u00e9ance est la plus longue, allant de 3 \u00e0 4 heures, ce qui comprend 60 \u00e0 90 minutes pour la phase d\u2019augmentation, 60 \u00e0 90 minutes pour la phase de plateau et 60 minutes pour la phase de repos.<\/p><\/div><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div><div class=\"wpb_content_element \"><div class=\"table-scroll-wrapper\"><table width=\"1151\"><tbody><tr><td width=\"278\">Indication<\/td><td width=\"99\">Nb de s\u00e9ances<\/td><td width=\"135\">Temp\u00e9rature cible<\/td><td colspan=\"2\" width=\"309\">Temps de th\u00e9rapie<br \/>Phase d\u2019augmentation\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Phase de plateau<\/td><td width=\"164\">Temps de repos<br \/>Phase de repos<\/td><td width=\"164\"><b>Total<\/b><br \/><b>Temps de s\u00e9ance HCE<\/b><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Hypertension Essentielle<\/td><td rowspan=\"2\" width=\"99\">12<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Dorsalgie<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,4 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Fibromyalgie<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Spondylarthrite Ankylosante<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Scl\u00e9rose Syst\u00e9mique<\/td><td rowspan=\"2\" width=\"99\">15<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Trouble D\u00e9pressif Majeur<\/td><td rowspan=\"2\" width=\"99\">1+<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>105 -170 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 2-3\u00a0<\/b><b>heures<\/b><\/td><\/tr><tr><td width=\"155\">45-110 min<\/td><td width=\"155\">60 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Traitement Compl\u00e9mentaire du Cancer<\/td><td rowspan=\"2\" width=\"99\">2+<\/td><td rowspan=\"2\" width=\"135\">39,0-40,0 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>120-180 min<\/b><\/td><td rowspan=\"2\" width=\"164\">60 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 3-4\u00a0<\/b><b>heures<\/b><\/td><\/tr><tr><td width=\"155\">60-90 min<\/td><td width=\"155\">60-90 min<\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div><div id=\"ut-row-inner-68e7a7d03e7dd\" class=\"vc_row wpb_row vc_inner vc_row-fluid ut-row-inner-68e7a7d03e7ec\"><div class=\"wpb_column vc_column_container vc_col-sm-6\"><div id=\"ut-column-inner-68e7a7d03eb05\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"wpb_content_element\"><div id=\"ut_bi_68e7a7d03ebdb\" class=\"bklyn-big-icon-wrap\"><div class=\"bklyn-big-icon bklyn-big-icon-square\">\u00a0<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>NOTE : cet article n\u2019est pas une liste exhaustive des \u00e9tudes et des effets de l\u2019HCE wIRA<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">R\u00e9f\u00e9rences et Citations<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<section><ol><li>Ardenne M. von. Moderate Hyperthermie als Behandlungsmethode mit vielen Indikationen. \u00c4rztzeitschr Naturheilverf 1994; 5:356-61.<\/li><li>B\u00e4umler H., Scherf H.P., Aurisch R., et al. Einflu\u00df einer Serie von Infrarot-Ganzk\u00f6rperbestrahlungen auf Flie\u00dfeigenschaften des Blutes und die H\u00e4modynamik. Perfusion 1990: 138-43.<\/li><li>Heckel M. Ganzk\u00f6rper-Hyperthermie und Fiebertherapie, Grundlagen und Praxis. Stuttgart: Hippokrates Verlag, 1990.<\/li><li>Kosaka M., Sugahara T., Schmidt K.L., Simon E. Thermotherapy: Principles and Practice. Heidelberg: Springer Verlag, 2000.<\/li><li>Meffert H., Hecht H.C., G\u00fcnther H., et al. Biophysikalische Ergebnisse des klinischen Tests der IRA-Therm-Hyperthermietechnik der 2. Generation. ThermoMed 1990; 6:71-78.