{"id":1906,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2025-12-22T08:56:48","modified_gmt":"2025-12-22T08:56:48","slug":"ensaios-clinicos-hipertermia-oncologia","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/pt-br\/ensaios-clinicos-hipertermia-oncologia\/","title":{"rendered":"Ensaios cl\u00ednicos"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1906\" class=\"elementor elementor-1906 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Hipertermia de Corpo Inteiro (HCI) em Oncologia e Outras Patologias: Sinergia Consolidada, Imunomodula\u00e7\u00e3o e Evid\u00eancia Cl\u00ednica<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header>Published: <time datetime=\"2025-10-13\">2025-10-13<\/time> | Last Reviewed: <time datetime=\"2025-10-13\">2025-10-13<\/time><\/header><p>By <a href=\"\/?p=139\">Veronica Iatan, MD<\/a>, <a href=\"\/?p=137\">Cristian Gologan, M.Sc.<\/a><\/p><section><p style=\"font-weight: bold; font-style: italic;\">A Hipertermia de Corpo Inteiro (HCI) \u00e9 uma estrat\u00e9gia oncol\u00f3gica sist\u00eamica que envolve o aquecimento controlado da temperatura central do corpo, frequentemente utilizando a tecnologia de Infravermelho-A Filtrado por \u00c1gua (wIRA). A HCI \u00e9 fundamentalmente um sensibilizador de quimioterapia\/radioterapia, melhorando significativamente a perfus\u00e3o e a oxigena\u00e7\u00e3o do tumor para amplificar a efic\u00e1cia dos tratamentos tradicionais. Crucialmente, ela funciona como um poderoso imunomodulador sist\u00eamico, mobilizando Prote\u00ednas de Choque T\u00e9rmico (HSPs) e c\u00e9lulas T, o que cria uma sinergia essencial com a Imunoterapia (ICI) de ponta e oferece al\u00edvio r\u00e1pido e dram\u00e1tico da dor e melhoria da Qualidade de Vida em v\u00e1rios tipos de c\u00e2nceres e patologias cr\u00f4nicas como a Fibromialgia.<\/p><\/section><section>* Isen\u00e7\u00e3o de Responsabilidade M\u00e9dica: Este artigo destina-se apenas a fins informativos e n\u00e3o substitui a consulta m\u00e9dica individualizada, diagn\u00f3stico ou tratamento fornecido por um m\u00e9dico licenciado.*<\/section><section><h2>\u00a0<\/h2><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\n1. Defini\u00e7\u00e3o de Hipertermia de Corpo Inteiro (HCI) e Tecnologia Terap\u00eautica<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\"><strong>Hipertermia de Corpo Inteiro (HCI)<\/strong>, ou \u201chipertermia sist\u00eamica\u201d, \u00e9 definida como o aumento controlado da temperatura central do corpo para fins terap\u00eauticos. Com base no espectro dos <strong>efeitos da febre natural em diferentes temperaturas,<\/strong> os procedimentos de HCI s\u00e3o diferenciados da seguinte forma:<\/p><ul style=\"text-align: left;\"><li><strong>HCI Suave:<\/strong> &lt; 38.5<strong>\u00b0<\/strong>C<\/li><li><strong>HCI Moderada:<\/strong> 38.5<strong>\u00b0<\/strong>C- 40.5 <strong>\u00b0<\/strong>C<\/li><li><strong>HCI Extrema:<\/strong> &gt; 40.5<strong>\u00b0<\/strong>C<\/li><\/ul><p style=\"text-align: left;\">A HCI suave e moderada, em particular, <strong>aumenta a perfus\u00e3o,<\/strong> estimula o metabolismo, reduz o t\u00f4nus muscular e <strong>estimula o sistema imunol\u00f3gico.<\/strong><\/p><p style=\"text-align: left;\">O <a title=\"Detalhes t\u00e9cnicos do dispositivo von Ardenne IRATHERM\u00ae 1000M WBH wIRA\" href=\"https:\/\/ardenneiratherm.com\/pt-br\/dispositivo-de-hipertermia-ardenne-iratherm\/\"><strong>dispositivo von Ardenne IRATHERM<\/strong>\u00ae <strong>1000M WBH wIRA<\/strong> <\/a>usa exclusivamente <strong>radia\u00e7\u00e3o de calor de Infravermelho-A (wIRA) filtrada por \u00e1gua, de penetra\u00e7\u00e3o profunda e compat\u00edvel com a pele<\/strong> (sem IR-B \/ IR-C) para este fim. Seu design de sistema aberto e n\u00e3o claustrof\u00f3bico garante uma intensidade de irradia\u00e7\u00e3o uniforme sobre todo o n\u00edvel do paciente (costas) e oferece ao usu\u00e1rio um fornecimento de calor ideal e espec\u00edfico para o paciente em termos de localiza\u00e7\u00e3o e intensidade.<\/p><p style=\"text-align: left;\">A radia\u00e7\u00e3o infravermelha-A filtrada por \u00e1gua corresponde \u00e0 radia\u00e7\u00e3o t\u00e9rmica natural do sol, fornecendo a base tecnol\u00f3gica para a aplica\u00e7\u00e3o uniforme e suave de calor [1, 5, 7, 8].