{"id":985,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2025-12-18T12:05:28","modified_gmt":"2025-12-18T12:05:28","slug":"studii-clinice-hipertermie-totala-wbh-wira","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/ro\/studii-clinice-hipertermie-totala-wbh-wira\/","title":{"rendered":"Studii clinice &#8211; Hipertermie Corporala Totala"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"985\" class=\"elementor elementor-985 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Hipertermia  Corporal\u0103  Total\u0103 (HCT-WBH) \u00een oncologie \u0219i alte patologii: sinergie consolidat\u0103, imunomodulare \u0219i dovezi din studii clinice<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header><p><strong><span dir=\"auto\">Publicat: 13.10.2025 | Ultima recenzie: 13.10.2025<\/span><\/strong><\/p><\/header><div class=\"authors\"><p><span dir=\"auto\">De<\/span><br \/><a href=\"https:\/\/ardenneiratherm.com\/ro\/our-team\/dr-hipertermie-veronica-iatan\/\"><span dir=\"auto\">Dr. Veronica Iatan,\u00a0<\/span><\/a><a href=\"https:\/\/ardenneiratherm.com\/ro\/our-team\/cristian-gologan\/\"><span dir=\"auto\">Cristian Gologan, M.Sc.<\/span><\/a><\/p><\/div><section class=\"ai-summary\"><p><span dir=\"auto\">Hipertermia corporal\u0103 total\u0103 (HCT-WBH) este o strategie oncologic\u0103 sistemic\u0103 ce implic\u0103 \u00eenc\u0103lzirea controlat\u0103 a temperaturii centrale a corpului, adesea utiliz\u00e2nd tehnologia radiatie <strong>infraro\u0219u-A filtrata cu ap\u0103<\/strong> (wIRA). HCT este fundamental un <strong>chimo\/radiosensibilizator<\/strong>, care <strong>\u00eembun\u0103t\u0103\u021be\u0219te semnificativ perfuzia \u0219i oxigenarea\u00a0tumorii<\/strong> pentru a amplifica eficacitatea tratamentelor tradi\u021bionale. \u00cen mod crucial, func\u021bioneaz\u0103 ca un <strong>imunomodulator sistemic<\/strong> puternic, mobiliz\u00e2nd proteinele de \u0219oc termic (HSP) \u0219i celulele T, ceea ce creeaz\u0103 o sinergie esen\u021bial\u0103 cu <strong>imunoterapia (ICI)<\/strong> de ultim\u0103 genera\u021bie \u0219i ofer\u0103 <strong>ameliorarea dramatic\u0103 \u0219i rapid\u0103 a durerii \u0219i o cre\u0219tere\u00a0 a calit\u0103\u021bii vie\u021bii<\/strong> \u00een diferite tipuri de cancer \u0219i patologii cronice<\/span><\/p><\/section><section class=\"disclaimer\"><span dir=\"auto\"><strong>Declinare de responsabilitate medical\u0103: Acest articol este destinat exclusiv scopurilor informative \u0219i nu \u00eenlocuie\u0219te consulta\u021bia medical\u0103 individualizat\u0103, diagnosticul sau tratamentul oferit de un medic autorizat.<\/strong><\/span><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. Definirea hipertermiei corporale totale (HCT - WBH) \u0219i a tehnologiei terapeutice\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\"><strong><span dir=\"auto\">Hipertermia corporal\u0103 total\u0103 (HCT &#8211; WBH)<\/span><\/strong><span dir=\"auto\">\u00a0\u00a0, sau \u201ehipertermia sistemic\u0103\u201d, este definit\u0103 ca cre\u0219tea controlat\u0103 a temperaturii centrale a corpului \u00een scopuri terapeutice. Pe baza spectrului de\u00a0<\/span><strong><span dir=\"auto\">efecte ale febrei naturale la diferite temperaturi,<\/span><\/strong><span dir=\"auto\">\u00a0procedurile HCT-WBH se diferen\u021biaz\u0103 dup\u0103 cum urmeaz\u0103:<\/span><\/p><ul style=\"text-align: left;\"><li><strong><span dir=\"auto\">HCT Temperatura medie u\u0219oar\u0103:<\/span><\/strong><span dir=\"auto\">\u00a0&lt; 38,5\u00a0<\/span><strong><span dir=\"auto\">\u00b0<\/span><\/strong><span dir=\"auto\">\u00a0C<\/span><\/li><li><strong><span dir=\"auto\">HCT &#8211; WBH moderata:<\/span><\/strong><span dir=\"auto\">\u00a038,5\u00a0<\/span><strong><span dir=\"auto\">\u00b0<\/span><\/strong><span dir=\"auto\">\u00a0C \u2013 40,5\u00a0<\/span><strong><span dir=\"auto\">\u00b0<\/span><\/strong><span dir=\"auto\">\u00a0C<\/span><\/li><li><strong><span dir=\"auto\">HCT Temperatura extrem\u0103:<\/span><\/strong><span dir=\"auto\">\u00a0&gt; 40,5\u00a0<\/span><strong><span dir=\"auto\">\u00b0<\/span><\/strong><span dir=\"auto\">\u00a0C<\/span><\/li><\/ul><p style=\"text-align: left;\"><span dir=\"auto\">\u00cen special, hipertermia total\u0103 u\u0219oar\u0103 \u0219i moderat\u0103\u00a0<\/span><strong><span dir=\"auto\">cre\u0219te perfuzia,<\/span><\/strong><span dir=\"auto\">\u00a0stimuleaz\u0103 metabolismul, reduce tonusul muscular \u0219i\u00a0<\/span><strong class=\"key-term\"><span dir=\"auto\">stimuleaz\u0103 sistemul imunitar.<\/span><\/strong><\/p><p style=\"text-align: left;\"><span dir=\"auto\">Dispozitivul de hipertermie HCT\u00a0<\/span><a href=\"https:\/\/ardenneiratherm.com\/ro\/iratherm-1000-dispozitiv-de-hipertermie-wbh\/\"><strong><span dir=\"auto\">von Ardenne IRATHERM<\/span><\/strong><span dir=\"auto\">\u00a0\u00ae\u00a0<\/span><strong><span dir=\"auto\">1000M WBH wIRA<\/span><\/strong>\u00a0<\/a><span dir=\"auto\">utilizeaz\u0103 \u00een acest scop exclusiv\u00a0<\/span><strong><span dir=\"auto\">radia\u021bii termice \u00een infraro\u0219u-A (wIRA), compatibile cu pielea, filtrate cu ap\u0103 \u0219i pentru \u021besuturile profunde<\/span><\/strong><span dir=\"auto\">\u00a0(f\u0103r\u0103 radia\u021bii tip IR-B \/ IR-C). Designul s\u0103u deschis, non-claustrofobic, asigur\u0103ri o intensitate uniform\u0103 a iradierii pe \u00eentregul nivel al pacientului (spatele) \u0219i ofer\u0103 utilizatorilor o alimentare optim\u0103, specific\u0103 pacientului, cu c\u0103ldur\u0103, \u00een ceea ce prive\u0219te localizarea \u0219i intensitatea.<\/span><\/p><p style=\"text-align: left;\"><span dir=\"auto\">Radia\u021bia infraro\u0219ie A filtrat\u0103 cu ap\u0103 corespunde radia\u021biei termice naturale a soarelui, oferind baza tehnologic\u0103 pentru aplicarea uniform\u0103 \u0219i bl\u00e2nd\u0103 a c\u0103ldurii\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[1, 5, 7, 8]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/p><p style=\"text-align: left;\"><span dir=\"auto\">Folosind principiul von Ardenne IRATHERM\u00a0<\/span><sup><span dir=\"auto\">\u00ae<\/span><\/sup><span dir=\"auto\">\u00a01000, dezvoltat \u0219i dovedit de peste 30 de ani,\u00a0<\/span><a href=\"https:\/\/ardenneiratherm.com\/ro\/our-team\/manfred-von-ardenne\/\"><span dir=\"auto\">prof. Manfred von Ardenne<\/span><\/a><span dir=\"auto\">\u00a0a reu\u0219it s\u0103 reproduc\u0103 fizic \u0219i aceast\u0103 tehnic\u0103 radia\u021bie termic\u0103 \u0219i s\u0103 fac\u0103 disponibil\u0103 industrial pentru utilizare medical\u0103 sustenabil\u0103 prin hipertermia corporala totala.<\/span><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Fundamente \u0219tiin\u021bifice \u0219i efecte sistemice<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\"><span dir=\"auto\">Hipertermia corporala total\u0103 HCT de tip WBH wIRA a evoluat \u00eentr-o strategie bazat\u0103 pe principii biofizice \u0219i fiziologice solide. \u00cen oncologie, accentul se pune pe hipertermia\u00a0<\/span><strong><span dir=\"auto\">moderat\u0103<\/span><\/strong><span dir=\"auto\">\u00a0\u0219i\u00a0<\/span><strong><span dir=\"auto\">cu febr\u0103 (FR-WBH)<\/span><\/strong><span dir=\"auto\">\u00a0, recunoscut\u0103 ca tratament cu indica\u021bii terapeutice multiple\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[1,3]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/p><p style=\"text-align: left;\"><span dir=\"auto\">Baza tehnologic\u0103 pentru aplicarea uniform\u0103 \u0219i bl\u00e2nd\u0103 a c\u0103ldurii este adesea asigurat\u0103 de dispozitive care utilizeaz\u0103\u00a0<\/span><strong><span dir=\"auto\">radia\u021bii infraro\u0219ii A filtrate cu ap\u0103 (wIRA)<\/span><\/strong><span dir=\"auto\">\u00a0. Studii biofizice au validat\u00a0<\/span><strong><span dir=\"auto\">capacitatea acestei tehnologii de asigurare o \u00eenc\u0103lzire profund\u0103 \u0219i controlat\u0103,<\/span><\/strong><span dir=\"auto\">\u00a0lu\u00e2nd \u00een considerare propriet\u0103\u021bile optice ale pielii \u0219i baza fotobiologic\u0103 dozimetrie [5,7,8].