{"id":987,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2025-12-19T20:11:33","modified_gmt":"2025-12-19T20:11:33","slug":"klinicke-studie-hypertermia-wira-onkologia","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/sk\/klinicke-studie-hypertermia-wira-onkologia\/","title":{"rendered":"Klinick\u00e9 \u0161t\u00fadie"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"987\" class=\"elementor elementor-987 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Celotelov\u00e1 Hypertermia (WBH) v Onkol\u00f3gii a In\u00fdch Patol\u00f3gi\u00e1ch: Konsolidovan\u00e1 Synergia, Imunomodul\u00e1cia a Klinick\u00e9 \u0161t\u00fadie<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header><p><strong>Zverejnen\u00e9:\u00a0<time datetime=\"2025-10-13\">2025-10-13<\/time>\u00a0| Posledn\u00e1 \u00daprava:\u00a0<time datetime=\"2025-10-13\">2025-10-13<\/time><\/strong><\/p><\/header><div class=\"authors\"><p>Autori:<br \/><a href=\"https:\/\/ardenneiratherm.com\/sk\/our-team\/veronica-iatan\/\">Veronica Iatan, M.D.<\/a>,<br \/><a href=\"https:\/\/ardenneiratherm.com\/sk\/our-team\/cristian-gologan\/\">Cristian Gologan, M.Sc.<\/a><\/p><\/div><section class=\"ai-summary\"><p><strong>Celotelov\u00e1 Hypertermia (WBH)<\/strong> je syst\u00e9mov\u00e1 onkologick\u00e1 strat\u00e9gia zah\u0155\u0148aj\u00faca kontrolovan\u00e9 zv\u00fd\u0161enie telesnej teploty, \u010dasto s vyu\u017eit\u00edm technol\u00f3gie <strong>vody-filtrovan\u00e9ho infra\u010derven\u00e9ho \u017eiarenia A (wIRA)<\/strong>. WBH je prim\u00e1rne <strong>Chemo\/R\u00e1dio-senzibiliz\u00e1tor<\/strong>, ktor\u00fd v\u00fdznamne zlep\u0161uje perf\u00faziu a okysli\u010denie n\u00e1doru, \u010d\u00edm zvy\u0161uje \u00fa\u010dinnos\u0165 tradi\u010dn\u00fdch terapi\u00ed. Z\u00e1sadne p\u00f4sob\u00ed ako siln\u00fd <strong>Syst\u00e9mov\u00fd Imunomodul\u00e1tor<\/strong>, mobilizuj\u00faci Prote\u00edny Teplotn\u00e9ho \u0160oku (PT\u0160) a T-lymfocyty. T\u00e1to \u010dinnos\u0165 vytv\u00e1ra esenci\u00e1lnu synergiu s pokro\u010dilou <strong>Imunoterapiou (ICI)<\/strong>\u00a0a poskytuje dramatick\u00fa, r\u00fdchlu \u00fa\u013eavu od bolesti, ako aj podstatn\u00e9 zlep\u0161enie Kvality \u017divota (K\u017d) pri r\u00f4znych typoch rakoviny a chronick\u00fdch stavoch, ako je Fibromyalgia.<\/p><\/section><section class=\"disclaimer\"><strong>Lek\u00e1rske Zrieknutie sa Zodpovednosti: Tento \u010dl\u00e1nok je ur\u010den\u00fd len na informa\u010dn\u00e9 \u00fa\u010dely a v \u017eiadnom pr\u00edpade nenahr\u00e1dza individu\u00e1lne lek\u00e1rske poradenstvo, diagnostiku alebo lie\u010dbu predp\u00edsan\u00fa licencovan\u00fdm lek\u00e1rom.<\/strong><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. Defin\u00edcia Celotelovej Hypertermie (WBH) a Terapeutick\u00e1 Technol\u00f3gia<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\"><strong>Celotelov\u00e1 Hypertermia (WBH)<\/strong>, alebo \u201esyst\u00e9mov\u00e1 hypertermia\u201c, je definovan\u00e1 ako kontrolovan\u00e9 zv\u00fd\u0161enie vn\u00fatornej telesnej teploty na terapeutick\u00e9 \u00fa\u010dely. Na z\u00e1klade spektra <strong>\u00fa\u010dinkov prirodzenej hor\u00fa\u010dky pri r\u00f4znych teplot\u00e1ch<\/strong> sa WBH postupy rozli\u0161uj\u00fa nasledovne:<\/p><ul style=\"text-align: left;\"><li><strong>Mierna WBT:<\/strong> &lt; 38.5<strong>\u00b0<\/strong>C<\/li><li><strong>Stredne \u0165a\u017ek\u00e1 WBT:<\/strong> 38.5<strong>\u00b0<\/strong>C \u2013 40.5 <strong>\u00b0<\/strong>C<\/li><li><strong>Extr\u00e9mna WBT:<\/strong> &gt; 40.5<strong>\u00b0<\/strong>C<\/li><\/ul><p style=\"text-align: left;\">Najm\u00e4 mierna a stredne \u0165a\u017ek\u00e1 WBH zvy\u0161uje perf\u00faziu, stimuluje metabolizmus, zni\u017euje svalov\u00fd tonus a <strong>stimuluje imunitn\u00fd syst\u00e9m.