<\/p><p style=\"text-align: left;\">Using the von Ardenne IRATHERM<sup>\u00ae<\/sup> 1000 principle, which has been developed and proven for more than 30 years, <a title=\"Prof. Manfred von Ardenne - Contribu\u021bii\" href=\"\/?p=5\">Prof. Manfred von Ardenne<\/a> has succeeded in reproducing this thermal radiation physically and technically and making it available industrially for sustainable medical use by means of whole-body hyperthermia<\/p><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Fundamentos Cient\u00edficos e Efeitos Sist\u00eamicos<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">A HCI evoluiu para uma estrat\u00e9gia baseada em s\u00f3lidos princ\u00edpios biof\u00edsicos e fisiol\u00f3gicos. Em oncologia, o foco est\u00e1 na <strong>Hipertermia Moderada<\/strong> e na <strong>Hipertermia na Faixa da Febre (HCI-FF)<\/strong>, reconhecidas como tratamentos com m\u00faltiplas indica\u00e7\u00f5es terap\u00eauticas [1, 3].<\/p><p style=\"text-align: left;\">A base tecnol\u00f3gica para a aplica\u00e7\u00e3o uniforme e suave de calor \u00e9 frequentemente fornecida por dispositivos que utilizam <strong>radia\u00e7\u00e3o de Infravermelho-A filtrada por \u00e1gua (wIRA)<\/strong>. Estudos biof\u00edsicos detalhados validaram a <strong>capacidade desta tecnologia de garantir um aquecimento profundo e controlado,<\/strong> considerando as propriedades \u00f3pticas da pele e a base fotobiol\u00f3gica para a dosimetria [5,7,8].<\/p><p style=\"text-align: left;\">Estudos biof\u00edsicos detalhados validaram a capacidade da <strong>tecnologia wIRA<\/strong> de garantir um <strong>aquecimento profundo e controlado<\/strong> [5, 7, 8]. No n\u00edvel fisiol\u00f3gico, a HCI tem efeitos sist\u00eamicos fundamentais:<\/p><ol style=\"text-align: left;\"><li><strong>Reologia Sangu\u00ednea Melhorada:<\/strong> A exposi\u00e7\u00e3o ao IR-HCI influencia favoravelmente as <strong>propriedades do fluxo sangu\u00edneo e a hemodin\u00e2mica<\/strong> [2], apoiando o mecanismo essencial de <strong>melhoria da perfus\u00e3o tumoral<\/strong> \u2014 uma pr\u00e9-condi\u00e7\u00e3o cr\u00edtica para o sucesso dos tratamentos sist\u00eamicos.<\/li><li><strong>Ativa\u00e7\u00e3o Biol\u00f3gica Geral:<\/strong> A HCI induz uma resposta ao estresse t\u00e9rmico que desencadeia uma cascata de processos biol\u00f3gicos, incluindo a <strong>modula\u00e7\u00e3o do sistema hormonal<\/strong> e a <strong>acelera\u00e7\u00e3o do metabolismo<\/strong> [6, 4].<\/li><\/ol><p style=\"text-align: left;\">Devido a estes fundamentos, a HCI funciona como um <strong>imunomodulador sist\u00eamico<\/strong>, otimizando o <strong>microambiente tumoral (TME)<\/strong> e <strong>amplificando a efic\u00e1cia dos tratamentos oncol\u00f3gicos de ponta<\/strong> [9].<\/p><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. Principais Mecanismos de A\u00e7\u00e3o (Moleculares, Fisiol\u00f3gicos e Imunol\u00f3gicos)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">Os efeitos terap\u00eauticos da HCI s\u00e3o complexos, mediados por mudan\u00e7as nos n\u00edveis celular, imunol\u00f3gico e fisiol\u00f3gico:<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. Sinergia com Quimioterapia e Radioterapia (Sensibilizador de Quimio\/R\u00e1dio)<\/h3><ul><li style=\"text-align: left;\"><strong>Otimiza\u00e7\u00e3o do Microambiente Tumoral (TME):<\/strong> A HCI melhora a <strong>perfus\u00e3o sangu\u00ednea<\/strong> e a <strong>oxigena\u00e7\u00e3o do tumor<\/strong>, revertendo a hip\u00f3xia tumoral. Isso \u00e9 essencial, pois as c\u00e9lulas tumorais bem oxigenadas s\u00e3o significativamente mais suscet\u00edveis \u00e0 destrui\u00e7\u00e3o pela <strong>Quimioterapia<\/strong> (QT) e <strong>Radioterapia<\/strong> (RT) [9, 41].<\/li><li style=\"text-align: left;\"><strong>Efic\u00e1cia de Quimio\/R\u00e1dio:<\/strong> A hipertermia atua como um <strong>sensibilizador de quimio e r\u00e1dio<\/strong>, melhorando o fornecimento de oxig\u00eanio ao tumor (<em>efeito de r\u00e1dio-sensibiliza\u00e7\u00e3o<\/em>) &amp; <strong>aumentando<\/strong> a efic\u00e1cia de medicamentos como Cisplatina, Gemcitabina e Carboplatina [12, 16, 36].<\/li><\/ul><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. Indu\u00e7\u00e3o de uma Resposta Imunol\u00f3gica Antitumoral Robusta (Imunomodula\u00e7\u00e3o)<\/h3><p style=\"text-align: left;\">A HCI \u00e9 um forte ativador do sistema de defesa do corpo [11]:<\/p><ul><li style=\"text-align: left;\"><strong>Prote\u00ednas de Choque T\u00e9rmico (HSPs):<\/strong> O estresse t\u00e9rmico estimula a s\u00edntese e libera\u00e7\u00e3o de <strong>HSP70<\/strong>. Essas prote\u00ednas atuam como &#8216;sinais de perigo&#8217; que marcam as c\u00e9lulas cancerosas para um ataque aprimorado pelos <strong>Linf\u00f3citos T Citot\u00f3xicos (CTLs)<\/strong> do sistema imunol\u00f3gico [9, 10, 29].