{"id":981,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2025-12-22T09:10:14","modified_gmt":"2025-12-22T09:10:14","slug":"kliniskie-petijumi-hipertermija-onkologija","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/lv\/kliniskie-petijumi-hipertermija-onkologija\/","title":{"rendered":"Kl\u012bniskie p\u0113t\u012bjumi"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"981\" class=\"elementor elementor-981 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Visp\u0101r\u0113j\u0101 \u0136erme\u0146a Hipertermija (WBH) Onkolo\u0123ij\u0101 un Cit\u0101s Patolo\u0123ij\u0101s: Konsolid\u0113ta Siner\u0123ija, Im\u016bnmodul\u0101cija un Kl\u012bniskie Pier\u0101d\u012bjumi<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header><strong>Public\u0113ts: <time datetime=\"2025-10-13\">2025-10-13<\/time> | P\u0113d\u0113j\u0101 P\u0101rskat\u012b\u0161ana: <time datetime=\"2025-10-13\">2025-10-13<\/time><\/strong><\/header><p>Autori<br \/><a href=\"\/?p=139\">Veronica Iatan, MD<\/a>,<br \/><a href=\"\/?p=137\">Cristian Gologan, M.Sc.<\/a><\/p><section><p style=\"font-weight: bold; font-style: italic;\">Visp\u0101r\u0113j\u0101 \u0136erme\u0146a Hipertermija (WBH) ir sist\u0113miska onkolo\u0123iska strat\u0113\u0123ija, kas ietver kontrol\u0113tu \u0137erme\u0146a pamata temperat\u016bras paaugstin\u0101\u0161anu, bie\u017ei izmantojot *ar \u016bdeni filtr\u0113tu Infrasarkano-A (wIRA)* tehnolo\u0123iju. WBH ir galvenok\u0101rt *\u0137\u012bmij\/radio sensibiliz\u0113t\u0101js*, kas iev\u0113rojami *uzlabo audz\u0113ja perf\u016bziju un oksigen\u0101ciju*, lai pastiprin\u0101tu tradicion\u0101l\u0101s \u0101rst\u0113\u0161anas efektivit\u0101ti. B\u016btiski, t\u0101 darbojas k\u0101 sp\u0113c\u012bgs *sist\u0113misks im\u016bnmodulators*, mobiliz\u0113jot Karstuma \u0160oka Olbaltumvielas (HSP) un T \u0161\u016bnas, kas rada b\u016btisku siner\u0123iju ar progres\u012bvu *Im\u016bnterapiju (ICI)* un nodro\u0161ina *dramatisku, \u0101tru s\u0101pju mazin\u0101\u0161anu un dz\u012bves kvalit\u0101tes uzlabo\u0161anos* da\u017e\u0101du v\u0113\u017ea veidu un hronisku patolo\u0123iju, piem\u0113ram, Fibromial\u0123ijas, gad\u012bjum\u0101.<\/p><\/section><section>* Medic\u012bnas Atruna: \u0160is raksts ir paredz\u0113ts tikai informat\u012bviem nol\u016bkiem un neaizst\u0101j individualiz\u0113tu medic\u012bnisko konsult\u0101ciju, diagnozi vai \u0101rst\u0113\u0161anu, ko sniedz licenc\u0113ts \u0101rsts.*<\/section><section><h2>\u00a0<\/h2><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\n1. Visp\u0101r\u0113j\u0101s \u0136erme\u0146a Hipertermijas (WBH) un Terapeitisk\u0101s Tehnolo\u0123ijas Defin\u012bcija<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\"><strong>Visp\u0101r\u0113j\u0101 \u0136erme\u0146a Hipertermija (WBH)<\/strong> jeb \u201csist\u0113misk\u0101 hipertermija\u201d tiek defin\u0113ta k\u0101 kontrol\u0113ta \u0137erme\u0146a pamata temperat\u016bras paaugstin\u0101\u0161ana terapeitiskiem m\u0113r\u0137iem. Pamatojoties uz <strong>dabisk\u0101 drud\u017ea iedarb\u012bbas spektru da\u017e\u0101d\u0101s temperat\u016br\u0101s<\/strong>, WBH proced\u016bras at\u0161\u0137iras \u0161\u0101di:<\/p><ul style=\"text-align: left;\"><li><strong>Viegla WBH:<\/strong> &lt; 38.5<strong>\u00b0<\/strong>C<\/li><li><strong>M\u0113rena WBH:<\/strong> 38.5<strong>\u00b0<\/strong>C- 40.5 <strong> \u00b0<\/strong>C<\/li><li><strong>Ekstr\u0113ma WBH:<\/strong> &gt; 40.5<strong>\u00b0<\/strong>C<\/li><\/ul><p style=\"text-align: left;\">Jo \u012bpa\u0161i viegla un m\u0113rena WBH <strong>palielina perf\u016bziju<\/strong>, stimul\u0113 vielmai\u0146u, samazina musku\u013cu tonusu un <strong>stimul\u0113 im\u016bnsist\u0113mu<\/strong>.<\/p><p style=\"text-align: left;\">The <a title=\"Tehnisk\u0101s deta\u013cas von Ardenne IRATHERM\u00ae 1000M WBH wIRA ier\u012bce\" href=\"\/?page_id=270\"><strong>von Ardenne IRATHERM<\/strong>\u00ae <strong>1000M WBH wIRA ier\u012bce<\/strong><\/a> \u0161im nol\u016bkam izmanto tikai <strong>\u0101dai draudz\u012bgu, dzi\u013cos audos iek\u013c\u016bsto\u0161u, ar \u016bdeni filtr\u0113tu Infrasarkano-A (wIRA) siltuma starojumu<\/strong> (bez IR-B \/ IR-C). T\u0101s ne-klaustrofobiskais, atv\u0113rtais sist\u0113mas dizains nodro\u0161ina vienm\u0113r\u012bgu apstaro\u0161anas intensit\u0101ti vis\u0101 pacienta (muguras) l\u012bmen\u012b un pied\u0101v\u0101 lietot\u0101jam optim\u0101lu, pacientam specifisku siltuma pieg\u0101di gan atra\u0161an\u0101s vietas, gan intensit\u0101tes zi\u0146\u0101.