<\/span><\/p><p style=\"text-align: left;\"><span dir=\"auto\">Studii biofizice detaliate au validat\u00a0capacitatea\u00a0<\/span><strong class=\"key-term\"><span dir=\"auto\">tehnologiei wIRA de asigurare\u00a0<\/span><\/strong><strong><span dir=\"auto\">o \u00eenc\u0103lzire profund\u0103 \u0219i controlat\u0103\u00a0<\/span><\/strong><span class=\"citation\"><span dir=\"auto\">[5, 7, 8]<\/span><\/span><span dir=\"auto\">\u00a0. La nivel fiziologic, HCT-WBH sunt efecte sistemice fundamentale:<\/span><\/p><ol style=\"text-align: left;\"><li><strong><span dir=\"auto\">Reologie sanguin\u0103<\/span><\/strong><span dir=\"auto\">\u00a0IR-WBH influen\u021beaz\u0103 favorabil\u00a0<\/span><strong><span dir=\"auto\">propriet\u0103\u021bile fluxului sanguin \u0219i hemodinamica\u00a0<\/span><\/strong><span class=\"citation\"><span dir=\"auto\">[2]<\/span><\/span><span dir=\"auto\">\u00a0, sus\u021bin\u00e2nd mecanismul esen\u021bial de\u00a0<\/span><strong class=\"key-term\"><span dir=\"auto\">creare a perfuziei tumorale<\/span><\/strong><span dir=\"auto\">\u00a0\u2013 o condi\u021bie prealabil\u0103 critic\u0103 pentru succesul tratamentelor sistemice.<\/span><\/li><li><strong><span dir=\"auto\">Activare biologic\u0103 general\u0103:<\/span><\/strong><span dir=\"auto\">\u00a0HCT-WBH induce un r\u0103spuns la stres termic care declan\u0219eaz\u0103 o cascad\u0103 de proces biologic, inclusiv\u00a0<\/span><strong><span dir=\"auto\">modularea sistemului hormonal<\/span><\/strong><span dir=\"auto\">\u00a0\u0219i\u00a0<\/span><strong><span dir=\"auto\">accelerarea metabolismului\u00a0<\/span><\/strong><span class=\"citation\"><span dir=\"auto\">[6, 4]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/li><\/ol><p style=\"text-align: left;\"><span dir=\"auto\">Datorit\u0103 acestor fundamente, HCT-WBH func\u021bioneaz\u0103 ca un\u00a0<\/span><strong class=\"key-term\"><span dir=\"auto\">imunomodulator sistemic<\/span><\/strong><span dir=\"auto\">\u00a0, optimiz\u00e2nd\u00a0<\/span><strong class=\"key-term\"><span dir=\"auto\">micromediul tumoral (TME)<\/span><\/strong><span dir=\"auto\">\u00a0\u0219i\u00a0<\/span><strong><span dir=\"auto\">amplific\u00e2nd eficacitatea tratamentelor oncologice de ultim\u0103 genera\u021bie\u00a0<\/span><\/strong><span class=\"citation\"><span dir=\"auto\">[9]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. Mecanisme cheie de ac\u021biune (moleculare, fiziologice \u0219i imunologice)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Efectele terapeutice ale hipertermiei corporale totale WBH-wIRA sunt complexe, mediate de modificare la nivel celular, imunitar \u0219i fiziologic:<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\"><span dir=\"auto\">A. Sinergie cu chimioterapia \u0219i radioterapia<\/span><\/h3><ul><li style=\"text-align: left;\"><strong><span dir=\"auto\">Optimizarea micromediului tumoral (TME):<\/span><\/strong><span dir=\"auto\">\u00a0WBH <b>\u00eembun\u0103t\u0103\u021be\u0219te perfuzia<\/b>\u00a0\u0219i\u00a0<strong>oxigenarea\u00a0<\/strong><\/span><strong><span dir=\"auto\">s\u00e2ngelui tumoral<\/span><\/strong><span dir=\"auto\">\u00a0, <b>invers\u00e2nd hipoxia tumoral\u0103<\/b>. Acest lucru este esen\u021bial, deoarece celulele tumorale bine oxigenate sunt semnificative mai susceptibile la distrugere prin\u00a0<strong>chimioterapie<\/strong>\u00a0(CT) \u0219i\u00a0<strong>radioterapie<\/strong>\u00a0(RT)\u00a0<span class=\"citation\">[9, 41]<\/span>\u00a0.<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\">Eficacitate\/radio:<\/span><\/strong><span dir=\"auto\">\u00a0Hipertermia ac\u021bioneaz\u0103 ca un\u00a0<\/span><strong><span dir=\"auto\">chimio- \u0219i radiosensibilizant\u00a0<\/span><\/strong><strong class=\"key-term\"><span dir=\"auto\">,<\/span><\/strong><span dir=\"auto\">\u00a0sporind aportul de oxigen tumoral (\u00a0<\/span><em><span dir=\"auto\">efect de radiosensibilizare<\/span><\/em><span dir=\"auto\">\u00a0) \u0219i sporind eficacitatea medicamentelor precum cisplatina, gemcitabina \u0219i carboplatina\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[12, 16, 36]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\"><span dir=\"auto\">B. Inducerea unui r\u0103spuns imun antitumoral robust (imunomodulare)<\/span><\/h3><p style=\"text-align: left;\"><span dir=\"auto\">Hipertermia Corporala Totala WBH-wIRA este un activator puternic al sistemului de ap\u0103rare al organismului\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[11]<\/span><\/span><span dir=\"auto\">\u00a0:<\/span><\/p><ul><li style=\"text-align: left;\"><strong><span dir=\"auto\">Proteine de \u0219oc termic (HSP):<\/span><\/strong><span dir=\"auto\">\u00a0Stresul termic stimuleaz\u0103 sinteza \u0219i eliberarea\u00a0<\/span><strong><span dir=\"auto\">HSP70 . Aceste proteine ac\u021bioneaz\u0103 ca \u201esemnale de pericol\u201d care marcheaz\u0103 celulele canceroase pentru un atac intensificat din partea\u00a0<\/span><\/strong><strong class=\"key-term\"><span dir=\"auto\">limfocitelor T citotoxice (CTL)<\/span><\/strong>\u00a0<span dir=\"auto\">ale sistemului imunitar\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[9, 10, 29]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\">Activarea celulelor imunitare cheie:<\/span><\/strong><span dir=\"auto\">\u00a0Intervalul de temperatur\u0103 de 39-43\u00a0<\/span><strong><span dir=\"auto\">\u00b0<\/span><\/strong><span dir=\"auto\">\u00a0C cre\u0219te activitatea\u00a0<\/span><strong><span dir=\"auto\">celulelor Natural Killer (NK)<\/span><\/strong><span dir=\"auto\">\u00a0\u0219i favorizeaz\u0103 activitatea\u00a0<\/span><strong><span dir=\"auto\">celulelor T helper Th1 \u0219i citotoxice<\/span><\/strong><span dir=\"auto\">\u00a0,\u00a0<\/span><strong><span dir=\"auto\">a celulelor dendritice\u00a0<\/span><\/strong><span dir=\"auto\"><strong>DC<\/strong>\u00a0\u0219i a\u00a0<\/span><strong><span dir=\"auto\">macrofagelor<\/span><\/strong><span dir=\"auto\">\u00a0,\u00a0<\/span><span dir=\"auto\">compromi\u021b\u00e2nd \u00een timp poten\u021bial celulele imunosupresoare [9<\/span><span class=\"citation\"><span dir=\"auto\">, 10, 11, 25, 26<\/span><\/span><span dir=\"auto\">\u00a0]<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\">Cre\u0219terea num\u0103rului de limfocite T:<\/span><\/strong><span dir=\"auto\">\u00a0FR-WBH poate\u00a0<\/span><strong><span dir=\"auto\">cre\u0219te semnificativ (de exemplu, de 3 ori) popula\u021bia de limfocite T citotoxice CTL<\/span><\/strong><span dir=\"auto\">\u00a0din organele limfoide,\u00a0<\/span><strong class=\"key-term\"><span dir=\"auto\">amplific\u00e2nd astfel atacul imun antitumoral sistemic\u00a0<\/span><\/strong><span class=\"citation\"><span dir=\"auto\">[10]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\">Vaccinuri \u0219i celule prezentatoare de antigen (APC):<\/span><\/strong><span dir=\"auto\">\u00a0HCT-WHT poate regla func\u021bia celulelor prezentatoare de antigen (APC) \u0219i poate cre\u0219te eficacitatea vaccinurilor \u00eempotriva cancerului, inclusiv a celor bazate pe HSP110 \u0219i GRP170 [37, 28].