<\/li><li style=\"text-align: left;\"><strong>Ativa\u00e7\u00e3o de C\u00e9lulas Imunes Chave:<\/strong> A faixa de temperatura de 39-43<strong>\u00b0<\/strong>C aumenta a atividade das <strong>C\u00e9lulas Natural Killer (NK)<\/strong> e estimula a atividade das <strong>c\u00e9lulas T auxiliares e citot\u00f3xicas<\/strong>, <strong>c\u00e9lulas dendr\u00edticas<\/strong> e <strong>macr\u00f3fagos<\/strong>, enquanto potencialmente compromete as c\u00e9lulas imunossupressoras [9, 10, 11, 25, 26].<\/li><li style=\"text-align: left;\"><strong>Aumento de Linf\u00f3citos T:<\/strong> A HCI-FF pode <strong>aumentar significativamente (por exemplo, 3 vezes) a popula\u00e7\u00e3o de linf\u00f3citos T citot\u00f3xicos<\/strong> em \u00f3rg\u00e3os linfoides, <strong>intensificando<\/strong> assim o <strong>ataque imunol\u00f3gico antitumoral sist\u00eamico<\/strong> [10].<\/li><li style=\"text-align: left;\"><strong>Vacinas e APCs:<\/strong> A HCI pode regular a fun\u00e7\u00e3o das C\u00e9lulas Apresentadoras de Ant\u00edgenos (APCs) e aumentar a efic\u00e1cia das vacinas contra o c\u00e2ncer, incluindo aquelas baseadas em HSP110 e GRP170 [37, 28].<\/li><\/ul><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Evid\u00eancia Cl\u00ednica e Sinergia na Terapia Multimodal<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. Sinergia com Imunoterapia (Inibidores de Checkpoint &#8211; ICI)<\/h3><p style=\"text-align: left;\">Uma s\u00e9rie de casos retrospectiva de 131 pacientes com c\u00e2ncer avan\u00e7ado (Est\u00e1gio IV) investigou um protocolo multimodal incluindo <strong>hipertermia de corpo inteiro<\/strong> juntamente com inibidores de checkpoint (Ipilimumab, Nivolumab) e IL-2 [18].<\/p><p style=\"text-align: left;\"><strong>Conclus\u00e3o Chave:<\/strong> A HCI wIRA foi determinada como um <strong>componente integrante e essencial<\/strong> que <strong>maximizou a resposta imunol\u00f3gica antitumoral.<\/strong> <strong>A HCI ativa e mobiliza as c\u00e9lulas T (induzindo HSP70 e liberando ant\u00edgenos tumorais);<\/strong> os inibidores de checkpoint ent\u00e3o &#8220;removem o freio&#8221; dessas c\u00e9lulas T pr\u00e9-ativadas, resultando em taxas de resposta cl\u00ednica favor\u00e1veis incomumente altas para doen\u00e7as avan\u00e7adas [18].<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. Aplica\u00e7\u00f5es Cl\u00ednicas em V\u00e1rios C\u00e2nceres<\/h3><ul><li style=\"text-align: left;\"><strong>C\u00e2ncer de P\u00e2ncreas:<\/strong> Protocolos de Fase I-II usando HCI suave (HCI-FF) combinada com quimioterapia e Interferon-alfa mostraram <strong>pelo menos 50% de regress\u00e3o tumoral em quase metade dos pacientes resistentes \u00e0 terapia<\/strong> [4, 22].<\/li><li style=\"text-align: left;\"><strong>C\u00e2ncer de Mama (Recorr\u00eancia):<\/strong> A HCI combinada com re-irradia\u00e7\u00e3o ou radioterapia tem demonstrado efic\u00e1cia para c\u00e2ncer de mama localmente avan\u00e7ado e recorr\u00eancia da parede tor\u00e1cica, confirmada por dados randomizados [39, 40].<\/li><li style=\"text-align: left;\"><strong>C\u00e2ncer de Ov\u00e1rio:<\/strong> A HCI combinada com <strong>carboplatina<\/strong> foi investigada em um estudo de Fase II para c\u00e2ncer de ov\u00e1rio recorrente [16, 20].<\/li><li style=\"text-align: left;\"><strong>C\u00e2ncer Colorretal:<\/strong> A HCI wIRA foi utilizada no contexto da Terapia Multietapas Sist\u00eamica do C\u00e2ncer (sCMT) de Von Ardenne combinada com quimioterapia em um estudo de Fase I\/II [15].<\/li><\/ul><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. Al\u00edvio R\u00e1pido da Dor e Melhoria Significativa da Qualidade de Vida (QoL)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">Os pacientes podem experimentar al\u00edvio r\u00e1pido da dor e uma melhoria geral no bem-estar, conforme observado no estudo do Dr. Bull [12] e especialmente no estudo cl\u00ednico de Fase III mais recente realizado por Sahinbas et al. [14].<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><section>Em <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\">2024, Sahinbas e colegas publicaram um estudo de fase III<\/a> para dor de met\u00e1stases \u00f3sseas, principalmente de c\u00e2ncer de mama e pr\u00f3stata, usando dispositivos de hipertermia HCI wIRA Iratherm al\u00e9m da RT [14]. Com base neste estudo, o grupo apenas com radioterapia (RT) apresentou a dor mais intensa. O estudo foi conclu\u00eddo ap\u00f3s a inclus\u00e3o de um total de 61 pacientes, 5 anos ap\u00f3s a primeira inscri\u00e7\u00e3o (abril de 2016 \u2013 fevereiro de 2021). Finalmente, a taxa de RC no grupo RT + HCI mostrou a diferen\u00e7a mais significativa com a RT isolada, <strong>47,4% vs. 5,3%, respectivamente, dentro de 2 meses p\u00f3s-tratamento<\/strong> (valor P &lt; 0,05). O <strong>tempo para al\u00edvio completo da dor foi de 10 dias para RT + HCI, enquanto o desfecho n\u00e3o foi alcan\u00e7ado no grupo apenas com RT.