{"id":972,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2025-12-19T19:01:41","modified_gmt":"2025-12-19T19:01:41","slug":"klinicka-ispitivanja-hipertermije-onkologija","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/hr\/klinicka-ispitivanja-hipertermije-onkologija\/","title":{"rendered":"Klini\u010dka ispitivanja"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"972\" class=\"elementor elementor-972 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Hipertermija Cijelog Tijela (WBH) u Onkologiji i Drugim Patologijama: Konsolidirana Sinergija, Imunomodulacija i Klini\u010dka ispitivanja<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<header><p style=\"text-align: center;\"><strong><span style=\"color: #6a6a6a;\">Objavljeno: <time datetime=\"2025-10-13\">2025-10-13<\/time> | Zadnja Revizija: <time datetime=\"2025-10-13\">2025-10-13<\/time><\/span><\/strong><\/p><\/header><div class=\"authors\" style=\"text-align: center;\"><p><br \/><a href=\"\/?p=1261\">Veronica Iatan, dr. med.<\/a>,<br \/><a href=\"\/?p=1324\">Cristian Gologan, M.Sc.<\/a><\/p><\/div><section class=\"ai-summary\"><p style=\"font-weight: bold; font-style: italic;\">Hipertermija Cijelog Tijela (WBH) je sistemska onkolo\u0161ka strategija koja uklju\u010duje kontrolirano podizanje tjelesne temperature, \u010desto kori\u0161tenjem tehnologije *Infracrvenog-A filtriranog vodom (wIRA)*. WBH je prvenstveno *kemo\/radio-senzibilizator*, zna\u010dajno pobolj\u0161avaju\u0107i perfuziju tumora i oksigenaciju kako bi poja\u010dao u\u010dinkovitost tradicionalnih tretmana. Klju\u010dno, djeluje kao sna\u017ean *sistemski imunomodulator*, mobiliziraju\u0107i Proteine Toplinskog \u0160oka (HSP) i T-stanice. Ova akcija stvara esencijalnu sinergiju s naprednom *Imunoterapijom (ICI)* te nudi dramati\u010dno, brzo ubla\u017eavanje boli i pobolj\u0161anje Kvalitete \u017divota (K\u017d) kod raznih karcinoma i kroni\u010dnih stanja poput Fibromijalgije.<\/p><\/section><section class=\"disclaimer\">* Medicinsko Odricanje od Odgovornosti: Ovaj \u010dlanak je namijenjen isklju\u010divo informativnim svrhama i nije zamjena za individualiziranu medicinsku konzultaciju, dijagnozu ili lije\u010denje od strane ovla\u0161tenog lije\u010dnika.*<\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. Definicija Hipertermije Cijelog Tijela (WBH) i Terapijska Tehnologija<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\"><strong>Hipertermija Cijelog Tijela (WBH)<\/strong>, ili &#8220;sistemska hipertermija&#8221;, definirana je kao kontrolirano podizanje tjelesne temperature u terapijske svrhe. Na temelju spektra <b>u\u010dinaka prirodne vru\u0107ice pri razli\u010ditim temperaturama<\/b>, WBH postupci se razlikuju na sljede\u0107i na\u010din:<\/p><ul style=\"text-align: left;\"><li><b>Blaga WBH:<\/b> &lt; 38,5\u00b0C<\/li><li><b>Umjerena WBH:<\/b>\u00a038,5\u00b0C &#8211; 40,5 \u00b0C<\/li><li><b>Ekstremna WBH:<\/b> &gt; 40,5\u00b0C<\/li><\/ul><p style=\"text-align: left;\">Posebno blaga i umjerena WBH <b>pove\u0107ava protok krvi (perfuziju)<\/b>, poti\u010de metabolizam, smanjuje mi\u0161i\u0107ni tonus i <strong class=\"key-term\">stimulira imunolo\u0161ki sustav.<\/strong><\/p><p style=\"text-align: left;\"><a title=\"Tehni\u010dki detalji von Ardenne IRATHERM\u00ae 1000M WBH wIRA ure\u0111aja\" href=\"\/?page_id=850\">Ure\u0111aj von Ardenne IRATHERM\u00ae 1000M WBH wIRA<\/a> za tu svrhu koristi isklju\u010divo <b>duboko prodiru\u0107e, vodenom filtrirano Infracrveno-A (wIRA) toplinsko zra\u010denje, blago za ko\u017eu<\/b>\u00a0(bez IR-B \/ IR-C). Otvoreni, ne-klaustrofobi\u010dni dizajn sustava osigurava ravnomjeran intenzitet zra\u010denja preko cijele povr\u0161ine pacijenta (le\u0111a) i nudi korisniku optimalan, pacijent-specifi\u010dan unos topline u smislu lokacije i intenziteta.<\/p><p style=\"text-align: left;\">Vodeno filtrirano Infracrveno-A zra\u010denje odgovara prirodnom toplinskom zra\u010denju sunca i pru\u017ea tehnolo\u0161ku osnovu za ravnomjernu i blagu primjenu topline <span class=\"citation\">[1, 5, 7, 8]<\/span>.<\/p><p style=\"text-align: left;\">Koriste\u0107i von Ardenne IRATHERM<sup>\u00ae<\/sup> 1000 princip, koji je razvijan i dokazan vi\u0161e od 30 godina, <a title=\"Prof. Manfred von Ardenne - Doprinosi\" href=\"\/?p=1352\">Prof. Manfred von Ardenne<\/a> je uspio fizi\u010dki i tehni\u010dki reproducirati to toplinsko zra\u010denje i u\u010diniti ga industrijski dostupnim za odr\u017eivu medicinsku upotrebu putem hipertermije cijelog tijela.