<\/p><p style=\"text-align: left;\">Ar \u016bdeni filtr\u0113ts infrasarkanais-A starojums atbilst dabiskajam saules termiskajam starojumam, nodro\u0161inot tehnolo\u0123isko pamatu vienm\u0113r\u012bgai un saudz\u012bgai siltuma pielieto\u0161anai [1, 5, 7, 8].<\/p><p style=\"text-align: left;\">Izmantojot von Ardenne IRATHERM<sup>\u00ae<\/sup> 1000 principu, kas ir izstr\u0101d\u0101ts un pier\u0101d\u012bts vair\u0101k nek\u0101 30 gadus, <a title=\"Prof. Manfred von Ardenne - Ieguld\u012bjums\" href=\"\/?p=5\">Prof. Manfred von Ardenne<\/a> ir izdevies fiziski un tehniski reproduc\u0113t \u0161o termisko starojumu un padar\u012bt to pieejamu r\u016bpnieciski ilgtsp\u0113j\u012bgai medic\u012bniskai lieto\u0161anai ar visp\u0101r\u0113jas \u0137erme\u0146a hipertermijas pal\u012bdz\u012bbu.<\/p><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Zin\u0101tniskie Pamati un Sist\u0113misk\u0101 Iedarb\u012bba<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h2>\u00a0<\/h2><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">WBH ir att\u012bst\u012bjusies par strat\u0113\u0123iju, kas balst\u012bta uz stingriem biofizik\u0101liem un fiziolo\u0123iskiem principiem. Onkolo\u0123ij\u0101 galven\u0101 uzman\u012bba tiek piev\u0113rsta <strong>M\u0113renai<\/strong> un <strong>Drud\u017ea Diapazona Hipertermijai (FR-WBH)<\/strong>, kas tiek atz\u012btas par \u0101rst\u0113\u0161anu ar vair\u0101k\u0101m terapeitisk\u0101m indik\u0101cij\u0101m [1, 3].<\/p><p style=\"text-align: left;\">Tehnolo\u0123isko pamatu vienm\u0113r\u012bgai un saudz\u012bgai siltuma pielieto\u0161anai bie\u017ei nodro\u0161ina ier\u012bces, kas izmanto <strong>ar \u016bdeni filtr\u0113tu Infrasarkano-A (wIRA) starojumu<\/strong>. Detaliz\u0113ti biofizik\u0101lie p\u0113t\u012bjumi ir apstiprin\u0101ju\u0161i \u0161\u012bs <strong>tehnolo\u0123ijas sp\u0113ju nodro\u0161in\u0101t dzi\u013cu un kontrol\u0113tu sild\u012b\u0161anu<\/strong>, \u0146emot v\u0113r\u0101 \u0101das optisk\u0101s \u012bpa\u0161\u012bbas un fotobiolo\u0123isko pamatu doz\u0113\u0161anai [5, 7, 8].<\/p><p style=\"text-align: left;\">Detaliz\u0113ti biofizik\u0101lie p\u0113t\u012bjumi ir apstiprin\u0101ju\u0161i <strong>wIRA tehnolo\u0123ijas<\/strong> sp\u0113ju nodro\u0161in\u0101t <strong>dzi\u013cu un kontrol\u0113tu sild\u012b\u0161anu<\/strong> [5, 7, 8]. Fiziolo\u0123isk\u0101 l\u012bmen\u012b WBH ir fundament\u0101la sist\u0113miska iedarb\u012bba:<\/p><ol style=\"text-align: left;\"><li><strong>Uzlabota Asins Reolo\u0123ija:<\/strong> IR-WBH iedarb\u012bba labv\u0113l\u012bgi ietekm\u0113 <strong>asins pl\u016bsmas \u012bpa\u0161\u012bbas un hemodinamiku<\/strong> [2], atbalstot b\u016btisku meh\u0101nismu \u2013 <strong>audz\u0113ja perf\u016bzijas uzlabo\u0161anu<\/strong> \u2013 kas ir kritisks priek\u0161noteikums sist\u0113misku \u0101rst\u0113\u0161anas veidu pan\u0101kumiem.<\/li><li><strong>Visp\u0101r\u0113ja Biolo\u0123isk\u0101 Aktiviz\u0113\u0161ana:<\/strong> WBH izraisa termisko stresa reakciju, kas aktiviz\u0113 biolo\u0123isko procesu kask\u0101di, tostarp <strong>hormon\u0101l\u0101s sist\u0113mas modul\u0101ciju<\/strong> un <strong>vielmai\u0146as pa\u0101trin\u0101\u0161anos<\/strong> [6, 4].<\/li><\/ol><p style=\"text-align: left;\">Pateicoties \u0161iem pamatiem, WBH darbojas k\u0101 <strong>sist\u0113misks im\u016bnmodulators<\/strong>, optimiz\u0113jot <strong>audz\u0113ja mikro vidi (TME)<\/strong> un <strong>pastiprinot progres\u012bvu onkolo\u0123isko \u0101rst\u0113\u0161anas veidu efektivit\u0101ti<\/strong> [9].<\/p><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. Galvenie Darb\u012bbas Meh\u0101nismi (Molekul\u0101rie, Fiziolo\u0123iskie un Imunolo\u0123iskie)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">WBH terapeitisk\u0101 iedarb\u012bba ir sare\u017e\u0123\u012bta, ko medi\u0113 p\u0101rmai\u0146as \u0161\u016bnu, im\u016bn\u0101s un fiziolo\u0123isk\u0101s l\u012bmen\u012b:<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. Siner\u0123ija ar \u0136\u012bmijterapiju un Staru Terapiju (\u0136\u012bmij\/Radio Sensibiliz\u0113t\u0101js)<\/h3><ul><li style=\"text-align: left;\"><strong>Audz\u0113ja Mikrovides (TME) Optimiz\u0113\u0161ana:<\/strong> WBH uzlabo <strong>audz\u0113ja asins perf\u016bziju<\/strong> un <strong>oksigen\u0101ciju<\/strong>, nov\u0113r\u0161ot audz\u0113ja hipoksiju. Tas ir b\u016btiski, jo labi oksigen\u0113tas audz\u0113ja \u0161\u016bnas ir iev\u0113rojami jut\u012bg\u0101kas pret izn\u012bcin\u0101\u0161anu, ko veic <strong>\u0136\u012bmijterapija<\/strong> (CT) un <strong>Staru Terapija<\/strong> (RT) [9, 41].