{"id":2025,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2026-01-15T17:15:08","modified_gmt":"2026-01-15T17:15:08","slug":"ujian-klinikal-hipertermia-onkologi","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/ms\/ujian-klinikal-hipertermia-onkologi\/","title":{"rendered":"Ujian klinikal"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2025\" class=\"elementor elementor-2025 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Hipertermia Seluruh Badan (WBH) dalam Onkologi &amp; Patologi Lain: Sinergi Terkonsolidasi, Imunomodulasi, dan Bukti Klinikal<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 800px; margin: 0 auto; text-align: center; font-family: sans-serif; line-height: 1.6;\">\n<header style=\"margin-bottom: 20px;\">\n<p style=\"margin-bottom: 5px;\"><strong><span style=\"color: #6a6a6a; font-size: 14px;\">Diterbitkan: <time datetime=\"2025-10-13\">13-10-2025<\/time> | Semakan Terakhir: <time datetime=\"2025-10-13\">13-10-2025<\/time><\/span><\/strong><\/p>\n\n<div style=\"font-size: 16px; color: #333;\">Oleh: \n<a style=\"text-decoration: none; color: #007bff;\" href=\"\/?p=139\">Dr. Veronica Iatan<\/a>, \n<a style=\"text-decoration: none; color: #007bff;\" href=\"\/?p=137\">Cristian Gologan, M.Sc.<\/a><\/div>\n<\/header>\n\n<hr style=\"border: 0; height: 1px; background: #eee; margin: 25px 0;\" \/>\n\n<section style=\"background-color: #f9f9f9; padding: 25px; border-radius: 10px; border-left: 4px solid #28a745; margin-bottom: 25px;\">\n<p style=\"font-weight: bold; font-style: italic; font-size: 18px; color: #2c3e50; margin: 0;\">Hipertermia Seluruh Badan (WBH) ialah satu strategi onkologi sistemik yang melibatkan pemanasan terkawal suhu teras badan, sering menggunakan teknologi Inframerah-A bertapis air (wIRA). WBH pada dasarnya berfungsi sebagai pemeka kemo\/radio, yang meningkatkan perfusi tumor dan pengoksigenan secara signifikan untuk menggandakan keberkesanan rawatan tradisional. Yang penting, ia berfungsi sebagai imunomodulator sistemik yang berkuasa, menggerakkan Protein Kejutan Haba (HSPs) dan sel-T, yang mewujudkan sinergi penting dengan Imunoterapi (ICI) terkini serta menawarkan kelegaan kesakitan yang dramatik dan pantas serta peningkatan Kualiti Hidup merentasi pelbagai jenis kanser dan patologi kronik seperti Fibromyalgia.<\/p>\n\n<\/section>\n<section style=\"padding: 15px; border: 1px dashed #ccc; border-radius: 6px; background-color: #fff;\">\n<p style=\"font-size: 13px; color: #777; margin: 0; line-height: 1.4;\"><strong>* Penafian Perubatan:<\/strong> Artikel ini bertujuan cho m\u1ee5c \u0111\u00edch maklumat sahaja dan bukan pengganti perundingan perubatan secara individu, diagnosis, atau rawatan yang diberikan oleh doktor berlesen.<\/p>\n<\/section>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. Mendefinisikan Hipertermia Seluruh Badan (WBH) dan Teknologi Terapeutik<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n\n<strong>Hipertermia Seluruh Badan (WBH)<\/strong>, atau &#8220;hipertermia sistemik,&#8221; ditakrifkan sebagai peningkatan terkawal suhu teras badan untuk tujuan terapeutik. Berdasarkan spektrum <strong>kesan demam semulajadi pada suhu yang berbeza<\/strong>, prosedur WBH dibezakan seperti berikut:\n<div style=\"background: #f4f7f9; padding: 20px; border-radius: 8px; margin: 20px 0; border-left: 5px solid #28a745;\">\n<ul style=\"list-style: none; padding-left: 0; margin: 0; font-size: 1.1em;\">\n    <li style=\"margin-bottom: 8px;\"><strong>\u2022 WBH Ringan:<\/strong> &lt; 38,5\u00b0C<\/li>\n    <li style=\"margin-bottom: 8px;\"><strong>\u2022 WBH Sederhana:<\/strong> 38,5\u00b0C \u2013 40,5\u00b0C<\/li>\n    <li><strong>\u2022 WBH Ekstrem:<\/strong> &gt; 40,5\u00b0C<\/li>\n<\/ul>\n<\/div>\nKhususnya, WBH ringan dan sederhana <strong>meningkatkan perfusi<\/strong>, merangsang metabolisme, mengurangkan ketegangan otot, dan <strong>merangsang sistem imun.<\/strong>\n\nPeranti <a style=\"color: #007bff; text-decoration: none;\" title=\"Butiran teknikal peranti von Ardenne IRATHERM\u00ae 1000M WBH wIRA\" href=\"\/?page_id=270\"><strong>von Ardenne IRATHERM\u00ae 1000M WBH wIRA<\/strong><\/a> menggunakan secara eksklusif <strong>sinaran haba Inframerah-A bertapis air (wIRA) yang serasi dengan kulit dan menembusi tisu dalam<\/strong> (tanpa IR-B \/ IR-C) untuk tujuan ini. Reka bentuk sistem terbuka yang tidak menyebabkan klaustrofobia memastikan keintensifan sinaran yang seragam ke atas seluruh bahagian (belakang) pesakit dan menawarkan bekalan haba yang optimum serta khusus untuk pesakit.\n\nSinaran inframerah-A bertapis air sepadan dengan sinaran terma semulajadi matahari, menyediakan asas teknologi untuk aplikasi haba yang seragam dan lembut <span style=\"color: #6a6a6a; font-size: 0.9em;\">[1, 5, 7, 8]<\/span>.\n\nMenggunakan prinsip von Ardenne IRATHERM\u00ae yang telah terbukti selama lebih daripada 30 n\u0103m, <a style=\"color: #007bff; text-decoration: none;\" title=\"Prof. Manfred von Ardenne - Sumbangan\" href=\"\/?p=5\">Prof. Manfred von Ardenne<\/a> telah berjaya menghasilkan semula sinaran haba ini secara fizikal dan teknikal, menjadikannya tersedia untuk kegunaan perubatan yang mampan dalam onkologi dan patologi lain.\n\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Asas Saintifik dan Kesan Sistemik<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n\nWBH telah berkembang menjadi satu strategi yang berasaskan prinsip biofizik dan fisiologi yang mantap. Dalam onkologi, tumpuan diberikan kepada <strong>Hipertermia Sederhana<\/strong> dan <strong>Hipertermia Julat Demam (FR-WBH)<\/strong>, yang diiktiraf sebagai rawatan dengan pelbagai petunjuk terapeutik <span style=\"color: #6a6a6a; font-size: 0.9em;\">[1, 3]<\/span>.