{"id":984,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2025-12-22T08:58:43","modified_gmt":"2025-12-22T08:58:43","slug":"ensaios-clinicos-hipertermia-oncologia","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/pt-pt\/ensaios-clinicos-hipertermia-oncologia\/","title":{"rendered":"Ensaios cl\u00ednicos"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"984\" class=\"elementor elementor-984 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Hipertermia de Corpo Inteiro (WBH) em Oncologia e Outras Patologias: Sinergia Consolidada, Imunomodula\u00e7\u00e3o e Evid\u00eancia Cl\u00ednica<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header><b>Publicado: <time datetime=\"2025-10-13\">2025-10-13<\/time> | \u00daltima Revis\u00e3o: <time datetime=\"2025-10-13\">2025-10-13<\/time><\/b><\/header><p>Por <a href=\"\/?p=139\">Veronica Iatan, MD<\/a>, <a href=\"\/?p=137\">Cristian Gologan, M.Sc.<\/a><\/p><section><p style=\"font-weight: bold; font-style: italic;\">A Hipertermia de Corpo Inteiro (WBH) \u00e9 uma estrat\u00e9gia oncol\u00f3gica sist\u00e9mica que envolve o aquecimento controlado da temperatura central do corpo, utilizando frequentemente tecnologia de water-filtered Infrared-A (wIRA). A WBH \u00e9 fundamentalmente um chemo\/radio sensitizer, significativamente improving tumor perfusion and oxygenation para amplificar a efic\u00e1cia dos tratamentos tradicionais. Crucialmente, funciona como um poderoso systemic immunomodulator, mobilizando Heat Shock Proteins (HSPs) e T-cells, o que cria uma sinergia essencial com a Immunotherapy (ICI) de ponta e oferece dramatic, rapid pain relief and Quality of Life improvement across various cancers and chronic pathologies like Fibromyalgia.<\/p><\/section><section>* Isen\u00e7\u00e3o de Responsabilidade M\u00e9dica: Este artigo destina-se apenas a fins informativos e n\u00e3o substitui a consulta m\u00e9dica individualizada, o diagn\u00f3stico ou o tratamento fornecido por um m\u00e9dico licenciado.*<\/section><section><h2>\u00a0<\/h2><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. Defini\u00e7\u00e3o da Hipertermia de Corpo Inteiro (WBH) e Tecnologia Terap\u00eautica<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\"><b>Hipertermia de Corpo Inteiro (WBH)<\/b>, ou \u201chipertermia sist\u00e9mica,\u201d \u00e9 definida como o aumento controlado da temperatura central do corpo para fins terap\u00eauticos. Com base no espectro de <b>efeitos da febre natural em diferentes temperaturas,<\/b> os procedimentos WBH s\u00e3o diferenciados da seguinte forma:<\/p><ul style=\"text-align: left;\"><li><b>WBT Suave:<\/b> &lt; 38.5<b>\u00b0<\/b>C<\/li><li><b>WBT Moderada:<\/b> 38.5<b>\u00b0<\/b>C- 40.5 <b> \u00b0<\/b>C<\/li><li><b>WBT Extrema:<\/b> &gt; 40.5<b>\u00b0<\/b>C<\/li><\/ul><p style=\"text-align: left;\">A WBH suave e moderada, em particular, <b>aumenta a perfus\u00e3o,<\/b> estimula o metabolismo, reduz o t\u00f3nus muscular e <b>estimula o sistema imunit\u00e1rio.<\/b><\/p><p style=\"text-align: left;\">O <a title=\"Detalhes t\u00e9cnicos von Ardenne IRATHERM\u00ae 1000M WBH wIRA dispositivo\" href=\"\/?page_id=270\"><b>dispositivo von Ardenne IRATHERM<\/b>\u00ae <b>1000M WBH wIRA<\/b> <\/a>utiliza exclusivamente <b>radia\u00e7\u00e3o de calor de Infravermelho-A (wIRA) filtrada por \u00e1gua, compat\u00edvel com a pele e de tecido profundo<\/b> (sem IR-B \/ IR-C) para este fim. O seu design de sistema aberto e n\u00e3o claustrof\u00f3bico garante uma intensidade de irradia\u00e7\u00e3o uniforme sobre todo o n\u00edvel do paciente (costas) e oferece ao utilizador um fornecimento de calor ideal e espec\u00edfico para o paciente em termos de localiza\u00e7\u00e3o e intensidade.<\/p><p style=\"text-align: left;\">A radia\u00e7\u00e3o infravermelha-A filtrada por \u00e1gua corresponde \u00e0 radia\u00e7\u00e3o t\u00e9rmica natural do sol, fornecendo a base tecnol\u00f3gica para uma aplica\u00e7\u00e3o uniforme e suave do calor [1, 5, 7, 8].