{"id":1903,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2026-01-20T15:59:05","modified_gmt":"2026-01-20T15:59:05","slug":"uji-klinis-hipertermia-wira-onkologi","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/id\/uji-klinis-hipertermia-wira-onkologi\/","title":{"rendered":"Uji klinis"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1903\" class=\"elementor elementor-1903 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Hipertermia Seluruh Tubuh (WBH) dalam Onkologi &amp; Patologi Lainnya: Sinergi Terkonsolidasi, Imunomodulasi, dan Bukti Klinis<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 800px; margin: 0 auto; text-align: center; font-family: sans-serif; line-height: 1.6;\"><header style=\"margin-bottom: 20px;\">\n<p style=\"margin-bottom: 5px;\"><strong><span style=\"color: #6a6a6a; font-size: 14px;\">Diterbitkan: <time datetime=\"2025-10-13\">2025-10-13<\/time> | Terakhir Ditinjau: <time datetime=\"2025-10-13\">2025-10-13<\/time><\/span><\/strong><\/p>\n\n<div style=\"font-size: 16px; color: #333;\">Oleh\n<a style=\"text-decoration: none; color: #007bff;\" href=\"\/?p=139\">Veronica Iatan, MD<\/a>,\n<a style=\"text-decoration: none; color: #007bff;\" href=\"\/?p=137\">Cristian Gologan, M.Sc.<\/a><\/div>\n<\/header>\n\n<hr style=\"border: 0; height: 1px; background: #eee; margin: 25px 0;\" \/>\n\n<section style=\"background-color: #f9f9f9; padding: 25px; border-radius: 10px; border-left: 4px solid #007bff; margin-bottom: 25px;\">\n<p style=\"font-weight: bold; font-style: italic; font-size: 18px; color: #2c3e50; margin: 0;\">Hipertermia Seluruh Tubuh (WBH) adalah strategi onkologi sistemik yang melibatkan pemanasan terkendali pada suhu inti tubuh, sering kali menggunakan teknologi Inframerah-A yang disaring air (wIRA). WBH pada dasarnya adalah sensitizer kemo\/radio, yang secara signifikan meningkatkan perfusi dan oksigenasi tumor untuk memperkuat efektivitas pengobatan tradisional. Yang terpenting, WBH berfungsi sebagai imunomodulator sistemik yang kuat, memobilisasi Heat Shock Proteins (HSPs) dan sel-T, yang menciptakan sinergi esensial dengan Imunoterapi mutakhir (ICI) serta menawarkan pereda nyeri yang dramatis dan cepat serta peningkatan Kualitas Hidup di berbagai jenis kanker dan patologi kronis seperti Fibromialgia.<\/p>\n\n<\/section><section style=\"padding: 15px; border: 1px dashed #ccc; border-radius: 6px; background-color: #fff;\">\n<p style=\"font-size: 13px; color: #777; margin: 0; line-height: 1.4;\"><strong>* Penafian Medis:<\/strong> Artikel ini ditujukan hanya untuk tujuan informasi dan bukan merupakan pengganti konsultasi medis, diagnosis, atau perawatan individual yang diberikan oleh dokter berlisensi.<\/p>\n\n<\/section><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. Definisi Hipertermia Seluruh Tubuh (WBH) dan Teknologi Terapeutik<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n\n<strong>Hipertermia Seluruh Tubuh (WBH)<\/strong>, atau \u201chipertermia sistemik,\u201d didefinisikan sebagai peningkatan suhu inti tubuh secara terkendali untuk tujuan terapeutik. Berdasarkan spektrum <strong>efek demam alami pada suhu yang berbeda<\/strong>, prosedur WBH dibedakan sebagai berikut:\n\n<div style=\"background: #f4f7f9; padding: 20px; border-radius: 8px; margin: 20px 0; border-left: 5px solid #007bff;\">\n<ul style=\"list-style: none; padding-left: 0; margin: 0; font-size: 1.1em;\">\n\u00a0\t<li style=\"margin-bottom: 8px;\"><strong>\u2022 WBH Ringan:<\/strong> &lt; 38,5\u00b0C<\/li>\n\u00a0\t<li style=\"margin-bottom: 8px;\"><strong>\u2022 WBH Moderat:<\/strong> 38,5\u00b0C \u2013 40,5\u00b0C<\/li>\n\u00a0\t<li><strong>\u2022 WBH Ekstrem:<\/strong> &gt; 40,5\u00b0C<\/li>\n<\/ul>\n<\/div>\nWBH ringan dan moderat secara khusus <strong>meningkatkan perfusi<\/strong>, menstimulasi metabolisme, mengurangi ketegangan otot, dan <strong>menstimulasi sistem imun.<\/strong>\n\n<a style=\"color: #007bff; text-decoration: none;\" title=\"Detail teknis perangkat von Ardenne IRATHERM\u00ae 1000M WBH wIRA\" href=\"\/?page_id=270\"><strong>Perangkat von Ardenne IRATHERM\u00ae 1000M WBH wIRA<\/strong><\/a> menggunakan secara eksklusif <strong>radiasi panas Inframerah-A yang disaring air (wIRA), yang kompatibel dengan kulit dan menjangkau jaringan dalam<\/strong> (tanpa IR-B \/ IR-C) untuk tujuan ini. Desain sistem terbukanya yang non-klaustrofobik memastikan intensitas iradiasi yang seragam di seluruh level (punggung) pasien dan menawarkan pasokan panas yang optimal dan spesifik bagi pasien kepada pengguna.\n\nRadiasi inframerah-A yang disaring air sesuai dengan radiasi termal alami matahari, memberikan dasar teknologi untuk penerapan panas yang seragam dan lembut <span style=\"color: #6a6a6a; font-size: 0.9em;\">[1, 5, 7, 8]<\/span>.\n\nMenggunakan prinsip von Ardenne IRATHERM\u00ae yang telah terbukti selama lebih dari 30 tahun, <a style=\"color: #007bff; text-decoration: none;\" title=\"Prof. Manfred von Ardenne - Kontribusi\" href=\"\/?p=5\">Prof. Manfred von Ardenne<\/a> telah berhasil mereproduksi radiasi termal ini secara fisik dan teknis, menjadikannya tersedia untuk penggunaan medis yang berkelanjutan dalam onkologi dan patologi lainnya.\n\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Landasan Ilmiah dan Efek Sistemik<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n\nWBH telah berkembang menjadi strategi yang didasarkan pada prinsip-prinsip biofisika dan fisiologis yang solid. Dalam onkologi, fokus utamanya adalah pada <strong>Hipertermia Moderat<\/strong> dan <strong>Rentang Demam (FR-WBH)<\/strong>, yang diakui sebagai perawatan dengan berbagai indikasi terapeutik <span style=\"color: #6a6a6a; font-size: 0.9em;\">[1, 3]<\/span>.\n\nDasar teknologi untuk penerapan panas yang seragam dan lembut sering kali disediakan oleh perangkat yang menggunakan <strong>radiasi Inframerah-A yang disaring air (wIRA)<\/strong>. Studi biofisika mendalam telah memvalidasi kemampuan <strong>teknologi ini untuk memastikan pemanasan yang mendalam dan terkendali<\/strong>, dengan mempertimbangkan sifat optik kulit dan dasar fotobiologis untuk dosimetri <span style=\"color: #6a6a6a; font-size: 0.9em;\">[5, 7, 8]<\/span>.