<\/li><li style=\"text-align: left;\"><strong>\u0136\u012bmij\/Radio Efektivit\u0101te:<\/strong> Hipertermija darbojas k\u0101 <strong>\u0137\u012bmij- &amp; radio sensibiliz\u0113t\u0101js<\/strong>, uzlabojot audz\u0113ja sk\u0101bek\u013ca pieg\u0101di (*radio-sensibiliz\u0113jo\u0161s efekts*) un pastiprinot t\u0101du z\u0101\u013cu k\u0101 Cisplat\u012bns, Gemcitab\u012bns un Karboplat\u012bns efektivit\u0101ti [12, 16, 36].<\/li><\/ul><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. Sp\u0113c\u012bgas Pretv\u0113\u017ea Im\u016bn\u0101s Atbildes Induc\u0113\u0161ana (Im\u016bnmodul\u0101cija)<\/h3><p style=\"text-align: left;\">WBH ir sp\u0113c\u012bgs organisma aizsardz\u012bbas sist\u0113mas aktivators [11]:<\/p><ul><li style=\"text-align: left;\"><strong>Karstuma \u0160oka Olbaltumvielas (HSP):<\/strong> Termiskais stress stimul\u0113 <strong>HSP70<\/strong> sint\u0113zi un izdal\u012b\u0161anos. \u0160\u012bs olbaltumvielas darbojas k\u0101 &#8216;briesmu sign\u0101li&#8217;, kas iez\u012bm\u0113 v\u0113\u017ea \u0161\u016bnas pastiprin\u0101tam im\u016bnsist\u0113mas <strong>Citotoksisko T Limfoc\u012btu (CTLs)<\/strong> uzbrukumam [9, 10, 29].<\/li><li style=\"text-align: left;\"><strong>Galveno Im\u016bn\u0161\u016bnu Aktiviz\u0113\u0161ana:<\/strong> Temperat\u016bras diapazons 39-43<strong>\u00b0<\/strong>C palielina <strong>Dabisk\u0101s Killer (NK) \u0161\u016bnu<\/strong> aktivit\u0101ti un veicina <strong>pal\u012bgu un citotoksisko T \u0161\u016bnu<\/strong>, <strong>dendr\u012btisko \u0161\u016bnu<\/strong> un <strong>makrof\u0101gu<\/strong> aktivit\u0101ti, vienlaikus potenci\u0101li apdraudot im\u016bnsupres\u012bv\u0101s \u0161\u016bnas [9, 10, 11, 25, 26].<\/li><li style=\"text-align: left;\"><strong>T-Limfoc\u012btu Pieaugums:<\/strong> FR-WBH var <strong>iev\u0113rojami palielin\u0101t (piem\u0113ram, 3 reizes) citotoksisko T limfoc\u012btu popul\u0101ciju<\/strong> limfo\u012bdajos org\u0101nos, t\u0101d\u0113j\u0101di <strong>pastiprinot sist\u0113misko pretv\u0113\u017ea im\u016bno uzbrukumu<\/strong> [10].<\/li><li style=\"text-align: left;\"><strong>Vakc\u012bnas un APC:<\/strong> WHT var regul\u0113t Antig\u0113nu Prezent\u0113jo\u0161o \u0160\u016bnu (APCs) funkciju un palielin\u0101t v\u0113\u017ea vakc\u012bnu efektivit\u0101ti, tostarp t\u0101s, kas balst\u012btas uz HSP110 un GRP170 [37, 28].<\/li><\/ul><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Kl\u012bniskie Pier\u0101d\u012bjumi un Siner\u0123ija Multimod\u0101laj\u0101 Terapij\u0101<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. Siner\u0123ija ar Im\u016bnterapiju (Kontrolpunkta Inhibitori &#8211; ICI)<\/h3><p style=\"text-align: left;\">Retrospekt\u012bvs gad\u012bjumu s\u0113rija ar 131 pacientu ar progres\u0113jo\u0161u (IV stadijas) v\u0113zi p\u0113t\u012bja multimod\u0101lu protokolu, kas ietv\u0113ra <strong>visp\u0101r\u0113jo \u0137erme\u0146a hipertermiju<\/strong> kop\u0101 ar kontrolpunkta inhibitoriem (Ipilimumabs, Nivolumabs) un IL-2 [18].<\/p><p style=\"text-align: left;\"><strong>Galvenais Secin\u0101jums:<\/strong> wIRA Visp\u0101r\u0113j\u0101 \u0136erme\u0146a Hipertermija tika noteikta k\u0101 <strong>neat\u0146emama un b\u016btiska sast\u0101vda\u013ca<\/strong>, kas <strong>maksim\u0101li palielin\u0101ja pretv\u0113\u017ea im\u016bno atbildi<\/strong>. <strong>WBH aktiviz\u0113 un mobiliz\u0113 T \u0161\u016bnas (induc\u0113jot HSP70 un atbr\u012bvojot audz\u0113ja antig\u0113nus);<\/strong> p\u0113c tam kontrolpunkta inhibitori &#8220;no\u0146em bremzes&#8221; \u0161\u012bm iepriek\u0161 aktiviz\u0113taj\u0101m T \u0161\u016bn\u0101m, k\u0101 rezult\u0101t\u0101 nov\u0113ro neparasti augstu labv\u0113l\u012bgu kl\u012bnisko atbildes reakciju l\u012bmeni progres\u0113jo\u0161as slim\u012bbas gad\u012bjum\u0101 [18].<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. Kl\u012bniskais Pielietojums Da\u017e\u0101dos V\u0113\u017ea Veidos<\/h3><ul><li style=\"text-align: left;\"><strong>Aizku\u0146\u0123a Dziedzera V\u0113zis:<\/strong> I-II f\u0101zes protokoli, izmantojot vieglu WBH (FR-WBH) kombin\u0101cij\u0101 ar \u0137\u012bmijterapiju un Interferonu-alfa, uzr\u0101d\u012bja <strong>vismaz 50% audz\u0113ja regresiju gandr\u012bz pusei no terapijai rezistentajiem pacientiem<\/strong> [4, 22].