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Znanstvene Osnove i Sistemski U\u010dinci<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p style=\"text-align: left;\">WBH se razvila u strategiju temeljenu na \u010dvrstim biofizi\u010dkim i fiziolo\u0161kim principima. U onkologiji, fokus je na <strong>Umjerenoj<\/strong>\u00a0i <strong>Hipertermiji Raspona Vru\u0107ice (HRV-WBH)<\/strong>, prepoznatim kao tretmani s vi\u0161estrukim terapijskim indikacijama <span class=\"citation\">[1, 3]<\/span>.<\/p><p style=\"text-align: left;\">Tehnolo\u0161ku osnovu za ravnomjernu i blagu primjenu topline \u010desto pru\u017eaju ure\u0111aji koji koriste <strong>Infracrveno-A zra\u010denje filtrirano vodom (wIRA).<\/strong> Detaljne biofizi\u010dke studije potvrdile su <strong>sposobnost ove tehnologije da osigura duboko i kontrolirano zagrijavanje,<\/strong> uzimaju\u0107i u obzir opti\u010dka svojstva ko\u017ee i fotobiolo\u0161ku osnovu za doziranje [5,7,8].<\/p><p style=\"text-align: left;\">Detaljne biofizi\u010dke studije potvrdile su <strong class=\"key-term\">sposobnost wIRA tehnologije<\/strong> da osigura <strong>duboko i kontrolirano zagrijavanje<\/strong> <span class=\"citation\">[5, 7, 8]<\/span>. Na fiziolo\u0161koj razini, WBH ima temeljne sistemske u\u010dinke:<\/p><ol style=\"text-align: left;\"><li><strong>Pobolj\u0161ana Reologija Krvi<\/strong>: Izlo\u017eenost IR-WBH povoljno utje\u010de na <strong>svojstva protoka krvi i hemodinamiku<\/strong> <span class=\"citation\">[2]<\/span>, podr\u017eavaju\u0107i temeljni mehanizam <strong>pobolj\u0161anja perfuzije tumora<\/strong> \u2014 kriti\u010dan preduvjet za uspjeh sistemskih tretmana.<\/li><li><strong>Op\u0107a Biolo\u0161ka Aktivacija:<\/strong>\u00a0WBH inducira odgovor na toplinski stres koji pokre\u0107e kaskadu biolo\u0161kih procesa, uklju\u010duju\u0107i <strong>modulaciju hormonskog sustava<\/strong> i <strong>ubrzanje metabolizma<\/strong>\u00a0<span class=\"citation\">[6, 4]<\/span>.<\/li><\/ol><p style=\"text-align: left;\">Na temelju ovih temelja, WBH funkcionira kao <strong class=\"key-term\">sistemski imunomodulator<\/strong>, optimiziraju\u0107i <strong class=\"key-term\">mikrookoli\u0161 tumora (MOT)<\/strong> i <strong>poja\u010davaju\u0107i u\u010dinkovitost naprednih onkolo\u0161kih tretmana<\/strong> <span class=\"citation\">[9]<\/span>.<\/p><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. Klju\u010dni Mehanizmi Djelovanja (Molekularni, Fiziolo\u0161ki i Imunolo\u0161ki)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>Terapijski u\u010dinci WBH su slo\u017eeni, posredovani promjenama na stani\u010dnoj, imunolo\u0161koj i fiziolo\u0161koj razini:<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Sinergija s Kemoterapijom i Radioterapijom (Kemo\/Radio-senzibilizator)<\/h3><ul style=\"text-align: left;\"><li><strong>Optimizacija Mikrookoli\u0161a Tumora (MOT\/TME)<\/strong>: WBH pobolj\u0161ava <strong>perfuziju tumora krvlju<\/strong> i <strong>oksigenaciju<\/strong>, preokre\u0107u\u0107i tumor hipoksiju. To je klju\u010dno, jer su dobro oksigenirane tumorske stanice zna\u010dajno osjetljivije na uni\u0161tenje <strong>Kemoterapijom<\/strong> (KT) i <strong>Radioterapijom<\/strong> (RT) <span class=\"citation\">[9, 41]<\/span>.<\/li><li><strong>Kemo\/Radio U\u010dinkovitost<\/strong>: Hipertermija djeluje kao <strong class=\"key-term\">senzibilizator<\/strong> <strong>kemo &amp; radio, pobolj\u0161avaju\u0107i isporuku kisika tumoru<\/strong> ( <strong>radio-senzibiliziraju\u0107i u\u010dinak<\/strong> ) i pove\u0107avaju\u0107i u\u010dinkovitost lijekova kao \u0161to su Cisplatin, Gemcitabin i Carboplatin <span class=\"citation\">[12, 16, 36]<\/span>.<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><h3 style=\"text-align: left;\">B. Indukcija Robusnog Anti-Tumorskog Imunolo\u0161kog Odgovora (Imunomodulacija)<\/h3><p style=\"text-align: left;\">WBH je sna\u017ean aktivator obrambenog sustava tijela <span class=\"citation\">[11]<\/span>:<\/p><ul style=\"text-align: left;\"><li><strong>Proteini Toplinskog \u0160oka (HSP)<\/strong>: Toplinski stres poti\u010de sintezu i osloba\u0111anje <b>HSP70<\/b>. Ti proteini djeluju kao &#8216;signali opasnosti&#8217; koji ozna\u010davaju stanice raka za poja\u010dani napad od strane <b>Citotoksi\u010dnih T-Limfocita (CTL)<\/b> imunolo\u0161kog sustava <span class=\"citation\">[9, 10, 29]<\/span>.<\/li><li><strong>Aktivacija Klju\u010dnih Imunolo\u0161kih Stanica<\/strong>: Temperaturni raspon od 39-43\u00b0C pove\u0107ava aktivnost <b>Prirodnih Ubojica (NK) stanica<\/b>\u00a0i poti\u010de aktivnost <b>pomo\u0107nih i citotoksi\u010dnih T-stanica<\/b>, <b>dendriti\u010dnih stanica<\/b>\u00a0i <b>makrofaga<\/b>, dok <span style=\"text-decoration: underline;\">potencijalno ugro\u017eava imunosupresivne stanice<\/span> <span class=\"citation\">[9, 10, 11, 25, 26]<\/span>.