{"id":3676,"date":"2025-10-13T13:41:37","date_gmt":"2025-10-13T13:41:37","guid":{"rendered":"https:\/\/ardenneiratherm.com\/whole-body-hyperthermia-ankylosing-spondylitis\/"},"modified":"2025-10-13T13:41:37","modified_gmt":"2025-10-13T13:41:37","slug":"whole-body-hyperthermia-ankylosing-spondylitis","status":"publish","type":"post","link":"https:\/\/ardenneiratherm.com\/ja\/whole-body-hyperthermia-ankylosing-spondylitis\/","title":{"rendered":"Immunomodulatory Effects of Whole-Body Hyperthermia (WBH) in Ankylosing Spondylitis"},"content":{"rendered":"<article>\n<header>\n<h1>Immunomodulatory Effects of Whole-Body Hyperthermia (WBH) in Ankylosing Spondylitis<\/h1>\n<p><strong><span style=\"color: #6a6a6a;\">Published: 2025-10-14 | Last Reviewed: 2025-10-14<\/span><\/strong><\/p>\n<\/header>\n<div class=\"authors\">\n<p>Author:<a href=\"https:\/\/ardenneiratherm.com\/ar\/our-team\/cristian-gologan\/\"> M.Sc. Cristian Gologan<\/a> . Reviewed by: [<a href=\"https:\/\/ardenneiratherm.com\/ar\/our-team\/veronica-iatan\/\">Dr. Iatan Veronica<\/a>].<\/p>\n<\/div>\n<section class=\"disclaimer\">**<strong>Medical Disclaimer: This article is for informational purposes only. Consult a rheumatologist for Ankylosing Spondylitis diagnosis and management<\/strong>.**<\/section>\n<section>\n<h2>1. How WBH Improves Functional Health and Modulates Cytokines in Ankylosing Spondylitis (AS)<\/h2>\n<p>Iterative *<strong>Mild Whole-Body Hyperthermia (WBH)<\/strong>* using water-filtered IR-A radiation wIRA is a proven adjuvant therapy for <strong>Ankylosing Spondylitis (AS)<\/strong>, validated by *<strong>controlled, randomized, prospective studies<\/strong>* <span class=\"citation\">[4]<\/span>. The key mechanism is <strong>immunomodulation<\/strong>, where WBH significantly *<strong>increases anti-inflammatory cytokines<\/strong>* like *<strong>Interleukin-10<\/strong> (<strong>IL-10<\/strong>)* while affecting pro-inflammatory mediators <em>(TNF-alpha, IL-6)<\/em> <span class=\"citation\">[3, 1]<\/span>. This results in *<strong>improved functional and subjective health<\/strong>* for AS patients <span class=\"citation\">[2, 4]<\/span>.<\/p>\n<h3>Immunological and Functional Outcomes<\/h3>\n<ul>\n<li>*<strong>Anti-Inflammatory Response<\/strong> <strong>(IL-10)<\/strong>:* WBH treatment has been shown to *<strong>increase Interleukin-10 (IL-10)<\/strong>* expression in AS patients, along with Toll-Like Receptor 4, suggesting a beneficial shift toward an anti-inflammatory state <span class=\"citation\">[3]<\/span>.<\/li>\n<li>*<strong>Pro-Inflammatory Cytokines:<\/strong>* Studies confirm that mild WBH affects systemic levels of pro-inflammatory cytokines, specifically *<strong>TNF-alpha, IL-1 beta and IL-6<\/strong>*, which are key drivers of AS pathology <span class=\"citation\">[1]<\/span>.<\/li>\n<li>*<strong>Functional Health Improvement:<\/strong>* Research from the Justus-Liebig-Universit\u00e4t Gie\u00dfen demonstrated that <strong>iterative WBH positively impacts the *functional and functional health* status of patients with AS<\/strong>\u00a0<span class=\"citation\">[2]<\/span>.<\/li>\n<li>*<strong>High-Level Evidence:<\/strong>* The efficacy of iterative WBH with water-filtered IR-A radiation (wIRA hyperthermia) in AS is confirmed by a *<strong>controlled, randomized, prospective study<\/strong>* <span class=\"citation\">[4]<\/span>.<\/li>\n<\/ul>\n<\/section>\n<section class=\"faq\">\n<h2>Frequently Asked Questions (FAQ)<\/h2>\n<div class=\"faq-item\">\n<h3>How does WBH reduce inflammation in Ankylosing Spondylitis?<\/h3>\n<div>\n<p>WBH reduces inflammation by acting as an <strong>immunomodulator<\/strong>. It specifically increases the production of the *<strong>anti-inflammatory cytokine Interleukin-10 (IL-10)<\/strong>* and affects systemic levels of pro-inflammatory cytokines like TNF-alpha <span class=\"citation\">[1, 3]<\/span>.<\/p>\n<section>\n<h3>How can von Ardenne Iratherm 1000 Whole-Body Hyperthermia wIRA device be used for treatment of Ankylosing Spondylitis ?<\/h3>\n<p>Overview of recommended WBH sessions with <a href=\"https:\/\/ardenneiratherm.com\/ja\/iratherm-1000-hyperthermia\/\">von Ardenne Iratherm 1000 WBH wIRA device<\/a> and target temperatures &#8211; <i>Treatments <\/i><i>shall<\/i> <i>only<\/i> <i>be<\/i> <i>performed<\/i><i> after final <\/i><i>consultation<\/i> <i>with<\/i><i> a <\/i><i>medical<\/i> <i>doctor<\/i><\/p>\n<div class=\"table-scroll-wrapper\" >\n<table width=\"1151\">\n<tbody>\n<tr>\n<td width=\"278\">Indication<\/td>\n<td width=\"99\">No. of sessions<\/td>\n<td width=\"135\">Target temperature<\/td>\n<td colspan=\"2\" width=\"309\">Therapy time<\/p>\n<p>Increase phase\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Plateau phase<\/td>\n<td width=\"164\">Rest time<\/p>\n<p>Resting phase<\/td>\n<td width=\"164\"><b>Total<\/b><\/p>\n<p><b>WBH <\/b><b>session<\/b><b> time<\/b><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\" width=\"278\">Ankolysing Spondylitis<\/td>\n<td rowspan=\"2\" width=\"99\">6<\/td>\n<td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td>\n<td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td>\n<td rowspan=\"2\" width=\"164\">30 min<\/td>\n<td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td>\n<\/tr>\n<tr>\n<td width=\"155\">45 min<\/td>\n<td width=\"155\">15 min<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>&nbsp;<\/p>\n<\/section>\n<section class=\"faq\">\n<div class=\"faq-item\">\n<div>\n<section class=\"faq\">\n<div class=\"faq-item\">\n<div>\n<h3>Can Whole-Body Hyperthermia with wIRA be used for other pathologies?