\n\nPada tingkat fisiologis, WBH memiliki efek sistemik yang mendasar:\n\n<div style=\"background: #ffffff; padding: 20px; border: 1px solid #eef2f6; border-radius: 10px; box-shadow: 0 2px 8px rgba(0,0,0,0.05); margin: 25px 0;\">\n<ol style=\"padding-left: 20px; margin: 0;\">\n\u00a0\t<li style=\"margin-bottom: 15px;\"><strong style=\"color: #007bff; font-size: 1.1em;\">Peningkatan Reologi Darah:<\/strong>\nPaparan IR-WBH memberikan pengaruh positif terhadap <strong>sifat aliran darah dan hemodinamika<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[2]<\/span>, mendukung mekanisme esensial dalam <strong>meningkatkan perfusi tumor<\/strong>\u2014sebuah prasyarat kritis bagi keberhasilan pengobatan sistemik.<\/li>\n\u00a0\t<li><strong style=\"color: #007bff; font-size: 1.1em;\">Aktivasi Biologis Umum:<\/strong>\nWBH menginduksi respons stres termal yang memicu serangkaian proses biologis, termasuk <strong>modulasi sistem hormonal<\/strong> dan <strong>akselerasi metabolisme<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[6, 4]<\/span>.<\/li>\n<\/ol>\n<\/div>\nBerkat landasan ini, WBH berfungsi sebagai <strong>imunomodulator sistemik<\/strong>, mengoptimalkan <strong>lingkungan mikro tumor (TME)<\/strong> dan <strong>memperkuat efektivitas pengobatan onkologi mutakhir<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[9]<\/span>.\n\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. Mekanisme Kerja Utama (Molekuler, Fisiologis, dan Imunologis)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<p style=\"font-size: 1.1em; border-left: 4px solid #007bff; padding-left: 15px; margin-bottom: 25px;\">Efek terapeutik dari WBH sangat kompleks, dimediasi oleh perubahan pada <strong>tingkat seluler, imun, dan fisiologis<\/strong>:<\/p>\n\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<h3 style=\"text-align: left; color: #2c3e50; border-bottom: 2px solid #eef2f6; padding-bottom: 10px; margin-top: 30px;\">A. Sinergi dengan Kemoterapi dan Radioterapi (Sensitizer Kemo\/Radio)<\/h3>\n<ul style=\"padding-left: 20px; list-style-type: square;\">\n\u00a0\t<li style=\"margin-bottom: 15px; text-align: left;\"><strong>Optimalisasi Mikro-lingkungan Tumor (TME):<\/strong> WBH meningkatkan <strong>perfusi darah tumor<\/strong> dan <strong>oksigenasi<\/strong>, membalikkan kondisi hipoksia tumor. Hal ini sangat penting, karena sel tumor yang teroksigenasi dengan baik menjadi jauh lebih rentan terhadap penghancuran oleh <strong>Kemoterapi<\/strong> (CT) dan <strong>Radioterapi<\/strong> (RT) <span style=\"color: #6a6a6a; font-size: 0.9em;\">[9, 41]<\/span>.<\/li>\n\u00a0\t<li style=\"margin-bottom: 15px; text-align: left;\"><strong>Efikasi Kemo\/Radio:<\/strong> Hipertermia bertindak sebagai <strong>kemo &amp; radio <strong style=\"color: #d32f2f;\">sensitizer<\/strong><\/strong>, meningkatkan pasokan oksigen tumor (<em>efek radio-sensitizing<\/em>) &amp; mendorong efektivitas obat-obatan seperti Cisplatin, Gemcitabine, dan Carboplatin <span style=\"color: #6a6a6a; font-size: 0.9em;\">[12, 16, 36]<\/span>.<\/li>\n<\/ul>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<h3 style=\"text-align: left; color: #2c3e50; border-bottom: 2px solid #eef2f6; padding-bottom: 10px; margin-top: 30px;\">B. Menginduksi Respons Imun Anti-Tumor yang Kuat (Imunomodulasi)<\/h3>\n<p style=\"text-align: left;\">WBH adalah aktivator kuat dari sistem pertahanan tubuh <span style=\"color: #6a6a6a; font-size: 0.9em;\">[11]<\/span>:<\/p>\n\n<ul style=\"padding-left: 20px; list-style-type: square;\">\n\u00a0\t<li style=\"margin-bottom: 15px; text-align: left;\"><strong>Heat Shock Proteins (HSPs):<\/strong> Stres termal menstimulasi sintesis dan pelepasan <strong>HSP70<\/strong>. Protein ini bertindak sebagai &#8216;sinyal bahaya&#8217; yang menandai sel kanker untuk serangan yang lebih intens oleh <strong>Limfosit T Sitotoksik (CTLs)<\/strong> dari sistem imun <span style=\"color: #6a6a6a; font-size: 0.9em;\">[9, 10, 29]<\/span>.<\/li>\n\u00a0\t<li style=\"margin-bottom: 15px; text-align: left;\"><strong>Aktivasi Sel Imun Utama:<\/strong> Rentang suhu 39\u201343\u00b0C meningkatkan aktivitas <strong>sel Pembunuh Alami (NK)<\/strong> dan mendorong aktivitas <strong>sel T helper dan sitotoksik<\/strong>, <strong>sel dendritik<\/strong>, serta <strong>makrofag<\/strong>, sekaligus <span style=\"text-decoration: underline;\">berpotensi melemahkan sel imunosupresif<\/span> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[9, 10, 11, 25, 26]<\/span>.<\/li>\n\u00a0\t<li style=\"margin-bottom: 15px; text-align: left;\"><strong>Peningkatan Limfosit-T:<\/strong> FR-WBH dapat secara <strong>signifikan meningkatkan (misal: hingga 3 kali lipat) populasi limfosit T sitotoksik<\/strong> di organ limfoid, sehingga <strong>memperkuat serangan imun anti-tumor sistemik<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[10]<\/span>.<\/li>\n\u00a0\t<li style=\"margin-bottom: 15px; text-align: left;\"><strong>Vaksin dan APCs:<\/strong> WHT dapat mengatur fungsi Sel Pembawa Antigen (APCs) dan meningkatkan efektivitas vaksin kanker, termasuk yang berbasis HSP110 dan GRP170 <span style=\"color: #6a6a6a; font-size: 0.9em;\">[37, 28]<\/span>.<\/li>\n<\/ul>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Bukti Klinis dan Sinergi dalam Terapi Multimodal<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\"> <h3 style=\"text-align: left; color: #2c3e50; border-bottom: 2px solid #eef2f6; padding-bottom: 10px; margin-top: 30px;\">A. Sinergi dengan Imunoterapi (Penghambat Pos Pemeriksaan &#8211; ICI)<\/h3> <p style=\"text-align: left;\">Sebuah rangkaian kasus retrospektif terhadap 131 pasien kanker stadium lanjut (Stadium IV) meneliti protokol multimodal yang mencakup <strong>hipertermia seluruh tubuh<\/strong> bersama dengan penghambat pos pemeriksaan (Ipilimumab, Nivolumab) dan IL-2 <span style=\"color: #6a6a6a; font-size: 0.9em;\">[18]<\/span>.