<\/span><\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Dovezi clinice \u0219i sinergie \u00een terapia multimodal\u0103<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\"><span dir=\"auto\">A. Sinergie cu imunoterapia (inhibitori ai punctelor de control \u2013 ICI)<\/span><\/h3><p style=\"text-align: left;\"><span dir=\"auto\">O serie de cazuri retrospective a 131 de pacien\u021bi cu cancer avansat (stadiul IV) a investigat un protocol multimodal care includea\u00a0<\/span><strong><span dir=\"auto\">hipertermie corporal\u0103 total\u0103<\/span><\/strong><span dir=\"auto\">\u00a0al\u0103turi de inhibitori ai punctelor de control (Ipilimumab, Nivolumab) \u0219i IL-2\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[18]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/p><p style=\"text-align: left;\"><strong><span dir=\"auto\">Concluzie cheie:<\/span><\/strong><span dir=\"auto\">\u00a0S-a constatat c\u0103 hipertermia corporal\u0103 total\u0103 HCT cu wIRA este o\u00a0<\/span><strong class=\"key-term\"><span dir=\"auto\">component\u0103 integral\u0103 \u0219i esen\u021bial\u0103<\/span><\/strong><span dir=\"auto\">\u00a0care\u00a0<\/span><strong><span dir=\"auto\">maximizeaz\u0103 r\u0103spunsul imun antitumoral<\/span><\/strong><span dir=\"auto\">\u00a0.\u00a0<\/span><strong><span dir=\"auto\">HCT activeaz\u0103 \u0219i mobilizeaz\u0103 celulele T (prin inducerea HSP70 \u0219i eliberarea de antigene tumorale);<\/span><\/strong><span dir=\"auto\">\u00a0inhibitorii punctelor de control \u201e\u00eendep\u0103rteaz\u0103 fr\u00e2na\u201d de pe aceste celule T preactivate, rezult\u00e2nd<b> rate de r\u0103spuns clinic favorabile neobi\u0219nuit de mari pentru boala avansat\u0103<\/b>\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[18]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h3><span dir=\"auto\">B. Aplica\u021bii clinice \u00een diverse tipuri de cancer<\/span><\/h3><ul><li><strong><span dir=\"auto\">Cancer pancreatic:<\/span><\/strong><span dir=\"auto\">\u00a0Protocoalele de faz\u0103 I-II care utilizeaz\u0103 WBH u\u0219oar\u0103 (FR-WBH) combinate cu chimioterapie \u0219i interferon-alfa au ar\u0103tat\u00a0<\/span><strong><span dir=\"auto\">o regresie tumoral\u0103 de cel pu\u021bin 50% la aproape jum\u0103tate dintre pacien\u021bii rezisten\u021bi la terapie\u00a0<\/span><\/strong><span class=\"citation\"><span dir=\"auto\">[4, 22]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/li><li><strong><span dir=\"auto\">Cancer la s\u00e2n (recidiv\u0103):<\/span><\/strong><span dir=\"auto\">\u00a0WHT combinat\u0103 cu re-iradiere sau radioterapie a demonstrat eficacitate pentru cancerul de s\u00e2n avansat local \u0219i recuren\u021ba peretelui toracic, confirmat\u0103 prin date randomizate\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[39, 40]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/li><li><strong><span dir=\"auto\">Cancer ovarian:<\/span><\/strong><span dir=\"auto\">\u00a0HCT combinat\u0103 cu\u00a0<\/span><strong><span dir=\"auto\">carboplatin\u0103<\/span><\/strong><span dir=\"auto\">\u00a0a fost investigat\u0103 \u00eentr-un studiu de faz\u0103 II pentru cancerul ovarian recurent\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[16, 20]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/li><li><strong><span dir=\"auto\">Cancer colorectal:<\/span><\/strong><span dir=\"auto\">\u00a0WBH wIRA a fost utilizat \u00een contextul terapiei sistemice multi-etape pentru cancer (sCMT) Von Ardenne combinat\u0103 cu chimioterapie \u00eentr-un studiu de faz\u0103 I\/II [15].<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. Ameliorarea rapid\u0103 a durerii \u0219i \u00eembun\u0103t\u0103\u021birea semnificativ\u0103 a calit\u0103\u021bii vie\u021bii (QoL)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\"><span dir=\"auto\">Pacien\u021bii pot experimenta o ameliorare rapid\u0103 a durerii \u0219i o \u00eembun\u0103t\u0103\u021bire general\u0103 a st\u0103rii de bine, a\u0219a cum s-a observat \u00een studiul Dr. Bull\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[12]<\/span><\/span><span dir=\"auto\">\u00a0\u0219i \u00een special \u00een studiul clinic de faz\u0103 III mai recent realizat de Sahinbas \u0219i colab.\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[14]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"text-align: center;\"><div><div><div><div><header><div style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"margin: 0px; padding: 0px; box-sizing: border-box; overflow-wrap: break-word; line-height: normal; font-family: Poppins; font-size: 24px; color: #282828; text-align: left;\"><span dir=\"auto\" style=\"margin: 0px; padding: 0px; box-sizing: border-box; vertical-align: inherit;\"><span dir=\"auto\" style=\"margin: 0px; padding: 0px; box-sizing: border-box; vertical-align: inherit;\">Studiu clinic de faz\u0103 III (2024) pentru metastaze osoase<\/span><\/span><\/h3><div style=\"margin-bottom: 0px; animation-fill-mode: both; align-self: auto; flex: 0 1 auto; order: 0; place-content: normal; align-items: normal; flex-flow: row; gap: 20px; --widgets-spacing: 20px 20px; --widgets-spacing-row: 20px; --widgets-spacing-column: 20px; font-family: Roboto, sans-serif; font-weight: 400; color: #7a7a7a; transition: background 0.3s, border 0.3s, border-radius 0.3s, box-shadow 0.3s, transform 0.4s; --kit-widget-spacing: 0px; max-width: 100%; font-size: 15px;\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\"><div style=\"text-align: center;\"><div><div><div><div><header><div data-delay=\"0\"><header><div style=\"text-align: left;\"><div><section><span dir=\"auto\">\u00cen\u00a0\u00a0<\/span><a style=\"transition-property: all;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\">2024, Sahinbas \u0219i colegii s\u0103i au publicat un studiu de faz\u0103 III<\/span><\/a><span dir=\"auto\">\u00a0privind durerea metastazelor osoase, \u00een principal din cauza cancerului de s\u00e2n \u0219i de prostat\u0103, utiliz\u00e2nd dispozitive de hipertermie WBH wIRA Iratherm \u00een plus fa\u021b\u0103 de radioterapie [14].\u00a0<\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Pe baza acestui studiu, grupul tratat doar cu radioterapie (RT) a prezentat cea mai intens\u0103 durere. Studiul a fost finalizat dup\u0103 \u00eenscrierea unui total de 61 de pacien\u021bi, la 5 ani de la prima \u00eenscriere (aprilie 2016 &#8211; februarie 2021). \u00cen cele din urm\u0103, rata RC \u00een grupul RT + WBH a ar\u0103tat cea mai semnificativ\u0103 diferen\u021b\u0103 cu RT \u00een monoterapie,\u00a0\u00a0<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">47,4% fa\u021b\u0103 de 5,3%, respectiv, \u00een decurs de 2 luni dup\u0103 tratament<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0\u00a0(valoare P &lt; 0,05). Timpul\u00a0\u00a0<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p\u00e2n\u0103 la ameliorarea complet\u0103 a durerii a fost de 10 zile pentru RT + WBH, \u00een timp ce criteriul final nu a fost atins \u00een grupul tratat doar cu RT.<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0\u00a0Progresia durerii sau stabilitatea bolii au fost observate la jum\u0103tate dintre pacien\u021bii din grupul RT \u00een decurs de 4 s\u0103pt\u0103m\u00e2ni dup\u0103 tratament. Cu toate acestea,\u00a0<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0acest scor a fost aproape de zero la pacien\u021bii cu RT + WBH \u00een decurs de dou\u0103 luni dup\u0103 tratament<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0.\u00a0<\/span><\/span><\/span><strong><span dir=\"auto\">Concluzii:\u00a0<\/span><\/strong><span dir=\"auto\">\u00a0\u00a0WBH plus RT a demonstrat cre\u0219teri semnificative ale amelior\u0103rii durerii \u0219i un timp de r\u0103spuns mai scurt comparativ cu RT singur\u0103 la pacien\u021bii cu leziuni osoase metastatice.