<\/strong> A progress\u00e3o da dor ou estabilidade da doen\u00e7a foi observada em metade dos pacientes no grupo RT dentro de 4 semanas ap\u00f3s o tratamento. No entanto,<strong> esta pontua\u00e7\u00e3o foi pr\u00f3xima de zero em pacientes com RT + HCI dentro de dois meses p\u00f3s-tratamento<\/strong>.<strong>Conclus\u00f5es: <\/strong> A HCI mais RT demonstrou aumentos significativos no al\u00edvio da dor e menor tempo de resposta em compara\u00e7\u00e3o com a RT isolada em pacientes com les\u00f5es \u00f3sseas metast\u00e1ticas.<\/section><table border=\"1\"><thead><tr><th>QoL Indicator\/Melhoria da Dor<\/th><th>RT em monoterapia<\/th><th>RT + Hipertermia (HCI wIRA)<\/th><th>Impacto na QoL<\/th><\/tr><\/thead><tbody><tr><td><strong>Taxa de Resposta Completa (RC) em 2 meses<\/strong> (pontua\u00e7\u00e3o de dor zero)<\/td><td>5,3 %<\/td><td>47,4 %<\/td><td>* <strong>Aumento de 894%<\/strong> * nas chances de elimina\u00e7\u00e3o total da dor.<\/td><\/tr><tr><td><strong>Time to complete pain relief<\/strong> (Tempo para al\u00edvio completo da dor)<\/td><td>was not touched<\/td><td>10 days<\/td><td><strong>\u201d benef\u00edcio significativo e r\u00e1pido\u201d<\/strong><\/td><\/tr><tr><td style=\"text-align: left;\"><strong>Duration of Pain Relief <\/strong> (Dura\u00e7\u00e3o do Al\u00edvio da Dor)<\/td><td style=\"text-align: left;\">Median: 28 days\/4 weeks in half of patients<\/td><td style=\"text-align: left;\">Median: Not included at 24 weeks<\/td><td style=\"text-align: left;\">A dura\u00e7\u00e3o do al\u00edvio * <strong>aumenta seis vezes<\/strong> *, reduzindo a depend\u00eancia de analg\u00e9sicos.<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">\u00a0<\/p><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">Em compara\u00e7\u00e3o com o <a title=\"Estudo Fase III Chi MS et al. 2017\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5\" target=\"_blank\" rel=\"noopener\">estudo de Fase III semelhante publicado por Chi MS et al<\/a>. (2017) com hipertermia locorregional de RF, os benef\u00edcios (em rela\u00e7\u00e3o \u00e0 QoL e redu\u00e7\u00e3o da dor) alcan\u00e7ados usando a hipertermia HCI wIRA foram far superior \u2013 resultados do estudo RF HT + RT:<\/p><table border=\"1\"><thead><tr><th>QoL Indicator\/Melhoria da Dor<\/th><th>RT em monoterapia<\/th><th>RT + Hipertermia (HT)<\/th><th>Impacto na QoL<\/th><\/tr><\/thead><tbody><tr><td><strong>Taxa de Resposta Completa (RC) em 3 Meses<\/strong> (pontua\u00e7\u00e3o de dor zero)<\/td><td>7,1 %<\/td><td>37,9 %<\/td><td>533% increase (aumento) in the chances of total pain relief.<\/td><\/tr><tr><td><strong>Duration of Pain Relief<\/strong> (Dura\u00e7\u00e3o do Al\u00edvio da Dor)<\/td><td>Median: 55 days\/7.9 weeks<\/td><td>Median: Not included at 24 weeks<\/td><td>The duration of relief triples, reducing dependence on painkillers.<\/td><\/tr><\/tbody><\/table><p style=\"text-align: left;\">Em resumo, a evid\u00eancia cient\u00edfica consolidada (from foundational studies on wIRA technology to crucial Phase III clinical trials) confirma o papel da HCI como uma terapia adjuvante de m\u00faltiplos impactos em oncologia: <strong>ela aumenta a efic\u00e1cia da QT\/RT, ativa o sistema imunol\u00f3gico sist\u00eamico (incluindo sinergia com imunoterapia) e melhora dramaticamente o controle da dor e a QoL<\/strong> para pacientes com c\u00e2ncer.<\/p><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Benef\u00edcios Fisiol\u00f3gicos Sist\u00eamicos e Potencial Terap\u00eautico em Outras Patologias<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>O calor suave e controlado fornecido pela HCI com radia\u00e7\u00e3o wIRA inicia respostas termorregulat\u00f3rias complexas que produzem amplos benef\u00edcios sist\u00eamicos, estendendo o potencial terap\u00eautico al\u00e9m da oncologia:<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. Controle Musculoesquel\u00e9tico e da Dor<\/h3><p style=\"text-align: left;\">A HCI \u00e9 effective in managing chronic pain syndromes, leveraging its physiological effects on muscle tone and microcirculation:<\/p><ul><li style=\"text-align: left;\"><strong>Dorsalgia (Dor Lombar Cr\u00f4nica):<\/strong> Studies show that mild WBH, when combined with stationary multimodal pain therapy, provides significant benefit for patients with chronic non-specific low back pain (dorsalgia) [53, 54].