<\/li><li><strong>Pove\u0107anje T-Limfocita<\/strong>: HRV-WBH mo\u017ee <b>zna\u010dajno pove\u0107ati (npr. 3 puta)<\/b> populaciju citotoksi\u010dnih T-limfocita u limfoidnim organima, <b>poja\u010davaju\u0107i sistemski anti-tumorski imunolo\u0161ki napad<\/b>\u00a0<span class=\"citation\">[10]<\/span>.<\/li><li><strong>Cjepiva i APC-i:<\/strong>\u00a0WBH mo\u017ee regulirati funkciju Stanica Koje Predstavljaju Antigen (APC) i pove\u0107ati u\u010dinkovitost cjepiva protiv raka, uklju\u010duju\u0107i ona temeljena na HSP110 i GRP170 [37, 28].<\/li><\/ul><\/section><section><h2 style=\"text-align: left;\">\u00a0<\/h2><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Klini\u010dki Dokazi i Sinergija u Multimodalnoj Terapiji<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Sinergija s Imunoterapijom (Inhibitori Kontrolnih To\u010daka &#8211; ICI)<\/h3><p style=\"text-align: left;\">Retrospektivna serija slu\u010dajeva od 131 pacijenta s uznapredovalim (Stadij IV) karcinomom istra\u017eivala je multimodalni protokol koji uklju\u010duje <strong>hipertermiju cijelog tijela<\/strong>\u00a0uz inhibitore kontrolnih to\u010daka (Ipilimumab, Nivolumab) i IL-2 <span class=\"citation\">[18]<\/span>.<\/p><p style=\"text-align: left;\"><strong>Klju\u010dni Zaklju\u010dak<\/strong>: WBH wIRA je utvr\u0111ena kao <strong>integralna i esencijalna komponenta<\/strong> koja <strong>maksimizira anti-tumorski imunolo\u0161ki odgovor<\/strong>. <strong>WBH aktivira i mobilizira T-stanice (induciranjem HSP70 i osloba\u0111anjem tumorskih antigena);<\/strong>\u00a0inhibitori kontrolnih to\u010daka zatim &#8220;uklanjaju ko\u010dnicu&#8221; s tih prethodno aktiviranih T-stanica, \u0161to rezultira neobi\u010dno visokim stopama povoljnog klini\u010dkog odgovora za uznapredovalu bolest <span class=\"citation\">[18]<\/span>.<\/p><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><h3 style=\"text-align: left;\">B. Klini\u010dke Primjene kod Razli\u010ditih Karcinoma<\/h3><ul style=\"text-align: left;\"><li><strong>Karcinom Gu\u0161tera\u010de (Pankreas)<\/strong>: Protokoli Faze I-II s blagom WBH (HRV-WBH) u kombinaciji s kemoterapijom i Interferonom-alfa pokazali su <strong>najmanje 50% regresije tumora kod gotovo polovice pacijenata otpornih na terapiju<\/strong>\u00a0<span class=\"citation\">[4, 22]<\/span>.<\/li><li><strong>Karcinom Dojke (Recidiv):<\/strong>\u00a0WBH u kombinaciji s re-ozra\u010divanjem ili radioterapijom pokazala je u\u010dinkovitost za lokalno uznapredovali karcinom dojke i recidiv na stijenci prsnog ko\u0161a, potvr\u0111eno randomiziranim podacima <span class=\"citation\">[39, 40]<\/span>.<\/li><li><strong>Karcinom Jajnika (Ovarijalni Karcinom):\u00a0<\/strong>WBH u kombinaciji s <b>karboplatinom<\/b>\u00a0istra\u017eena je u studiji Faze II za rekurentni karcinom jajnika <span class=\"citation\">[16, 20]<\/span>.<\/li><li><strong>Kolorektalni Karcinom:<\/strong>\u00a0WBH wIRA kori\u0161tena je u kontekstu von Ardenneovog Sistemskog Vi\u0161estupanjskog Lije\u010denja Raka (sCMT) u kombinaciji s kemoterapijom u studiji Faze I\/II [15].<\/li><\/ul><\/section><section><h2 style=\"text-align: left;\">\u00a0<\/h2><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. Brzo Ubla\u017eavanje Boli i Zna\u010dajno Pobolj\u0161anje Kvalitete \u017divota (K\u017d)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Pacijenti mogu do\u017eivjeti brzo ubla\u017eavanje boli i op\u0107e pobolj\u0161anje blagostanja, kao \u0161to je primije\u0107eno u studiji dr. Bulla <span class=\"citation\">[12]<\/span>, a posebno u novijem klini\u010dkom ispitivanju Faze III koje su proveli Sahinbas i sur. <span class=\"citation\">[14]<\/span>.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3>Klini\u010dko Ispitivanje Faze III (2024) za Metastaze u Kostima<\/h3><div class=\"container\"><div class=\"section\"><section><span dir=\"auto\">U\u00a0<\/span><a title=\"Studija Faze III Sahinbas 2024\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\">2024. godine, Sahinbas i kolege objavili su studiju Faze III<\/span><\/a><span dir=\"auto\"> za bol uzrokovanu metastazama u kostima, uglavnom zbog karcinoma dojke i prostate, koriste\u0107i WBH wIRA Iratherm ure\u0111aje za hipertermiju kao dodatak RT [14].<\/span><span dir=\"auto\">Na temelju ove studije, grupa samo s RT-om predstavljala je najintenzivniju bol. Studija je zavr\u0161ena nakon uklju\u010divanja ukupno 61 pacijenta, 5 godina nakon prve registracije (travanj 2016. \u2013 velja\u010da 2021.). Kona\u010dno, stopa Potpunog Odgovora (PO) u grupi RT + WBH pokazala je najzna\u010dajniju razliku u odnosu na samo RT: *47,4 % naspram 5,3 %, respektivno, **unutar 2 mjeseca nakon lije\u010denja* (P-vrijednost &lt; 0,05). *Vrijeme do potpunog ubla\u017eavanja boli bilo je 10 dana za RT + WBH, dok krajnja to\u010dka nije dosegnuta u grupi samo s RT-om.