<\/p><p style=\"text-align: left;\">Ao utilizar o princ\u00edpio von Ardenne IRATHERM<sup>\u00ae<\/sup> 1000, que foi desenvolvido e comprovado h\u00e1 mais de 30 anos, <a title=\"Prof. Manfred von Ardenne - Contribui\u00e7\u00f5es\" href=\"\/?p=5\">Prof. Manfred von Ardenne<\/a> conseguiu reproduzir esta radia\u00e7\u00e3o t\u00e9rmica f\u00edsica e tecnicamente e disponibiliz\u00e1-la industrialmente para uso m\u00e9dico sustent\u00e1vel por meio da hipertermia de corpo inteiro<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Fundamentos Cient\u00edficos e Efeitos Sist\u00e9micos<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">A WBH evoluiu para uma estrat\u00e9gia baseada em s\u00f3lidos princ\u00edpios biof\u00edsicos e fisiol\u00f3gicos. Em oncologia, o foco est\u00e1 na <b>Hipertermia Moderada<\/b> e na <b>Hipertermia de Intervalo de Febre (FR-WBH)<\/b>, reconhecidas como tratamentos com m\u00faltiplas indica\u00e7\u00f5es terap\u00eauticas [1, 3].<\/p><p style=\"text-align: left;\">A base tecnol\u00f3gica para a aplica\u00e7\u00e3o uniforme e suave do calor \u00e9 frequentemente fornecida por dispositivos que utilizam <b>radia\u00e7\u00e3o Infravermelho-A filtrada por \u00e1gua (wIRA)<\/b>. Estudos biof\u00edsicos detalhados validaram esta <b>capacidade da tecnologia de garantir um aquecimento profundo e controlado,<\/b> considerando as propriedades \u00f3ticas da pele e a base fotobiol\u00f3gica para a dosimetria [5,7,8].<\/p><p style=\"text-align: left;\">Estudos biof\u00edsicos detalhados validaram a capacidade da <b>tecnologia wIRA<\/b> de garantir um <b>aquecimento profundo e controlado<\/b> [5, 7, 8]. A n\u00edvel fisiol\u00f3gico, a WBH tem efeitos sist\u00e9micos fundamentais:<\/p><ol style=\"text-align: left;\"><li><b>Melhoria da Reologia do Sangue:<\/b> A exposi\u00e7\u00e3o a IR-WBH influencia favoravelmente as <b>propriedades do fluxo sangu\u00edneo e a hemodin\u00e2mica<\/b> [2], apoiando o mecanismo essencial de <b>melhoria da perfus\u00e3o tumoral<\/b>\u2014uma condi\u00e7\u00e3o cr\u00edtica para o sucesso dos tratamentos sist\u00e9micos.<\/li><li><b>Ativa\u00e7\u00e3o Biol\u00f3gica Geral:<\/b> A WBH induz uma resposta ao stress t\u00e9rmico que desencadeia uma cascata de processos biol\u00f3gicos, incluindo a <b>modula\u00e7\u00e3o do sistema hormonal<\/b> e a <b>acelera\u00e7\u00e3o do metabolismo<\/b> [6, 4].<\/li><\/ol><p style=\"text-align: left;\">Devido a estes fundamentos, a WBH funciona como um <b>imunomodulador sist\u00e9mico<\/b>, otimizando o <b>microambiente tumoral (TME)<\/b> e <b>amplificando a efic\u00e1cia dos tratamentos oncol\u00f3gicos de ponta<\/b> [9].<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. Principais Mecanismos de A\u00e7\u00e3o (Molecular, Fisiol\u00f3gico e Imunol\u00f3gico)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Os efeitos terap\u00eauticos da WBH s\u00e3o complexos, mediados por mudan\u00e7as a n\u00edvel celular, imunit\u00e1rio e fisiol\u00f3gico:<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Sinergia com Quimioterapia e Radioterapia (Sensibilizador Qu\u00edmico\/Radioativo)<\/h3><ul><li style=\"text-align: left;\"><b>Otimiza\u00e7\u00e3o do Microambiente Tumoral (TME):<\/b> A WBH melhora a <b>perfus\u00e3o sangu\u00ednea<\/b> e a <b>oxigena\u00e7\u00e3o do tumor<\/b>, revertendo a hip\u00f3xia tumoral. Isto \u00e9 essencial, pois as c\u00e9lulas tumorais bem oxigenadas s\u00e3o significativamente mais suscet\u00edveis \u00e0 destrui\u00e7\u00e3o pela <b>Quimioterapia<\/b> (QT) e <b>Radioterapia<\/b> (RT) [9, 41].