<\/li><li style=\"text-align: left;\"><strong>S\u00edndrome da Fibromialgia (SFM):<\/strong> A HCI \u00e9 um tratamento adjuvante documentado para SFM. Ensaios controlados randomizados demonstraram a efic\u00e1cia da HCI wIRA suave em um ambiente de reabilita\u00e7\u00e3o multimodal padr\u00e3o, mostrando efeitos na <strong>intensidade da dor<\/strong> e no <strong>estado mental<\/strong> [17, 56, 57]. This benefit is partly linked to improved microcirculation, a known issue in FMS patients [55].<\/li><li style=\"text-align: left;\"><strong>Espondilite Anquilosante (EA):<\/strong> A HCI demonstrou efeitos imunomoduladores em pacientes com EA, com estudos relatando a capacidade da HCI de aumentar mediadores anti-inflamat\u00f3rios como a <strong>Interleucina-10<\/strong> (IL-10) e modular citocinas pr\u00f3-inflamat\u00f3rias como o TNF-alfa, sugerindo um papel ben\u00e9fico no gerenciamento da inflama\u00e7\u00e3o cr\u00f4nica associada \u00e0 condi\u00e7\u00e3o [58, 59, 52].<\/li><li style=\"text-align: left;\"><strong>Fen\u00f4meno de Raynaud na Esclerose Sist\u00eamica:<\/strong> A hipertermia mediada por infravermelho demonstrou ser eficaz no tratamento dos sintomas vasoconstritores associados ao Scleroderma-Associated Raynaud\u2019s Phenomenon, demonstrating vascular benefits [49].<\/li><\/ul><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. Sa\u00fade Cardiovascular e Circulat\u00f3ria \u2764\ufe0f<\/h3><p style=\"text-align: left;\">Al\u00e9m de melhorar a perfus\u00e3o tumoral, a HCI tem efeitos espec\u00edficos no sistema circulat\u00f3rio:<\/p><ul><li style=\"text-align: left;\"><strong>Hipertens\u00e3o Essencial:<\/strong> Uma s\u00e9rie de estudos investigou o uso de hipertermia IR-A suave em pacientes com hipertens\u00e3o arterial (WHO Stages I and II). Findings indicate that serial treatments can positively affect <strong>ondas de pulso centrais e perif\u00e9ricas<\/strong>, blood pressure, and <strong>viscosidade do sangue<\/strong>, confirming WBH&#8217;s role as a non-pharmacological physical therapy option [44, 47].<\/li><\/ul><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \" style=\"text-align: left;\"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">C. Efeitos Neuroend\u00f3crinos e Psicol\u00f3gicos<\/h3><p style=\"text-align: left;\">A HCI envolve os sistemas neuroend\u00f3crinos do corpo, influenciando o humor e o metabolismo:<\/p><ul><li style=\"text-align: left;\"><strong>Transtorno Depressivo Maior (TDM):<\/strong> A randomized clinical trial demonstrated that a single session of WBH could act as a rapid-acting antidepressant, resulting in a reduction of depressive symptoms for several weeks. This effect is linked to the heat-induced activation of immune and inflammatory pathways that influence the brain [51].<\/li><li style=\"text-align: left;\"><strong>Modula\u00e7\u00e3o Hormonal (Endocrinologia):<\/strong> A HCI estimula o <strong>eixo Hipot\u00e1lamo-Hip\u00f3fise-Adrenal (HPA)<\/strong> e influencia os n\u00edveis hormonais. Estudos documentaram respostas do <strong>Horm\u00f4nio do Crescimento<\/strong> e da <strong>Prolactina<\/strong> durante a hipertermia de corpo inteiro, destacando seu impacto na regula\u00e7\u00e3o end\u00f3crina [42, 43].<\/li><li style=\"text-align: left;\"><strong>Metabolismo e Rea\u00e7\u00e3o Celular:<\/strong> A HCI acelera a taxa metab\u00f3lica basal. No n\u00edvel celular, o calor influencia a cin\u00e9tica de pO2 e est\u00e1 ligado \u00e0 s\u00edntese de prote\u00ednas protetoras como a <strong>ferritina<\/strong> na pele, auxiliando na repara\u00e7\u00e3o tecidual [48; 46].<\/li><\/ul><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Perguntas Frequentes (FAQ) sobre Sess\u00f5es de HCI Recomendadas e Temperaturas Alvo<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><i>Os tratamentos <\/i><i>devem<\/i> <i>ser<\/i> <i>realizados<\/i> <i>somente<\/i> <i>ap\u00f3s<\/i> <i>consulta<\/i> <i>final<\/i> <i>com<\/i> <i>um<\/i> <i>m\u00e9dico<\/i><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h4>\u00a0<\/h4><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h4>Qual \u00e9 o protocolo recomendado de Hipertermia de Corpo Inteiro (HCI) para Hipertens\u00e3o Essencial?<\/h4><p>O protocolo para Hipertens\u00e3o Essencial recomenda 12 sess\u00f5es a uma temperatura alvo de 38,3 \u00b0C. Cada sess\u00e3o dura aproximadamente 45 minutos, compreendendo uma fase de aumento de 30 minutos e uma fase de repouso de 15 minutos (sem fase de plat\u00f4).