<\/span><\/section><\/div><\/div><div><table border=\"1\"><thead><tr><th><span dir=\"auto\">Indicator QoL\/\u00cembun\u0103t\u0103\u021birea durerii<\/span><\/th><th><span dir=\"auto\">Monoterapie cu rat\u0103 de radia\u021bie<\/span><\/th><th><span dir=\"auto\">RT + Hipertermie (WBH wIRA)<\/span><\/th><th><span dir=\"auto\">Impactul calit\u0103\u021bii vie\u021bii<\/span><\/th><\/tr><\/thead><tbody><tr><td><strong><span dir=\"auto\">Rata de r\u0103spuns complet (RC) la 2 luni<\/span><\/strong><span dir=\"auto\">\u00a0\u00a0(scor zero durere)<\/span><\/td><td><span dir=\"auto\" style=\"vertical-align: inherit;\">5,3%<\/span><\/td><td><span dir=\"auto\" style=\"vertical-align: inherit;\"><b>47,4%<\/b><\/span><\/td><td><span dir=\"auto\">*\u00a0\u00a0<\/span><strong><span dir=\"auto\">Cre\u0219tere cu 894%<\/span><\/strong><span dir=\"auto\">\u00a0\u00a0* a \u0219anselor de eliminare total\u0103 a durerii.<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Timpul pentru ameliorarea complet\u0103 a durerii<\/span><\/strong><\/td><td><span dir=\"auto\">nu a fost atins<\/span><\/td><td><span dir=\"auto\"><b>10 zile<\/b><\/span><\/td><td><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0\u00a0beneficiu\u00a0<\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\">\u201esemnificativ \u0219i rapid\u201d<\/span><\/strong><\/span><\/span><\/td><\/tr><tr><td style=\"text-align: left;\"><strong><span dir=\"auto\">Durata amelior\u0103rii durerii\u00a0<\/span><\/strong><\/td><td style=\"text-align: left;\"><span dir=\"auto\">Median\u0103: 28 de zile\/4 s\u0103pt\u0103m\u00e2ni la jum\u0103tate dintre pacien\u021bi<\/span><\/td><td style=\"text-align: left;\"><span dir=\"auto\">Median\u0103: <b>Nu a fost inclus\u0103 la 24 de s\u0103pt\u0103m\u00e2ni<\/b><\/span><\/td><td style=\"text-align: left;\"><span dir=\"auto\">Durata amelior\u0103rii *\u00a0\u00a0<\/span><strong><span dir=\"auto\">cre\u0219te de \u0219ase ori<\/span><\/strong><span dir=\"auto\">\u00a0\u00a0*, reduc\u00e2nd dependen\u021ba de analgezice.<\/span><\/td><\/tr><\/tbody><\/table><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div><\/div><div style=\"animation-fill-mode: both; align-self: auto; flex: 0 1 auto; order: 0; place-content: normal; align-items: normal; flex-flow: row; gap: 20px; --widgets-spacing: 20px 20px; --widgets-spacing-row: 20px; --widgets-spacing-column: 20px; font-family: Roboto, sans-serif; font-weight: 400; color: #7a7a7a; transition: background 0.3s, border 0.3s, border-radius 0.3s, box-shadow 0.3s, transform 0.4s; --kit-widget-spacing: 0px; max-width: 100%; font-size: 15px;\" data-id=\"e97cd55\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\"><div style=\"text-align: center;\"><header><div data-delay=\"0\"><header><p style=\"text-align: left;\">\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><div>\u00a0<\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p><span dir=\"auto\">Comparativ cu\u00a0<\/span><a title=\"Studiu de faz\u0103 III Chi MS \u0219i colab. 2017\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\">\u00a0studiul similar de faz\u0103 III publicat de Chi MS \u0219i colab\u00a0<\/span><\/a><span dir=\"auto\">\u00a0. (2017) cu hipertermie locoregional\u0103 RF, beneficiile (\u00a0<em>\u00een ceea ce prive\u0219te calitatea vie\u021bii \u0219i reducerea durerii)<\/em>\u00a0\u00a0ob\u021binute utiliz\u00e2nd hipertermia WBH wIRA au fost mult superioare &#8211; rezultatele studiului RF HT + RT:<\/span><\/p><div><table border=\"1\"><thead><tr><th><span dir=\"auto\">Indicator QoL\/\u00cembun\u0103t\u0103\u021birea durerii<\/span><\/th><th><span dir=\"auto\">Monoterapie cu rat\u0103 de radia\u021bie<\/span><\/th><th><span dir=\"auto\">RT + Hipertermie (RF HT)<\/span><\/th><th><span dir=\"auto\">Impactul calit\u0103\u021bii vie\u021bii<\/span><\/th><\/tr><\/thead><tbody><tr><td><strong><span dir=\"auto\">Rata de r\u0103spuns complet (RC) la 3 luni<\/span><\/strong><span dir=\"auto\">\u00a0\u00a0(scor zero durere)<\/span><\/td><td><span dir=\"auto\">7,1%<\/span><\/td><td><span dir=\"auto\">37,9%<\/span><\/td><td><span dir=\"auto\">Cre\u0219tere cu 533% a \u0219anselor de ameliorare total\u0103 a durerii.<\/span><\/td><\/tr><tr><td><strong><span dir=\"auto\">Durata amelior\u0103rii durerii<\/span><\/strong><\/td><td><span dir=\"auto\">Median\u0103: 55 zile\/7,9 s\u0103pt\u0103m\u00e2ni<\/span><\/td><td><span dir=\"auto\">Median\u0103: Nu a fost inclus\u0103 la 24 de s\u0103pt\u0103m\u00e2ni<\/span><\/td><td><span dir=\"auto\">Durata amelior\u0103rii se tripleaz\u0103, reduc\u00e2nd dependen\u021ba de analgezice.<\/span><\/td><\/tr><\/tbody><\/table><\/div><p><span dir=\"auto\">\u00cen concluzie, dovezile \u0219tiin\u021bifice consolidate (\u00a0<\/span><em><span dir=\"auto\">de la studiile fundamentale privind tehnologia wIRA p\u00e2n\u0103 la studiile clinice cruciale de faz\u0103 III<\/span><\/em><span dir=\"auto\">\u00a0) confirm\u0103 rolul HCT-WBH ca terapie adjuvant\u0103 cu impact multiplu \u00een oncologie:\u00a0<\/span><strong><span dir=\"auto\">spore\u0219te eficacitatea CT\/RT, activeaz\u0103 sistemul imunitar sistemic (inclusiv sinergia cu imunoterapia) \u0219i \u00eembun\u0103t\u0103\u021be\u0219te dramatic controlul durerii \u0219i calitatea vie\u021bii<\/span><\/strong><span dir=\"auto\">\u00a0la pacien\u021bii cu cancer.<\/span><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Beneficii fiziologice sistemice \u0219i poten\u021bial terapeutic \u00een alte patologii<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>C\u0103ldura bl\u00e2nd\u0103 \u0219i controlat\u0103 furnizat\u0103 de WBH cu radia\u021bii wIRA ini\u021biaz\u0103 r\u0103spunsuri termoreglatoare complexe care produc beneficii sistemice ample, extinz\u00e2nd poten\u021bialul terapeutic dincolo de oncologie:<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\"><span dir=\"auto\">A. Managementul musculo-scheletic \u0219i al durerii<\/span><\/h3><p style=\"text-align: left;\"><span dir=\"auto\">HCT-WBH este eficient \u00een gestionarea sindroamelor de durere cronic\u0103, valorific\u00e2nd efectele sale fiziologice asupra tonusului muscular \u0219i microcircula\u021biei:<\/span><\/p><ul><li style=\"text-align: left;\"><strong><span dir=\"auto\">Dorsalgie (durere cronic\u0103 de spate):<\/span><\/strong><span dir=\"auto\">\u00a0Studiile arat\u0103 c\u0103 HCT-WBH u\u0219oar\u0103, atunci c\u00e2nd este combinat\u0103 cu terapia sta\u021bionar\u0103 multimodal\u0103 a durerii, ofer\u0103 beneficii semnificative pentru pacien\u021bii cu durere cronic\u0103 nespecific\u0103 lombar\u0103 (dorsalgie)\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[53, 54]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\">Sindromul fibromialgiei (SFM):<\/span><\/strong><span dir=\"auto\">\u00a0HCT este un tratament adjuvant documentat pentru SFM. Studiile clinice randomizate controlate au demonstrat eficacitatea HCT cu wIRA u\u0219oar\u0103 \u00eentr-un cadru standard de reabilitare multimodal\u0103, ar\u0103t\u00e2nd efecte asupra\u00a0<\/span><strong><span dir=\"auto\">intensit\u0103\u021bii durerii<\/span><\/strong><span dir=\"auto\">\u00a0\u0219i\u00a0<\/span><strong><span dir=\"auto\">st\u0103rii mentale<\/span><\/strong><span dir=\"auto\">\u00a0[\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">17, 56, 57<\/span><\/span><span dir=\"auto\">\u00a0]. Acest beneficiu este par\u021bial legat de \u00eembun\u0103t\u0103\u021birea microcircula\u021biei, o problem\u0103 cunoscut\u0103 la pacien\u021bii cu SFM [55].