<\/li><li style=\"text-align: left;\"><b>Efic\u00e1cia Qu\u00edmica\/Radioativa:<\/b> A hipertermia atua como um<b> sensibilizador qu\u00edmico &amp; radioativo<\/b>, melhorando o fornecimento de oxig\u00e9nio ao tumor (<i> efeito r\u00e1dio-sensibilizador<\/i> ) e aumentando a efic\u00e1cia de medicamentos como Cisplatina, Gencitabina e Carboplatina [12, 16, 36].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Indu\u00e7\u00e3o de uma Resposta Imunol\u00f3gica Antitumoral Robusta (Imunomodula\u00e7\u00e3o)<\/h3><p style=\"text-align: left;\">A WBH \u00e9 um forte ativador do sistema de defesa do corpo [11]:<\/p><ul><li style=\"text-align: left;\"><b>Heat Shock Proteins (HSPs):<\/b> O stress t\u00e9rmico estimula a s\u00edntese e liberta\u00e7\u00e3o de <b>HSP70<\/b>. Estas prote\u00ednas atuam como &#8216;sinais de perigo&#8217; que marcam as c\u00e9lulas cancerosas para um ataque melhorado pelos <b>Linf\u00f3citos T Citot\u00f3xicos (CTLs)<\/b> do sistema imunit\u00e1rio [9, 10, 29].<\/li><li style=\"text-align: left;\"><b>Ativa\u00e7\u00e3o de C\u00e9lulas Imunol\u00f3gicas Chave:<\/b> O intervalo de temperatura de 39-43<b>\u00b0<\/b>C aumenta a atividade das <b>C\u00e9lulas Natural Killer (NK)<\/b> e promove a atividade das <b>c\u00e9lulas T auxiliares e citot\u00f3xicas<\/b>, <b>c\u00e9lulas dendr\u00edticas<\/b> e <b>macr\u00f3fagos<\/b>, ao mesmo tempo que pode comprometer as c\u00e9lulas imunossupressoras [9, 10, 11, 25, 26].<\/li><li style=\"text-align: left;\"><b>Aumento de Linf\u00f3citos T:<\/b> A FR-WBH pode <b>aumentar significativamente (por exemplo, 3 vezes) a popula\u00e7\u00e3o de linf\u00f3citos T citot\u00f3xicos<\/b> em \u00f3rg\u00e3os linfoides, <b>melhorando assim o ataque imunol\u00f3gico antitumoral sist\u00e9mico<\/b> [10].<\/li><li style=\"text-align: left;\"><b>Vacinas e APCs:<\/b> A WHT pode regular a fun\u00e7\u00e3o das C\u00e9lulas Apresentadoras de Antig\u00e9nio (APCs) e aumentar a efic\u00e1cia das vacinas contra o cancro, incluindo aquelas baseadas em HSP110 e GRP170 [37, 28].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Evid\u00eancia Cl\u00ednica e Sinergia na Terapia Multimodal<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Sinergia com Imunoterapia (Inibidores de Checkpoint &#8211; ICI)<\/h3><p style=\"text-align: left;\">Uma s\u00e9rie de casos retrospetivos de 131 pacientes com cancro avan\u00e7ado (Est\u00e1dio IV) investigou um protocolo multimodal que inclu\u00eda <b>hipertermia de corpo inteiro<\/b> juntamente com inibidores de checkpoint (Ipilimumab, Nivolumab) e IL-2 [18].<\/p><p style=\"text-align: left;\"><b>Conclus\u00e3o Chave:<\/b> A Hipertermia de Corpo Inteiro wIRA foi determinada como um <b>componente integral e essencial<\/b> que <b>maximizou a resposta imunol\u00f3gica antitumoral<\/b>.<b> A WBH ativa e mobiliza c\u00e9lulas T (induzindo HSP70 e libertando antig\u00e9nios tumorais);<\/b> os inibidores de checkpoint ent\u00e3o &#8220;removem o trav\u00e3o&#8221; destas c\u00e9lulas T pr\u00e9-ativadas, resultando em taxas de resposta cl\u00ednica favor\u00e1veis invulgarmente altas para doen\u00e7a avan\u00e7ada [18].<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Aplica\u00e7\u00f5es Cl\u00ednicas em V\u00e1rios Tipos de Cancro<\/h3><ul><li style=\"text-align: left;\"><b>Cancro do P\u00e2ncreas:<\/b> Protocolos de Fase I-II utilizando WBH suave (FR-WBH) combinada com quimioterapia e Interferon-alfa mostraram <b>pelo menos 50% de regress\u00e3o tumoral em quase metade dos pacientes resistentes \u00e0 terapia<\/b> [4, 22].<\/li><li style=\"text-align: left;\"><b>Cancro da Mama (Recorr\u00eancia):<\/b> A WHT combinada com re-irradia\u00e7\u00e3o ou radioterapia demonstrou efic\u00e1cia para o cancro da mama localmente avan\u00e7ado e recorr\u00eancia da parede tor\u00e1cica, confirmada por dados randomizados [39, 40].<\/li><li style=\"text-align: left;\"><b>Cancro do Ov\u00e1rio:<\/b> A WBH combinada com <b>carboplatina<\/b> foi investigada num estudo de Fase II para cancro do ov\u00e1rio recorrente [16, 20].