<\/p><h4>Quais s\u00e3o os par\u00e2metros WBH recomendados para dor lombar cr\u00f4nica (dorsalgia)?<\/h4><p>Para Dorsalgia, s\u00e3o tipicamente recomendadas 6 sess\u00f5es, visando 38,4 \u00b0C. O tempo total da sess\u00e3o \u00e9 de aproximadamente 90 minutos, com um aumento de 45 minutos, uma fase de plat\u00f4 de 15 minutos e um repouso de 30 minutos.<\/p><h4>Qual \u00e9 o protocolo WBH para fibromialgia e espondilite anquilosante??<\/h4><p>Tanto a Fibromialgia quanto a Espondilite Anquilosante seguem tipicamente um protocolo de 6 sess\u00f5es, visando 38,5 \u00b0C. O tempo total da sess\u00e3o \u00e9 de cerca de 90 minutos, incluindo um aumento de 45 minutos, um plat\u00f4 de 15 minutos e um repouso de 30 minutos.<\/p><h4>Qual \u00e9 o protocolo recomendado para a acupuntura de corpo inteiro como tratamento adjuvante para o c\u00e2ncer?<\/h4><p>Como tratamento aditivo do c\u00e2ncer, o protocolo requer 2 ou mais sess\u00f5es visando uma temperatura central entre 39,0 \u00b0C e 40,0 \u00b0C. O tempo total da sess\u00e3o \u00e9 o mais longo, variando de 3 a 4 horas, o que inclui 60-90 minutos para a fase de aumento, 60-90 minutos para a fase de plat\u00f4 e 60 minutos para a fase de repouso.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div><div class=\"wpb_content_element \"><div><div><header id=\"ut_header_68e7a7d03d95c\"><header><table width=\"1151\"><tbody><tr><td width=\"278\">Indication (Indica\u00e7\u00e3o)<\/td><td width=\"99\">No. of sessions (N\u00ba de sess\u00f5es)<\/td><td width=\"135\">Target temperature (Temperatura Alvo)<\/td><td colspan=\"2\" width=\"309\">Therapy time (Tempo de Terapia) Increase phase (Fase de Aumento)\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Plateau phase (Fase de Plat\u00f4)<\/td><td width=\"164\">Rest time (Tempo de Repouso) Resting phase (Fase de Repouso)<\/td><td width=\"164\"><b>Total<\/b> <b>WBH <\/b><b>session<\/b><b> time<\/b> (Tempo Total da Sess\u00e3o de HCI)<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Essential Hypertension (Hipertens\u00e3o Essencial)<\/td><td rowspan=\"2\" width=\"99\">12<\/td><td rowspan=\"2\" width=\"135\">38.3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Dorsalgia<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.4 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Fibromyalgia (Fibromialgia)<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Ankolysing Spondylitis (Espondilite Anquilosante)<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Systemic Sclerosis (Esclerose Sist\u00eamica)<\/td><td rowspan=\"2\" width=\"99\">15<\/td><td rowspan=\"2\" width=\"135\">38.3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Major Depressive Disorder (Transtorno Depressivo Maior)<\/td><td rowspan=\"2\" width=\"99\">1+<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>105 -170 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 2-3 <\/b><b>hours<\/b><\/td><\/tr><tr><td width=\"155\">45-110 min<\/td><td width=\"155\">60 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Additive Cancer Treatment (Tratamento Aditivo do C\u00e2ncer)<\/td><td rowspan=\"2\" width=\"99\">2+<\/td><td rowspan=\"2\" width=\"135\">39.0-40.0 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>120-180 min<\/b><\/td><td rowspan=\"2\" width=\"164\">60 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 3-4 <\/b><b>hours<\/b><\/td><\/tr><tr><td width=\"155\">60-90 min<\/td><td width=\"155\">60-90 min<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><\/header><h2>\u00a0<\/h2><\/div><\/div><\/div><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header>NOTA: este artigo n\u00e3o \u00e9 uma lista exaustiva de estudos e efeitos da HCI wIRA<\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Refer\u00eancias e Cita\u00e7\u00f5es<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><ol><li style=\"text-align: left;\">Ardenne M. von. 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Hyperthermie und Fieber, Wirkungen bei Mensch und Tier. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1987.<\/li><li style=\"text-align: left;\">Vaupel P., Kr\u00fcger W. W\u00e4rmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsm\u00f6glichkeiten. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1995.<\/li><li style=\"text-align: left;\">Piazena H., Meffert H. Optische Eigenschaften der Haut und die photobiologischen Grundlagen zur Dosierung von IR-Hautbestrahlungen in vivo und in vitro. 6. Symposium Licht und Gesundheit 2008 13.-14.03. Berlin, 2008:162-178.