* Progresija boli ili stabilnost bolesti primije\u0107ena je kod polovice pacijenata u RT grupi unutar 4 tjedna nakon lije\u010denja. Me\u0111utim, *ovaj rezultat je bio blizu nule kod pacijenata s RT + WBH unutar dva mjeseca nakon lije\u010denja*.<\/span><strong class=\"sub-title\"><span dir=\"auto\">Zaklju\u010dci:\u00a0<\/span><\/strong><span dir=\"auto\">\u00a0WBH plus RT pokazao je zna\u010dajno pove\u0107anje ubla\u017eavanja boli i kra\u0107e vrijeme odgovora u usporedbi sa samo RT-om kod pacijenata s metastatskim ko\u0161tanim lezijama.<\/span><\/section><\/div><\/div><div class=\"table-scroll-wrapper\"><table border=\"1\"><thead><tr><th><span dir=\"auto\">K\u017d Indikator\/Pobolj\u0161anje Boli<\/span><\/th><th><span dir=\"auto\">RT monoterapija<\/span><\/th><th><span dir=\"auto\">RT + Hipertermija (WBH wIRA)<\/span><\/th><th><span dir=\"auto\">Utjecaj na K\u017d<\/span><\/th><\/tr><\/thead><tbody><tr><td><strong><span dir=\"auto\">Potpuni Odgovor (PO) pri 2 mjeseca<\/span><\/strong><span dir=\"auto\">\u00a0(nulta ocjena boli)<\/span><\/td><td>5,3 %<\/td><td><strong>47,4 %<\/strong><\/td><td><span dir=\"auto\">*\u00a0<\/span><strong><span dir=\"auto\">Pove\u0107anje od 894 %<\/span><\/strong><span dir=\"auto\">\u00a0* u \u0161ansi za potpunu eliminaciju boli.<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Vrijeme do potpunog ubla\u017eavanja boli<\/span><\/strong><\/td><td><span dir=\"auto\">nije dosegnuto<\/span><\/td><td><strong><span dir=\"auto\">10 dana<\/span><\/strong><\/td><td><span dir=\"auto\"><strong>\u201czna\u010dajna i brza\u201d<\/strong>\u00a0\u00a0korist<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Trajanje Ubla\u017eavanja Boli\u00a0<\/span><\/strong><\/td><td><span dir=\"auto\">Medijan: 28 dana\/4 tjedna kod polovice pacijenata<\/span><\/td><td><span dir=\"auto\">Medijan: <strong>Nije dosegnuto pri 24 tjedna<\/strong><\/span><\/td><td><span dir=\"auto\">Trajanje olak\u0161anja *\u00a0<\/span><strong><span dir=\"auto\">\u0161estostruko je dulje<\/span><\/strong><span dir=\"auto\">\u00a0*, smanjuju\u0107i ovisnost o analgeticima.<\/span><\/td><\/tr><\/tbody><\/table><\/div><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">U usporedbi sa sli\u010dnom <a title=\"Studija Faze III Chi MS et al. 2017\" href=\"[https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5](https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5)\" target=\"_blank\" rel=\"noopener\">\u00a0studijom Faze III koju su objavili Chi MS i sur<\/a><span dir=\"auto\">\u00a0. (2017) s RF lokoregionalnom hipertermijom, prednosti (<em>u pogledu K\u017d i smanjenja boli)<\/em>\u00a0postignute kori\u0161tenjem WBH wIRA hipertermije bile su nadmo\u0107nije \u2013 rezultati studije RF HT + RT:<\/span><\/p><div class=\"table-scroll-wrapper\" style=\"text-align: left;\"><table border=\"1\"><thead><tr><th><span dir=\"auto\">K\u017d Indikator\/Pobolj\u0161anje Boli<\/span><\/th><th><span dir=\"auto\">RT monoterapija<\/span><\/th><th><span dir=\"auto\">RT + Hipertermija (HT)<\/span><\/th><th>Utjecaj na K\u017d<\/th><\/tr><\/thead><tbody><tr><td><strong><span dir=\"auto\">Potpuni Odgovor (PO) pri 3 Mjeseca<\/span><\/strong><span dir=\"auto\">\u00a0(nulta ocjena boli)<\/span><\/td><td>7,1 %<\/td><td>37,9 %<\/td><td><span dir=\"auto\">533% pove\u0107anje u \u0161ansi za potpuno ubla\u017eavanje boli.<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Trajanje Ubla\u017eavanja Boli<\/span><\/strong><\/td><td><span dir=\"auto\">Medijan: 55 dana\/7,9 tjedana<\/span><\/td><td><span dir=\"auto\">Medijan: Nije dosegnuto pri 24 tjedna<\/span><\/td><td><span dir=\"auto\">Trajanje olak\u0161anja utrostru\u010duje se, smanjuju\u0107i ovisnost o analgeticima.<\/span><\/td><\/tr><\/tbody><\/table><\/div><p style=\"text-align: left;\">\u00a0<\/p><p style=\"text-align: left;\">Ukratko, konsolidirani znanstveni dokazi (<em>od temeljnih studija o wIRA tehnologiji do klju\u010dnih klini\u010dkih ispitivanja Faze III<\/em>) potvr\u0111uju ulogu WBH kao adjuvantne terapije s vi\u0161estrukim utjecajem u onkologiji: *pove\u0107ava u\u010dinkovitost KT\/RT, aktivira sistemski imunolo\u0161ki sustav (uklju\u010duju\u0107i sinergiju s imunoterapijom) i dramati\u010dno pobolj\u0161ava kontrolu boli i K\u017d* kod pacijenata s rakom.