<\/li><li>Schmidt K.L. Hyperthermie und Fieber, Wirkungen bei Mensch und Tier. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1987.<\/li><li>Vaupel P., Kr\u00fcger W. W\u00e4rmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsm\u00f6glichkeiten. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1995.<\/li><li>Piazena H., Meffert H. Optische Eigenschaften der Haut und die photobiologischen Grundlagen zur Dosierung von IR-Hautbestrahlungen in vivo und in vitro. 6. Symposium Licht und Gesundheit 2008 13.-14.03. Berlin, 2008:162-178.<\/li><li>Zschaeck S. and Beck M. Chapter 8 Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?<\/li><li>Zhang H, Wang W, Zhang S, Huang W. Comparison of the anti-tumor effects of various whole-body hyperthermia protocols\u2026 Immunol Invest. 2005;34(3):245-58.<\/li><li>Abreu MM, Chocron AF, Smadja DM. From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. Front Immunol. 2025 Feb 28;16:1487296.<\/li><li>Bull JMC. et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-\u03b1: A description of a phase I-II protocol. Journal of Hyperthermia. 2008; 24(8): 649-662.<\/li><li>Weigelin B. Visualization of the immune effect of hyperthermia. ICHO 2021, Session: Hyperthermia and immunology.<\/li><li>Faghihi Moghaddam F, Bakhshandeh M, Mofid B, et al. Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone\u2026 J Therm Biol. 2024 Feb;120:103804.<\/li><li>Hildebrandt B, Dr\u00e4ger J, Kerner T. et al. Whole-body hyperthermia in the scope of von Ardenne\u2019s systemic cancer multistep therapy (sCMT)\u2026 International Journal of Hyperthermia. 2004;3:317\u2013333.<\/li><li>Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin in patients with recurrent ovarian cancer \u2013 a phase II study. Gynecol Oncol 2009; 2:384-88.<\/li><li>Brockow T., Wagner A., Franke A., Offenb\u00e4cher M., Resch K.L. A Randomized Controlled Trial on the Effectiveness of Mild Water-filtered Near Infrared Whole-body Hyperthermia\u2026 Clin J Pain 2007; 1:67-75.<\/li><li>Kleef R, Nagy R, Baierl A, et al. Low-dose Ipilimumab plus Nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series\u2026 Cancer Immunol Immunother. 2021;70:1393\u2013403.<\/li><li>Adachi H., Katsuno M., Waza M., et al. Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications. Int J Hyperthermia 2009; 8:647-54.<\/li><li>Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin\u2026 Gynecol Oncol 2009; 2:384-88.<\/li><li>Bull J.M., Scott G.L., Figueroa G., et al. An Update of a Phase II Clinical Trial Using Fever-Range Whole-Body Thermal Therapy (FR-WB-TT)\u2026 Soc for Thermal Med Joint Annual Meeting, 14.-17.5.2007.<\/li><li>Bull J.M., Scott G.L., Strebel F.R., et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine and daily interferon-\u03b1: A description of a phase I-II protocol. Int J Hyperthermia 2008; 8:649-62.<\/li><li>Bull J.M., Nagle V.L., Scott G., et al. A phase-I-study of optimally-timed Gemcitabine + Cisplatin\/Interferon-a combined with long-duration, low-temperature whole-body hyperthermia. ESHO 2001, Verona\/ Italy, 30.05.-02.06.2001:67.<\/li><li>Capitano M., Mace T., Nemeth M., et al. A novel strategy for improving neutrophil recovery following total body irradiation. Soc for Thermal Med Joint Annual Meeting, 24.-26.4.2010.<\/li><li>Dayanc B.E., Ostberg J.R., Repasky E.A. Enhancement of NK Cell Cytotoxic Activity by Mild Thermal Stress. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li>Hajto T., Hostanska K. Effect of in vivo hyperthermia on human natural killer cells. Clin Trials J 1985; 6:514-20.<\/li><li>Hattori T., Kokura S., Okuda T., et al. Antitumor effect of whole body hyperthermia with \u03b1-galactosylceramide in a subcutaneous tumor model of colon cancer. Int J Hyperthermia 2007; 7:591-98.