<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\">Spondilita anchilozant\u0103 (SA):<\/span><\/strong><span dir=\"auto\">\u00a0WBH a demonstrat efecte imunomodulatoare la pacien\u021bii cu SA, studiile raport\u00e2nd capacitatea WBH de a cre\u0219te mediatorii antiinflamatori precum\u00a0<\/span><strong><span dir=\"auto\">interleukina-10<\/span><\/strong><span dir=\"auto\">\u00a0(IL-10) \u0219i de a modula citokinele proinflamatorii precum TNF-\u03b1, suger\u00e2nd un rol benefic \u00een gestionarea inflama\u021biei cronice asociate cu afec\u021biunea\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">[58, 59, 52]<\/span><\/span><span dir=\"auto\">\u00a0.<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\">Fenomenul Raynaud \u00een scleroza sistemic\u0103:<\/span><\/strong><span dir=\"auto\">\u00a0S-a constatat c\u0103 hipertermia mediat\u0103 prin infraro\u0219u WBH wIRA este eficient\u0103 \u00een tratarea simptomelor vasoconstrictive asociate cu fenomenul Raynaud asociat sclerodermiei, demonstr\u00e2nd beneficii vasculare [49].<\/span><\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h3><span dir=\"auto\">B. S\u0103n\u0103tate cardiovascular\u0103 \u0219i circulatorie \u2764\ufe0f<\/span><\/h3><p><span dir=\"auto\">Dincolo de \u00eembun\u0103t\u0103\u021birea perfuziei tumorale, HCT are efecte specifice asupra sistemului circulator:<\/span><\/p><ul><li><strong><span dir=\"auto\">Hipertensiune arterial\u0103 esen\u021bial\u0103:<\/span><\/strong><span dir=\"auto\">\u00a0O serie de studii au investigat utilizarea hipertermiei corporale totale WBH wIR-A u\u0219oare la pacien\u021bii cu hipertensiune arterial\u0103 (stadiile I \u0219i II OMS). Rezultatele indic\u0103 faptul c\u0103 tratamentele seriale pot afecta pozitiv\u00a0<\/span><strong><span dir=\"auto\">undele pulsului central \u0219i periferic<\/span><\/strong><span dir=\"auto\">\u00a0, tensiunea arterial\u0103 \u0219i\u00a0<\/span><strong><span dir=\"auto\">v\u00e2scozitatea s\u00e2ngelui<\/span><\/strong><span dir=\"auto\">\u00a0, confirm\u00e2nd rolul hipertermiei ca op\u021biune de kinetoterapie non-farmacologic\u0103 [\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">44, 47<\/span><\/span><span dir=\"auto\">\u00a0].<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \" style=\"text-align: left;\"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\"><span dir=\"auto\">C. Efecte neuroendocrine \u0219i psihologice<\/span><\/h3><p style=\"text-align: left;\"><span dir=\"auto\">HCT-WBH angajeaz\u0103 sistemele neuro-endocrine ale organismului, influen\u021b\u00e2nd starea de spirit \u0219i metabolismul:<\/span><\/p><ul><li style=\"text-align: left;\"><strong><span dir=\"auto\">Tulburare depresiv\u0103 major\u0103 (TDM):<\/span><\/strong><span dir=\"auto\">\u00a0Un studiu clinic randomizat a demonstrat c\u0103 o singur\u0103 sesiune de terapie cu c\u0103ldur\u0103 poate ac\u021biona ca un antidepresiv cu ac\u021biune rapid\u0103, rezult\u00e2nd o reducere a simptomelor depresive timp de c\u00e2teva s\u0103pt\u0103m\u00e2ni. Acest efect este legat de activarea indus\u0103 de c\u0103ldur\u0103 a c\u0103ilor imune \u0219i inflamatorii care influen\u021beaz\u0103 creierul [51].<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\">Modularea hormonal\u0103 (endocrinologie):<\/span><\/strong><span dir=\"auto\">\u00a0HCT stimuleaz\u0103\u00a0<\/span><strong><span dir=\"auto\">axa hipotalamo-hipofizo-adrenal\u0103 (HPA)<\/span><\/strong><span dir=\"auto\">\u00a0\u0219i influen\u021beaz\u0103 nivelurile hormonale. Studiile au documentat r\u0103spunsurile\u00a0<\/span><strong><span dir=\"auto\">hormonului de cre\u0219tere<\/span><\/strong><span dir=\"auto\">\u00a0\u0219i\u00a0<\/span><strong><span dir=\"auto\">ale prolactinei<\/span><\/strong><span dir=\"auto\">\u00a0\u00een timpul hipertermiei la nivelul \u00eentregului corp, eviden\u021biind impactul acesteia asupra regl\u0103rii endocrine [\u00a0<\/span><span class=\"citation\"><span dir=\"auto\">42, 43<\/span><\/span><span dir=\"auto\">\u00a0].<\/span><\/li><li style=\"text-align: left;\"><strong><span dir=\"auto\">Metabolism \u0219i reac\u021bie celular\u0103:<\/span><\/strong><span dir=\"auto\">\u00a0C\u0103ldura WBH accelereaz\u0103 rata metabolic\u0103 bazal\u0103. La nivel celular, c\u0103ldura influen\u021beaz\u0103 cinetica pO2 \u0219i este legat\u0103 de sinteza proteinelor protectoare precum\u00a0<\/span><strong><span dir=\"auto\">feritina<\/span><\/strong><span dir=\"auto\">\u00a0din piele, sus\u021bin\u00e2nd repararea \u021besuturilor [48; 46].<\/span><\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u00centreb\u0103ri frecvente (FAQ) despre sesiunile Hipertermie Corporala Totala WBH recomandate \u0219i temperaturile \u021bint\u0103<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p><i><span dir=\"auto\">Tratamentele <\/span><\/i><i><span dir=\"auto\">se\u00a0<\/span><\/i><span dir=\"auto\"><i>efectueaz\u0103\u00a0<\/i><\/span><i><span dir=\"auto\">numai\u00a0<\/span><\/i><span dir=\"auto\"><i>dup\u0103\u00a0<\/i><i>consultarea\u00a0<\/i><i>final\u0103\u00a0<\/i><i>cu\u00a0<\/i><i>un\u00a0<\/i><i>medic<\/i><\/span><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div><h4><span dir=\"auto\">Care este protocolul recomandat pentru hipertermia corporal\u0103 total\u0103 (WBH) pentru hipertensiunea arterial\u0103 esen\u021bial\u0103?<\/span><\/h4><div><p><span dir=\"auto\">Protocolul pentru hipertensiunea arterial\u0103 esen\u021bial\u0103 recomand\u0103 12 sesiuni la o temperatur\u0103 \u021bint\u0103 de 38,3 \u00b0C. Fiecare sesiune dureaz\u0103 aproximativ 45 de minute, cuprinz\u00e2nd o faz\u0103 de cre\u0219tere de 30 de minute \u0219i o faz\u0103 de odihn\u0103 de 15 minute (f\u0103r\u0103 faz\u0103 de platou).<\/span><\/p><\/div><\/div><div><h4><span dir=\"auto\">Care sunt parametrii HCT recomanda\u021bi pentru durerea cronic\u0103 de spate (dorsalgia)?<\/span><\/h4><div><p><span dir=\"auto\">Pentru dorsalgie, se recomand\u0103 de obicei 6 \u0219edin\u021be HCT, viz\u00e2nd atingerea unei temperaturi de 38,4 \u00b0C. Durata total\u0103 a \u0219edin\u021bei este de aproximativ 90 de minute, cu o cre\u0219tere de 45 de minute, o faz\u0103 de platou de 15 minute \u0219i o pauz\u0103 de 30 de minute.<\/span><\/p><\/div><\/div><div><h4><span dir=\"auto\">Care este protocolul WBH pentru fibromialgie \u0219i spondilita anchilozant\u0103?<\/span><\/h4><div><p><span dir=\"auto\">At\u00e2t fibromialgia, c\u00e2t \u0219i spondilita anchilozant\u0103 urmeaz\u0103 de obicei un protocol de 6 \u0219edin\u021be HCT, viz\u00e2nd atingerea unei temperaturi de 38,5 \u00b0C. Durata total\u0103 a \u0219edin\u021bei este de aproximativ 90 de minute, inclusiv o cre\u0219tere de 45 de minute, un platou de 15 minute \u0219i o pauz\u0103 de 30 de minute.<\/span><\/p><\/div><\/div><div><h4><span dir=\"auto\">Care este protocolul recomandat pentru HCT ca tratament aditiv pentru cancer?<\/span><\/h4><div><p><span dir=\"auto\">Ca tratament aditiv pentru cancer, protocolul HCT necesit\u0103 6 sau mai multe sesiuni care vizeaz\u0103 o temperatur\u0103 central\u0103 \u00eentre 39,0 \u00b0C \u0219i 40,0 \u00b0C. Durata total\u0103 a sesiunii este cea mai lung\u0103, variind \u00eentre 3 \u0219i 4 ore, incluz\u00e2nd 60-90 de minute pentru faza de cre\u0219tere, 60-90 de minute pentru faza de platou \u0219i 60 de minute pentru faza de repaus.<\/span><\/p><\/div><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div><div class=\"wpb_content_element \"><div><div><div><div class=\"wpb_content_element \"><div><div><p><span dir=\"auto\">.