\n\nAsas teknologi untuk aplikasi haba yang seragam dan lembut sering disediakan oleh peranti yang menggunakan <strong>sinaran Inframerah-A bertapis air (wIRA)<\/strong>. Kajian biofizik terperinci telah mengesahkan <strong>keupayaan teknologi ini untuk memastikan pemanasan dalaman yang terkawal<\/strong>, dengan mengambil kira sifat optik kulit dan asas fotobiologi bagi dosimetri <span style=\"color: #6a6a6a; font-size: 0.9em;\">[5, 7, 8]<\/span>.\n\nPada peringkat fisiologi, WBH mempunyai kesan sistemik yang asas:\n<div style=\"background: #ffffff; padding: 20px; border: 1px solid #eef2f6; border-radius: 10px; box-shadow: 0 2px 8px rgba(0,0,0,0.05); margin: 25px 0;\">\n<ol style=\"padding-left: 20px; margin: 0;\">\n    <li style=\"margin-bottom: 15px;\"><strong style=\"color: #007bff; font-size: 1.1em;\">Penambahbaikan Reologi Darah:<\/strong>\nPendedahan kepada IR-WBH mempengaruhi secara positif <strong>sifat aliran darah dan hemodinamik<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[2]<\/span>, menyokong mekanisme penting dalam <strong>meningkatkan perfusi tumor<\/strong>\u2014satu prasyarat kritikal untuk kejayaan rawatan sistemik.<\/li>\n    <li><strong style=\"color: #007bff; font-size: 1.1em;\">Pengaktifan Biologi Umum:<\/strong>\nWBH mengaruh tindak balas tekanan terma yang mencetuskan lata proses biologi, termasuk <strong>modulasi sistem hormon<\/strong> dan <strong>pemecutan metabolisme<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[6, 4]<\/span>.<\/li>\n<\/ol>\n<\/div>\nDisebabkan oleh asas-asas ini, WBH berfungsi sebagai <strong>imunomodulator sistemik<\/strong>, mengoptimumkan <strong>mikropersekitaran tumor (TME)<\/strong> dan <strong>menggandakan keberkesanan rawatan onkologi terkini<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[9]<\/span>.\n\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. Mekanisme Utama Tindakan (Molekul, Fisiologi, dan Imunologi)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<p style=\"font-size: 1.1em; border-left: 4px solid #28a745; padding-left: 15px; margin-bottom: 25px;\">Kesan terapeutik WBH adalah kompleks, dimediasi oleh perubahan pada peringkat <strong>selular, imun, dan fisiologi<\/strong>:<\/p>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<h3 style=\"text-align: left; color: #2c3e50; border-bottom: 2px solid #eef2f6; padding-bottom: 10px; margin-top: 30px;\">A. Sinergi dengan Kemoterapi dan Radioterapi (Pemeka Kemo\/Radio)<\/h3>\n<ul style=\"padding-left: 20px; list-style-type: square;\">\n    <li style=\"margin-bottom: 15px; text-align: left;\"><strong>Pengoptimuman Mikropersekitaran Tumor (TME):<\/strong> WBH meningkatkan <strong>perfusi darah tumor<\/strong> dan <strong>pengoksigenan<\/strong>, memulihkan keadaan hipoksia tumor. Ini adalah penting, memandangkan sel tumor yang mendapat oksigen secukupnya adalah jauh lebih terdedah kepada pemusnahan oleh <strong>Kemoterapi<\/strong> (CT) dan <strong>Radioterapi<\/strong> (RT) <span style=\"color: #6a6a6a; font-size: 0.9em;\">[9, 41]<\/span>.<\/li>\n    <li style=\"margin-bottom: 15px; text-align: left;\"><strong>Keberkesanan Kemo\/Radio:<\/strong> Hipertermia bertindak sebagai <strong><strong style=\"color: #d32f2f;\">pemeka<\/strong> kemo &#038; radio<\/strong>, meningkatkan bekalan oksigen tumor (<em>kesan pemeka radio<\/em>) &#038; mempertingkatkan keberkesanan ubat-ubatan seperti Cisplatin, Gemcitabine, dan Carboplatin <span style=\"color: #6a6a6a; font-size: 0.9em;\">[12, 16, 36]<\/span>.<\/li>\n<\/ul>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<h3 style=\"text-align: left; color: #2c3e50; border-bottom: 2px solid #eef2f6; padding-bottom: 10px; margin-top: 30px;\">B. Mengaruh Tindak Balas Imun Anti-Tumor yang Teguh (Imunomodulasi)<\/h3>\n<p style=\"text-align: left;\">WBH ialah pengaktif sistem pertahanan badan yang kuat <span style=\"color: #6a6a6a; font-size: 0.9em;\">[11]<\/span>:<\/p>\n\n<ul style=\"padding-left: 20px; list-style-type: square;\">\n    <li style=\"margin-bottom: 15px; text-align: left;\"><strong>Protein Kejutan Haba (HSPs):<\/strong> Tekanan terma merangsang sintesis dan pembebasan <strong>HSP70<\/strong>. Protein ini bertindak sebagai &#8216;isyarat bahaya&#8217; yang menandakan sel kanser untuk serangan dipertingkatkan oleh <strong>Limfosit T Sitotoksik (CTLs)<\/strong> sistem imun <span style=\"color: #6a6a6a; font-size: 0.9em;\">[9, 10, 29]<\/span>.<\/li>\n    <li style=\"margin-bottom: 15px; text-align: left;\"><strong>Pengaktifan Sel Imun Utama:<\/strong> Julat suhu 39\u201343\u00b0C meningkatkan aktiviti <strong>sel Pembunuh Semulajadi (NK)<\/strong> dan memupuk aktiviti <strong>sel T pembantu dan sitotoksik<\/strong>, <strong>sel dendritik<\/strong>, dan <strong>makrofaj<\/strong>, manakala <span style=\"text-decoration: underline;\">berpotensi menjejaskan sel penindas imun<\/span> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[9, 10, 11, 25, 26]<\/span>.<\/li>\n    <li style=\"margin-bottom: 15px; text-align: left;\"><strong>Peningkatan Limfosit-T:<\/strong> FR-WBH boleh <strong>meningkatkan secara signifikan (cth., 3 kali ganda) populasi limfosit T sitotoksik<\/strong> dalam organ limfoid, seterusnya <strong>mempertingkatkan serangan imun anti-tumor sistemik<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[10]<\/span>.