<\/p><p style=\"text-align: left;\">\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Sistemske Fiziolo\u0161ke Prednosti i Terapijski Potencijal u Drugim Patologijama<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>Blaga, kontrolirana toplina koju pru\u017ea WBH s wIRA zra\u010denjem pokre\u0107e slo\u017eene termoregulacijske odgovore koji stvaraju \u0161iroke sistemske prednosti, pro\u0161iruju\u0107i terapijski potencijal izvan onkologije:<\/p><h3>\u00a0<\/h3><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Mi\u0161i\u0107no-Ko\u0161tano i Lije\u010denje Boli<\/h3><p style=\"text-align: left;\">WBH je u\u010dinkovita u lije\u010denju kroni\u010dnih bolnih sindroma, koriste\u0107i svoje fiziolo\u0161ke u\u010dinke na mi\u0161i\u0107ni tonus i mikrocirkulaciju:<\/p><ul style=\"text-align: left;\"><li>*<strong>Dorsalgija (Kroni\u010dna Bol u Le\u0111ima)<\/strong>:* Studije pokazuju da blaga WBH, u kombinaciji sa stacionarnom multimodalnom terapijom boli, pru\u017ea zna\u010dajnu korist pacijentima s kroni\u010dnom nespecifi\u010dnom boli u donjem dijelu le\u0111a (dorsalgija) <span class=\"citation\">[53, 54]<\/span>.<\/li><li>*<strong>Sindrom Fibromijalgije (SFM)<\/strong>:* WBH je dokumentirani dodatni tretman za SFM. Randomizirana kontrolirana ispitivanja pokazala su u\u010dinkovitost blage wIRA WBH u standardnom multimodalnom rehabilitacijskom okru\u017eenju, s u\u010dincima na *intenzitet boli* i *mentalno stanje* [<span class=\"citation\">17, 56, 57<\/span>]. Ova korist je djelomi\u010dno povezana s pobolj\u0161anom mikrocirkulacijom, poznatim problemom kod pacijenata sa SFM [55].<\/li><li>*<strong>Ankilozantni Spondilitis (AS):<\/strong>* WBH je pokazala imunomodulatorne u\u010dinke kod pacijenata s AS-om, a studije izvje\u0161\u0107uju o sposobnosti WBH da pove\u0107a antiupalne medijatore poput *Interleukina-10* (IL-10) i modulira proupalne citokine poput TNF-\u03b1, sugeriraju\u0107i povoljnu ulogu u lije\u010denju kroni\u010dne upale povezane sa stanjem <span class=\"citation\">[58, 59, 52]<\/span>.<\/li><li>*<strong>Raynaudov Fenomen kod Sistemske Skleroze:<\/strong>* Hipertermija posredovana infracrvenim zra\u010denjem pokazala se u\u010dinkovitom u lije\u010denju vazokonstriktivnih simptoma povezanih s Raynaudovim Fenomenom povezanim sa sklerodermijom, pokazuju\u0107i vaskularne prednosti [49].<\/li><\/ul><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Kardiovaskularno i Cirkulacijsko Zdravlje \u2764\ufe0f<\/h3><p style=\"text-align: left;\">Osim pobolj\u0161anja perfuzije tumora, WBH ima specifi\u010dne u\u010dinke na cirkulacijski sustav:<\/p><ul style=\"text-align: left;\"><li>*<strong>Esencijalna Hipertenzija:<\/strong>* Niz studija istra\u017eivao je primjenu blage IR-A hipertermije kod pacijenata s arterijskom hipertenzijom (WHO Stadiji I i II). Nalazi ukazuju da serijski tretmani mogu pozitivno utjecati na *centralne i periferne pulsne valove, krvni tlak i **viskoznost krvi*, potvr\u0111uju\u0107i ulogu WBH kao ne-farmakolo\u0161ke opcije fizikalne terapije [<span class=\"citation\">44, 47<\/span>].<\/li><\/ul><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \" style=\"text-align: left;\"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">C. Neuro-Endokrini i Psiholo\u0161ki U\u010dinci<\/h3><p style=\"text-align: left;\">WBH uklju\u010duje neuro-endokrine sustave tijela, utje\u010du\u0107i na raspolo\u017eenje i metabolizam:<\/p><ul style=\"text-align: left;\"><li>*<strong>Veliki Depresivni Poreme\u0107aj (VDP):<\/strong>* Randomizirano klini\u010dko ispitivanje pokazalo je da jedna sesija WBH mo\u017ee djelovati kao brzi antidepresiv, \u0161to rezultira smanjenjem simptoma depresije tijekom nekoliko tjedana. Ovaj u\u010dinak povezan je s toplinom induciranom aktivacijom imunolo\u0161kih i upalnih putova koji utje\u010du na mozak [51].<\/li><li>*<strong>Hormonska Modulacija (Endokrinologija)<\/strong>:* WBH stimulira *Hipotalamus-Hipofiza-Nadbubre\u017ena \u017dlijezda (HPA) os* i utje\u010de na razine hormona. Studije su dokumentirale odgovore *Hormona Rasta* i *Prolaktina* tijekom hipertermije cijelog tijela, nagla\u0161avaju\u0107i njezin utjecaj na endokrinu regulaciju [<span class=\"citation\">42, 43<\/span>].<\/li><li>*<strong>Metabolizam i Stani\u010dna Reakcija:<\/strong>* WBH ubrzava bazalni metabolizam. Na stani\u010dnoj razini, toplina utje\u010de na kinetiku pO2 i povezana je sa sintezom za\u0161titnih proteina poput *feritina* u ko\u017ei, podr\u017eavaju\u0107i obnovu tkiva [48; 46].<\/li><\/ul><div class=\"mceTemp\" style=\"text-align: left;\">\u00a0<\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u010cesto Postavljana Pitanja (FAQ) o Preporu\u010denim WBH Sesijama i Ciljnim Temperaturama<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p><i>Tretmani <\/i><i>se<\/i> <i>smiju<\/i> <i>provoditi<\/i><i> samo nakon <\/i><i>kona\u010dne<\/i> <i>konzultacije<\/i> <i>s<\/i><i> lije\u010dnikom<\/i><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><h3>\u00a0<\/h3><p>\u00a0<\/p><\/div><\/header><div><h4>Koji je preporu\u010deni protokol Hipertermije Cijelog Tijela (WBH) za Esencijalnu Hipertenziju?