<\/p>\n\n<div style=\"background: #f0f7ff; padding: 25px; border-radius: 12px; border-left: 5px solid #007bff; margin: 25px 0;\"> <p style=\"text-align: left; margin: 0; font-size: 1.05em;\"><strong style=\"color: #0056b3;\">Kesimpulan Utama:<\/strong> wIRA Hipertermia Seluruh Tubuh ditentukan sebagai <strong>komponen integral dan esensial<\/strong> yang <strong>memaksimalkan respons imun anti-tumor<\/strong>.<\/p> <p style=\"text-align: left; margin-top: 15px; margin-bottom: 0;\"><strong>WBH mengaktifkan dan memobilisasi sel T<\/strong> (dengan menginduksi HSP70 dan melepaskan antigen tumor); penghambat pos pemeriksaan kemudian &#8220;melepaskan rem&#8221; dari sel-sel T yang telah diaktifkan sebelumnya, menghasilkan tingkat respons klinis menguntungkan yang sangat tinggi untuk penyakit stadium lanjut <span style=\"color: #6a6a6a; font-size: 0.9em;\">[18]<\/span>.<\/p>\n\n<\/div> <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\"> <h3 style=\"text-align: left; color: #2c3e50; border-bottom: 2px solid #eef2f6; padding-bottom: 10px; margin-top: 30px;\">B. Aplikasi Klinis pada Berbagai Jenis Kanker<\/h3> <ul style=\"padding-left: 20px; list-style-type: none;\"> \u00a0 <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #007bff; padding-left: 15px;\"><strong style=\"color: #007bff;\">Kanker Pankreas:<\/strong> Protokol Fase I-II menggunakan WBH ringan (FR-WBH) yang dikombinasikan dengan kemoterapi dan Interferon-alpha menunjukkan <strong>setidaknya 50% regresi tumor pada hampir setengah dari pasien yang resisten terhadap terapi<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[4, 22]<\/span>.<\/li> \u00a0 <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #007bff; padding-left: 15px;\"><strong style=\"color: #007bff;\">Kanker Payudara (Kekambuhan):<\/strong> WHT yang dikombinasikan dengan re-iradiasi atau radioterapi telah menunjukkan efektivitas untuk kanker payudara stadium lanjut lokal dan kekambuhan pada dinding dada, dikonfirmasi oleh data acak <span style=\"color: #6a6a6a; font-size: 0.9em;\">[39, 40]<\/span>.<\/li> \u00a0 <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #007bff; padding-left: 15px;\"><strong style=\"color: #007bff;\">Kanker Ovarium:<\/strong> WBH yang dikombinasikan dengan <strong>carboplatin<\/strong> diteliti dalam studi Fase II untuk kanker ovarium yang kambuh <span style=\"color: #6a6a6a; font-size: 0.9em;\">[16, 20]<\/span>.<\/li> \u00a0 <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #007bff; padding-left: 15px;\"><strong style=\"color: #007bff;\">Kanker Kolorektal:<\/strong> WBH wIRA digunakan dalam konteks Terapi Multilangkah Kanker Sistemik (sCMT) Von Ardenne yang dikombinasikan dengan kemoterapi dalam studi Fase I\/II <span style=\"color: #6a6a6a; font-size: 0.9em;\">[15]<\/span>.<\/li> <\/ul> <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. Pereda Nyeri yang Cepat dan Peningkatan Kualitas Hidup (QoL) yang Signifikan<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\"> <p style=\"font-size: 1.1em; text-align: left;\">Pasien dapat mengalami <strong>pereda nyeri yang cepat<\/strong> dan peningkatan kesejahteraan secara umum, sebagaimana diamati dalam studi Dr. Bull <span style=\"color: #6a6a6a; font-size: 0.9em;\">[12]<\/span> dan terutama dalam <strong>studi klinis Fase III<\/strong> terbaru yang dilakukan oleh Sahinbas et al. <span style=\"color: #6a6a6a; font-size: 0.9em;\">[14]<\/span>.<\/p>\n\n<div style=\"background: #fff9e6; padding: 20px; border-radius: 10px; border-left: 5px solid #ffcc00; margin: 25px 0;\"> <p style=\"margin: 0; color: #856404; font-weight: bold;\"><i class=\"fa fa-info-circle\"><\/i> Wawasan Klinis:<\/p> <p style=\"margin-top: 10px; margin-bottom: 0; font-style: italic;\">Terapi wIRA tidak hanya berkontribusi pada pengendalian tumor, tetapi juga pada pengurangan signifikan dalam kebutuhan analgesik, memulihkan mobilitas dan vitalitas bahkan pada pasien dengan penyakit stadium lanjut.<\/p>\n\n<\/div> <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\"> <h3 style=\"text-align: left; color: #d32f2f; border-bottom: 2px solid #f2f2f2; padding-bottom: 10px;\">Uji Klinis Fase III (2024) untuk Metastasis Tulang<\/h3> <p style=\"text-align: left;\">Pada tahun 2024, <a style=\"color: #007bff;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\">Sahinbas dan rekan-rekannya menerbitkan studi fase III<\/a> untuk nyeri metastasis tulang yang utamanya berasal dari kanker payudara dan prostat, menggunakan perangkat hipertermia WBH wIRA Iratherm sebagai tambahan untuk RT <span style=\"color: #6a6a6a; font-size: 0.9em;\">[14]<\/span>.<\/p>\n\n<div style=\"background: #fdfdfd; padding: 20px; border: 1px solid #e0e0e0; border-radius: 8px; margin: 20px 0;\">\n\n<strong>Temuan Utama:<\/strong> Kelompok radioterapi (RT) saja menunjukkan nyeri yang paling intens. Kelompok <strong>RT + WBH<\/strong> menunjukkan <strong>tingkat CR sebesar 47,4% vs. 5,3%<\/strong> untuk RT saja dalam waktu 2 bulan setelah perawatan.\n\n<strong>Waktu untuk mencapai pereda nyeri total hanya 10 hari<\/strong> untuk kelompok RT + WBH, sementara titik akhir tersebut tidak tercapai pada kelompok RT saja.