<\/li>\n    <li style=\"margin-bottom: 15px; text-align: left;\"><strong>Vaksin dan APCs:<\/strong> WHT boleh mengawal selia fungsi Sel Pembentang Antigen (APCs) dan meningkatkan keberkesanan vaksin kanser, termasuk yang berasaskan HSP110 dan GRP170 <span style=\"color: #6a6a6a; font-size: 0.9em;\">[37, 28]<\/span>.<\/li>\n<\/ul>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Bukti Klinikal dan Sinergi dalam Terapi Multimodal<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<h3 style=\"text-align: left; color: #2c3e50; border-bottom: 2px solid #eef2f6; padding-bottom: 10px; margin-top: 30px;\">A. Sinergi dengan Imunoterapi (Penghalang Titik Semak &#8211; ICI)<\/h3>\n<p style=\"text-align: left;\">Satu siri kes retrospektif terhadap 131 pesakit kanser tahap lanjutan (Tahap IV) telah menyiasat protokol multimodal termasuk <strong>hipertermia seluruh badan<\/strong> bersama penghalang titik semak (Ipilimumab, Nivolumab) dan IL-2 <span style=\"color: #6a6a6a; font-size: 0.9em;\">[18]<\/span>.<\/p>\n\n<div style=\"background: #f0f7ff; padding: 25px; border-radius: 12px; border-left: 5px solid #007bff; margin: 25px 0;\">\n<p style=\"text-align: left; margin: 0; font-size: 1.05em;\"><strong style=\"color: #0056b3;\">Kesimpulan Utama:<\/strong> Hipertermia Seluruh Badan wIRA ditentukan sebagai <strong>komponen integral v\u00e0 penting<\/strong> yang <strong>memaksimumkan tindak balas imun anti-tumor<\/strong>.<\/p>\n<p style=\"text-align: left; margin-top: 15px; margin-bottom: 0;\"><strong>WBH mengaktifkan dan menggerakkan sel T<\/strong> (dengan mengaruh HSP70 dan membebaskan antigen tumor); penghalang titik semak kemudiannya &#8220;melepaskan brek&#8221; daripada sel T yang telah diaktifkan terlebih dahulu ini, menghasilkan kadar tindak balas klinikal yang memuaskan secara luar biasa bagi penyakit tahap lanjutan <span style=\"color: #6a6a6a; font-size: 0.9em;\">[18]<\/span>.<\/p>\n\n<\/div>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<h3 style=\"text-align: left; color: #2c3e50; border-bottom: 2px solid #eef2f6; padding-bottom: 10px; margin-top: 30px;\">B. Aplikasi Klinikal dalam Pelbagai Jenis Kanser<\/h3>\n<ul style=\"padding-left: 20px; list-style-type: none;\">\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #007bff; padding-left: 15px;\"><strong style=\"color: #007bff;\">Kanser Pankreas:<\/strong> Protokol Fasa I-II menggunakan WBH ringan (FR-WBH) yang digabungkan dengan kemoterapi dan Interferon-alpha menunjukkan <strong>sekurang-kurangnya 50% regresi tumor dalam hampir separuh daripada pesakit yang rintang terhadap terapi<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[4, 22]<\/span>.<\/li>\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #007bff; padding-left: 15px;\"><strong style=\"color: #007bff;\">Kanser Payudara (Berulang):<\/strong> WHT yang digabungkan dengan radiasi semula atau radioterapi telah menunjukkan keberkesanan bagi kanser payudara tahap lanjutan setempat dan ulangan pada dinding dada, disahkan oleh data rawak <span style=\"color: #6a6a6a; font-size: 0.9em;\">[39, 40]<\/span>.<\/li>\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #007bff; padding-left: 15px;\"><strong style=\"color: #007bff;\">Kanser Ovari:<\/strong> WBH digabungkan dengan <strong>carboplatin<\/strong> telah disiasat dalam kajian Fasa II untuk kanser ovari yang berulang <span style=\"color: #6a6a6a; font-size: 0.9em;\">[16, 20]<\/span>.<\/li>\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #007bff; padding-left: 15px;\"><strong style=\"color: #007bff;\">Kanser Kolorektal:<\/strong> WBH wIRA telah digunakan dalam konteks Terapi Multilangkah Kanser Sistemik (sCMT) Von Ardenne yang digabungkan dengan kemoterapi dalam kajian Fasa I\/II <span style=\"color: #6a6a6a; font-size: 0.9em;\">[15]<\/span>.<\/li>\n<\/ul>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. Kelegaan Kesakitan Pantas dan Peningkatan Kualiti Hidup (QoL) yang Signifikan<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<p style=\"font-size: 1.1em; text-align: left;\">Pesakit mungkin mengalami <strong>kelegaan kesakitan yang pantas<\/strong> dan peningkatan umum dalam kesejahteraan, seperti yang diperhatikan dalam kajian Dr. Bull <span style=\"color: #6a6a6a; font-size: 0.9em;\">[12]<\/span> dan terutamanya dalam <strong>kajian klinikal Fasa III<\/strong> baru-baru ini yang dijalankan oleh Sahinbas et al. <span style=\"color: #6a6a6a; font-size: 0.9em;\">[14]<\/span>.<\/p>\n\n<div style=\"background: #fff9e6; padding: 20px; border-radius: 10px; border-left: 5px solid #ffcc00; margin: 25px 0;\">\n<p style=\"margin: 0; color: #856404; font-weight: bold;\"><i class=\"fa fa-info-circle\"><\/i> Wawasan Klinikal:<\/p>\n<p style=\"margin-top: 10px; margin-bottom: 0; font-style: italic;\">Terapi wIRA bukan sahaja menyumbang kepada kawalan tumor tetapi juga kepada pengurangan ketara dalam keperluan ubat analgesik, memulihkan mobiliti dan kecergasan walaupun dalam kalangan pesakit dengan penyakit tahap lanjutan.<\/p>\n\n<\/div>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<h3 style=\"text-align: left; color: #d32f2f; border-bottom: 2px solid #f2f2f2; padding-bottom: 10px;\">Ujian Klinikal Fasa III (2024) untuk Metastasis Tulang<\/h3>\n<p style=\"text-align: left;\">Pada tahun 2024, <a style=\"color: #007bff;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\">Sahinbas dan rakan sekerja menerbitkan kajian fasa III<\/a> untuk kesakitan metastasis tulang terutamanya daripada kanser payudara dan prostat menggunakan peranti hipertermia WBH wIRA Iratherm sebagai tambahan kepada RT <span style=\"color: #6a6a6a; font-size: 0.9em;\">[14]<\/span>.