<\/li><li style=\"text-align: left;\"><b>Cancro Colorretal:<\/b> A WBH wIRA foi utilizada no contexto da Terapia Multietapas Sist\u00e9mica do Cancro (sCMT) de Von Ardenne combinada com quimioterapia num estudo de Fase I\/II [15].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. Al\u00edvio R\u00e1pido da Dor e Melhoria Significativa da Qualidade de Vida (QoL)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Os pacientes podem experienciar um al\u00edvio r\u00e1pido da dor e uma melhoria geral do bem-estar, conforme observado no estudo do Dr. Bull [12] e, especialmente, no mais recente estudo cl\u00ednico de Fase III realizado por Sahinbas et al. [14].<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">Ensaio Cl\u00ednico Fase III (2024) para Met\u00e1stases \u00d3sseas<\/h3><section>Em <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\">2024, Sahinbas e colegas publicaram um estudo de fase III<\/a> para dor de met\u00e1stases \u00f3sseas, principalmente de cancro da mama e pr\u00f3stata, utilizando dispositivos de hipertermia WBH wIRA Iratherm em adi\u00e7\u00e3o \u00e0 RT [14].Com base neste estudo, o grupo de radioterapia (RT) isolada apresentou a dor mais intensa. O estudo foi conclu\u00eddo ap\u00f3s o recrutamento de um total de 61 pacientes, 5 anos ap\u00f3s a primeira inscri\u00e7\u00e3o (abril de 2016 \u2013 fevereiro de 2021). Finalmente, a taxa de Resposta Completa (RC) no grupo RT + WBH mostrou a diferen\u00e7a mais significativa com a RT isolada, <b>47,4% vs. 5,3%, respetivamente, dentro de 2 meses p\u00f3s-tratamento<\/b> (P value &lt; 0,05). O <b>tempo para o al\u00edvio completo da dor foi de 10 dias para RT + WBH, enquanto o ponto final n\u00e3o foi alcan\u00e7ado no grupo RT isolada.<\/b> A progress\u00e3o da dor ou a estabilidade da doen\u00e7a foi observada em metade dos pacientes no grupo RT dentro de 4 semanas ap\u00f3s o tratamento. No entanto,<b> este \u00edndice estava pr\u00f3ximo de zero em pacientes com RT + WBH dentro de dois meses p\u00f3s-tratamento<\/b>.<b>Conclus\u00f5es: <\/b> A WBH mais RT demonstrou aumentos significativos no al\u00edvio da dor e um tempo de resposta mais curto em compara\u00e7\u00e3o com a RT isolada em pacientes com les\u00f5es \u00f3sseas metast\u00e1ticas.<\/section><table border=\"1\"><thead><tr><th>Indicador de QoL\/Melhoria da Dor<\/th><th>RT em monoterapia<\/th><th>RT + Hipertermia (WBH wIRA)<\/th><th>Impacto QoL<\/th><\/tr><\/thead><tbody><tr><td><b>Taxa de Resposta Completa (RC) aos 2 meses<\/b> (\u00edndice de dor zero)<\/td><td>5,3 %<\/td><td>47,4 %<\/td><td>* <b>Aumento de 894%<\/b> * nas chances de elimina\u00e7\u00e3o total da dor.<\/td><\/tr><tr><td><b>Tempo para o al\u00edvio completo da dor<\/b><\/td><td>n\u00e3o foi atingido<\/td><td>10 dias<\/td><td><b>\u201d Benef\u00edcio significativo e r\u00e1pido\u201d<\/b><\/td><\/tr><tr><td style=\"text-align: left;\"><b>Dura\u00e7\u00e3o do Al\u00edvio da Dor <\/b><\/td><td style=\"text-align: left;\">Mediana: 28 dias\/4 semanas em metade dos pacientes<\/td><td style=\"text-align: left;\">Mediana: N\u00e3o inclu\u00edda \u00e0s 24 semanas<\/td><td style=\"text-align: left;\">A dura\u00e7\u00e3o do al\u00edvio * <b>aumenta em seis vezes<\/b> *, reduzindo a depend\u00eancia de analg\u00e9sicos.<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">\u00a0<\/p><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Em compara\u00e7\u00e3o com o <a title=\"Estudo de Fase III Chi MS et al. 2017\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5\" target=\"_blank\" rel=\"noopener\">estudo de Fase III semelhante publicado por Chi MS et al<\/a> . (2017) com hipertermia locorregional de RF, os benef\u00edcios (<i>em rela\u00e7\u00e3o \u00e0 QoL e redu\u00e7\u00e3o da dor)<\/i> alcan\u00e7ados usando a hipertermia WBH wIRA foram muito superiores \u2013 Resultados do estudo RF HT + RT:<\/p><table border=\"1\"><thead><tr><th>Indicador de QoL\/Melhoria da Dor<\/th><th>RT em monoterapia<\/th><th>RT + Hipertermia (HT)<\/th><th>Impacto QoL<\/th><\/tr><\/thead><tbody><tr><td><b>Taxa de Resposta Completa (RC) aos 3 Meses<\/b> (\u00edndice de dor zero)<\/td><td>7,1 %<\/td><td>37,9 %<\/td><td>533% increase in the chances of total pain relief.