\n\n<\/div> <div style=\"overflow-x: auto; margin-top: 25px;\"> <table style=\"width: 100%; border-collapse: collapse; text-align: left; border: 1px solid #ddd;\"> <thead> <tr style=\"background-color: #007bff; color: white;\"> <th style=\"padding: 12px; border: 1px solid #ddd;\">Indikator QoL\/Peningkatan Nyeri<\/th> <th style=\"padding: 12px; border: 1px solid #ddd;\">Monoterapi RT<\/th> <th style=\"padding: 12px; border: 1px solid #ddd;\">RT + Hipertermia (wIRA)<\/th> <th style=\"padding: 12px; border: 1px solid #ddd;\">Dampak QoL<\/th> <\/tr> <\/thead> <tbody> <tr> <td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>Tingkat Respons Lengkap (CR)<\/strong> (2 bulan)<\/td> <td style=\"padding: 12px; border: 1px solid #ddd;\">5,3 %<\/td> <td style=\"padding: 12px; border: 1px solid #ddd; background: #eef9ee;\"><strong>47,4 %<\/strong><\/td> <td style=\"padding: 12px; border: 1px solid #ddd; color: #28a745;\"><strong>Peningkatan +894%<\/strong> dalam peluang eliminasi nyeri total<\/td> <\/tr> <tr style=\"background-color: #f9f9f9;\"> <td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>Waktu untuk pereda nyeri total<\/strong><\/td> <td style=\"padding: 12px; border: 1px solid #ddd;\">tidak tercapai<\/td> <td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>10 hari<\/strong><\/td> <td style=\"padding: 12px; border: 1px solid #ddd;\">manfaat &#8220;signifikan dan cepat&#8221;<\/td> <\/tr> <tr> <td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>Durasi Pereda Nyeri<\/strong><\/td> <td style=\"padding: 12px; border: 1px solid #ddd;\">Median: 28 hari<\/td> <td style=\"padding: 12px; border: 1px solid #ddd;\">Median: Lebih dari 24 minggu<\/td> <td style=\"padding: 12px; border: 1px solid #ddd;\">Durasi pereda nyeri <strong>meningkat enam kali lipat<\/strong><\/td> <\/tr> <\/tbody> <\/table> <\/div> <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\"> <p style=\"text-align: left;\">Dibandingkan dengan <a style=\"color: #007bff;\" title=\"Studi Fase III Chi MS et al. 2017\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5\" target=\"_blank\" rel=\"noopener\">studi Fase III serupa yang diterbitkan oleh Chi MS et al. (2017)<\/a> dengan hipertermia lokoregional RF, manfaat yang dicapai menggunakan <strong>hipertermia WBH wIRA<\/strong> jauh lebih unggul.<\/p> <p style=\"text-align: left; font-style: italic; color: #666; margin-bottom: 10px;\">Hasil Studi RF HT + RT (Hipertermia Lokal):<\/p>\n\n<div style=\"overflow-x: auto; margin-bottom: 30px;\"> <table style=\"width: 100%; border-collapse: collapse; text-align: left; border: 1px solid #ddd; font-size: 14px;\"> <thead> <tr style=\"background-color: #6c757d; color: white;\"> <th style=\"padding: 10px; border: 1px solid #ddd;\">Indikator QoL\/Peningkatan Nyeri<\/th> <th style=\"padding: 10px; border: 1px solid #ddd;\">Monoterapi RT<\/th> <th style=\"padding: 10px; border: 1px solid #ddd;\">RT + Hipertermia (RF HT)<\/th> <th style=\"padding: 10px; border: 1px solid #ddd;\">Dampak QoL<\/th> <\/tr> <\/thead> <tbody> <tr> <td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Tingkat Respons Lengkap (CR)<\/strong> (3 Bulan)<\/td> <td style=\"padding: 10px; border: 1px solid #ddd;\">7,1 %<\/td> <td style=\"padding: 10px; border: 1px solid #ddd;\">37,9 %<\/td> <td style=\"padding: 10px; border: 1px solid #ddd;\">Peningkatan 533% dalam peluang pereda nyeri total<\/td> <\/tr> <tr> <td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Durasi Pereda Nyeri<\/strong><\/td> <td style=\"padding: 10px; border: 1px solid #ddd;\">Median: 55 hari<\/td> <td style=\"padding: 10px; border: 1px solid #ddd;\">Median: Tidak tercapai pada 24 minggu<\/td> <td style=\"padding: 10px; border: 1px solid #ddd;\">Durasi pereda nyeri meningkat tiga kali lipat<\/td> <\/tr> <\/tbody> <\/table> <\/div> <div style=\"background: #2c3e50; color: #ffffff; padding: 30px; border-radius: 15px; margin-top: 40px; box-shadow: 0 4px 15px rgba(0,0,0,0.1);\"> <h4 style=\"color: #007bff; margin-top: 0; text-transform: uppercase; letter-spacing: 1px;\">Ringkasan dan Kesimpulan<\/h4> <p style=\"font-size: 1.1em; margin-bottom: 0;\">Bukti ilmiah yang terkonsolidasi (<em>mulai dari studi dasar tentang teknologi wIRA hingga uji klinis Fase III yang krusial<\/em>) mengonfirmasi peran WBH sebagai <strong>terapi ajuvan berdampak ganda<\/strong> dalam onkologi: terapi ini <strong>meningkatkan efikasi CT\/RT, mengaktifkan sistem imun sistemik (termasuk sinergi dengan imunoterapi), dan secara dramatis meningkatkan pengendalian nyeri serta QoL<\/strong> bagi pasien kanker.<\/p>\n\n<\/div> <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Manfaat Fisiologis Sistemik dan Potensi Terapeutik dalam Patologi Lainnya<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\"> <p style=\"font-size: 1.15em; color: #2c3e50; background: #f8f9fa; padding: 20px; border-radius: 10px; border-right: 4px solid #28a745; text-align: left;\">Panas yang lembut dan terkendali yang diberikan oleh WBH dengan <strong>radiasi wIRA<\/strong> menginisiasi respons termoregulasi kompleks yang menghasilkan <strong>manfaat sistemik yang luas<\/strong>, memperluas potensi terapeutik di luar onkologi:<\/p>\n\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\"><h3 style=\"text-align: left; color: #2c3e50; border-bottom: 2px solid #eef2f6; padding-bottom: 10px; margin-top: 30px;\">A. Manajemen Muskuloskeletal dan Nyeri<\/h3><p style=\"text-align: left;\">WBH efektif dalam mengelola sindrom nyeri kronis, memanfaatkan efek fisiologisnya pada ketegangan otot dan mikrosirkulasi:<\/p><ul style=\"padding-left: 20px; list-style-type: none;\">\u00a0\t<li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #28a745; padding-left: 15px;\"><strong>Dorsalgia (Nyeri Punggung Kronis):<\/strong> Studi menunjukkan bahwa WBH ringan, bila dikombinasikan dengan terapi nyeri multimodal stasioner, memberikan manfaat signifikan bagi pasien dengan nyeri punggung bawah non-spesifik kronis <span style=\"color: #6a6a6a; font-size: 0.9em;\">[53, 54]<\/span>.<\/li>\u00a0\t<li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #28a745; padding-left: 15px;\"><strong>Sindrom Fibromialgia (FMS):<\/strong> WBH adalah pengobatan tambahan yang terdokumentasi untuk FMS. Uji terkontrol secara acak telah mendemonstrasikan efektivitas wIRA WBH ringan, menunjukkan efek pada <strong>intensitas nyeri<\/strong> dan <strong>kondisi mental<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[17, 56, 57]<\/span>.<\/li>\u00a0\t<li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #28a745; padding-left: 15px;\"><strong>Ankylosing Spondylitis (AS):<\/strong> WBH telah menunjukkan efek imunomodulator pada pasien AS, meningkatkan mediator anti-inflamasi seperti <strong>Interleukin-10 (IL-10)<\/strong> dan memodulasi sitokin pro-inflamasi seperti TNF-$\u03b1$ <span style=\"color: #6a6a6a; font-size: 0.9em;\">[58, 59, 52]<\/span>.