<\/span><\/p><\/div><\/div><div class=\"table-scroll-wrapper\"><table width=\"1151\"><tbody><tr><td width=\"278\"><span dir=\"auto\">Indica\u0163ie<\/span><\/td><td width=\"99\"><span dir=\"auto\">Num\u0103r de sesiuni<\/span><\/td><td width=\"135\"><span dir=\"auto\">Temperatura \u021bint\u0103<\/span><\/td><td colspan=\"2\" width=\"309\"><span dir=\"auto\">Timp de terapie Faza<\/span><br \/><span dir=\"auto\">de cre\u0219tere Faza de platou<\/span><\/td><td width=\"164\"><span dir=\"auto\">Timp de odihn\u0103<\/span><br \/><span dir=\"auto\">Faza de odihn\u0103<\/span><\/td><td width=\"164\"><b><\/b><span dir=\"auto\"><b>Timp\u00a0<\/b><b>total\u00a0<\/b><b>sesiune<\/b><\/span><br \/><b><span dir=\"auto\">HCT-WBH<\/span><\/b><b><\/b><b><\/b><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\"><span dir=\"auto\">Hipertensiune arterial\u0103 esen\u021bial\u0103<\/span><\/td><td rowspan=\"2\" width=\"99\"><span dir=\"auto\">12<\/span><\/td><td rowspan=\"2\" width=\"135\"><span dir=\"auto\">38,3 \u00b0C<\/span><\/td><td colspan=\"2\" width=\"309\"><b><span dir=\"auto\">30 de minute<\/span><\/b><\/td><td rowspan=\"2\" width=\"164\"><span dir=\"auto\">15 minute<\/span><\/td><td rowspan=\"2\" width=\"164\"><b><span dir=\"auto\">~ 45 min<\/span><\/b><\/td><\/tr><tr><td width=\"155\"><span dir=\"auto\">30 de minute<\/span><\/td><td width=\"155\"><span dir=\"auto\">0 minute<\/span><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\"><span dir=\"auto\">Dorsalgie<\/span><\/td><td rowspan=\"2\" width=\"99\"><span dir=\"auto\">6<\/span><\/td><td rowspan=\"2\" width=\"135\"><span dir=\"auto\">38,4 \u00b0C<\/span><\/td><td colspan=\"2\" width=\"309\"><b><span dir=\"auto\">60 de minute<\/span><\/b><\/td><td rowspan=\"2\" width=\"164\"><span dir=\"auto\">30 de minute<\/span><\/td><td rowspan=\"2\" width=\"164\"><b><span dir=\"auto\">~ 90 de minute<\/span><\/b><\/td><\/tr><tr><td width=\"155\"><span dir=\"auto\">45 de minute<\/span><\/td><td width=\"155\"><span dir=\"auto\">15 minute<\/span><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\"><span dir=\"auto\">Fibromialgie<\/span><\/td><td rowspan=\"2\" width=\"99\"><span dir=\"auto\">6<\/span><\/td><td rowspan=\"2\" width=\"135\"><span dir=\"auto\">38,5 \u00b0C<\/span><\/td><td colspan=\"2\" width=\"309\"><b><span dir=\"auto\">60 de minute<\/span><\/b><\/td><td rowspan=\"2\" width=\"164\"><span dir=\"auto\">30 de minute<\/span><\/td><td rowspan=\"2\" width=\"164\"><b><span dir=\"auto\">~ 90 de minute<\/span><\/b><\/td><\/tr><tr><td width=\"155\"><span dir=\"auto\">45 de minute<\/span><\/td><td width=\"155\"><span dir=\"auto\">15 minute<\/span><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\"><span dir=\"auto\">Spondilita ancolizant\u0103<\/span><\/td><td rowspan=\"2\" width=\"99\"><span dir=\"auto\">6<\/span><\/td><td rowspan=\"2\" width=\"135\"><span dir=\"auto\">38,5 \u00b0C<\/span><\/td><td colspan=\"2\" width=\"309\"><b><span dir=\"auto\">60 de minute<\/span><\/b><\/td><td rowspan=\"2\" width=\"164\"><span dir=\"auto\">30 de minute<\/span><\/td><td rowspan=\"2\" width=\"164\"><b><span dir=\"auto\">~ 90 de minute<\/span><\/b><\/td><\/tr><tr><td width=\"155\"><span dir=\"auto\">45 de minute<\/span><\/td><td width=\"155\"><span dir=\"auto\">15 minute<\/span><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\"><span dir=\"auto\">Scleroz\u0103 sistemic\u0103<\/span><\/td><td rowspan=\"2\" width=\"99\"><span dir=\"auto\">15<\/span><\/td><td rowspan=\"2\" width=\"135\"><span dir=\"auto\">38,3 \u00b0C<\/span><\/td><td colspan=\"2\" width=\"309\"><b><span dir=\"auto\">30 de minute<\/span><\/b><\/td><td rowspan=\"2\" width=\"164\"><span dir=\"auto\">15 minute<\/span><\/td><td rowspan=\"2\" width=\"164\"><b><span dir=\"auto\">~ 45 min<\/span><\/b><\/td><\/tr><tr><td width=\"155\"><span dir=\"auto\">30 de minute<\/span><\/td><td width=\"155\"><span dir=\"auto\">0 minute<\/span><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\"><span dir=\"auto\">Tulburare depresiv\u0103 major\u0103<\/span><\/td><td rowspan=\"2\" width=\"99\"><span dir=\"auto\">1+<\/span><\/td><td rowspan=\"2\" width=\"135\"><span dir=\"auto\">38,5 \u00b0C<\/span><\/td><td colspan=\"2\" width=\"309\"><b><span dir=\"auto\">105 &#8211; 170 minute<\/span><\/b><\/td><td rowspan=\"2\" width=\"164\"><span dir=\"auto\">30 de minute<\/span><\/td><td rowspan=\"2\" width=\"164\"><b><span dir=\"auto\">~ 2-3\u00a0<\/span><\/b><b><span dir=\"auto\">ore<\/span><\/b><\/td><\/tr><tr><td width=\"155\"><span dir=\"auto\">45-110 minute<\/span><\/td><td width=\"155\"><span dir=\"auto\">60 de minute<\/span><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\"><span dir=\"auto\">Tratamentul aditiv al cancerului<\/span><\/td><td rowspan=\"2\" width=\"99\"><span dir=\"auto\">2+<\/span><\/td><td rowspan=\"2\" width=\"135\"><span dir=\"auto\">39,0-40,0 \u00b0C<\/span><\/td><td colspan=\"2\" width=\"309\"><b><span dir=\"auto\">120-180 minute<\/span><\/b><\/td><td rowspan=\"2\" width=\"164\"><span dir=\"auto\">60 de minute<\/span><\/td><td rowspan=\"2\" width=\"164\"><b><span dir=\"auto\">~ 3-4\u00a0<\/span><\/b><b><span dir=\"auto\">ore<\/span><\/b><\/td><\/tr><tr><td width=\"155\"><span dir=\"auto\">60-90 minute<\/span><\/td><td width=\"155\"><span dir=\"auto\">60-90 minute<\/span><\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div><div id=\"ut-row-inner-68e7a7d03e7dd\" class=\"vc_row wpb_row vc_inner vc_row-fluid ut-row-inner-68e7a7d03e7ec\"><div class=\"wpb_column vc_column_container vc_col-sm-6\"><div id=\"ut-column-inner-68e7a7d03eb05\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"wpb_content_element\"><div id=\"ut_bi_68e7a7d03ebdb\" class=\"bklyn-big-icon-wrap\"><div class=\"bklyn-big-icon bklyn-big-icon-square\">\u00a0<\/div><p class=\"bklyn-big-icon-title\">\u00a0<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>NOT\u0102: acest articol nu este o list\u0103 exhaustiv\u0103 a studiilor \u0219i efectelor HCT-WBH wIRA<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Referin\u021be \u0219i cit\u0103ri<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><ol><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Ardenne M. von. Moderat Hyperthermie als Behandlungsmethode mit vielen Indikationen. \u00c4rztzeitschr Naturheilverf 1994; 5:356-61.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">B\u00e4umler H., Scherf HP, Aurisch R., \u0219i colab. Einflu\u00df einer Serie von Infrarot-Ganzk\u00f6rperbestrahlungen auf Flie\u00dfeigenschaften des Blutes und die H\u00e4modynamik. Perfusion 1990: 138-43.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Heckel M. Ganzk\u00f6rper-Hyperthermie und Fiebertherapie, Grundlagen und Praxis. Stuttgart: Hippokrates Verlag, 1990.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Kosaka M., Sugahara T., Schmidt KL, Simon E. Termoterapie: principii \u0219i practic\u0103. Heidelberg: Springer Verlag, 2000.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Meffert H., Hecht HC, G\u00fcnther H., \u0219i colab. Biophysikalische Ergebnisse des klinischen Tests der IRA-Therm-Hyperthermietechnik der 2. Genera\u021bie. ThermoMed 1990; 6:71-78.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Schmidt KL Hyperthermie und Fieber, Wirkungen bei Mensch und Tier. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1987.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Vaupel P., Kr\u00fcger W. W\u00e4rmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsm\u00f6glichkeiten. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1995.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Piazena H., Meffert H. Optische Eigenschaften der Haut und die photobiologischen Grundlagen zur Dosierung von IR-Hautbestrahlungen in vivo \u0219i in vitro. 6. Simpozion Licht und Gesundheit 2008 13.-14.03. Berlin, 2008:162-178.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Zschaeck S. \u0219i Beck M. Capitolul 8 Hipertermia corporal\u0103 integral\u0103 \u00een oncologie: Rena\u0219terea \u00een era imunoterapiei?