<\/p>\n\n<div style=\"background: #fdfdfd; padding: 20px; border: 1px solid #e0e0e0; border-radius: 8px; margin: 20px 0;\">\n\n<strong>Penemuan Utama:<\/strong> Kumpulan radioterapi (RT) sahaja mengalami kesakitan yang paling sengit. Kumpulan <strong>RT + WBH<\/strong> menunjukkan <strong>kadar CR sebanyak 47.4% berbanding 5.3%<\/strong> bagi RT sahaja dalam tempoh 2 bulan selepas rawatan.\n\n<strong>Masa untuk pelepasan kesakitan lengkap hanyalah 10 hari<\/strong> bagi kumpulan RT + WBH, manakala titik akhir tidak dicapai dalam kumpulan RT sahaja.\n\n<\/div>\n<div style=\"overflow-x: auto; margin-top: 25px;\">\n<table style=\"width: 100%; border-collapse: collapse; text-align: left; border: 1px solid #ddd;\">\n<thead>\n<tr style=\"background-color: #007bff; color: white;\">\n<th style=\"padding: 12px; border: 1px solid #ddd;\">Indikator QoL\/Penambahbaikan Kesakitan<\/th>\n<th style=\"padding: 12px; border: 1px solid #ddd;\">Monoterapi RT<\/th>\n<th style=\"padding: 12px; border: 1px solid #ddd;\">RT + Hipertermia (wIRA)<\/th>\n<th style=\"padding: 12px; border: 1px solid #ddd;\">Impak QoL<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>Kadar Tindak Balas Lengkap (CR)<\/strong> (2 bulan)<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\">5.3 %<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd; background: #eef9ee;\"><strong>47.4 %<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd; color: #28a745;\"><strong>Peningkatan +894%<\/strong> dalam peluang penghapusan kesakitan total<\/td>\n<\/tr>\n<tr style=\"background-color: #f9f9f9;\">\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>Masa untuk kelegaan kesakitan lengkap<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\">tidak dicapai<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>10 hari<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\">manfaat &#8220;signifikan dan pantas&#8221;<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>Tempoh Kelegaan Kesakitan<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\">Median: 28 hari<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\">Median: Melebihi 24 minggu<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\">Tempoh kelegaan <strong>meningkat enam kali ganda<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<p style=\"text-align: left;\">Berbanding dengan <a style=\"color: #007bff;\" title=\"Kajian Fasa III Chi MS et al. 2017\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5\" target=\"_blank\" rel=\"noopener\">kajian Fasa III serupa yang diterbitkan oleh Chi MS et al. (2017)<\/a> dengan hipertermia lokoregional RF, manfaat yang dicapai menggunakan <strong>hipertermia WBH wIRA<\/strong> adalah jauh lebih unggul.<\/p>\n<p style=\"text-align: left; font-style: italic; color: #666; margin-bottom: 10px;\">Keputusan Kajian RF HT + RT (Hipertermia Tempatan):<\/p>\n\n<div style=\"overflow-x: auto; margin-bottom: 30px;\">\n<table style=\"width: 100%; border-collapse: collapse; text-align: left; border: 1px solid #ddd; font-size: 14px;\">\n<thead>\n<tr style=\"background-color: #6c757d; color: white;\">\n<th style=\"padding: 10px; border: 1px solid #ddd;\">Indikator QoL\/Penambahbaikan Kesakitan<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd;\">Monoterapi RT<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd;\">RT + Hipertermia (RF HT)<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd;\">Impak QoL<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Kadar Tindak Balas Lengkap (CR)<\/strong> (3 Bulan)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">7.1 %<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">37.9 %<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Peningkatan 533% dalam peluang pelepasan kesakitan total<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Tempoh Kelegaan Kesakitan<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Median: 55 hari<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Median: Tidak dicapai pada 24 minggu<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Tempoh kelegaan meningkat tiga kali ganda<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div style=\"background: #2c3e50; color: #ffffff; padding: 30px; border-radius: 15px; margin-top: 40px; box-shadow: 0 4px 15px rgba(0,0,0,0.1);\">\n<h4 style=\"color: #007bff; margin-top: 0; text-transform: uppercase; letter-spacing: 1px;\">Ringkasan dan Kesimpulan<\/h4>\n<p style=\"font-size: 1.1em; margin-bottom: 0;\">Bukti saintifik yang terkonsolidasi (<em>daripada kajian asas mengenai teknologi wIRA hingga ujian klinikal Fasa III yang kritikal<\/em>) mengesahkan peranan WBH sebagai <strong>terapi adjuvan berbilang impak<\/strong> dalam onkologi: ia <strong>meningkatkan keberkesanan CT\/RT, mengaktifkan sistem imun sistemik (termasuk sinergi dengan imunoterapi), serta mempertingkatkan kawalan kesakitan dan Kualiti Hidup (QoL)<\/strong> secara dramatik bagi pesakit kanser.