<\/h4><div><p>Protokol za Esencijalnu Hipertenziju preporu\u010duje 12 sesija s ciljnom temperaturom od 38,3 \u00b0C. Svaka sesija traje otprilike 45 minuta, uklju\u010duju\u0107i fazu podizanja od 30 minuta i fazu odmora od 15 minuta (bez faze platoa).<\/p><\/div><\/div><div><h4>Koji su preporu\u010deni WBH parametri za Kroni\u010dnu Bol u Le\u0111ima (Dorsalgija)?<\/h4><div><p>Za Dorsalgiju se obi\u010dno preporu\u010duje 6 sesija, ciljaju\u0107i 38,4 \u00b0C. Ukupno trajanje sesije je otprilike 90 minuta, s 45 minuta podizanja, fazom platoa od 15 minuta i 30 minuta odmora.<\/p><\/div><\/div><div><h4>Koji je WBH protokol za Fibromijalgiju i Ankilozantni Spondilitis?<\/h4><div><p>I Fibromijalgija i Ankilozantni Spondilitis obi\u010dno slijede protokol od 6 sesija, ciljaju\u0107i 38,5 \u00b0C. Ukupno trajanje sesije je otprilike 90 minuta, uklju\u010duju\u0107i 45 minuta podizanja, plato od 15 minuta i 30 minuta odmora.<\/p><\/div><\/div><div><h4>Koji je preporu\u010deni protokol za WBH kao Komplementarno Lije\u010denje Raka?<\/h4><div><p>Kao komplementarno lije\u010denje raka, protokol zahtijeva 2 ili vi\u0161e sesija s ciljnom temperaturom jezgre izme\u0111u 39,0 \u00b0C i 40,0 \u00b0C. Ukupno trajanje sesije je najdu\u017ee, u rasponu od 3 do 4 sata, \u0161to uklju\u010duje 60-90 minuta za fazu podizanja, 60-90 minuta za fazu platoa i 60 minuta za fazu odmora.<\/p><\/div><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div><div class=\"wpb_content_element \"><div><div><div><div class=\"wpb_content_element \"><div><div><p>\u00a0<\/p><\/div><\/div><div class=\"table-scroll-wrapper\"><table width=\"1151\"><tbody><tr><td width=\"278\">Indikacija<\/td><td width=\"99\">Broj sesija<\/td><td width=\"135\">Ciljna temperatura<\/td><td colspan=\"2\" width=\"309\">Vrijeme terapije<br \/>Faza podizanja\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Faza platoa<\/td><td width=\"164\">Vrijeme odmora<br \/>Faza odmora<\/td><td width=\"164\"><b>Ukupno<\/b><br \/><b>Vrijeme WBH sesije<\/b><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Esencijalna Hipertenzija<\/td><td rowspan=\"2\" width=\"99\">12<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Dorsalgija<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,4 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Fibromijalgija<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Ankilozantni Spondilitis<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Sistemska Skleroza<\/td><td rowspan=\"2\" width=\"99\">15<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Veliki Depresivni Poreme\u0107aj<\/td><td rowspan=\"2\" width=\"99\">1+<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>105 -170 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 2-3 <\/b><b>sata<\/b><\/td><\/tr><tr><td width=\"155\">45-110 min<\/td><td width=\"155\">60 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Komplementarno Lije\u010denje Raka<\/td><td rowspan=\"2\" width=\"99\">2+<\/td><td rowspan=\"2\" width=\"135\">39,0-40,0 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>120-180 min<\/b><\/td><td rowspan=\"2\" width=\"164\">60 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 3-4 <\/b><b>sata<\/b><\/td><\/tr><tr><td width=\"155\">60-90 min<\/td><td width=\"155\">60-90 min<\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div><div id=\"ut-row-inner-68e7a7d03e7dd\" class=\"vc_row wpb_row vc_inner vc_row-fluid ut-row-inner-68e7a7d03e7ec\" style=\"text-align: center;\"><div class=\"wpb_column vc_column_container vc_col-sm-6\"><div id=\"ut-column-inner-68e7a7d03eb05\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"wpb_content_element\"><div id=\"ut_bi_68e7a7d03ebdb\" class=\"bklyn-big-icon-wrap\"><div class=\"bklyn-big-icon bklyn-big-icon-square\">\u00a0<\/div><p class=\"bklyn-big-icon-title\">\u00a0<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>NAPOMENA: ovaj \u010dlanak nije iscrpan popis studija i u\u010dinaka WBH wIRA<\/p><\/section><section><h2>\u00a0<\/h2><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Reference i Citati<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><ol><li style=\"text-align: left;\">Ardenne M. von. 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Comparison of the anti-tumor effects of various whole-body hyperthermia protocols&#8230; Immunol Invest. 2005;34(3):245-58.<\/li><li style=\"text-align: left;\">Abreu MM, Chocron AF, Smadja DM. From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. Front Immunol. 2025 Feb 28;16:1487296.<\/li><li style=\"text-align: left;\">Bull JMC. et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-\u03b1: A description of a phase I-II protocol. Journal of Hyperthermia. 2008; 24(8): 649-662.