<\/li>\u00a0\t<li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #28a745; padding-left: 15px;\"><strong>Fenomena Raynaud pada Sklerosis Sistemik:<\/strong> Hipertermia yang dimediasi inframerah ditemukan efektif dalam mengobati gejala vasokonstriktif, menunjukkan manfaat vaskular yang jelas <span style=\"color: #6a6a6a; font-size: 0.9em;\">[49]<\/span>.<\/li><\/ul><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\"> <h3 style=\"text-align: left; color: #c0392b; border-bottom: 2px solid #f8d7da; padding-bottom: 10px; margin-top: 30px;\">B. Kesehatan Kardiovaskular dan Sirkulasi \u2764\ufe0f<\/h3> <p style=\"text-align: left;\">Selain meningkatkan perfusi tumor, WBH memiliki efek spesifik pada sistem sirkulasi:<\/p>\n\n<ul style=\"padding-left: 20px; list-style-type: none;\"> \u00a0 <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #c0392b; padding-left: 15px;\"><strong>Hipertensi Esensial:<\/strong> Serangkaian studi meneliti penggunaan hipertermia IR-A ringan pada pasien dengan hipertensi arterial (WHO Stadium I dan II). Temuan menunjukkan bahwa perawatan berseri dapat memberikan efek positif pada <strong>gelombang denyut sentral dan perifer<\/strong>, tekanan darah, serta <strong>viskositas darah<\/strong>, mengonfirmasi peran WBH sebagai opsi terapi fisik non-farmakologis <span style=\"color: #6a6a6a; font-size: 0.9em;\">[44, 47]<\/span>.<\/li> <\/ul> <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\"> <h3 style=\"text-align: left; color: #673ab7; border-bottom: 2px solid #ede7f6; padding-bottom: 10px; margin-top: 30px;\">C. Efek Neuro-Endokrin dan Psikologis<\/h3> <p style=\"text-align: left;\">WBH melibatkan sistem neuro-endokrin tubuh, yang memengaruhi suasana hati dan metabolisme:<\/p>\n\n<ul style=\"padding-left: 20px; list-style-type: none;\"> \u00a0 <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #673ab7; padding-left: 15px;\"><strong>Gangguan Depresi Mayor (MDD):<\/strong> Sebuah uji klinis acak menunjukkan bahwa satu sesi WBH dapat bertindak sebagai antidepresan yang bekerja cepat, menghasilkan pengurangan gejala depresi selama beberapa minggu. Efek ini dikaitkan dengan aktivasi jalur imun dan inflamasi akibat panas yang memengaruhi otak <span style=\"color: #6a6a6a; font-size: 0.9em;\">[51]<\/span>.<\/li> \u00a0 <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #673ab7; padding-left: 15px;\"><strong>Modulasi Hormonal (Endokrinologi):<\/strong> WBH menstimulasi <strong>poros Hipotalamus-Hipofisis-Adrenal (HPA)<\/strong> dan memengaruhi kadar hormon. Studi telah mendokumentasikan respons <strong>Hormon Pertumbuhan<\/strong> dan <strong>Prolaktin<\/strong> selama hipertermia seluruh tubuh, menyoroti dampaknya pada regulasi endokrin <span style=\"color: #6a6a6a; font-size: 0.9em;\">[42, 43]<\/span>.<\/li> \u00a0 <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #673ab7; padding-left: 15px;\"><strong>Metabolisme dan Reaksi Sel:<\/strong> WBH mempercepat laju metabolisme basal. Pada tingkat seluler, panas memengaruhi kinetika pO2 dan dikaitkan dengan sintesis protein pelindung seperti <strong>feritin<\/strong> di kulit, yang mendukung perbaikan jaringan <span style=\"color: #6a6a6a; font-size: 0.9em;\">[48, 46]<\/span>.<\/li> <\/ul> <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><p style=\"text-align: left\"><strong>Pertanyaan yang Sering Diajukan (FAQ) Mengenai Rekomendasi Sesi WBH dan Target Suhu<\/strong><\/p><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background-color: #fff4f4; border: 1px solid #f5c6cb; color: #721c24; padding: 15px; border-radius: 8px; text-align: center; margin: 20px 0; font-weight: bold;\"> <i class=\"fa fa-exclamation-triangle\" style=\"margin-right: 10px;\"><\/i> Perawatan hanya boleh dilakukan setelah konsultasi akhir dengan dokter medis.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\"> <div style=\"margin-bottom: 25px; border-bottom: 1px solid #eee; padding-bottom: 15px;\"> <h4 style=\"color: #007bff;\">Apa protokol Hipertermia Seluruh Tubuh (WBH) yang direkomendasikan untuk Hipertensi Esensial?<\/h4> Protokol untuk Hipertensi Esensial merekomendasikan <strong>12 sesi<\/strong> dengan target suhu <strong>38,3 \u00b0C<\/strong>. Setiap sesi berlangsung sekitar 45 menit, yang terdiri dari fase peningkatan selama 30 menit dan fase istirahat selama 15 menit (tanpa fase plateau).\n\n<\/div> <div style=\"margin-bottom: 25px; border-bottom: 1px solid #eee; padding-bottom: 15px;\"> <h4 style=\"color: #007bff;\">Apa parameter WBH yang direkomendasikan untuk Nyeri Punggung Kronis (Dorsalgia)?<\/h4> Untuk Dorsalgia, biasanya direkomendasikan <strong>6 sesi<\/strong>, dengan target <strong>38,4 \u00b0C<\/strong>. Total waktu sesi adalah sekitar 90 menit, dengan 45 menit fase peningkatan, 15 menit fase plateau, dan 30 menit istirahat.\n\n<\/div> <div style=\"margin-bottom: 25px; border-bottom: 1px solid #eee; padding-bottom: 15px;\"> <h4 style=\"color: #007bff;\">Apa protokol WBH untuk Fibromialgia dan Ankylosing Spondylitis?<\/h4> Baik Fibromialgia maupun Ankylosing Spondylitis biasanya mengikuti <strong>protokol 6 sesi<\/strong>, dengan target <strong>38,5 \u00b0C<\/strong>. Total waktu sesi adalah sekitar 90 menit, termasuk 45 menit peningkatan, 15 menit plateau, dan 30 menit istirahat.\n\n<\/div> <div style=\"margin-bottom: 25px; border-bottom: 1px solid #eee; padding-bottom: 15px;\"> <h4 style=\"color: #007bff;\">Apa protokol yang direkomendasikan untuk WBH sebagai Terapi Kanker Tambahan?<\/h4> Sebagai terapi kanker tambahan, protokol ini membutuhkan <strong>2 sesi atau lebih<\/strong> dengan target suhu inti antara <strong>39,0 \u00b0C hingga 40,0 \u00b0C<\/strong>. Total waktu sesi adalah yang paling lama, berkisar antara <strong>3 hingga 4 jam<\/strong>, yang mencakup 60-90 menit untuk fase peningkatan, 60-90 menit untuk fase plateau, dan 60 menit untuk fase istirahat.