<\/li><li style=\"text-align: left;\"><strong>Kr\u016bts V\u0113zis (Recid\u012bvs):<\/strong> WHT kombin\u0101cij\u0101 ar atk\u0101rtotu apstaro\u0161anu vai staru terapiju ir uzr\u0101d\u012bjusi efektivit\u0101ti lok\u0101li progres\u0113jo\u0161a kr\u016bts v\u0113\u017ea un kr\u016b\u0161kurvja sienas recid\u012bva gad\u012bjum\u0101, ko apstiprina randomiz\u0113ti dati [39, 40].<\/li><li style=\"text-align: left;\"><strong>Oln\u012bcu V\u0113zis:<\/strong> WBH kombin\u0101cij\u0101 ar <strong>karboplat\u012bnu<\/strong> tika p\u0113t\u012bta II f\u0101zes p\u0113t\u012bjum\u0101 recidiv\u0113jo\u0161a oln\u012bcu v\u0113\u017ea gad\u012bjum\u0101 [16, 20].<\/li><li style=\"text-align: left;\"><strong>Kolorekt\u0101lais V\u0113zis:<\/strong> WBH wIRA tika izmantota Von Ardenne Sist\u0113misk\u0101s V\u0113\u017ea Daudzpak\u0101pju Terapijas (sCMT) kontekst\u0101 kombin\u0101cij\u0101 ar \u0137\u012bmijterapiju I\/II f\u0101zes p\u0113t\u012bjum\u0101 [15].<\/li><\/ul><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. \u0100tra S\u0101pju Mazin\u0101\u0161ana un Iev\u0113rojama Dz\u012bves Kvalit\u0101tes (DzK) Uzlabo\u0161ana<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">Pacienti var piedz\u012bvot \u0101tru s\u0101pju mazin\u0101\u0161anu un visp\u0101r\u0113ju labsaj\u016btas uzlabo\u0161anos, k\u0101 nov\u0113rots Dr. Bull p\u0113t\u012bjum\u0101 [12] un jo \u012bpa\u0161i jaun\u0101kaj\u0101 III f\u0101zes kl\u012bniskaj\u0101 p\u0113t\u012bjum\u0101, ko veica Sahinbas et al. [14].<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">III F\u0101zes Kl\u012bniskais P\u0113t\u012bjums (2024) par Kaulu Metast\u0101z\u0113m<\/h3><section>2024. gad\u0101 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\">Sahinbas un kol\u0113\u0123i public\u0113ja III f\u0101zes p\u0113t\u012bjumu<\/a> par kaulu metast\u0101\u017eu s\u0101p\u0113m, galvenok\u0101rt no kr\u016bts un prostatas v\u0113\u017ea, izmantojot WBH wIRA Iratherm hipertermijas ier\u012bces papildus RT [14]. Pamatojoties uz \u0161o p\u0113t\u012bjumu, tikai staru terapijas (RT) grup\u0101 tika nov\u0113rotas visintens\u012bv\u0101k\u0101s s\u0101pes. P\u0113t\u012bjums tika pabeigts, iek\u013caujot kopum\u0101 61 pacientu, 5 gadus p\u0113c pirm\u0101s re\u0123istr\u0101cijas (2016. gada apr\u012blis \u2013 2021. gada febru\u0101ris). Visbeidzot, Piln\u012bgas Atbildes (CR) l\u012bmenis RT + WBH grup\u0101 uzr\u0101d\u012bja visliel\u0101ko at\u0161\u0137ir\u012bbu sal\u012bdzin\u0101jum\u0101 ar tikai RT, attiec\u012bgi <strong>47.4% pret 5.3%, 2 m\u0113ne\u0161u laik\u0101 p\u0113c \u0101rst\u0113\u0161anas<\/strong> (P v\u0113rt\u012bba &lt; 0.05). <strong>Laiks l\u012bdz piln\u012bgai s\u0101pju mazin\u0101\u0161anai bija 10 dienas RT + WBH gad\u012bjum\u0101, savuk\u0101rt RT vien grup\u0101 \u0161is m\u0113r\u0137is netika sasniegts.<\/strong> S\u0101pju progres\u0113\u0161ana vai slim\u012bbas stabilit\u0101te tika nov\u0113rota pusei pacientu RT grup\u0101 4 ned\u0113\u013cu laik\u0101 p\u0113c \u0101rst\u0113\u0161anas. Tom\u0113r <strong>\u0161is r\u0101d\u012bt\u0101js bija tuvu nullei RT + WBH pacientiem divu m\u0113ne\u0161u laik\u0101 p\u0113c \u0101rst\u0113\u0161anas<\/strong>. <strong>Secin\u0101jumi:<\/strong> WBH plus RT uzr\u0101d\u012bja iev\u0113rojamu s\u0101pju mazin\u0101\u0161an\u0101s pieaugumu un \u012bs\u0101ku atbildes laiku, sal\u012bdzinot ar tikai RT pacientiem ar metast\u0101tisk\u0101m kaulu boj\u0101jumiem.<\/section><table border=\"1\"><thead><tr><th>DzK R\u0101d\u012bt\u0101js\/S\u0101pju Uzlabo\u0161ana<\/th><th>RT monoterapija<\/th><th>RT + Hipertermija (WBH wIRA)<\/th><th>DzK Ietekme<\/th><\/tr><\/thead><tbody><tr><td><strong>Piln\u012bgas Atbildes L\u012bmenis (CR) p\u0113c 2 m\u0113ne\u0161iem<\/strong> (nulle s\u0101pju r\u0101d\u012bt\u0101js)<\/td><td>5,3 %<\/td><td>47,4 %<\/td><td>* <strong>894% pieaugums<\/strong> * kop\u0113jo s\u0101pju nov\u0113r\u0161anas iesp\u0113jam\u012bb\u0101.<\/td><\/tr><tr><td><strong>Laiks l\u012bdz piln\u012bgai s\u0101pju mazin\u0101\u0161anai<\/strong><\/td><td>netika sasniegts<\/td><td>10 dienas<\/td><td><strong>\u201d iev\u0113rojams un \u0101trs\u201d<\/strong> labums<\/td><\/tr><tr><td style=\"text-align: left;\"><strong>S\u0101pju Mazin\u0101\u0161anas Ilgums <\/strong><\/td><td style=\"text-align: left;\">Medi\u0101na: 28 dienas\/4 ned\u0113\u013cas pusei pacientu<\/td><td style=\"text-align: left;\">Medi\u0101na: Netika iek\u013cauta pie 24 ned\u0113\u013c\u0101m<\/td><td style=\"text-align: left;\">Mazin\u0101\u0161anas ilgums * <strong>palielin\u0101s se\u0161as reizes<\/strong> *, samazinot atkar\u012bbu no prets\u0101pju l\u012bdzek\u013ciem.