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Immunomodulatory Effects of Whole-Body Hyperthermia (WBH) in Ankylosing Spondylitis

Published: 2025-10-14 | Last Reviewed: 2025-10-14

Author: M.Sc. Cristian Gologan . Reviewed by: [Dr. Iatan Veronica].

**Medical Disclaimer: This article is for informational purposes only. Consult a rheumatologist for Ankylosing Spondylitis diagnosis and management.**

1. How WBH Improves Functional Health and Modulates Cytokines in Ankylosing Spondylitis (AS)

Iterative *Mild Whole-Body Hyperthermia (WBH)* using water-filtered IR-A radiation wIRA is a proven adjuvant therapy for Ankylosing Spondylitis (AS), validated by *controlled, randomized, prospective studies* [4]. The key mechanism is immunomodulation, where WBH significantly *increases anti-inflammatory cytokines* like *Interleukin-10 (IL-10)* while affecting pro-inflammatory mediators (TNF-alpha, IL-6) [3, 1]. This results in *improved functional and subjective health* for AS patients [2, 4].

Immunological and Functional Outcomes

  • *Anti-Inflammatory Response (IL-10):* WBH treatment has been shown to *increase Interleukin-10 (IL-10)* expression in AS patients, along with Toll-Like Receptor 4, suggesting a beneficial shift toward an anti-inflammatory state [3].
  • *Pro-Inflammatory Cytokines:* Studies confirm that mild WBH affects systemic levels of pro-inflammatory cytokines, specifically *TNF-alpha, IL-1 beta and IL-6*, which are key drivers of AS pathology [1].
  • *Functional Health Improvement:* Research from the Justus-Liebig-Universität Gießen demonstrated that iterative WBH positively impacts the *functional and functional health* status of patients with AS [2].
  • *High-Level Evidence:* The efficacy of iterative WBH with water-filtered IR-A radiation (wIRA hyperthermia) in AS is confirmed by a *controlled, randomized, prospective study* [4].

Frequently Asked Questions (FAQ)

How does WBH reduce inflammation in Ankylosing Spondylitis?

WBH reduces inflammation by acting as an immunomodulator. It specifically increases the production of the *anti-inflammatory cytokine Interleukin-10 (IL-10)* and affects systemic levels of pro-inflammatory cytokines like TNF-alpha [1, 3].

How can von Ardenne Iratherm 1000 Whole-Body Hyperthermia wIRA device be used for treatment of Ankylosing Spondylitis ?

Overview of recommended WBH sessions with von Ardenne Iratherm 1000 WBH wIRA device and target temperatures – Treatments shall only be performed after final consultation with a medical doctor

Indication No. of sessions Target temperature Therapy time

Increase phase          Plateau phase

 Rest time

Resting phase

 Total

WBH session time
Ankolysing Spondylitis 6 38.5 °C 60 min 30 min ~ 90 min
45 min 15 min

 

Can Whole-Body Hyperthermia with wIRA be used for other pathologies?

Yes. Other benefits and areas of application of Whole Body Hyperthermia include Oncology, accelerated metabolism , stimulation of the hormonal system , reduction in muscle tone , enhanced nerve conduction, Systemic sclerosis, Depressive episode, Essential (primary) hypertension, Dorsalgia, Fibromyalgia, Ankylosing spondylitis

A more detailed list of studies and effects ( (from foundational studies on wIRA technology to crucial Phase III clinical trials) can be found here

 

von Ardenne Iratherm 10000 Whole-Body Hyperthermia wIRA hyperthermia-device-summary

von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary

References (E-E-A-T)

  1. Tarner I.H., Ladner U.M., Uhlemann C., Lange U.
    The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1 beta and IL-6 in patients with ankylosing spondylitis.
    Clin Rheumatol 2009; 4:397-402
  2. Neumann S.
    Wirkung der iterativer Ganzkörperhyper­thermie mit wassergefilterter Infrarot-A-Strahlung auf die funktionelle und funktionale Gesundheit sowie pro- und anti- inflamatorische Zytokine bei Patienten mit ankylosierender Spondylitis
    Diss. Justus-Liebig-Universität Gießen, Internist. Rheumatol. 2011
  3. Zauner D., Quehenberger F., Hermann J., Dejaco C., Stradner M.H., Stojakovic T., Angerer H., Rinner B., Graninger W.B.
    Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study
    Int J Hyperthermia 2014; 6:393-401, Volltext-Link
  4. Lange U., Müller-Ladner U., Dischereit G.
    Wirkung iterativer Ganzkörperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis – eine kontrollierte, randomisierte, prospektive Studie
    Akt Rheumatol 2017; 2:122-128
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