<\/p>\n\n<\/div>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Manfaat Fisiologi Sistemik dan Potensi Terapeutik dalam Patologi Lain<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<p style=\"font-size: 1.15em; color: #2c3e50; background: #f8f9fa; padding: 20px; border-radius: 10px; border-right: 4px solid #28a745; text-align: left;\">Haba lembut dan terkawal yang disediakan oleh WBH dengan <strong>sinaran wIRA<\/strong> memulakan tindak balas kawal atur haba yang kompleks, menghasilkan <strong>manfaat sistemik yang luas<\/strong>, serta memperluaskan potensi terapeutik melangkaui bidang onkologi:<\/p>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<h3 style=\"text-align: left; color: #2c3e50; border-bottom: 2px solid #eef2f6; padding-bottom: 10px; margin-top: 30px;\">A. Pengurusan Muskuloskeletal dan Kesakitan<\/h3>\n<p style=\"text-align: left;\">WBH berkesan dalam menguruskan sindrom kesakitan kronik, dengan memanfaatkan kesan fisiologinya terhadap ketegangan otot dan mikrosirkulasi:<\/p>\n\n<ul style=\"padding-left: 20px; list-style-type: none;\">\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #28a745; padding-left: 15px;\"><strong>Dorsalgia (Sakit Belakang Kronik):<\/strong> Kajian menunjukkan bahawa WBH ringan, apabila digabungkan dengan terapi kesakitan multimodal pegun (in-patient), memberikan manfaat signifikan bagi pesakit dengan sakit belakang bawah tidak spesifik yang kronik <span style=\"color: #6a6a6a; font-size: 0.9em;\">[53, 54]<\/span>.<\/li>\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #28a745; padding-left: 15px;\"><strong>Sindrom Fibromyalgia (FMS):<\/strong> WBH adalah rawatan adjun yang didokumentasikan untuk FMS. Ujian terkawal rawak telah menunjukkan keberkesanan wIRA WBH ringan, memaparkan kesan terhadap <strong>keintensifan kesakitan<\/strong> dan <strong>keadaan mental<\/strong> <span style=\"color: #6a6a6a; font-size: 0.9em;\">[17, 56, 57]<\/span>.<\/li>\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #28a745; padding-left: 15px;\"><strong>Spondilitis Ankilosing (AS):<\/strong> WBH telah menunjukkan kesan imunomodulator dalam pesakit AS, meningkatkan perantara anti-radang seperti <strong>Interleukin-10 (IL-10)<\/strong> dan mengawal selia sitokin pro-radang seperti TNF-$\u03b1$ <span style=\"color: #6a6a6a; font-size: 0.9em;\">[58, 59, 52]<\/span>.<\/li>\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #28a745; padding-left: 15px;\"><strong>Fenomena Raynaud dalam Sklerosis Sistemik:<\/strong> Hipertermia melalui inframerah didapati berkesan dalam merawat simptom vasokonstriktif, menunjukkan manfaat vaskular yang jelas <span style=\"color: #6a6a6a; font-size: 0.9em;\">[49]<\/span>.<\/li>\n<\/ul>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<h3 style=\"text-align: left; color: #c0392b; border-bottom: 2px solid #f8d7da; padding-bottom: 10px; margin-top: 30px;\">B. Kesihatan Kardiovaskular dan Peredaran Darah \u2764\ufe0f<\/h3>\n<p style=\"text-align: left;\">Selain meningkatkan perfusi tumor, WBH mempunyai kesan khusus terhadap sistem peredaran darah:<\/p>\n\n<ul style=\"padding-left: 20px; list-style-type: none;\">\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #c0392b; padding-left: 15px;\"><strong>Hipertensi Penting (Essential Hypertension):<\/strong> Rangkaian kajian telah menyiasat penggunaan hipertermia IR-A ringan dalam kalangan pesakit hipertensi arteri (Peringkat I dan II WHO). Penemuan menunjukkan bahawa rawatan bersiri boleh memberi kesan positif kepada <strong>gelombang nadi pusat dan periferi<\/strong>, tekanan darah, dan <strong>kepekatan (viskositi) darah<\/strong>, mengesahkan peranan WBH sebagai pilihan terapi fizikal bukan farmakologi <span style=\"color: #6a6a6a; font-size: 0.9em;\">[44, 47]<\/span>.<\/li>\n<\/ul>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<h3 style=\"text-align: left; color: #673ab7; border-bottom: 2px solid #ede7f6; padding-bottom: 10px; margin-top: 30px;\">C. Kesan Neuro-Endokrin dan Psikologi<\/h3>\n<p style=\"text-align: left;\">WBH melibatkan sistem neuro-endokrin badan, serta mempengaruhi mood v\u00e0 metabolisme:<\/p>\n\n<ul style=\"padding-left: 20px; list-style-type: none;\">\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #673ab7; padding-left: 15px;\"><strong>Gangguan Kemurungan Utama (MDD):<\/strong> Ujian klinikal rawak menunjukkan bahawa satu sesi WBH boleh bertindak sebagai antidepresan bertindak pantas, mengakibatkan pengurangan simptom kemurungan selama beberapa minggu. Kesan ini dikaitkan dengan pengaktifan laluan imun dan keradangan akibat haba yang mempengaruhi otak <span style=\"color: #6a6a6a; font-size: 0.9em;\">[51]<\/span>.<\/li>\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #673ab7; padding-left: 15px;\"><strong>Modulasi Hormon (Endokrinologi):<\/strong> WBH merangsang <strong>paksi Hipotalamus-Pituitari-Adrenal (HPA)<\/strong> v\u00e0 mempengaruhi tahap hormon. Kajian telah mendokumentasikan tindak balas <strong>Hormon Pertumbuhan<\/strong> v\u00e0 <strong>Prolaktin<\/strong> semasa hipertermia seluruh badan, menonjolkan impaknya terhadap pengawalaturan endokrin <span style=\"color: #6a6a6a; font-size: 0.9em;\">[42, 43]<\/span>.<\/li>\n    <li style=\"margin-bottom: 18px; text-align: left; border-left: 3px solid #673ab7; padding-left: 15px;\"><strong>Metabolisme dan Reaksi Sel:<\/strong> WBH memacu kadar metabolisme basal. Pada peringkat selular, haba mempengaruhi kinetik pO2 v\u00e0 dikaitkan dengan sintesis protein pelindung seperti <strong>feritin<\/strong> dalam kulit, bagi menyokong pembaikan tisu <span style=\"color: #6a6a6a; font-size: 0.9em;\">[48, 46]<\/span>.<\/li>\n<\/ul>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Soalan Lazim (FAQ) mengenai Sesi WBH yang Disyorkan dan Suhu Sasaran<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"color: #d32f2f; font-weight: bold; border: 1px solid #d32f2f; padding: 10px; border-radius: 5px; text-align: center; background-color: #fff5f5;\">\n    Rawatan hanya boleh dijalankan selepas rundingan muktamad dengan doktor perubatan.