\n\n<\/div> <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 100%; overflow-x: auto; margin: 20px 0;\"> <table style=\"width: 100%; border-collapse: collapse; font-family: sans-serif; min-width: 800px; border: 1px solid #e0e0e0;\"> <thead> <tr style=\"background-color: #2c3e50; color: white; text-align: left;\"> <th style=\"padding: 15px; border: 1px solid #34495e;\">Indikasi<\/th> <th style=\"padding: 15px; border: 1px solid #34495e;\">Sesi<\/th> <th style=\"padding: 15px; border: 1px solid #34495e;\">Target Suhu<\/th> <th style=\"padding: 15px; border: 1px solid #34495e;\">Terapi (Peningkatan + Plateau)<\/th> <th style=\"padding: 15px; border: 1px solid #34495e;\">Waktu Istirahat<\/th> <th style=\"padding: 15px; border: 1px solid #34495e;\">Total Sesi<\/th> <\/tr> <\/thead> <tbody style=\"color: #333;\"> <tr> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Hipertensi Esensial<\/strong><\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">12<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38,3 \u00b0C<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 mnt (30+0)<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">15 mnt<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 45 mnt<\/strong><\/td> <\/tr> <tr style=\"background-color: #f8f9fa;\"> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Dorsalgia<\/strong><\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">6<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38,4 \u00b0C<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">60 mnt (45+15)<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 mnt<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 90 mnt<\/strong><\/td> <\/tr> <tr> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Fibromialgia<\/strong><\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">6<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38,5 \u00b0C<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">60 mnt (45+15)<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 mnt<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 90 mnt<\/strong><\/td> <\/tr> <tr style=\"background-color: #f8f9fa;\"> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Ankylosing Spondylitis<\/strong><\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">6<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38,5 \u00b0C<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">60 mnt (45+15)<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 mnt<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 90 mnt<\/strong><\/td> <\/tr> <tr> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Sklerosis Sistemik<\/strong><\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">15<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38,3 \u00b0C<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 mnt (30+0)<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">15 mnt<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 45 mnt<\/strong><\/td> <\/tr> <tr style=\"background-color: #f8f9fa;\"> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Gangguan Depresi Mayor<\/strong><\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">1+<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38,5 \u00b0C<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">105-170 mnt<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 mnt<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 2-3 jam<\/strong><\/td> <\/tr> <tr style=\"background-color: #eef2ff;\"> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Terapi Kanker Tambahan<\/strong><\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">2+<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">39,0-40,0 \u00b0C<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">120-180 mnt<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0;\">60 mnt<\/td> <td style=\"padding: 12px; border: 1px solid #e0e0e0; color: #d32f2f;\"><strong>~ 3-4 jam<\/strong><\/td> <\/tr> <\/tbody> <\/table> <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background-color: #fcf8e3; border: 1px solid #faebcc; color: #8a6d3b; padding: 15px; border-radius: 8px; text-align: center; margin: 20px 0; font-style: italic;\"> <strong>CATATAN:<\/strong> Artikel ini bukan merupakan daftar lengkap dari seluruh studi dan efek dari WBH wIRA. <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Referensi dan Kutipan<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 1000px; margin: 0 auto; background: #ffffff; padding: 30px; border: 1px solid #e0e0e0; border-radius: 5px;\"><h3 style=\"color: #2c3e50; border-bottom: 2px solid #3498db; padding-bottom: 10px; margin-bottom: 25px; font-family: sans-serif;\">Referensi dan Kutipan<\/h3><ol style=\"line-height: 1.6; color: #555; font-size: 0.9em; font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;\"><li style=\"margin-bottom: 10px;\">Ardenne M. von. Moderate Hyperthermie als Behandlungsmethode mit vielen Indikationen. <em>\u00c4rztzeitschr Naturheilverf<\/em> 1994; 5:356-61.<\/li><li style=\"margin-bottom: 10px;\">B\u00e4umler H., Scherf H.P., Aurisch R., et al. Einflu\u00df einer Serie von Infrarot-Ganzk\u00f6rperbestrahlungen auf Flie\u00dfeigenschaften des Blutes und die H\u00e4modynamik. <em>Perfusion<\/em> 1990: 138-43.<\/li><li style=\"margin-bottom: 10px;\">Heckel M. Ganzk\u00f6rper-Hyperthermie und Fiebertherapie, Grundlagen und Praxis. Stuttgart: <em>Hippokrates Verlag<\/em>, 1990.<\/li><li style=\"margin-bottom: 10px;\">Kosaka M., Sugahara T., Schmidt K.L., Simon E. Thermotherapy: Principles and Practice. Heidelberg: <em>Springer Verlag<\/em>, 2000.<\/li><li style=\"margin-bottom: 10px;\">Meffert H., Hecht H.C., G\u00fcnther H., et al. Biophysikalische Ergebnisse des klinischen Tests der IRA-Therm-Hyperthermietechnik der 2. Generation. <em>ThermoMed<\/em> 1990; 6:71-78.<\/li><li style=\"margin-bottom: 10px;\">Schmidt K.L. Hyperthermie und Fieber, Wirkungen bei Mensch und Tier. 2. \u00fcberarb Aufl. Stuttgart: <em>Hippokrates Verlag<\/em>, 1987.