<\/td><\/tr><tr><td><b>Dura\u00e7\u00e3o do Al\u00edvio da Dor<\/b><\/td><td>Mediana: 55 dias\/7,9 semanas<\/td><td>Mediana: N\u00e3o inclu\u00edda \u00e0s 24 semanas<\/td><td>A dura\u00e7\u00e3o do al\u00edvio triplica, reduzindo a depend\u00eancia de analg\u00e9sicos.<\/td><\/tr><\/tbody><\/table><p style=\"text-align: left;\">Em resumo, a evid\u00eancia cient\u00edfica consolidada (<i>desde estudos fundamentais sobre a tecnologia wIRA at\u00e9 ensaios cl\u00ednicos cruciais de Fase III<\/i>) confirma o papel da WBH como uma terapia adjuvante de multi-impacto em oncologia: <b>aumenta a efic\u00e1cia da QT\/RT, ativa o sistema imunit\u00e1rio sist\u00e9mico (incluindo sinergia com imunoterapia) e melhora drasticamente o controlo da dor e a QoL<\/b> para pacientes com cancro.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Benef\u00edcios Fisiol\u00f3gicos Sist\u00e9micos e Potencial Terap\u00eautico em Outras Patologias<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>O calor suave e controlado fornecido pela WBH com radia\u00e7\u00e3o wIRA inicia respostas termorreguladoras complexas que produzem amplos benef\u00edcios sist\u00e9micos, estendendo o potencial terap\u00eautico para al\u00e9m da oncologia:<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Gest\u00e3o Musculoesquel\u00e9tica e da Dor<\/h3><p style=\"text-align: left;\">A WBH \u00e9 eficaz no tratamento de s\u00edndromes de dor cr\u00f3nica, aproveitando os seus efeitos fisiol\u00f3gicos no t\u00f3nus muscular e na microcircula\u00e7\u00e3o:<\/p><ul><li style=\"text-align: left;\"><b>Dorsalgia (Dor Cr\u00f3nica nas Costas):<\/b> Estudos mostram que a WBH suave, quando combinada com terapia multimodal estacion\u00e1ria para a dor, oferece um benef\u00edcio significativo para pacientes com dor lombar cr\u00f3nica n\u00e3o espec\u00edfica (dorsalgia) [53, 54].<\/li><li style=\"text-align: left;\"><b>S\u00edndrome de Fibromialgia (FMS):<\/b> A WBH \u00e9 um tratamento adjuvante documentado para a FMS. Ensaios controlados randomizados demonstraram a efic\u00e1cia da WBH wIRA suave num ambiente padr\u00e3o de reabilita\u00e7\u00e3o multimodal, mostrando efeitos na <b>intensidade da dor<\/b> e no <b>estado mental<\/b> [17, 56, 57]. Este benef\u00edcio est\u00e1 parcialmente ligado \u00e0 melhoria da microcircula\u00e7\u00e3o, um problema conhecido em pacientes com FMS [55].<\/li><li style=\"text-align: left;\"><b>Espondilite Anquilosante (EA):<\/b> A WBH demonstrou efeitos imunomoduladores em pacientes com EA, com estudos a relatar a capacidade da WBH de aumentar os mediadores anti-inflamat\u00f3rios como a <b>Interleucina-10<\/b> (IL-10) e modular as citocinas pr\u00f3-inflamat\u00f3rias como o TNF-alfa, sugerindo um papel ben\u00e9fico no tratamento da inflama\u00e7\u00e3o cr\u00f3nica associada \u00e0 condi\u00e7\u00e3o [58, 59, 52].<\/li><li style=\"text-align: left;\"><b>Fen\u00f3meno de Raynaud na Esclerose Sist\u00e9mica:<\/b> A hipertermia mediada por infravermelhos demonstrou ser eficaz no tratamento dos sintomas vasoconstritores associados ao Fen\u00f3meno de Raynaud Associado \u00e0 Esclerodermia, demonstrando benef\u00edcios vasculares [49].