\n<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 850px; margin: 0 auto; line-height: 1.7; color: #333;\">\n<div style=\"margin-bottom: 25px; border-bottom: 1px solid #eee; padding-bottom: 15px;\">\n<h4 style=\"color: #007bff;\">Apakah protokol Hipertermia Seluruh Badan (WBH) yang disyorkan untuk Hipertensi Penting?<\/h4>\nProtokol untuk Hipertensi Penting mengesyorkan <strong>12 sesi<\/strong> pada suhu sasaran <strong>38.3 \u00b0C<\/strong>. Setiap sesi berlangsung kira-kira 45 minit, merangkumi fasa peningkatan selama 30 minit dan fasa rehat selama 15 minit (tiada fasa dataran\/plateau).\n\n<\/div>\n<div style=\"margin-bottom: 25px; border-bottom: 1px solid #eee; padding-bottom: 15px;\">\n<h4 style=\"color: #007bff;\">Apakah parameter WBH yang disyorkan untuk Sakit Belakang Kronik (Dorsalgia)?<\/h4>\nUntuk Dorsalgia, <strong>6 sesi<\/strong> biasanya disyorkan, mensasarkan <strong>38.4 \u00b0C<\/strong>. Jumlah masa sesi adalah kira-kira 90 minit, dengan 45 minit peningkatan, 15 minit fasa dataran (plateau), dan 30 minit rehat.\n\n<\/div>\n<div style=\"margin-bottom: 25px; border-bottom: 1px solid #eee; padding-bottom: 15px;\">\n<h4 style=\"color: #007bff;\">Apakah protokol WBH untuk Fibromyalgia dan Spondilitis Ankilosing?<\/h4>\nKedua-dua Fibromyalgia dan Spondilitis Ankilosing biasanya mengikuti <strong>protokol 6 sesi<\/strong>, mensasarkan <strong>38.5 \u00b0C<\/strong>. Jumlah masa sesi adalah kira-kira 90 minit, termasuk 45 minit peningkatan, 15 minit fasa dataran, dan 30 minit rehat.\n\n<\/div>\n<div style=\"margin-bottom: 25px; border-bottom: 1px solid #eee; padding-bottom: 15px;\">\n<h4 style=\"color: #007bff;\">Apakah protokol yang disyorkan untuk WBH sebagai Rawatan Kanser Tambahan?<\/h4>\nSebagai rawatan kanser tambahan, protokol memerlukan <strong>2 atau lebih sesi<\/strong> mensasarkan suhu teras antara <strong>39.0 \u00b0C dan 40.0 \u00b0C<\/strong>. Jumlah masa sesi adalah yang paling lama, antara <strong>3 hingga 4 jam<\/strong>, yang merangkumi 60-90 minit untuk fasa peningkatan, 60-90 minit untuk fasa dataran, dan 60 minit untuk fasa rehat.\n\n<\/div>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 100%; overflow-x: auto; margin: 20px 0;\">\n<table style=\"width: 100%; border-collapse: collapse; font-family: sans-serif; min-width: 800px; border: 1px solid #e0e0e0;\">\n<thead>\n<tr style=\"background-color: #2c3e50; color: white; text-align: left;\">\n<th style=\"padding: 15px; border: 1px solid #34495e;\">Indikasi<\/th>\n<th style=\"padding: 15px; border: 1px solid #34495e;\">Sesi<\/th>\n<th style=\"padding: 15px; border: 1px solid #34495e;\">Suhu Sasaran<\/th>\n<th style=\"padding: 15px; border: 1px solid #34495e;\">Terapi (Peningkatan + Dataran)<\/th>\n<th style=\"padding: 15px; border: 1px solid #34495e;\">Masa Rehat<\/th>\n<th style=\"padding: 15px; border: 1px solid #34495e;\">Jumlah Masa Sesi<\/th>\n<\/tr>\n<\/thead>\n<tbody style=\"color: #333;\">\n<tr>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Hipertensi Penting<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">12<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38.3 \u00b0C<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 min (30+0)<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">15 min<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 45 min<\/strong><\/td>\n<\/tr>\n<tr style=\"background-color: #f8f9fa;\">\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Dorsalgia<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">6<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38.4 \u00b0C<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">60 min (45+15)<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 min<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 90 min<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Fibromyalgia<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">6<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38.5 \u00b0C<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">60 min (45+15)<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 min<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 90 min<\/strong><\/td>\n<\/tr>\n<tr style=\"background-color: #f8f9fa;\">\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Spondilitis Ankilosing<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">6<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38.5 \u00b0C<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">60 min (45+15)<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 min<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 90 min<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Sklerosis Sistemik<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">15<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38.3 \u00b0C<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 min (30+0)<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">15 min<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 45 min<\/strong><\/td>\n<\/tr>\n<tr style=\"background-color: #f8f9fa;\">\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Gangguan Kemurungan Utama<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">1+<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">38.5 \u00b0C<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">105-170 min<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">30 min<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>~ 2-3 jam<\/strong><\/td>\n<\/tr>\n<tr style=\"background-color: #eef2ff;\">\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\"><strong>Rawatan Kanser Tambahan<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">2+<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; text-align: center;\">39.0-40.0 \u00b0C<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">120-180 min<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0;\">60 min<\/td>\n<td style=\"padding: 12px; border: 1px solid #e0e0e0; color: #d32f2f;\"><strong>~ 3-4 jam<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-style: italic; color: #666; border-top: 1px solid #eee; padding-top: 15px; margin-top: 20px; font-size: 0.95em;\">\n    <strong>NOTA:<\/strong> Artikel ini bukan merupakan senarai lengkap bagi semua kajian dan kesan WBH wIRA.