<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">\u00a0<\/p><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Sal\u012bdzinot ar l\u012bdz\u012bgu <a title=\"Phase III Chi MS et al. 2017 Study\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5\" target=\"_blank\" rel=\"noopener\">III f\u0101zes p\u0113t\u012bjumu, ko public\u0113ja Chi MS et al<\/a>. (2017) ar RF lokore\u0123ion\u0101lo hipertermiju, ieguvumi (*attiec\u012bb\u0101 uz DzK un s\u0101pju mazin\u0101\u0161anu*), kas tika sasniegti, izmantojot WBH wIRA hipertermiju, bija iev\u0113rojami lab\u0101ki \u2013 RF HT + RT p\u0113t\u012bjuma rezult\u0101ti:<\/p><table border=\"1\"><thead><tr><th>DzK R\u0101d\u012bt\u0101js\/S\u0101pju Uzlabo\u0161ana<\/th><th>RT monoterapija<\/th><th>RT + Hipertermija (HT)<\/th><th>DzK Ietekme<\/th><\/tr><\/thead><tbody><tr><td><strong>Piln\u012bgas Atbildes L\u012bmenis (CR) p\u0113c 3 M\u0113ne\u0161iem<\/strong> (nulle s\u0101pju r\u0101d\u012bt\u0101js)<\/td><td>7,1 %<\/td><td>37,9 %<\/td><td>533% palielin\u0101\u0161an\u0101s kop\u0113jo s\u0101pju mazin\u0101\u0161anas iesp\u0113jam\u012bb\u0101.<\/td><\/tr><tr><td><strong>S\u0101pju Mazin\u0101\u0161anas Ilgums<\/strong><\/td><td>Medi\u0101na: 55 dienas\/7,9 ned\u0113\u013cas<\/td><td>Medi\u0101na: Netika iek\u013cauta pie 24 ned\u0113\u013c\u0101m<\/td><td>Mazin\u0101\u0161anas ilgums tr\u012bsk\u0101r\u0161ojas, samazinot atkar\u012bbu no prets\u0101pju l\u012bdzek\u013ciem.<\/td><\/tr><\/tbody><\/table><p style=\"text-align: left;\">Rezum\u0113jot, konsolid\u0113tie zin\u0101tniskie pier\u0101d\u012bjumi (*no fundament\u0101liem p\u0113t\u012bjumiem par wIRA tehnolo\u0123iju l\u012bdz svar\u012bgiem III f\u0101zes kl\u012bniskajiem p\u0113t\u012bjumiem*) apstiprina WBH lomu k\u0101 daudzpus\u012bgu adjuvant\u0101s terapijas veidu onkolo\u0123ij\u0101: t\u0101 <strong>pastiprina CT\/RT efektivit\u0101ti, aktiviz\u0113 sist\u0113misko im\u016bnsist\u0113mu (tostarp siner\u0123iju ar im\u016bnterapiju) un dramatiski uzlabo s\u0101pju kontroli un DzK<\/strong> v\u0113\u017ea pacientiem.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Sist\u0113miskie Fiziolo\u0123iskie Ieguvumi un Terapeitiskais Potenci\u0101ls Cit\u0101s Patolo\u0123ij\u0101s<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header>Saudz\u012bgais, kontrol\u0113tais siltums, ko nodro\u0161ina WBH ar wIRA starojumu, inici\u0113 sare\u017e\u0123\u012btas termoregul\u0101cijas atbildes reakcijas, kas sniedz pla\u0161us sist\u0113miskus ieguvumus, papla\u0161inot terapeitisko potenci\u0101lu \u0101rpus onkolo\u0123ijas:<\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Musku\u013cu un Skeleta Sist\u0113mas un S\u0101pju Vad\u012bba<\/h3><p style=\"text-align: left;\">WBH ir efekt\u012bva hronisku s\u0101pju sindromu vad\u012bb\u0101, izmantojot t\u0101s fiziolo\u0123isko ietekmi uz musku\u013cu tonusu un mikrocirkul\u0101ciju:<\/p><ul><li style=\"text-align: left;\"><strong>Dorsal\u0123ija (Hroniskas Muguras S\u0101pes):<\/strong> P\u0113t\u012bjumi liecina, ka viegla WBH, kombin\u0101cij\u0101 ar stacion\u0101ru multimod\u0101lu s\u0101pju terapiju, sniedz iev\u0113rojamu labumu pacientiem ar hronisk\u0101m nespecifisk\u0101m muguras lejasda\u013cas s\u0101p\u0113m (dorsal\u0123ija) [53, 54].<\/li><li style=\"text-align: left;\"><strong>Fibromial\u0123ijas Sindroms (FMS):<\/strong> WBH ir dokument\u0113ts papildino\u0161s \u0101rst\u0113\u0161anas veids FMS. Randomiz\u0113ti kontrol\u0113ti p\u0113t\u012bjumi ir pier\u0101d\u012bju\u0161i vieglas wIRA WBH efektivit\u0101ti standarta multimod\u0101las rehabilit\u0101cijas vid\u0113, uzr\u0101dot ietekmi uz <strong>s\u0101pju intensit\u0101ti<\/strong> un <strong>gar\u012bgo st\u0101vokli<\/strong> [17, 56, 57]. \u0160is labums da\u013c\u0113ji ir saist\u012bts ar uzlabotu mikrocirkul\u0101ciju, kas ir zin\u0101ma probl\u0113ma FMS pacientiem [55].