<\/li><li>Kisailus A., Pritchard M., Li Y., Ostberg J., Repasky E.A. Thermal Regulation of Antigen Presenting Cells: Use of Hyperthermia as an Adjuvant for Cancer Vaccines. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li>Multhoff G. Letter to Editor, Hyperthermia classic commentary: Activation of natural killer (NK) cells by heat shock protein 70\u2026 Int J Hyperthermia 2009; 3:176-79.<\/li><li>Peer A.J., Grimm M.J., Zynda E.R., Repasky E.A. Diverse immune mechanisms may contribute to the survival benefit seen in cancer patients receiving hyperthermia. Immunol Res 2010; 1-3:137-154.<\/li><li>Rowe R.W., Stebel F.R., Proett J.M., et al. Fever-range whole body thermotherapy combined with oxaliplatin: A curative regimen in a pre-clinical breast cancer model. Int J Hyperthermia 2010; 6:565-76.<\/li><li>Schencking M., Frese T., Sandholzer H. Behandlung einer Radikulopathie bei oss\u00e4rer Metastasierung der Lendenwirbels\u00e4ule durch Infrarot-A-Ganzk\u00f6rperhyperthermie. Forsch Komplementmed 2008; 15:273-76.<\/li><li>Scott G.L., Bull J.M.C., Kochn M. Management of Conscious Sedation\u2026 9th Int Congress on Hyperthermic Oncology, 20.-24.4.2004.<\/li><li>Shecterle L.M., Cyr J.A.S. Hyperthermia Aids Patients with Advanced Lung Cancer. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li>Skitzki J.J., Repasky E.A., Evans S.S. Hyperthermia as an immunotherapy strategy for cancer. Current Opnion in Investigational Drugs 2009; 6: 550-58.<\/li><li>Toyota N., Strebel F.R., Stephens L.C., et al. Long-duration, mild whole body hyperthermia with cisplatin: tumour response and kinetics of apoptosis and necrosis\u2026 Int. J. Hyperthermia 1997; 5:497-506.<\/li><li>Wang X.Y., Kazim L., Repasky E.A., Subjeck J.R. Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines\u2026 J of Immunology 2001; 165:490-97.<\/li><li>VanderZee J., DeBruijne M., Mens J.W.M., et al. Reirradiation combined with hyperthermia in breast cancer recurrences\u2026 Int J Hyperthermia 2010; 7:638-48.<\/li><li>Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia for locally advanced breast cancer. Int J Hyperthermia 2010; 7:618-24.<\/li><li>Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence\u2026 Int J Hyperthermia 2010; 7: 612\u201317.<\/li><li>Sen A., Capitano M., Dommer M., et al. Thermoregulatory responses to mild systemic thermal stress increase tumor perfusion\u2026 Cancer Res. 2011; 71(11):3872-3880.<\/li><li>Koska J., Rovensky J., Zimanova T., Vigas M. Growth hormone and prolactin responses during partial and whole body warm-water immersions. Acta Physiol Scand. 2003 May;178(1):19-23.<\/li><li>Vigas M., Rovensky J., Zimanova T., Koska J. Responses of growth hormone and prolactin to local and whole-body application of Piestany mud. Acta Rheumatol et Balneol Pistiniana 2002:31-38.<\/li><li>Meffert B., Hochmuth O., Steiner M. Effects of a multiple mild infrared a induced hyperthermia on central and peripheral pulse waves in hypertensive patients. North Sea Conference on Biomedical Engineering 1990.<\/li><li>Meffert H., Scherf HP., Meffert B. Milde Infrarot-A-Hyperthermie. Auswirkungen von Serienbestrahlungen mit wassergefilterter Infrarotstrahlung\u2026 Akt Dermatol 1993; 19:142-48.<\/li><li>Applegate L.A., Scaletta C., Panizzon R., et al. Induction of the putative protein ferritin by infrared radiation: Implications in skin repair. Int J of Molecular Med 2000; 5:247-51.<\/li><li>Scherf H.P., Meffert H., B\u00e4umler H., et al. Wirkung einer einmaligen milden Infrarot-A-Hyperthermie auf K\u00f6rpertemperatur, Herzfrequenz, Blutdruck und Blutviskosit\u00e4t\u2026 Dermatol Monatsschr 1989; 175:733-40.