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Sa\u00fade Cardiovascular e Circulat\u00f3ria \u2764\ufe0f<\/h3><p style=\"text-align: left;\">Para al\u00e9m de melhorar a perfus\u00e3o tumoral, a WBH tem efeitos espec\u00edficos no sistema circulat\u00f3rio:<\/p><ul><li style=\"text-align: left;\"><b>Hipertens\u00e3o Essencial:<\/b> Uma s\u00e9rie de estudos investigou o uso da hipertermia IR-A suave em pacientes com hipertens\u00e3o arterial (Est\u00e1dios I e II da OMS). Os resultados indicam que os tratamentos em s\u00e9rie podem afetar positivamente as <b>ondas de pulso centrais e perif\u00e9ricas<\/b>, a press\u00e3o arterial e a <b>viscosidade do sangue<\/b>, confirmando o papel da WBH como uma op\u00e7\u00e3o de terapia f\u00edsica n\u00e3o farmacol\u00f3gica [44, 47].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \" style=\"text-align: left;\"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">C. Efeitos Neuroend\u00f3crinos e Psicol\u00f3gicos<\/h3><p style=\"text-align: left;\">A WBH envolve os sistemas neuroend\u00f3crinos do corpo, influenciando o humor e o metabolismo:<\/p><ul><li style=\"text-align: left;\"><b>Perturba\u00e7\u00e3o Depressiva Major (PDM):<\/b> Um ensaio cl\u00ednico randomizado demonstrou que uma \u00fanica sess\u00e3o de WBH pode atuar como um antidepressivo de a\u00e7\u00e3o r\u00e1pida, resultando numa redu\u00e7\u00e3o dos sintomas depressivos durante v\u00e1rias semanas. Este efeito est\u00e1 ligado \u00e0 ativa\u00e7\u00e3o de vias imunit\u00e1rias e inflamat\u00f3rias induzidas pelo calor que influenciam o c\u00e9rebro [51].<\/li><li style=\"text-align: left;\"><b>Modula\u00e7\u00e3o Hormonal (Endocrinologia):<\/b> A WBH estimula o <b>eixo Hipotal\u00e2mico-Pituit\u00e1rio-Adrenal (HPA)<\/b> e influencia os n\u00edveis hormonais. Estudos documentaram respostas da <b>Hormona do Crescimento<\/b> e da <b>Prolactina<\/b> durante a hipertermia de corpo inteiro, destacando o seu impacto na regula\u00e7\u00e3o end\u00f3crina [42, 43].<\/li><li style=\"text-align: left;\"><b>Metabolismo e Rea\u00e7\u00e3o Celular:<\/b> A WBH acelera a taxa metab\u00f3lica basal. A n\u00edvel celular, o calor influencia a cin\u00e9tica de pO2 e est\u00e1 ligado \u00e0 s\u00edntese de prote\u00ednas protetoras como a <b>ferritina<\/b> na pele, apoiando a repara\u00e7\u00e3o tecidual [48; 46].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Perguntas Frequentes (FAQ) sobre Sess\u00f5es Recomendadas de WBH e Temperaturas Alvo<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p><i>Os tratamentos <\/i><i>s\u00f3 devem<\/i> <i>ser<\/i> <i>realizados<\/i><i> ap\u00f3s <\/i><i>consulta<\/i> <i>final<\/i> <i>com<\/i><i> um <\/i><i>m\u00e9dico<\/i><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h2>\u00a0<\/h2><header id=\"ut_header_68e7a7d03d95c\"><header><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h4>Qual \u00e9 o protocolo de Hipertermia de Corpo Inteiro (WBH) recomendado para Hipertens\u00e3o Essencial?<\/h4><p>O protocolo para Hipertens\u00e3o Essencial recomenda 12 sess\u00f5es com uma temperatura alvo de 38.3 \u00b0C. Cada sess\u00e3o dura aproximadamente 45 minutos, compreendendo uma fase de aumento de 30 minutos e uma fase de repouso de 15 minutos (sem fase de plat\u00f4).<\/p><h4>Quais s\u00e3o os par\u00e2metros WBH recomendados para Dor Cr\u00f3nica nas Costas (Dorsalgia)?<\/h4><p>Para Dorsalgia, 6 sess\u00f5es s\u00e3o tipicamente recomendadas, visando 38.4 \u00b0C. O tempo total da sess\u00e3o \u00e9 de aproximadamente 90 minutos, com 45 minutos de aumento, 15 minutos de fase de plat\u00f4 e 30 minutos de repouso.<\/p><h4>Qual \u00e9 o protocolo WBH para Fibromialgia e Espondilite Anquilosante?<\/h4><p>Tanto a Fibromialgia quanto a Espondilite Anquilosante seguem tipicamente um protocolo de 6 sess\u00f5es, visando 38.5 \u00b0C. O tempo total da sess\u00e3o \u00e9 de cerca de 90 minutos, incluindo 45 minutos de aumento, 15 minutos de plat\u00f4 e 30 minutos de repouso.<\/p><h4>Qual \u00e9 o protocolo recomendado para WBH como Tratamento Oncol\u00f3gico Aditivo?