<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Zhang H, Wang W, Zhang S, Huang W. Compara\u021bie a efectelor antitumorale ale diferitelor protocoale de hipertermie corporal\u0103\u2026 Immunol Invest. 2005;34(3):245-58.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Abreu MM, Chocron AF, Smadja DM. De la rece la cald: mecanisme ale hipertermiei \u00een modularea imunologiei tumorale pentru imunoterapie \u00eembun\u0103t\u0103\u021bit\u0103. Front Immunol. 28 februarie 2025;16:1487296.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Bull JMC \u0219i colab. Terapie termic\u0103 a \u00eentregului corp cu valori ale febrei, combinat\u0103 cu cisplatin\u0103, gemcitabin\u0103 \u0219i interferon-\u03b1 administrat zilnic: O descriere a unui protocol de faz\u0103 I-II. Journal of Hyperthermia. 2008; 24(8): 649-662.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Weigelin B. Vizualizarea efectului imun al hipertermiei. ICHO 2021, Sesiune: Hipertermie \u0219i imunologie.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Faghihi Moghaddam F, Bakhshandeh M, Mofid B \u0219i al\u021bii. Eficacitatea clinic\u0103 a hipertermiei corporale integrale \u0219i a radioterapiei cu fascicul extern (EBRT) combinate versus EBRT singur\u0103\u2026 J Therm Biol. 2024 Feb;120:103804.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Hildebrandt B, Dr\u00e4ger J, Kerner T. \u0219i al\u021bii. Hipertermie corporal\u0103 integral\u0103 \u00een cadrul terapiei sistemice multi-etape pentru cancer (sCMT) a lui von Ardenne&#8230; International Journal of Hyperthermia. 2004;3:317\u2013333.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Atmaca A., Al-Batran SE, Neumann A. \u0219i al\u021bii. Hipertermie corporal\u0103 integral\u0103 (HTC) \u00een combina\u021bie cu carboplatin\u0103 la pacien\u021bii cu cancer ovarian recurent \u2013 un studiu de faz\u0103 II. Gynecol Oncol 2009; 2:384-88.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Brockow T., Wagner A., Franke A., Offenb\u00e4cher M., Resch KL Un studiu controlat randomizat privind eficacitatea hipertermiei corporale integrale \u00een infraro\u0219u apropiat, filtrat\u0103 cu ap\u0103 u\u0219oar\u0103&#8230; Clin J Pain 2007; 1:67-75.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Kleef R, Nagy R, Baierl A \u0219i colab. Ipilimumab \u00een doze mici plus Nivolumab combinat cu IL-2 \u0219i hipertermie la pacien\u021bii cu cancer cu boal\u0103 avansat\u0103: constat\u0103ri exploratorii ale unei serii de cazuri\u2026 Cancer Immunol Immunother. 2021;70:1393\u2013403.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Adachi H., Katsuno M., Waza M. \u0219i colab. Proteinele de \u0219oc termic \u00een bolile neurodegenerative: roluri patogene \u0219i implica\u021bii terapeutice. Int J Hyperthermia 2009; 8:647-54.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Atmaca A., Al-Batran SE, Neumann A., et al. Hipertermie corporal\u0103 integral\u0103 (HTC) \u00een combina\u021bie cu carboplatin\u0103\u2026 Gynecol Oncol 2009; 2:384-88.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Bull JM, Scott GL, Figueroa G. \u0219i al\u021bii. O actualizare a unui studiu clinic de faz\u0103 II care utilizeaz\u0103 terapia termic\u0103 a \u00eentregului corp \u00een func\u021bie de intervalul febril (FR-WB-TT)&#8230; Reuniunea anual\u0103 comun\u0103 a Soc for Thermal Med, 14-17.5.2007.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Bull JM, Scott GL, Strebel FR \u0219i al\u021bii. Terapie termic\u0103 a \u00eentregului corp cu valori ale febrei, combinat\u0103 cu cisplatin\u0103, gemcitabin\u0103 \u0219i interferon-\u03b1 zilnic: O descriere a unui protocol de faz\u0103 I-II. Int J Hyperthermia 2008; 8:649-62.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Bull JM, Nagle VL, Scott G. \u0219i al\u021bii. Un studiu de faz\u0103 I privind administrarea optim\u0103 de Gemcitabin\u0103 + Cisplatin\u0103\/Interferon-a \u00een combina\u021bie cu hipertermie corporal\u0103 de lung\u0103 durat\u0103 \u0219i la temperatur\u0103 sc\u0103zut\u0103. ESHO 2001, Verona\/Italia, 30.05.-02.06.2001:67.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Capitano M., Mace T., Nemeth M. \u0219i al\u021bii. O strategie nou\u0103 pentru \u00eembun\u0103t\u0103\u021birea recuper\u0103rii neutrofilelor dup\u0103 iradierea total\u0103 a corpului. \u00cent\u00e2lnirea anual\u0103 comun\u0103 a Societ\u0103\u021bii pentru Thermal Med, 24-26.4.2010.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Dayanc BE, Ostberg JR, Repasky EA \u00cembun\u0103t\u0103\u021birea activit\u0103\u021bii citotoxice a celulelor NK prin stres termic u\u0219or. Reuniunea anual\u0103 a Societ\u0103\u021bii de Medicin\u0103 Thermal\u0103, 6-8.4.2006.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Hajto T., Hostanska K. Efectul hipertermiei in vivo asupra celulelor killer naturale umane. Clin Trials J 1985; 6:514-20.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Hattori T., Kokura S., Okuda T. \u0219i al\u021bii. Efect antitumoral al hipertermiei la nivelul \u00eentregului corp cu \u03b1-galactozilceramid\u0103 \u00eentr-un model tumoral subcutanat de cancer de colon. Int J Hyperthermia 2007; 7:591-98.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Kisailus A., Pritchard M., Li Y., Ostberg J., Repasky EA Reglarea termic\u0103 a celulelor prezentatoare de antigen: utilizarea hipertermiei ca adjuvant pentru vaccinurile \u00eempotriva cancerului. Reuniunea anual\u0103 a Societ\u0103\u021bii Thermal Med, 6-8.4.2006.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Multhoff G. Scrisoare c\u0103tre editor, Comentariu clasic despre hipertermie: Activarea celulelor killer naturale (NK) prin proteina de \u0219oc termic 70\u2026 Int J Hyperthermia 2009; 3:176-79.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Peer AJ, Grimm MJ, Zynda ER, Repasky EA Diverse mecanisme imune pot contribui la beneficiul \u00een ceea ce prive\u0219te supravie\u021buirea observat la pacien\u021bii cu cancer care primesc hipertermie. Immunol Res 2010; 1-3:137-154.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Rowe RW, Stebel FR, Proett JM \u0219i al\u021bii. Termoterapie corporal\u0103 integral\u0103 cu grad ridicat de febr\u0103 combinat\u0103 cu oxaliplatin\u0103: un regim curativ \u00eentr-un model preclinic de cancer mamar. Int J Hyperthermia 2010; 6:565-76.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Schencking M., Frese T., Sandholzer H. Behandlung einer Radikulopathie bei oss\u00e4rer Metastasierung der Lendenwirbels\u00e4ule durch Infrarot-A-Ganzk\u00f6rperhyperthermie. Forsch Komplementmed 2008; 15:273-76.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Scott GL, Bull JMC, Kochn M. Managementul sed\u0103rii con\u0219tiente\u2026 Al 9-lea Congres Interna\u021bional de Oncologie Hipertermic\u0103, 20-24.4.2004.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Shecterle LM, Cyr JAS Hipertermia ajut\u0103 pacien\u021bii cu cancer pulmonar avansat. Reuniunea anual\u0103 a Societ\u0103\u021bii de Medicin\u0103 Termal\u0103, 6-8.4.2006.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Skitzki JJ, Repasky EA, Evans SS Hipertermia ca strategie de imunoterapie pentru cancer. Current Opnion in Investigational Drugs 2009; 6: 550-58.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Toyota N., Strebel FR, Stephens LC \u0219i al\u021bii. Hipertermie u\u0219oar\u0103, de lung\u0103 durat\u0103, la nivelul \u00eentregului corp, cu cisplatin\u0103: r\u0103spunsul tumoral \u0219i cinetica apoptozei \u0219i necrozei\u2026 Int. J. Hyperthermia 1997; 5:497-506.