<\/li><li>Streffer C. Metabolic changes during and after hyperthermia. Int J Hyperthermia 1985; 4:305-319.<\/li><li>F\u00f6rster J., Fleischanderl S., Wittstock S., et al. Infrared-Mediated Hyperthermia is Effective in the Treatment of Scleroderma-Associated Raynaud\u2019s Phenomenon. J of Investigative Dermatology 2005; 6:1313-16.<\/li><li>Koska J., Rovensky J., Zimanova T., et al. Sympathoadrenal regulation of circulatory responses to whole-body hyperthermia\u2026 Acta Rheumatol et Balneol Pistiniana 2002:23-30.<\/li><li>Janssen C.W., Lowry C.A., Mehl M.R., et al. Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder \u2013 A Randomized Clinical Trial. JAMA Psychiatry. 2016 May 12.<\/li><li>Tarner I.H., Ladner U.M., Uhlemann C., Lange U. The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1 beta and IL-6 in patients with ankylosing spondylitis. Clin Rheumatol 2009; 4:397-402.<\/li><li>Ettrich U., Konrad B., Prate K., et al. Milde Ganzk\u00f6rperhyperthermie in Kombination mit station\u00e4rer multimodal orientierter Schmerztherapie\u2026 Orthop\u00e4de 2014; 2:165-74.<\/li><li>Weller E., Ullrich D. Infrarot-A-Hyperthermie-Anwendung bei Patienten mit Analgetica-Abusus wegen chronischer R\u00fcckenschmerzen. Vortrag auf dem 95. Kongre\u00df der Gesellschaft f\u00fcr Phys Med und Rehab 5.10.1990.<\/li><li>Morf S., Vesti B.A., Forster A., et al. Microcirculation abnormalities in patients with fibromyalgia \u2013 measured by capillary and laser fluxmetry. Arthritis Res Ther 2005; 7:R209-16.<\/li><li>Walz J., Hinzmann J., Haase I., Witte T. Ganzk\u00f6rperhyperthermie in der Schmerztherapie \u2013 eine kontrollierte Studie an Patienten mit Fibromyalgiesyndrom. Schmerz 2013; 27:38-45.<\/li><li>Romeyke T., Stummer H. Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic whole-body hyperthermia\u2026 J Musculoskel Pain 2014; 4:341-55.<\/li><li>Zauner D., Quehenberger F., Hermann J., et al. Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study. Int J Hyperthermia 2014; 6:393-401.<\/li><li>Lange U., M\u00fcller-Ladner U., Dischereit G. Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis\u2026 Akt Rheumatol 2017; 2:122-128.<\/li><\/ol><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><\/section><footer>\u00a9\u00a0<time>2025<\/time>\u00a0Romanian Society Oncologic Hyperthermia Tous droits r\u00e9serv\u00e9s. Source : Analyse bas\u00e9e sur la litt\u00e9rature scientifique.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Hyperthermie Corps Entier (HCE\/WBH) en Oncologie : Synergie Th\u00e9rapeutique, Immunomodulation et \u00c9vidence Clinique Publi\u00e9:\u00a02025-10-13\u00a0| Derni\u00e8re R\u00e9vision:\u00a02025-10-13 Par Veronica Iatan, MD, Cristian Gologan, M.Sc. L\u2019Hyperthermie du Corps Entier ( HCE\/WBH) est une strat\u00e9gie oncologique syst\u00e9mique impliquant une \u00e9l\u00e9vation contr\u00f4l\u00e9e de la temp\u00e9rature corporelle centrale, souvent r\u00e9alis\u00e9e par la technologie d\u2019Infrarouge-A filtr\u00e9 par l\u2019eau (wIRA). L\u2019HCE est<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/fr\/essais-cliniques-hyperthermie-oncologie\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-977","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/fr\/wp-json\/wp\/v2\/pages\/977","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/fr\/wp-json\/wp\/v2\/comments?post=977"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/fr\/wp-json\/wp\/v2\/pages\/977\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/fr\/wp-json\/wp\/v2\/media?parent=977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}