<\/li><li style=\"text-align: left;\">Weigelin B. Visualization of the immune effect of hyperthermia. ICHO 2021, Session: Hyperthermia and immunology.<\/li><li style=\"text-align: left;\">Faghihi Moghaddam F, Bakhshandeh M, Mofid B, et al. 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Low-dose Ipilimumab plus Nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series&#8230; Cancer Immunol Immunother. 2021;70:1393\u2013403.<\/li><li style=\"text-align: left;\">Adachi H., Katsuno M., Waza M., et al. Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications. Int J Hyperthermia 2009; 8:647-54.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin&#8230; Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Figueroa G., et al. An Update of a Phase II Clinical Trial Using Fever-Range Whole-Body Thermal Therapy (FR-WB-TT)&#8230; Soc for Thermal Med Joint Annual Meeting, 14.-17.5.2007.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Strebel F.R., et al. 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Clin Trials J 1985; 6:514-20.<\/li><li style=\"text-align: left;\">Hattori T., Kokura S., Okuda T., et al. Antitumor effect of whole body hyperthermia with \u03b1-galactosylceramide in a subcutaneous tumor model of colon cancer. Int J Hyperthermia 2007; 7:591-98.<\/li><li style=\"text-align: left;\">Kisailus A., Pritchard M., Li Y., Ostberg J., Repasky E.A. Thermal Regulation of Antigen Presenting Cells: Use of Hyperthermia as an Adjuvant for Cancer Vaccines. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Multhoff G. Letter to Editor, Hyperthermia classic commentary: Activation of natural killer (NK) cells by heat shock protein 70&#8230; Int J Hyperthermia 2009; 3:176-79.<\/li><li style=\"text-align: left;\">Peer A.J., Grimm M.J., Zynda E.R., Repasky E.A. Diverse immune mechanisms may contribute to the survival benefit seen in cancer patients receiving hyperthermia. Immunol Res 2010; 1-3:137-154.<\/li><li style=\"text-align: left;\">Rowe R.W., Stebel F.R., Proett J.M., et al. Fever-range whole body thermotherapy combined with oxaliplatin: A curative regimen in a pre-clinical breast cancer model. Int J Hyperthermia 2010; 6:565-76.<\/li><li style=\"text-align: left;\">Schencking M., Frese T., Sandholzer H. Behandlung einer Radikulopathie bei oss\u00e4rer Metastasierung der Lendenwirbels\u00e4ule durch Infrarot-A-Ganzk\u00f6rperhyperthermie. Forsch Komplementmed 2008; 15:273-76.<\/li><li style=\"text-align: left;\">Scott G.L., Bull J.M.C., Kochn M. Management of Conscious Sedation&#8230; 9th Int Congress on Hyperthermic Oncology, 20.-24.4.2004.<\/li><li style=\"text-align: left;\">Shecterle L.M., Cyr J.A.S. Hyperthermia Aids Patients with Advanced Lung Cancer. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Skitzki J.J., Repasky E.A., Evans S.S. Hyperthermia as an immunotherapy strategy for cancer. Current Opnion in Investigational Drugs 2009; 6: 550-58.<\/li><li style=\"text-align: left;\">Toyota N., Strebel F.R., Stephens L.C., et al. Long-duration, mild whole body hyperthermia with cisplatin: tumour response and kinetics of apoptosis and necrosis&#8230; Int. J. Hyperthermia 1997; 5:497-506.<\/li><li style=\"text-align: left;\">Wang X.Y., Kazim L., Repasky E.A., Subjeck J.R. Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines&#8230; J of Immunology 2001; 165:490-97.<\/li><li style=\"text-align: left;\">VanderZee J., DeBruijne M., Mens J.W.M., et al. Reirradiation combined with hyperthermia in breast cancer recurrences&#8230; Int J Hyperthermia 2010; 7:638-48.<\/li><li style=\"text-align: left;\">Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia for locally advanced breast cancer. Int J Hyperthermia 2010; 7:618-24.<\/li><li style=\"text-align: left;\">Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence&#8230; Int J Hyperthermia 2010; 7: 612\u201317.<\/li><li style=\"text-align: left;\">Sen A., Capitano M., Dommer M., et al. Thermoregulatory responses to mild systemic thermal stress increase tumor perfusion&#8230; Cancer Res. 2011; 71(11):3872-3880.<\/li><li style=\"text-align: left;\">Koska J., Rovensky J., Zimanova T., Vigas M. Growth hormone and prolactin responses during partial and whole body warm-water immersions. Acta Physiol Scand. 2003 May;178(1):19-23.<\/li><li style=\"text-align: left;\">Vigas M., Rovensky J., Zimanova T., Koska J. Responses of growth hormone and prolactin to local and whole-body application of Piestany mud. Acta Rheumatol et Balneol Pistiniana 2002:31-38.<\/li><li style=\"text-align: left;\">Meffert B., Hochmuth O., Steiner M. Effects of a multiple mild infrared a induced hyperthermia on central and peripheral pulse waves in hypertensive patients. North Sea Conference on Biomedical Engineering 1990.