<\/li><li style=\"text-align: left;\">Zschaeck S. and Beck M. Chapter 8 Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?<\/li><li style=\"text-align: left;\">Zhang H, Wang W, Zhang S, Huang W. Comparison of the anti-tumor effects of various whole-body hyperthermia protocols&#8230; Immunol Invest. 2005;34(3):245-58.<\/li><li style=\"text-align: left;\">Abreu MM, Chocron AF, Smadja DM. From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. Front Immunol. 2025 Feb 28;16:1487296.<\/li><li style=\"text-align: left;\">Bull JMC. et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-\u03b1: A description of a phase I-II protocol. Journal of Hyperthermia. 2008; 24(8): 649-662.<\/li><li style=\"text-align: left;\">Weigelin B. Visualization of the immune effect of hyperthermia. ICHO 2021, Session: Hyperthermia and immunology.<\/li><li style=\"text-align: left;\">Faghihi Moghaddam F, Bakhshandeh M, Mofid B, et al. 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Low-dose Ipilimumab plus Nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series&#8230; Cancer Immunol Immunother. 2021;70:1393\u2013403.<\/li><li style=\"text-align: left;\">Adachi H., Katsuno M., Waza M., et al. Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications. Int J Hyperthermia 2009; 8:647-54.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin&#8230; Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Figueroa G., et al. An Update of a Phase II Clinical Trial Using Fever-Range Whole-Body Thermal Therapy (FR-WB-TT)&#8230; Soc for Thermal Med Joint Annual Meeting, 14.-17.5.2007.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Strebel F.R., et al. 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Immunol Res 2010; 1-3:137-154.<\/li><li style=\"text-align: left;\">Rowe R.W., Stebel F.R., Proett J.M., et al. Fever-range whole body thermotherapy combined with oxaliplatin: A curative regimen in a pre-clinical breast cancer model. Int J Hyperthermia 2010; 6:565-76.<\/li><li style=\"text-align: left;\">Schencking M., Frese T., Sandholzer H. Behandlung einer Radikulopathie bei oss\u00e4rer Metastasierung der Lendenwirbels\u00e4ule durch Infrarot-A-Ganzk\u00f6rperhyperthermie. Forsch Komplementmed 2008; 15:273-76.<\/li><li style=\"text-align: left;\">Scott G.L., Bull J.M.C., Kochn M. Management of Conscious Sedation&#8230; 9th Int Congress on Hyperthermic Oncology, 20.-24.4.2004.<\/li><li style=\"text-align: left;\">Shecterle L.M., Cyr J.A.S. Hyperthermia Aids Patients with Advanced Lung Cancer. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Skitzki J.J., Repasky E.A., Evans S.S. Hyperthermia as an immunotherapy strategy for cancer. Current Opnion in Investigational Drugs 2009; 6: 550-58.<\/li><li style=\"text-align: left;\">Toyota N., Strebel F.R., Stephens L.C., et al. Long-duration, mild whole body hyperthermia with cisplatin: tumour response and kinetics of apoptosis and necrosis&#8230; Int. J. Hyperthermia 1997; 5:497-506.<\/li><li style=\"text-align: left;\">Wang X.Y., Kazim L., Repasky E.A., Subjeck J.R. Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines&#8230; J of Immunology 2001; 165:490-97.<\/li><li style=\"text-align: left;\">VanderZee J., DeBruijne M., Mens J.W.M., et al. Reirradiation combined with hyperthermia in breast cancer recurrences&#8230; Int J Hyperthermia 2010; 7:638-48.<\/li><li style=\"text-align: left;\">Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia for locally advanced breast cancer. Int J Hyperthermia 2010; 7:618-24.<\/li><li style=\"text-align: left;\">Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence&#8230; Int J Hyperthermia 2010; 7: 612\u201317.<\/li><li style=\"text-align: left;\">Sen A., Capitano M., Dommer M., et al. Thermoregulatory responses to mild systemic thermal stress increase tumor perfusion&#8230; Cancer Res. 2011; 71(11):3872-3880.<\/li><li style=\"text-align: left;\">Koska J., Rovensky J., Zimanova T., Vigas M. Growth hormone and prolactin responses during partial and whole body warm-water immersions. Acta Physiol Scand. 2003 May;178(1):19-23.<\/li><li style=\"text-align: left;\">Vigas M., Rovensky J., Zimanova T., Koska J. Responses of growth hormone and prolactin to local and whole-body application of Piestany mud. Acta Rheumatol et Balneol Pistiniana 2002:31-38.<\/li><li style=\"text-align: left;\">Meffert B., Hochmuth O., Steiner M. Effects of a multiple mild infrared a induced hyperthermia on central and peripheral pulse waves in hypertensive patients. North Sea Conference on Biomedical Engineering 1990.