<\/li><li style=\"text-align: left;\"><strong>Ankiloz\u0113jo\u0161ais Spondil\u012bts (AS):<\/strong> WBH ir uzr\u0101d\u012bjusi im\u016bnmodul\u0113jo\u0161u iedarb\u012bbu AS pacientiem, p\u0113t\u012bjumiem zi\u0146ojot par WBH sp\u0113ju palielin\u0101t pretiekaisuma mediatorus, piem\u0113ram, <strong>Interleik\u012bnu-10<\/strong> (IL-10), un modul\u0113t pro-iekaisuma citok\u012bnus, piem\u0113ram, TNF-alfa, kas liecina par labv\u0113l\u012bgu lomu hroniska iekaisuma vad\u012bb\u0101, kas saist\u012bts ar \u0161o st\u0101vokli [58, 59, 52].<\/li><li style=\"text-align: left;\"><strong>Reino Fenomens Sist\u0113misk\u0101 Skleroz\u0113:<\/strong> Ar infrasarkano starojumu medi\u0113ta hipertermija ir atz\u012bta par efekt\u012bvu vazokonstrikt\u012bvo simptomu \u0101rst\u0113\u0161an\u0101, kas saist\u012bti ar Sklerodermas Asoci\u0113tu Reino Fenomenu, demonstr\u0113jot asinsvadu ieguvumus [49].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Sirds un Asinsvadu un Asinsrites Vesel\u012bba \u2764\ufe0f<\/h3><p style=\"text-align: left;\">Papildus audz\u0113ja perf\u016bzijas uzlabo\u0161anai WBH ir \u012bpa\u0161a ietekme uz asinsrites sist\u0113mu:<\/p><ul><li style=\"text-align: left;\"><strong>Esenci\u0101la Hipertensija:<\/strong> P\u0113t\u012bjumu s\u0113rija p\u0113t\u012bja vieglas IR-A hipertermijas izmanto\u0161anu pacientiem ar arteri\u0101lo hipertensiju (PVO I un II stadija). Secin\u0101jumi liecina, ka s\u0113rijveida \u0101rst\u0113\u0161ana var pozit\u012bvi ietekm\u0113t <strong>centr\u0101los un perif\u0113ros pulsa vi\u013c\u0146us<\/strong>, asinsspiedienu un <strong>asins viskozit\u0101ti<\/strong>, apstiprinot WBH lomu k\u0101 nefarmakolo\u0123iskai fizioterapijas iesp\u0113jai [44, 47].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \" style=\"text-align: left;\"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">C. Neiroendokr\u012bn\u0101 un Psiholo\u0123isk\u0101 Iedarb\u012bba<\/h3><p style=\"text-align: left;\">WBH iesaista organisma neiroendokr\u012bn\u0101s sist\u0113mas, ietekm\u0113jot garast\u0101vokli un vielmai\u0146u:<\/p><ul><li style=\"text-align: left;\"><strong>Smaga Depres\u012bva Trauc\u0113jumi (SDT):<\/strong> Randomiz\u0113ts kl\u012bniskais p\u0113t\u012bjums demonstr\u0113ja, ka viena WBH sesija var darboties k\u0101 \u0101tras darb\u012bbas antidepresants, k\u0101 rezult\u0101t\u0101 depresijas simptomi samazin\u0101s uz vair\u0101k\u0101m ned\u0113\u013c\u0101m. \u0160is efekts ir saist\u012bts ar siltuma izrais\u012btu im\u016bn\u0101s un iekaisuma ce\u013cu aktiv\u0101ciju, kas ietekm\u0113 smadzenes [51].<\/li><li style=\"text-align: left;\"><strong>Hormon\u0101l\u0101 Modul\u0101cija (Endokrinolo\u0123ija):<\/strong> WBH stimul\u0113 <strong>Hipotal\u0101ma-Hipof\u012bzes-Virsnieku Ass (HPA)<\/strong> un ietekm\u0113 hormonu l\u012bmeni. P\u0113t\u012bjumi ir dokument\u0113ju\u0161i <strong>Aug\u0161anas Hormona<\/strong> un <strong>Prolakt\u012bna<\/strong> atbildes reakcijas visp\u0101r\u0113jas \u0137erme\u0146a hipertermijas laik\u0101, uzsverot t\u0101s ietekmi uz endokr\u012bno regul\u0101ciju [42, 43].<\/li><li style=\"text-align: left;\"><strong>Vielmai\u0146a un \u0160\u016bnu Reakcija:<\/strong> WBH pa\u0101trina baz\u0101lo vielmai\u0146as \u0101trumu. \u0160\u016bnu l\u012bmen\u012b siltums ietekm\u0113 pO2 kin\u0113tiku un ir saist\u012bts ar aizsarg\u0101jo\u0161u olbaltumvielu, piem\u0113ram, <strong>ferit\u012bna<\/strong>, sint\u0113zi \u0101d\u0101, atbalstot audu atjauno\u0161anos [48; 46].<\/li><\/ul><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Bie\u017e\u0101k Uzdotie Jaut\u0101jumi (BUJ) par Ieteicamaj\u0101m WBH Sesij\u0101m un M\u0113r\u0137a Temperat\u016br\u0101m<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p><i>\u0100rst\u0113\u0161ana <\/i><i>dr\u012bkst<\/i> <i>tikt<\/i> <i>veikta<\/i> <i>tikai<\/i> <i>p\u0113c<\/i> <i>gal\u012bg\u0101s<\/i> <i>konsult\u0101cijas<\/i> <i>ar<\/i> <i>\u0101rstu<\/i><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h4>K\u0101ds ir ieteicamais Visp\u0101r\u0113j\u0101s \u0136erme\u0146a Hipertermijas (WBH) protokols esenci\u0101lajai hipertensijai?<\/h4><p>Esenci\u0101lajai hipertensijai ieteicamais protokols ir 12 sesijas ar m\u0113r\u0137a temperat\u016bru 38.3 \u00b0C. Katra sesija ilgst aptuveni 45 min\u016btes, ietverot 30 min\u016b\u0161u temperat\u016bras paaugstin\u0101\u0161anas f\u0101zi un 15 min\u016b\u0161u atp\u016btas f\u0101zi (bez plato f\u0101zes).<\/p><h4>K\u0101di ir ieteicamie WBH parametri hronisk\u0101m muguras s\u0101p\u0113m (Dorsal\u0123ija)?