<\/h4><p>Como tratamento oncol\u00f3gico aditivo, o protocolo requer 2 ou mais sess\u00f5es visando uma temperatura central entre 39.0 \u00b0C e 40.0 \u00b0C. O tempo total da sess\u00e3o \u00e9 o mais longo, variando de 3 a 4 horas, o que inclui 60-90 minutos para a fase de aumento, 60-90 minutos para a fase de plat\u00f4 e 60 minutos para a fase de repouso.<\/p><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\"><header><table width=\"1151\"><tbody><tr><td width=\"278\">Indica\u00e7\u00e3o<\/td><td width=\"99\">N.\u00ba de sess\u00f5es<\/td><td width=\"135\">Temperatura Alvo<\/td><td colspan=\"2\" width=\"309\">Tempo de Terapia Fase de Aumento\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Fase de Plat\u00f4<\/td><td width=\"164\">Tempo de Repouso Fase de Repouso<\/td><td width=\"164\"><b>Total<\/b> <b>Tempo de sess\u00e3o WBH<\/b><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Hipertens\u00e3o Essencial<\/td><td rowspan=\"2\" width=\"99\">12<\/td><td rowspan=\"2\" width=\"135\">38.3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Dorsalgia<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.4 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Fibromialgia<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Espondilite Anquilosante<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 min<\/b><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Esclerose Sist\u00e9mica<\/td><td rowspan=\"2\" width=\"99\">15<\/td><td rowspan=\"2\" width=\"135\">38.3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 min<\/b><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 min<\/b><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Perturba\u00e7\u00e3o Depressiva Major<\/td><td rowspan=\"2\" width=\"99\">1+<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>105 -170 min<\/b><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 2-3 horas<\/b><\/td><\/tr><tr><td width=\"155\">45-110 min<\/td><td width=\"155\">60 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Tratamento Oncol\u00f3gico Aditivo<\/td><td rowspan=\"2\" width=\"99\">2+<\/td><td rowspan=\"2\" width=\"135\">39.0-40.0 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>120-180 min<\/b><\/td><td rowspan=\"2\" width=\"164\">60 min<\/td><td rowspan=\"2\" width=\"164\"><b>~ 3-4 horas<\/b><\/td><\/tr><tr><td width=\"155\">60-90 min<\/td><td width=\"155\">60-90 min<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><\/header><\/header><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>NOTA: este artigo n\u00e3o \u00e9 uma lista exaustiva de estudos e efeitos da WBH wIRA<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Refer\u00eancias e Cita\u00e7\u00f5es<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><ol><li style=\"text-align: left;\">Ardenne M. von. Moderate Hyperthermie als Behandlungsmethode mit vielen Indikationen. \u00c4rztzeitschr Naturheilverf 1994; 5:356-61.<\/li><li style=\"text-align: left;\">B\u00e4umler H., Scherf H.P., Aurisch R., et al. Einflu\u00df einer Serie von Infrarot-Ganzk\u00f6rperbestrahlungen auf Flie\u00dfeigenschaften des Blutes und die H\u00e4modynamik. Perfusion 1990: 138-43.<\/li><li style=\"text-align: left;\">Heckel M. Ganzk\u00f6rper-Hyperthermie und Fiebertherapie, Grundlagen und Praxis. Stuttgart: Hippokrates Verlag, 1990.<\/li><li style=\"text-align: left;\">Kosaka M., Sugahara T., Schmidt K.L., Simon E. Thermotherapy: Principles and Practice. Heidelberg: Springer Verlag, 2000.<\/li><li style=\"text-align: left;\">Meffert H., Hecht H.C., G\u00fcnther H., et al. Biophysikalische Ergebnisse des klinischen Tests der IRA-Therm-Hyperthermietechnik der 2. Generation. ThermoMed 1990; 6:71-78.<\/li><li style=\"text-align: left;\">Schmidt K.L. Hyperthermie und Fieber, Wirkungen bei Mensch und Tier. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1987.