<\/li><li style=\"text-align: left;\">Meffert H., Scherf HP., Meffert B. Milde Infrarot-A-Hyperthermie. Auswirkungen von Serienbestrahlungen mit wassergefilterter Infrarotstrahlung&#8230; Akt Dermatol 1993; 19:142-48.<\/li><li style=\"text-align: left;\">Applegate L.A., Scaletta C., Panizzon R., et al. Induction of the putative protein ferritin by infrared radiation: Implications in skin repair. Int J of Molecular Med 2000; 5:247-51.<\/li><li style=\"text-align: left;\">Scherf H.P., Meffert H., B\u00e4umler H., et al. Wirkung einer einmaligen milden Infrarot-A-Hyperthermie auf K\u00f6rpertemperatur, Herzfrequenz, Blutdruck und Blutviskosit\u00e4t&#8230; Dermatol Monatsschr 1989; 175:733-40.<\/li><li style=\"text-align: left;\">Streffer C. Metabolic changes during and after hyperthermia. Int J Hyperthermia 1985; 4:305-319.<\/li><li style=\"text-align: left;\">F\u00f6rster J., Fleischanderl S., Wittstock S., et al. Infrared-Mediated Hyperthermia is Effective in the Treatment of Scleroderma-Associated Raynaud\u2019s Phenomenon. J of Investigative Dermatology 2005; 6:1313-16.<\/li><li style=\"text-align: left;\">Koska J., Rovensky J., Zimanova T., et al. Sympathoadrenal regulation of circulatory responses to whole-body hyperthermia&#8230; Acta Rheumatol et Balneol Pistiniana 2002:23-30.<\/li><li style=\"text-align: left;\">Janssen C.W., Lowry C.A., Mehl M.R., et al. Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder \u2013 A Randomized Clinical Trial. JAMA Psychiatry. 2016 May 12.<\/li><li style=\"text-align: left;\">Tarner I.H., Ladner U.M., Uhlemann C., Lange U. The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1 beta and IL-6 in patients with ankylosing spondylitis. Clin Rheumatol 2009; 4:397-402.<\/li><li style=\"text-align: left;\">Ettrich U., Konrad B., Prate K., et al. Milde Ganzk\u00f6rperhyperthermie in Kombination mit station\u00e4rer multimodal orientierter Schmerztherapie&#8230; Orthop\u00e4de 2014; 2:165-74.<\/li><li style=\"text-align: left;\">Weller E., Ullrich D. Infrarot-A-Hyperthermie-Anwendung bei Patienten mit Analgetica-Abusus wegen chronischer R\u00fcckenschmerzen. Vortrag auf dem 95. Kongre\u00df der Gesellschaft f\u00fcr Phys Med und Rehab 5.10.1990.<\/li><li style=\"text-align: left;\">Morf S., Vesti B.A., Forster A., et al. Microcirculation abnormalities in patients with fibromyalgia \u2013 measured by capillary and laser fluxmetry. Arthritis Res Ther 2005; 7:R209-16.<\/li><li style=\"text-align: left;\">Walz J., Hinzmann J., Haase I., Witte T. Ganzk\u00f6rperhyperthermie in der Schmerztherapie \u2013 eine kontrollierte Studie an Patienten mit Fibromyalgiesyndrom. Schmerz 2013; 27:38-45.<\/li><li style=\"text-align: left;\">Romeyke T., Stummer H. Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic whole-body hyperthermia&#8230; J Musculoskel Pain 2014; 4:341-55.<\/li><li style=\"text-align: left;\">Zauner D., Quehenberger F., Hermann J., et al. Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study. Int J Hyperthermia 2014; 6:393-401.<\/li><li style=\"text-align: left;\">Lange U., M\u00fcller-Ladner U., Dischereit G. Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis&#8230; Akt Rheumatol 2017; 2:122-128.<\/li><\/ol><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>\u00a0<\/p><\/section><footer>\u00a9 <time>2025<\/time> Romanian Society Oncologic Hyperthermia All rights reserved. Source: Analysis based on scientific literature.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Hipertermia de Corpo Inteiro (HCI) em Oncologia e Outras Patologias: Sinergia Consolidada, Imunomodula\u00e7\u00e3o e Evid\u00eancia Cl\u00ednica Published: 2025-10-13 | Last Reviewed: 2025-10-13 By Veronica Iatan, MD, Cristian Gologan, M.Sc. A Hipertermia de Corpo Inteiro (HCI) \u00e9 uma estrat\u00e9gia oncol\u00f3gica sist\u00eamica que envolve o aquecimento controlado da temperatura central do corpo, frequentemente utilizando a tecnologia de<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/pt-br\/ensaios-clinicos-hipertermia-oncologia\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-1906","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/pt-br\/wp-json\/wp\/v2\/pages\/1906","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/pt-br\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/pt-br\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/pt-br\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/pt-br\/wp-json\/wp\/v2\/comments?post=1906"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/pt-br\/wp-json\/wp\/v2\/pages\/1906\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/pt-br\/wp-json\/wp\/v2\/media?parent=1906"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}