<\/li><li style=\"margin-bottom: 10px;\">Vaupel P., Kr\u00fcger W. W\u00e4rmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsm\u00f6glichkeiten. 2. \u00fcberarb Aufl. Stuttgart: <em>Hippokrates Verlag<\/em>, 1995.<\/li><li style=\"margin-bottom: 10px;\">Piazena H., Meffert H. Optische Eigenschaften der Haut und die photobiologischen Grundlagen zur Dosierung von IR-Hautbestrahlungen in vivo und in vitro. <em>6. Symposium Licht und Gesundheit<\/em> 2008.<\/li><li style=\"margin-bottom: 10px;\">Zschaeck S. and Beck M. Chapter 8 Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?<\/li><li style=\"margin-bottom: 10px;\">Zhang H, Wang W, Zhang S, Huang W. Comparison of the anti-tumor effects of various whole-body hyperthermia protocols&#8230; <em>Immunol Invest.<\/em> 2005;34(3):245-58.<\/li><li style=\"margin-bottom: 10px;\">Abreu MM, Chocron AF, Smadja DM. From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. <em>Front Immunol.<\/em> 2025 Feb 28;16:1487296.<\/li><li style=\"margin-bottom: 10px;\">Bull JMC. et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-\u03b1. <em>Journal of Hyperthermia.<\/em> 2008; 24(8): 649-662.<\/li><li style=\"margin-bottom: 10px;\">Weigelin B. Visualization of the immune effect of hyperthermia. <em>ICHO 2021<\/em>, Session: Hyperthermia and immunology.<\/li><li style=\"margin-bottom: 10px;\">Faghihi Moghaddam F, Bakhshandeh M, Mofid B, et al. Clinical effectiveness of combined WBH and EBRT versus EBRT alone&#8230; <em>J Therm Biol.<\/em> 2024 Feb;120:103804.<\/li><li style=\"margin-bottom: 10px;\">Hildebrandt B, Dr\u00e4ger J, Kerner T. et al. Whole-body hyperthermia in the scope of von Ardenne\u2019s systemic cancer multistep therapy (sCMT)&#8230; <em>International Journal of Hyperthermia.<\/em> 2004;3:317\u2013333.<\/li><li style=\"margin-bottom: 10px;\">Atmaca A., Al-Batran S.E., Neumann A., et al. WBH in combination with carboplatin in patients with recurrent ovarian cancer \u2013 a phase II study. <em>Gynecol Oncol<\/em> 2009; 2:384-88.<\/li><li style=\"margin-bottom: 10px;\">Brockow T., et al. A Randomized Controlled Trial on the Effectiveness of Mild Water-filtered Near Infrared WBH&#8230; <em>Clin J Pain<\/em> 2007; 1:67-75.<\/li><li style=\"margin-bottom: 10px;\">Kleef R, Nagy R, Baierl A, et al. Low-dose Ipilimumab plus Nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease. <em>Cancer Immunol Immunother.<\/em> 2021;70:1393\u2013403.<\/li><li style=\"margin-bottom: 10px;\">Adachi H., Katsuno M., Waza M., et al. Heat shock proteins in neurodegenerative diseases. <em>Int J Hyperthermia<\/em> 2009; 8:647-54.<\/li><li style=\"margin-bottom: 10px;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin&#8230; <em>Gynecol Oncol<\/em> 2009; 2:384-88.<\/li><li style=\"margin-bottom: 10px;\">Bull J.M., et al. An Update of a Phase II Clinical Trial Using Fever-Range Whole-Body Thermal Therapy (FR-WB-TT)&#8230; <em>Soc for Thermal Med<\/em>, 2007.<\/li><li style=\"margin-bottom: 10px;\">Bull J.M., et al. Fever-range WBH combined with cisplatin, gemcitabine and daily interferon-\u03b1. <em>Int J Hyperthermia<\/em> 2008; 8:649-62.<\/li><li style=\"margin-bottom: 10px;\">Bull J.M., et al. A phase-I-study of optimally-timed Gemcitabine + Cisplatin\/Interferon-a combined with WBH. <em>ESHO 2001<\/em>, Verona, Italy.<\/li><li style=\"margin-bottom: 10px;\">Capitano M., Mace T., Nemeth M., et al. A novel strategy for improving neutrophil recovery following total body irradiation. <em>Soc for Thermal Med<\/em>, 2010.<\/li><li style=\"margin-bottom: 10px;\">Dayanc B.E., Ostberg J.R., Repasky E.A. Enhancement of NK Cell Cytotoxic Activity by Mild Thermal Stress. <em>Soc of Thermal Med<\/em>, 2006.<\/li><li style=\"margin-bottom: 10px;\">Hajto T., Hostanska K. Effect of in vivo hyperthermia on human natural killer cells. <em>Clin Trials J<\/em> 1985; 6:514-20.<\/li><li style=\"margin-bottom: 10px;\">Hattori T., et al. Antitumor effect of WBH with \u03b1-galactosylceramide in a subcutaneous tumor model of colon cancer. <em>Int J Hyperthermia<\/em> 2007; 7:591-98.<\/li><li style=\"margin-bottom: 10px;\">Kisailus A., et al. Thermal Regulation of Antigen Presenting Cells: Use of Hyperthermia as an Adjuvant for Cancer Vaccines. <em>Soc of Thermal Med<\/em>, 2006.<\/li><li style=\"margin-bottom: 10px;\">Multhoff G. Activation of natural killer (NK) cells by heat shock protein 70&#8230; <em>Int J Hyperthermia<\/em> 2009; 3:176-79.<\/li><li style=\"margin-bottom: 10px;\">Peer A.J., et al. Diverse immune mechanisms may contribute to the survival benefit seen in cancer patients receiving hyperthermia. <em>Immunol Res<\/em> 2010; 1-3:137-154.<\/li><li style=\"margin-bottom: 10px;\">Rowe R.W., et al. Fever-range WBH combined with oxaliplatin: A curative regimen in a pre-clinical breast cancer model. <em>Int J Hyperthermia<\/em> 2010; 6:565-76.<\/li><li style=\"margin-bottom: 10px;\">Schencking M., Frese T., Sandholzer H. Behandlung einer Radikulopathie bei oss\u00e4rer Metastasierung durch Infrarot-A-Ganzk\u00f6rperhyperthermie. <em>Forsch Komplementmed<\/em> 2008; 15:273-76.<\/li><li style=\"margin-bottom: 10px;\">Scott G.L., Bull J.M.C., Kochn M. Management of Conscious Sedation&#8230; <em>9th Int Congress on Hyperthermic Oncology<\/em>, 2004.<\/li><li style=\"margin-bottom: 10px;\">Shecterle L.M., Cyr J.A.S. Hyperthermia Aids Patients with Advanced Lung Cancer. <em>Soc of Thermal Med<\/em>, 2006.<\/li><li style=\"margin-bottom: 10px;\">Skitzki J.J., Repasky E.A., Evans S.S. Hyperthermia as an immunotherapy strategy for cancer. <em>Current Opinion in Investigational Drugs<\/em> 2009; 6: 550-58.<\/li><li style=\"margin-bottom: 10px;\">Toyota N., et al. Long-duration, mild whole body hyperthermia with cisplatin: tumour response and kinetics of apoptosis and necrosis&#8230; <em>Int. J. Hyperthermia<\/em> 1997; 5:497-506.<\/li><li style=\"margin-bottom: 10px;\">Wang X.Y., et al. Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines&#8230; <em>J of Immunology<\/em> 2001; 165:490-97.