<\/h3>\n<p>Yes. Other benefits and areas of application of Whole Body Hyperthermia include <strong><a href=\"https:\/\/ardenneiratherm.com\/ja\/clinical-research\/\">Oncology, accelerated metabolism , stimulation of the hormonal system , reduction in muscle tone , enhanced nerve conduction, Systemic sclerosis, Depressive episode, Essential (primary) hypertension, Dorsalgia, Fibromyalgia, Ankylosing spondylitis<\/a><\/strong><\/p>\n<p>A more detailed list of studies and effects ( (<em>from foundational studies on wIRA technology to crucial Phase III clinical trials<\/em>) can be found\u00a0<a href=\"https:\/\/ardenneiratherm.com\/ja\/clinical-research\/\">here<\/a><\/p>\n<div>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"attachment_612\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/ardenneiratherm.com\/ja\/clinical-research\/\"><img fetchpriority=\"high\" decoding=\"async\" aria-describedby=\"caption-attachment-612\" class=\"wp-image-612 size-large\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary-1024x529.jpg\" alt=\"von Ardenne Iratherm 10000 Whole-Body Hyperthermia wIRA hyperthermia-device-summary\" width=\"1024\" height=\"529\" srcset=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary-1024x529.jpg 1024w, https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary-300x155.jpg 300w, https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary-768x397.jpg 768w, https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg 1414w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><p id=\"caption-attachment-612\" class=\"wp-caption-text\">von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary<\/p><\/div>\n<\/div>\n<\/div>\n<\/section>\n<section>\n<h2><\/h2>\n<\/section>\n<\/div>\n<\/div>\n<\/section>\n<section><\/section>\n<section class=\"faq\">\n<h2><\/h2>\n<\/section>\n<\/div>\n<\/div>\n<\/section>\n<section>\n<h2>References (E-E-A-T)<\/h2>\n<ol>\n<li><em>Tarner I.H., Ladner U.M., Uhlemann C., Lange U.<\/em><br \/>\n<strong>The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1 beta and IL-6 in patients with ankylosing spondylitis.<\/strong><br \/>\nClin Rheumatol 2009; 4:397-402<\/li>\n<li><em>Neumann S.<\/em><br \/>\n<strong>Wirkung der iterativer Ganzk\u00f6rperhyper\u00adthermie mit wassergefilterter Infrarot-A-Strahlung auf die funktionelle und funktionale Gesundheit sowie pro- und anti- inflamatorische Zytokine bei Patienten mit ankylosierender Spondylitis<\/strong><br \/>\nDiss. Justus-Liebig-Universit\u00e4t Gie\u00dfen, Internist. Rheumatol. 2011<\/li>\n<li><em>Zauner D., Quehenberger F., Hermann J., Dejaco C., Stradner M.H., Stojakovic T., Angerer H., Rinner B., Graninger W.B.<\/em><br \/>\n<strong>Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study<\/strong><br \/>\nInt J Hyperthermia 2014; 6:393-401,\u00a0<a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.3109\/02656736.2014.956810\" target=\"_blank\" rel=\"noopener noreferrer\">Volltext-Link<\/a><\/li>\n<li><em>Lange U., M\u00fcller-Ladner U., Dischereit G.<\/em><br \/>\n<strong>Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis \u2013 eine kontrollierte, randomisierte, prospektive Studie<\/strong><br \/>\nAkt Rheumatol 2017; 2:122-128<\/li>\n<\/ol>\n<\/section>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>Immunomodulatory Effects of Whole-Body Hyperthermia (WBH) in Ankylosing Spondylitis Published: 2025-10-14 | La<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/ja\/whole-body-hyperthermia-ankylosing-spondylitis\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[376],"tags":[714,384],"class_list":["post-3676","post","type-post","status-publish","format-standard","hentry","category-wbh-wira-pathologies","tag-ankylosing-spondylitis","tag-whole-body-hyperthermia"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/ja\/wp-json\/wp\/v2\/posts\/3676","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/ja\/wp-json\/wp\/v2\/comments?post=3676"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/ja\/wp-json\/wp\/v2\/posts\/3676\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/ja\/wp-json\/wp\/v2\/media?parent=3676"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ardenneiratherm.com\/ja\/wp-json\/wp\/v2\/categories?post=3676"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ardenneiratherm.com\/ja\/wp-json\/wp\/v2\/tags?post=3676"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}