<\/li><li style=\"text-align: left;\">Meffert H., Scherf HP., Meffert B. Milde Infrarot-A-Hyperthermie. Auswirkungen von Serienbestrahlungen mit wassergefilterter Infrarotstrahlung&#8230; Akt Dermatol 1993; 19:142-48.<\/li><li style=\"text-align: left;\">Applegate L.A., Scaletta C., Panizzon R., et al. Induction of the putative protein ferritin by infrared radiation: Implications in skin repair. Int J of Molecular Med 2000; 5:247-51.<\/li><li style=\"text-align: left;\">Scherf H.P., Meffert H., B\u00e4umler H., et al. Wirkung einer einmaligen milden Infrarot-A-Hyperthermie auf K\u00f6rpertemperatur, Herzfrequenz, Blutdruck und Blutviskosit\u00e4t&#8230; Dermatol Monatsschr 1989; 175:733-40.<\/li><li style=\"text-align: left;\">Streffer C. Metabolic changes during and after hyperthermia. Int J Hyperthermia 1985; 4:305-319.<\/li><li style=\"text-align: left;\">F\u00f6rster J., Fleischanderl S., Wittstock S., et al. Infrared-Mediated Hyperthermia is Effective in the Treatment of Scleroderma-Associated Raynaud\u2019s Phenomenon. J of Investigative Dermatology 2005; 6:1313-16.<\/li><li style=\"text-align: left;\">Koska J., Rovensky J., Zimanova T., et al. Sympathoadrenal regulation of circulatory responses to whole-body hyperthermia&#8230; Acta Rheumatol et Balneol Pistiniana 2002:23-30.<\/li><li style=\"text-align: left;\">Janssen C.W., Lowry C.A., Mehl M.R., et al. Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder \u2013 A Randomized Clinical Trial. JAMA Psychiatry. 2016 May 12.<\/li><li style=\"text-align: left;\">Tarner I.H., Ladner U.M., Uhlemann C., Lange U. The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1 beta and IL-6 in patients with ankylosing spondylitis. Clin Rheumatol 2009; 4:397-402.<\/li><li style=\"text-align: left;\">Ettrich U., Konrad B., Prate K., et al. Milde Ganzk\u00f6rperhyperthermie in Kombination mit station\u00e4rer multimodal orientierter Schmerztherapie&#8230; Orthop\u00e4de 2014; 2:165-74.<\/li><li style=\"text-align: left;\">Weller E., Ullrich D. Infrarot-A-Hyperthermie-Anwendung bei Patienten mit Analgetica-Abusus wegen chronischer R\u00fcckenschmerzen. Vortrag auf dem 95. Kongre\u00df der Gesellschaft f\u00fcr Phys Med und Rehab 5.10.1990.<\/li><li style=\"text-align: left;\">Morf S., Vesti B.A., Forster A., et al. Microcirculation abnormalities in patients with fibromyalgia \u2013 measured by capillary and laser fluxmetry. Arthritis Res Ther 2005; 7:R209-16.<\/li><li style=\"text-align: left;\">Walz J., Hinzmann J., Haase I., Witte T. Ganzk\u00f6rperhyperthermie in der Schmerztherapie \u2013 eine kontrollierte Studie an Patienten mit Fibromyalgiesyndrom. Schmerz 2013; 27:38-45.<\/li><li style=\"text-align: left;\">Romeyke T., Stummer H. Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic whole-body hyperthermia&#8230; J Musculoskel Pain 2014; 4:341-55.<\/li><li style=\"text-align: left;\">Zauner D., Quehenberger F., Hermann J., et al. Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study. Int J Hyperthermia 2014; 6:393-401.<\/li><li style=\"text-align: left;\">Lange U., M\u00fcller-Ladner U., Dischereit G. Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis&#8230; Akt Rheumatol 2017; 2:122-128.<\/li><\/ol><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>\u00a0<\/p><\/section><footer>\u00a9 <time>2025<\/time> Romanian Society Oncologic Hyperthermia All rights reserved. Source: Analysis based on scientific literature.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Hipertermija Cijelog Tijela (WBH) u Onkologiji i Drugim Patologijama: Konsolidirana Sinergija, Imunomodulacija i Klini\u010dka ispitivanja Objavljeno: 2025-10-13 | Zadnja Revizija: 2025-10-13 Veronica Iatan, dr. med., Cristian Gologan, M.Sc. Hipertermija Cijelog Tijela (WBH) je sistemska onkolo\u0161ka strategija koja uklju\u010duje kontrolirano podizanje tjelesne temperature, \u010desto kori\u0161tenjem tehnologije *Infracrvenog-A filtriranog vodom (wIRA)*. WBH je prvenstveno *kemo\/radio-senzibilizator*, zna\u010dajno pobolj\u0161avaju\u0107i<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/hr\/klinicka-ispitivanja-hipertermije-onkologija\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-972","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/hr\/wp-json\/wp\/v2\/pages\/972","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/hr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/hr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/hr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/hr\/wp-json\/wp\/v2\/comments?post=972"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/hr\/wp-json\/wp\/v2\/pages\/972\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/hr\/wp-json\/wp\/v2\/media?parent=972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}