<\/h4><p>Dorsal\u0123ijai parasti tiek ieteiktas 6 sesijas, kuru m\u0113r\u0137a temperat\u016bra ir 38.4 \u00b0C. Kop\u0113jais sesijas ilgums ir aptuveni 90 min\u016btes, ar 45 min\u016b\u0161u paaugstin\u0101\u0161anu, 15 min\u016b\u0161u plato f\u0101zi un 30 min\u016b\u0161u atp\u016btu.<\/p><h4>K\u0101ds ir WBH protokols Fibromial\u0123ijai un Ankiloz\u0113jo\u0161ajam Spondil\u012btam?<\/h4><p>Gan Fibromial\u0123ijai, gan Ankiloz\u0113jo\u0161ajam Spondil\u012btam parasti seko 6 sesiju protokolam ar m\u0113r\u0137a temperat\u016bru 38.5 \u00b0C. Kop\u0113jais sesijas ilgums ir aptuveni 90 min\u016btes, ietverot 45 min\u016b\u0161u paaugstin\u0101\u0161anu, 15 min\u016b\u0161u plato un 30 min\u016b\u0161u atp\u016btu.<\/p><h4>K\u0101ds ir ieteicamais WBH protokols k\u0101 papildu v\u0113\u017ea \u0101rst\u0113\u0161anai?<\/h4><p>K\u0101 papildu v\u0113\u017ea \u0101rst\u0113\u0161anas protokols prasa 2 vai vair\u0101k sesijas ar m\u0113r\u0137a \u0137erme\u0146a temperat\u016bru no 39.0 \u00b0C l\u012bdz 40.0 \u00b0C. Kop\u0113jais sesijas laiks ir visilg\u0101kais, sv\u0101rstoties no 3 l\u012bdz 4 stund\u0101m, kas ietver 60-90 min\u016btes paaugstin\u0101\u0161anas f\u0101zei, 60-90 min\u016btes plato f\u0101zei un 60 min\u016btes atp\u016btas f\u0101zei.<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header>.<\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\"><header>.<table width=\"1151\"><tbody><tr><td width=\"278\">Indik\u0101cija<\/td><td width=\"99\">Sesiju skaits<\/td><td width=\"135\">M\u0113r\u0137a temperat\u016bra<\/td><td colspan=\"2\" width=\"309\">Terapijas laiks<br \/>Paaugstin\u0101\u0161anas f\u0101ze\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Plato f\u0101ze<\/td><td width=\"164\">Atp\u016btas laiks<br \/>Atp\u016btas f\u0101ze<\/td><td width=\"164\"><b>Kop\u0113jais<\/b><br \/><b>WBH sesijas laiks<\/b><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Esenci\u0101la Hipertensija<\/td><td rowspan=\"2\" width=\"99\">12<\/td><td rowspan=\"2\" width=\"135\">38.3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Dorsal\u0123ija<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.4 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Fibromial\u0123ija<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Ankiloz\u0113jo\u0161ais Spondil\u012bts<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Sist\u0113misk\u0101 Skleroze<\/td><td rowspan=\"2\" width=\"99\">15<\/td><td rowspan=\"2\" width=\"135\">38.3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Smaga Depres\u012bva Trauc\u0113jumi<\/td><td rowspan=\"2\" width=\"99\">1+<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>105 -170 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 2-3 stundas<\/b><\/td><\/tr><tr><td width=\"155\">45-110 min<\/td><td width=\"155\">60 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Papildu V\u0113\u017ea \u0100rst\u0113\u0161ana<\/td><td rowspan=\"2\" width=\"99\">2+<\/td><td rowspan=\"2\" width=\"135\">39.0-40.0 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>120-180 min<\/b><\/td><td rowspan=\"2\" width=\"164\">60 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 3-4 stundas<\/b><\/td><\/tr><tr><td width=\"155\">60-90 min<\/td><td width=\"155\">60-90 min<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><\/header><\/header><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>PIEZ\u012aME: \u0161is raksts nav izsme\u013co\u0161s saraksts ar p\u0113t\u012bjumiem un WBH wIRA iedarb\u012bbu<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Atsauces un Cit\u0101ti<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><ol><li style=\"text-align: left;\">Ardenne M. von. 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Hyperthermie und Fieber, Wirkungen bei Mensch und Tier. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1987.<\/li><li style=\"text-align: left;\">Vaupel P., Kr\u00fcger W. W\u00e4rmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsm\u00f6glichkeiten. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1995.<\/li><li style=\"text-align: left;\">Piazena H., Meffert H. Optische Eigenschaften der Haut und die photobiologischen Grundlagen zur Dosierung von IR-Hautbestrahlungen in vivo und in vitro. 6. Symposium Licht und Gesundheit 2008 13.-14.03. Berlin, 2008:162-178.<\/li><li style=\"text-align: left;\">Zschaeck S. and Beck M. Chapter 8 Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?