\n<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Rujukan dan Petikan<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"max-width: 1000px; margin: 0 auto; background: #ffffff; padding: 30px; border: 1px solid #e0e0e0; border-radius: 5px;\">\n<h3 style=\"color: #2c3e50; border-bottom: 2px solid #3498db; padding-bottom: 10px; margin-bottom: 25px; font-family: sans-serif;\">References<\/h3>\n<ol style=\"line-height: 1.6; color: #555; font-size: 0.9em; font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;\">\n<li style=\"margin-bottom: 10px;\">Ardenne M. von. 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Comparison of the anti-tumor effects of various whole-body hyperthermia protocols&#8230; <em>Immunol Invest.<\/em> 2005;34(3):245-58.<\/li>\n<li style=\"margin-bottom: 10px;\">Abreu MM, Chocron AF, Smadja DM. From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. <em>Front Immunol.<\/em> 2025 Feb 28;16:1487296.<\/li>\n<li style=\"margin-bottom: 10px;\">Bull JMC. et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-\u03b1. <em>Journal of Hyperthermia.<\/em> 2008; 24(8): 649-662.<\/li>\n<li style=\"margin-bottom: 10px;\">Weigelin B. Visualization of the immune effect of hyperthermia. <em>ICHO 2021<\/em>, Session: Hyperthermia and immunology.<\/li>\n<li style=\"margin-bottom: 10px;\">Faghihi Moghaddam F, Bakhshandeh M, Mofid B, et al. 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A phase-I-study of optimally-timed Gemcitabine + Cisplatin\/Interferon-a combined with WBH. <em>ESHO 2001<\/em>, Verona, Italy.<\/li>\n<li style=\"margin-bottom: 10px;\">Capitano M., Mace T., Nemeth M., et al. A novel strategy for improving neutrophil recovery following total body irradiation. <em>Soc for Thermal Med<\/em>, 2010.<\/li>\n<li style=\"margin-bottom: 10px;\">Dayanc B.E., Ostberg J.R., Repasky E.A. Enhancement of NK Cell Cytotoxic Activity by Mild Thermal Stress. <em>Soc of Thermal Med<\/em>, 2006.<\/li>\n<li style=\"margin-bottom: 10px;\">Hajto T., Hostanska K. Effect of in vivo hyperthermia on human natural killer cells. <em>Clin Trials J<\/em> 1985; 6:514-20.<\/li>\n<li style=\"margin-bottom: 10px;\">Hattori T., et al. Antitumor effect of WBH with \u03b1-galactosylceramide in a subcutaneous tumor model of colon cancer. <em>Int J Hyperthermia<\/em> 2007; 7:591-98.<\/li>\n<li style=\"margin-bottom: 10px;\">Kisailus A., et al. Thermal Regulation of Antigen Presenting Cells: Use of Hyperthermia as an Adjuvant for Cancer Vaccines. <em>Soc of Thermal Med<\/em>, 2006.<\/li>\n<li style=\"margin-bottom: 10px;\">Multhoff G. Activation of natural killer (NK) cells by heat shock protein 70&#8230; <em>Int J Hyperthermia<\/em> 2009; 3:176-79.<\/li>\n<li style=\"margin-bottom: 10px;\">Peer A.J., et al. Diverse immune mechanisms may contribute to the survival benefit seen in cancer patients receiving hyperthermia. <em>Immunol Res<\/em> 2010; 1-3:137-154.<\/li>\n<li style=\"margin-bottom: 10px;\">Rowe R.W., et al. Fever-range WBH combined with oxaliplatin: A curative regimen in a pre-clinical breast cancer model. <em>Int J Hyperthermia<\/em> 2010; 6:565-76.<\/li>\n<li style=\"margin-bottom: 10px;\">Schencking M., Frese T., Sandholzer H. Behandlung einer Radikulopathie bei oss\u00e4rer Metastasierung durch Infrarot-A-Ganzk\u00f6rperhyperthermie. <em>Forsch Komplementmed<\/em> 2008; 15:273-76.<\/li>\n<li style=\"margin-bottom: 10px;\">Scott G.L., Bull J.M.C., Kochn M. Management of Conscious Sedation&#8230; <em>9th Int Congress on Hyperthermic Oncology<\/em>, 2004.<\/li>\n<li style=\"margin-bottom: 10px;\">Shecterle L.M., Cyr J.A.S. Hyperthermia Aids Patients with Advanced Lung Cancer. <em>Soc of Thermal Med<\/em>, 2006.<\/li>\n<li style=\"margin-bottom: 10px;\">Skitzki J.J., Repasky E.A., Evans S.S. Hyperthermia as an immunotherapy strategy for cancer. <em>Current Opinion in Investigational Drugs<\/em> 2009; 6: 550-58.<\/li>\n<li style=\"margin-bottom: 10px;\">Toyota N., et al. Long-duration, mild whole body hyperthermia with cisplatin: tumour response and kinetics of apoptosis and necrosis&#8230; <em>Int. J. Hyperthermia<\/em> 1997; 5:497-506.<\/li>\n<li style=\"margin-bottom: 10px;\">Wang X.Y., et al. Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines&#8230; <em>J of Immunology<\/em> 2001; 165:490-97.<\/li>\n<li style=\"margin-bottom: 10px;\">VanderZee J., et al. Reirradiation combined with hyperthermia in breast cancer recurrences&#8230; <em>Int J Hyperthermia<\/em> 2010; 7:638-48.<\/li>\n<li style=\"margin-bottom: 10px;\">Zagar T.M., et al. Hyperthermia for locally advanced breast cancer. <em>Int J Hyperthermia<\/em> 2010; 7:618-24.<\/li>\n<li style=\"margin-bottom: 10px;\">Zagar T.M., et al. Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence&#8230; <em>Int J Hyperthermia<\/em> 2010; 7: 612\u201317.