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Wang XY, Kazim L., Repasky EA, Subjeck JR Caracterizarea proteinei de \u0219oc termic 110 \u0219i a proteinei 170 reglate de glucoz\u0103 ca vaccinuri \u00eempotriva cancerului\u2026 J of Immunology 2001; 165:490-97.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">VanderZee J., DeBruijne M., Mens JWM \u0219i al\u021bii. Reiradierea combinat\u0103 cu hipertermie \u00een recuren\u021bele cancerului de s\u00e2n\u2026 Int J Hyperthermia 2010; 7:638-48.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Zagar TM, Oleson JR, Vujaskovic Z., \u0219i al\u021bii. Hipertermie pentru cancerul de s\u00e2n local avansat. Int J Hyperthermia 2010; 7:618-24.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Zagar TM, Oleson JR, Vujaskovic Z., \u0219i al\u021bii. Hipertermie combinat\u0103 cu radioterapie pentru cancerul mamar superficial \u0219i recidiva peretelui toracic\u2026 Int J Hyperthermia 2010; 7: 612\u201317.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Sen A., Capitano M., Dommer M. \u0219i colab. R\u0103spunsurile termoreglatoare la stresul termic sistemic u\u0219or cresc perfuzia tumoral\u0103\u2026 Cancer Res. 2011; 71(11):3872-3880.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Koska J., Rovensky J., Zimanova T., Vigas M. R\u0103spunsurile la hormonul de cre\u0219tere \u0219i prolactin\u0103 \u00een timpul imersiunilor par\u021biale \u0219i totale \u00een ap\u0103 cald\u0103. Acta Physiol Scand. Mai 2003;178(1):19-23.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Vigas M., Rovensky J., Zimanova T., Koska J. R\u0103spunsurile hormonului de cre\u0219tere \u0219i prolactinei la aplicarea local\u0103 \u0219i pe \u00eentregul corp a n\u0103molului Piestany. Acta Rheumatol et Balneol Pistiniana 2002:31-38.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Meffert B., Hochmuth O., Steiner M. Efectele hipertermiei induse de radia\u021bii infraro\u0219ii u\u0219oare multiple asupra undelor de puls centrale \u0219i periferice la pacien\u021bii hipertensivi. Conferin\u021ba M\u0103rii Nordului privind Ingineria Biomedical\u0103 1990.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Meffert H., Scherf HP., Meffert B. Milde Infrarot-A-Hyperthermie. Auswirkungen von Serienbestrahlungen mit wassergefilterter Infrarotstrahlung\u2026 Akt Dermatol 1993; 19:142-48.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Applegate LA, Scaletta C., Panizzon R. \u0219i colab. Inducerea presupusei proteine feritin\u0103 prin radia\u021bii infraro\u0219ii: Implica\u021bii \u00een repararea pielii. Int J of Molecular Med 2000; 5:247-51.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Scherf HP, Meffert H., B\u00e4umler H., \u0219i colab. Wirkung einer einmaligen milden Infrarot-A-Hyperthermie auf K\u00f6rpertemperatur, Herzfrequenz, Blutdruck und Blutviskosit\u00e4t\u2026 Dermatol Monatsschr 1989; 175:733-40.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Streffer C. Modific\u0103ri metabolice \u00een timpul \u0219i dup\u0103 hipertermie. Int J Hyperthermia 1985; 4:305-319.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">F\u00f6rster J., Fleischanderl S., Wittstock S. \u0219i al\u021bii. Hipertermia mediat\u0103 prin infraro\u0219u este eficient\u0103 \u00een tratamentul fenomenului Raynaud asociat cu sclerodermia. J of Investigative Dermatology 2005; 6:1313-16.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Koska J., Rovensky J., Zimanova T., et al. Reglarea simpatoadrenal\u0103 a r\u0103spunsurilor circulatorii la hipertermia la nivelul \u00eentregului corp\u2026 Acta Rheumatol et Balneol Pistiniana 2002:23-30.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Janssen CW, Lowry CA, Mehl MR \u0219i al\u021bii. Hipertermie corporal\u0103 integral\u0103 pentru tratamentul tulbur\u0103rii depresive majore &#8211; Un studiu clinic randomizat. JAMA Psychiatry. 12 mai 2016.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Tarner IH, Ladner UM, Uhlemann C., Lange U. Efectul hipertermiei u\u0219oare a \u00eentregului corp asupra nivelurilor sistemice de TNF-alfa, IL-1 beta \u0219i IL-6 la pacien\u021bii cu spondilit\u0103 anchilozant\u0103. Clin Rheumatol 2009; 4:397-402.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Ettrich U., Konrad B., Prate K., et al. Milde Ganzk\u00f6rperhyperthermie in Kombination mit station\u00e4rer multimodal orientierter Schmerztherapie\u2026 Orthop\u00e4de 2014; 2:165-74.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Weller E., Ullrich D. Infrarot-A-Hyperthermie-Anwendung bei Patienten mit Analgetica-Abusus wegen chronischer R\u00fcckenschmerzen. Vortrag auf dem 95. Kongre\u00df der Gesellschaft f\u00fcr Phys Med und Rehab 5.10.1990.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Morf S., Vesti BA, Forster A. \u0219i colab. Anomalii ale microcircula\u021biei la pacien\u021bii cu fibromialgie \u2013 m\u0103surate prin fluxometrie capilar\u0103 \u0219i cu laser. Arthritis Res Ther 2005; 7:R209-16.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Walz J., Hinzmann J., Haase I., Witte T. Ganzk\u00f6rperhyperthermie in der Schmerztherapie \u2013 eine controlierte Studie an Patienten mit Fibromyalgiesyndrom. Schmerz 2013; 27:38-45.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Romeyke T., Stummer H. Terapia multimodal\u0103 a durerii \u00een sindromul fibromialgiei cu integrarea hipertermiei sistemice a \u00eentregului corp\u2026 J Musculoskel Pain 2014; 4:341-55.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Zauner D., Quehenberger F., Hermann J. \u0219i al\u021bii. Tratamentul hipertermiei la nivelul \u00eentregului corp cre\u0219te expresia interleukinei 10 \u0219i a receptorilor Toll-like 4 la pacien\u021bii cu spondilit\u0103 anchilozant\u0103: Un studiu pilot. Int J Hyperthermia 2014; 6:393-401.<\/span><\/span><\/li><li style=\"text-align: left;\"><span dir=\"auto\"><span dir=\"auto\">Lange U., M\u00fcller-Ladner U., Dischereit G. Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis\u2026 Akt Rheumatol 2017; 2:122-128.<\/span><\/span><\/li><\/ol><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><\/section><footer><span dir=\"auto\">\u00a9<\/span><time><span dir=\"auto\">2025 <\/span><\/time><span dir=\"auto\">Societatea Rom\u00e2n\u0103 de Hipertermie Oncologic\u0103 Toate drepturile rezervate. Sursa: Analiz\u0103 bazat\u0103 pe literatura \u0219tiin\u021bific\u0103.<\/span><\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Hipertermia Corporal\u0103 Total\u0103 (HCT-WBH) \u00een oncologie \u0219i alte patologii: sinergie consolidat\u0103, imunomodulare \u0219i dovezi din studii clinice Publicat: 13.10.2025 | Ultima recenzie: 13.10.2025 DeDr. Veronica Iatan,\u00a0Cristian Gologan, M.Sc. Hipertermia corporal\u0103 total\u0103 (HCT-WBH) este o strategie oncologic\u0103 sistemic\u0103 ce implic\u0103 \u00eenc\u0103lzirea controlat\u0103 a temperaturii centrale a corpului, adesea utiliz\u00e2nd tehnologia radiatie infraro\u0219u-A filtrata cu ap\u0103 (wIRA).<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/ro\/studii-clinice-hipertermie-totala-wbh-wira\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-985","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/ro\/wp-json\/wp\/v2\/pages\/985","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/ro\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/ro\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/ro\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/ro\/wp-json\/wp\/v2\/comments?post=985"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/ro\/wp-json\/wp\/v2\/pages\/985\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/ro\/wp-json\/wp\/v2\/media?parent=985"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}