<\/li><li style=\"text-align: left;\">Zhang H, Wang W, Zhang S, Huang W. Comparison of the anti-tumor effects of various whole-body hyperthermia protocols&#8230; Immunol Invest. 2005;34(3):245-58.<\/li><li style=\"text-align: left;\">Abreu MM, Chocron AF, Smadja DM. From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. Front Immunol. 2025 Feb 28;16:1487296.<\/li><li style=\"text-align: left;\">Bull JMC. et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-\u03b1: A description of a phase I-II protocol. Journal of Hyperthermia. 2008; 24(8): 649-662.<\/li><li style=\"text-align: left;\">Weigelin B. Visualization of the immune effect of hyperthermia. ICHO 2021, Session: Hyperthermia and immunology.<\/li><li style=\"text-align: left;\">Faghihi Moghaddam F, Bakhshandeh M, Mofid B, et al. Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone&#8230; J Therm Biol. 2024 Feb;120:103804.<\/li><li style=\"text-align: left;\">Hildebrandt B, Dr\u00e4ger J, Kerner T. et al. Whole-body hyperthermia in the scope of von Ardenne\u2019s systemic cancer multistep therapy (sCMT)&#8230; International Journal of Hyperthermia. 2004;3:317\u2013333.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin in patients with recurrent ovarian cancer \u2013 a phase II study. Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Brockow T., Wagner A., Franke A., Offenb\u00e4cher M., Resch K.L. A Randomized Controlled Trial on the Effectiveness of Mild Water-filtered Near Infrared Whole-body Hyperthermia&#8230; Clin J Pain 2007; 1:67-75.<\/li><li style=\"text-align: left;\">Kleef R, Nagy R, Baierl A, et al. Low-dose Ipilimumab plus Nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series&#8230; Cancer Immunol Immunother. 2021;70:1393\u2013403.<\/li><li style=\"text-align: left;\">Adachi H., Katsuno M., Waza M., et al. Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications. Int J Hyperthermia 2009; 8:647-54.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin&#8230; Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Figueroa G., et al. An Update of a Phase II Clinical Trial Using Fever-Range Whole-Body Thermal Therapy (FR-WB-TT)&#8230; Soc for Thermal Med Joint Annual Meeting, 14.-17.5.2007.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Strebel F.R., et al. 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Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic whole-body hyperthermia&#8230; J Musculoskel Pain 2014; 4:341-55.<\/li><li style=\"text-align: left;\">Zauner D., Quehenberger F., Hermann J., et al. Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study. Int J Hyperthermia 2014; 6:393-401.<\/li><li style=\"text-align: left;\">Lange U., M\u00fcller-Ladner U., Dischereit G. Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis&#8230; Akt Rheumatol 2017; 2:122-128.<\/li><\/ol><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>\u00a0<\/p><\/section><footer>\u00a9 <time>2025<\/time> Romanian Society Oncologic Hyperthermia All rights reserved. Source: Analysis based on scientific literature.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Visp\u0101r\u0113j\u0101 \u0136erme\u0146a Hipertermija (WBH) Onkolo\u0123ij\u0101 un Cit\u0101s Patolo\u0123ij\u0101s: Konsolid\u0113ta Siner\u0123ija, Im\u016bnmodul\u0101cija un Kl\u012bniskie Pier\u0101d\u012bjumi Public\u0113ts: 2025-10-13 | P\u0113d\u0113j\u0101 P\u0101rskat\u012b\u0161ana: 2025-10-13 Autori Veronica Iatan, MD, Cristian Gologan, M.Sc. Visp\u0101r\u0113j\u0101 \u0136erme\u0146a Hipertermija (WBH) ir sist\u0113miska onkolo\u0123iska strat\u0113\u0123ija, kas ietver kontrol\u0113tu \u0137erme\u0146a pamata temperat\u016bras paaugstin\u0101\u0161anu, bie\u017ei izmantojot *ar \u016bdeni filtr\u0113tu Infrasarkano-A (wIRA)* tehnolo\u0123iju. WBH ir galvenok\u0101rt *\u0137\u012bmij\/radio sensibiliz\u0113t\u0101js*,<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/lv\/kliniskie-petijumi-hipertermija-onkologija\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-981","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/lv\/wp-json\/wp\/v2\/pages\/981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/lv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/lv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/lv\/wp-json\/wp\/v2\/comments?post=981"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/lv\/wp-json\/wp\/v2\/pages\/981\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/lv\/wp-json\/wp\/v2\/media?parent=981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}