<\/li>\n<li style=\"margin-bottom: 10px;\">Sen A., Capitano M., Dommer M., et al. Thermoregulatory responses to mild systemic thermal stress increase tumor perfusion&#8230; <em>Cancer Res.<\/em> 2011; 71(11):3872-3880.<\/li>\n<li style=\"margin-bottom: 10px;\">Koska J., Rovensky J., Zimanova T., Vigas M. Growth hormone and prolactin responses during partial and whole body warm-water immersions. <em>Acta Physiol Scand.<\/em> 2003.<\/li>\n<li style=\"margin-bottom: 10px;\">Vigas M., Rovensky J., Zimanova T., Koska J. Responses of growth hormone and prolactin to local and whole-body application of Piestany mud. <em>Acta Rheumatol<\/em> 2002:31-38.<\/li>\n<li style=\"margin-bottom: 10px;\">Meffert B., Hochmuth O., Steiner M. Effects of multiple mild infrared-induced hyperthermia on central and peripheral pulse waves. <em>North Sea Conference<\/em> 1990.<\/li>\n<li style=\"margin-bottom: 10px;\">Meffert H., Scherf HP., Meffert B. Milde Infrarot-A-Hyperthermie. Auswirkungen von Serienbestrahlungen&#8230; <em>Akt Dermatol<\/em> 1993; 19:142-48.<\/li>\n<li style=\"margin-bottom: 10px;\">Applegate L.A., et al. Induction of the putative protein ferritin by infrared radiation: Implications in skin repair. <em>Int J of Molecular Med<\/em> 2000; 5:247-51.<\/li>\n<li style=\"margin-bottom: 10px;\">Scherf H.P., et al. Wirkung einer einmaligen milden Infrarot-A-Hyperthermie auf K\u00f6rpertemperatur, Herzfrequenz, Blutdruck und Blutviskosit\u00e4t&#8230; <em>Dermatol Monatsschr<\/em> 1989.<\/li>\n<li style=\"margin-bottom: 10px;\">Streffer C. Metabolic changes during and after hyperthermia. <em>Int J Hyperthermia<\/em> 1985; 4:305-319.<\/li>\n<li style=\"margin-bottom: 10px;\">F\u00f6rster J., et al. Infrared-Mediated Hyperthermia is Effective in the Treatment of Scleroderma-Associated Raynaud\u2019s Phenomenon. <em>J Invest Dermatol<\/em> 2005.<\/li>\n<li style=\"margin-bottom: 10px;\">Koska J., Rovensky J., Zimanova T., et al. Sympathoadrenal regulation of circulatory responses to WBH&#8230; <em>Acta Rheumatol<\/em> 2002:23-30.<\/li>\n<li style=\"margin-bottom: 10px;\">Janssen C.W., et al. Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder \u2013 A Randomized Clinical Trial. <em>JAMA Psychiatry<\/em> 2016.<\/li>\n<li style=\"margin-bottom: 10px;\">Tarner I.H., et al. The effect of mild WBH on systemic levels of TNF-alpha, IL-1 beta and IL-6 in patients with ankylosing spondylitis. <em>Clin Rheumatol<\/em> 2009.<\/li>\n<li style=\"margin-bottom: 10px;\">Ettrich U., et al. Milde Ganzk\u00f6rperhyperthermie in Kombination mit station\u00e4rer multimodal orientierter Schmerztherapie&#8230; <em>Orthop\u00e4de<\/em> 2014; 2:165-74.<\/li>\n<li style=\"margin-bottom: 10px;\">Weller E., Ullrich D. Infrarot-A-Hyperthermie-Anwendung bei Patienten cu Analgetica-Abusus wegen chronischer R\u00fcckenschmerzen. <em>95. Kongre\u00df Phys Med<\/em> 1990.<\/li>\n<li style=\"margin-bottom: 10px;\">Morf S., Vesti B.A., Forster A., et al. Microcirculation abnormalities in patients with fibromyalgia \u2013 measured by capillary and laser fluxmetry. <em>Arthritis Res Ther<\/em> 2005.<\/li>\n<li style=\"margin-bottom: 10px;\">Walz J., et al. Ganzk\u00f6rperhyperthermie in der Schmerztherapie \u2013 eine kontrollierte Studie an Patienten mit Fibromyalgiesyndrom. <em>Schmerz<\/em> 2013; 27:38-45.<\/li>\n<li style=\"margin-bottom: 10px;\">Romeyke T., Stummer H. Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic WBH&#8230; <em>J Musculoskel Pain<\/em> 2014; 4:341-55.<\/li>\n<li style=\"margin-bottom: 10px;\">Zauner D., et al. WBH treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis. <em>Int J Hyperthermia<\/em> 2014.<\/li>\n<li style=\"margin-bottom: 10px;\">Lange U., et al. Wirkung iterativer Ganzk\u00f6rperhyperthermie cu wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis&#8230; <em>Akt Rheumatol<\/em> 2017.<\/li><\/ol><div style=\"margin-top: 30px; padding: 15px; background-color: #f8f9fa; border-left: 4px solid #3498db; font-style: italic;\"><p style=\"margin: 0; font-size: 0.9em;\">        <strong>EN:<\/strong> The complete database of over 60 clinical studies on wIRA technology is available upon request.<\/p>\n<\/div>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>\u00a0<\/p><\/section><footer>\u00a9 <time>2025<\/time> Romanian Society Oncologic Hyperthermia All rights reserved. Source: Analysis based on scientific literature.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Hipertermia Seluruh Badan (WBH) dalam Onkologi &amp; Patologi Lain: Sinergi Terkonsolidasi, Imunomodulasi, dan Bukti Klinikal Diterbitkan: 13-10-2025 | Semakan Terakhir: 13-10-2025 Oleh: Dr. Veronica Iatan, Cristian Gologan, M.Sc. Hipertermia Seluruh Badan (WBH) ialah satu strategi onkologi sistemik yang melibatkan pemanasan terkawal suhu teras badan, sering menggunakan teknologi Inframerah-A bertapis air (wIRA). WBH pada dasarnya berfungsi<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/ms\/ujian-klinikal-hipertermia-onkologi\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-2025","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/ms\/wp-json\/wp\/v2\/pages\/2025","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/ms\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/ms\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/ms\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/ms\/wp-json\/wp\/v2\/comments?post=2025"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/ms\/wp-json\/wp\/v2\/pages\/2025\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/ms\/wp-json\/wp\/v2\/media?parent=2025"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}