<\/li><li style=\"margin-bottom: 10px;\">VanderZee J., et al. Reirradiation combined with hyperthermia in breast cancer recurrences&#8230; <em>Int J Hyperthermia<\/em> 2010; 7:638-48.<\/li><li style=\"margin-bottom: 10px;\">Zagar T.M., et al. Hyperthermia for locally advanced breast cancer. <em>Int J Hyperthermia<\/em> 2010; 7:618-24.<\/li><li style=\"margin-bottom: 10px;\">Zagar T.M., et al. Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence&#8230; <em>Int J Hyperthermia<\/em> 2010; 7: 612\u201317.<\/li><li style=\"margin-bottom: 10px;\">Sen A., Capitano M., Dommer M., et al. Thermoregulatory responses to mild systemic thermal stress increase tumor perfusion&#8230; <em>Cancer Res.<\/em> 2011; 71(11):3872-3880.<\/li><li style=\"margin-bottom: 10px;\">Koska J., Rovensky J., Zimanova T., Vigas M. Growth hormone and prolactin responses during partial and whole body warm-water immersions. <em>Acta Physiol Scand.<\/em> 2003.<\/li><li style=\"margin-bottom: 10px;\">Vigas M., Rovensky J., Zimanova T., Koska J. Responses of growth hormone and prolactin to local and whole-body application of Piestany mud. <em>Acta Rheumatol<\/em> 2002:31-38.<\/li><li style=\"margin-bottom: 10px;\">Meffert B., Hochmuth O., Steiner M. Effects of multiple mild infrared-induced hyperthermia on central and peripheral pulse waves. <em>North Sea Conference<\/em> 1990.<\/li><li style=\"margin-bottom: 10px;\">Meffert H., Scherf HP., Meffert B. Milde Infrarot-A-Hyperthermie. Auswirkungen von Serienbestrahlungen&#8230; <em>Akt Dermatol<\/em> 1993; 19:142-48.<\/li><li style=\"margin-bottom: 10px;\">Applegate L.A., et al. Induction of the putative protein ferritin by infrared radiation: Implications in skin repair. <em>Int J of Molecular Med<\/em> 2000; 5:247-51.<\/li><li style=\"margin-bottom: 10px;\">Scherf H.P., et al. Wirkung einer einmaligen milden Infrarot-A-Hyperthermie auf K\u00f6rpertemperatur, Herzfrequenz, Blutdruck und Blutviskosit\u00e4t&#8230; <em>Dermatol Monatsschr<\/em> 1989.<\/li><li style=\"margin-bottom: 10px;\">Streffer C. Metabolic changes during and after hyperthermia. <em>Int J Hyperthermia<\/em> 1985; 4:305-319.<\/li><li style=\"margin-bottom: 10px;\">F\u00f6rster J., et al. Infrared-Mediated Hyperthermia is Effective in the Treatment of Scleroderma-Associated Raynaud\u2019s Phenomenon. <em>J Invest Dermatol<\/em> 2005.<\/li><li style=\"margin-bottom: 10px;\">Koska J., Rovensky J., Zimanova T., et al. Sympathoadrenal regulation of circulatory responses to WBH&#8230; <em>Acta Rheumatol<\/em> 2002:23-30.<\/li><li style=\"margin-bottom: 10px;\">Janssen C.W., et al. Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder \u2013 A Randomized Clinical Trial. <em>JAMA Psychiatry<\/em> 2016.<\/li><li style=\"margin-bottom: 10px;\">Tarner I.H., et al. The effect of mild WBH on systemic levels of TNF-alpha, IL-1 beta and IL-6 in patients with ankylosing spondylitis. <em>Clin Rheumatol<\/em> 2009.<\/li><li style=\"margin-bottom: 10px;\">Ettrich U., et al. Milde Ganzk\u00f6rperhyperthermie in Kombination mit station\u00e4rer multimodal orientierter Schmerztherapie&#8230; <em>Orthop\u00e4de<\/em> 2014; 2:165-74.<\/li><li style=\"margin-bottom: 10px;\">Weller E., Ullrich D. Infrarot-A-Hyperthermie-Anwendung bei Patienten cu Analgetica-Abusus wegen chronischer R\u00fcckenschmerzen. <em>95. Kongre\u00df Phys Med<\/em> 1990.<\/li><li style=\"margin-bottom: 10px;\">Morf S., Vesti B.A., Forster A., et al. Microcirculation abnormalities in patients with fibromyalgia \u2013 measured by capillary and laser fluxmetry. <em>Arthritis Res Ther<\/em> 2005.<\/li><li style=\"margin-bottom: 10px;\">Walz J., et al. Ganzk\u00f6rperhyperthermie in der Schmerztherapie \u2013 eine kontrollierte Studie an Patienten mit Fibromyalgiesyndrom. <em>Schmerz<\/em> 2013; 27:38-45.<\/li><li style=\"margin-bottom: 10px;\">Romeyke T., Stummer H. Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic WBH&#8230; <em>J Musculoskel Pain<\/em> 2014; 4:341-55.<\/li><li style=\"margin-bottom: 10px;\">Zauner D., et al. WBH treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis. <em>Int J Hyperthermia<\/em> 2014.<\/li><li style=\"margin-bottom: 10px;\">Lange U., et al. Wirkung iterativer Ganzk\u00f6rperhyperthermie cu wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis&#8230; <em>Akt Rheumatol<\/em> 2017.<\/li><\/ol><div style=\"margin-top: 30px; padding: 15px; background-color: #f8f9fa; border-left: 4px solid #3498db; font-style: italic;\"><p style=\"margin: 0; font-size: 0.9em;\"><strong>EN:<\/strong> The complete database of over 60 clinical studies on wIRA technology is available upon request.<\/p><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>\u00a0<\/p><\/section><footer>\u00a9 <time>2025<\/time> Romanian Society Oncologic Hyperthermia All rights reserved. Source: Analysis based on scientific literature.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Hipertermia Seluruh Tubuh (WBH) dalam Onkologi &amp; Patologi Lainnya: Sinergi Terkonsolidasi, Imunomodulasi, dan Bukti Klinis Diterbitkan: 2025-10-13 | Terakhir Ditinjau: 2025-10-13 Oleh Veronica Iatan, MD, Cristian Gologan, M.Sc. Hipertermia Seluruh Tubuh (WBH) adalah strategi onkologi sistemik yang melibatkan pemanasan terkendali pada suhu inti tubuh, sering kali menggunakan teknologi Inframerah-A yang disaring air (wIRA). WBH pada<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/id\/uji-klinis-hipertermia-wira-onkologi\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-1903","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/id\/wp-json\/wp\/v2\/pages\/1903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/id\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/id\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/id\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/id\/wp-json\/wp\/v2\/comments?post=1903"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/id\/wp-json\/wp\/v2\/pages\/1903\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/id\/wp-json\/wp\/v2\/media?parent=1903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}