<\/li><li style=\"text-align: left;\">Vaupel P., Kr\u00fcger W. W\u00e4rmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsm\u00f6glichkeiten. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1995.<\/li><li style=\"text-align: left;\">Piazena H., Meffert H. Optische Eigenschaften der Haut und die photobiologischen Grundlagen zur Dosierung von IR-Hautbestrahlungen in vivo und in vitro. 6. Symposium Licht und Gesundheit 2008 13.-14.03. Berlin, 2008:162-178.<\/li><li style=\"text-align: left;\">Zschaeck S. and Beck M. Chapter 8 Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?<\/li><li style=\"text-align: left;\">Zhang H, Wang W, Zhang S, Huang W. Comparison of the anti-tumor effects of various whole-body hyperthermia protocols&#8230; Immunol Invest. 2005;34(3):245-58.<\/li><li style=\"text-align: left;\">Abreu MM, Chocron AF, Smadja DM. From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. Front Immunol. 2025 Feb 28;16:1487296.<\/li><li style=\"text-align: left;\">Bull JMC. et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-\u03b1: A description of a phase I-II protocol. Journal of Hyperthermia. 2008; 24(8): 649-662.<\/li><li style=\"text-align: left;\">Weigelin B. Visualization of the immune effect of hyperthermia. ICHO 2021, Session: Hyperthermia and immunology.<\/li><li style=\"text-align: left;\">Faghihi Moghaddam F, Bakhshandeh M, Mofid B, et al. Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone&#8230; J Therm Biol. 2024 Feb;120:103804.<\/li><li style=\"text-align: left;\">Hildebrandt B, Dr\u00e4ger J, Kerner T. et al. Whole-body hyperthermia in the scope of von Ardenne\u2019s systemic cancer multistep therapy (sCMT)&#8230; International Journal of Hyperthermia. 2004;3:317\u2013333.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin in patients with recurrent ovarian cancer \u2013 a phase II study. Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Brockow T., Wagner A., Franke A., Offenb\u00e4cher M., Resch K.L. A Randomized Controlled Trial on the Effectiveness of Mild Water-filtered Near Infrared Whole-body Hyperthermia&#8230; Clin J Pain 2007; 1:67-75.<\/li><li style=\"text-align: left;\">Kleef R, Nagy R, Baierl A, et al. 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Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis&#8230; Akt Rheumatol 2017; 2:122-128.<\/li><\/ol><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>\u00a0<\/p><\/section><footer>\u00a9 <time>2025<\/time> Romanian Society Oncologic Hyperthermia All rights reserved. Source: Analysis based on scientific literature.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Hipertermia de Corpo Inteiro (WBH) em Oncologia e Outras Patologias: Sinergia Consolidada, Imunomodula\u00e7\u00e3o e Evid\u00eancia Cl\u00ednica Publicado: 2025-10-13 | \u00daltima Revis\u00e3o: 2025-10-13 Por Veronica Iatan, MD, Cristian Gologan, M.Sc. A Hipertermia de Corpo Inteiro (WBH) \u00e9 uma estrat\u00e9gia oncol\u00f3gica sist\u00e9mica que envolve o aquecimento controlado da temperatura central do corpo, utilizando frequentemente tecnologia de water-filtered<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/pt-pt\/ensaios-clinicos-hipertermia-oncologia\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-984","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/pt-pt\/wp-json\/wp\/v2\/pages\/984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/pt-pt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/pt-pt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/pt-pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/pt-pt\/wp-json\/wp\/v2\/comments?post=984"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/pt-pt\/wp-json\/wp\/v2\/pages\/984\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/pt-pt\/wp-json\/wp\/v2\/media?parent=984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}