<\/strong><\/p><p style=\"text-align: left;\"><a href=\"https:\/\/ardenneiratherm.com\/sk\/ardenne-iratherm-hypertermicke-zariadenie\/\"><strong>\u00a0Zariadenie von Ardenne IRATHERM\u00ae 1000M WBH wIRA<\/strong><\/a> pou\u017e\u00edva na tento \u00fa\u010del v\u00fdhradne pre poko\u017eku kompatibiln\u00e9, do h\u013abky prenikaj\u00face, vodou filtrovan\u00e9 infra\u010derven\u00e9 A \u017eiarenie (wIRA) (bez IR-B \/ IR-C). Jeho ne-klaustrof\u00f3bny, otvoren\u00fd syst\u00e9mov\u00fd dizajn zabezpe\u010duje rovnomern\u00fa intenzitu o\u017eiarenia po celej \u00farovni pacienta (chrbta) a pon\u00faka u\u017e\u00edvate\u013eovi optim\u00e1lnu, pacientom \u0161pecifick\u00fa dod\u00e1vku tepla z h\u013eadiska polohy a intenzity.<\/p><p style=\"text-align: left;\">Vodou filtrovan\u00e9 infra\u010derven\u00e9 A \u017eiarenie zodpoved\u00e1 prirodzen\u00e9mu tepeln\u00e9mu \u017eiareniu slnka, \u010d\u00edm poskytuje technologick\u00fd z\u00e1klad pre rovnomern\u00fa a \u0161etrn\u00fa aplik\u00e1ciu tepla [1, 5, 7, 8].<\/p><p style=\"text-align: left;\">Vyu\u017eit\u00edm princ\u00edpu von Ardenne IRATHERM<sup>\u00ae<\/sup> 1000, ktor\u00fd bol vyvinut\u00fd a preuk\u00e1zan\u00fd po dobu viac ako 30 rokov, sa [link: Prof. Manfred von Ardenne &#8211; Pr\u00edspevky] Profesorovi Manfredovi von Ardenne podarilo toto tepeln\u00e9 \u017eiarenie fyzicky a technicky reprodukova\u0165 a priemyselne spr\u00edstupni\u0165 pre trvalo udr\u017eate\u013en\u00e9 lek\u00e1rske pou\u017eitie prostredn\u00edctvom celotelovej hypertermie.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Vedeck\u00e9 Z\u00e1klady a Syst\u00e9mov\u00e9 \u00da\u010dinky<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">WBH sa vyvinula do strat\u00e9gie zalo\u017eenej na pevn\u00fdch bi ofyziologick\u00fdch princ\u00edpoch. V onkol\u00f3gii sa zameriava na <strong>stredne \u0165a\u017ek\u00fa (Moderate)<\/strong> a <strong>hypertermiu v rozsahu hor\u00fa\u010dky (FR-WBH)<\/strong>, uzn\u00e1van\u00fa ako lie\u010dba s viacer\u00fdmi terapeutick\u00fdmi indik\u00e1ciami [1, 3].<\/p><p style=\"text-align: left;\">Technologick\u00fd z\u00e1klad pre rovnomern\u00fa a \u0161etrn\u00fa aplik\u00e1ciu tepla \u010dasto poskytuj\u00fa zariadenia vyu\u017e\u00edvaj\u00face <strong>vodou filtrovan\u00e9 Infra\u010derven\u00e9 A \u017eiarenie (wIRA)<\/strong>. Podrobn\u00e9 biofyzik\u00e1lne \u0161t\u00fadie potvrdili <strong>schopnos\u0165 tejto technol\u00f3gie zabezpe\u010di\u0165 hlbok\u00e9 a kontrolovan\u00e9 zahrievanie<\/strong>, s oh\u013eadom na optick\u00e9 vlastnosti ko\u017ee a fotobiologick\u00e9 z\u00e1klady pre dozimetriu [5, 7, 8].<\/p><p style=\"text-align: left;\">Podrobn\u00e9 biofyzik\u00e1lne \u0161t\u00fadie potvrdili schopnos\u0165 <strong>technol\u00f3gie wIRA<\/strong> zabezpe\u010di\u0165 <strong>hlbok\u00e9 a kontrolovan\u00e9 zahrievanie<\/strong> [5, 7, 8]. Na fyziologickej \u00farovni m\u00e1 WBH z\u00e1sadn\u00e9 syst\u00e9mov\u00e9 \u00fa\u010dinky:<\/p><ol style=\"text-align: left;\"><li><strong>Zlep\u0161en\u00e1 Reol\u00f3gia Krvi:<\/strong> Vystavenie IR-WBH priaznivo ovplyv\u0148uje <strong>vlastnosti prietoku krvi a hemodynamiku<\/strong> [2], \u010d\u00edm podporuje z\u00e1kladn\u00fd mechanizmus <strong>zlep\u0161enia perf\u00fazie n\u00e1doru<\/strong>\u2014kritick\u00fa predpodmienku pre \u00faspech syst\u00e9mov\u00fdch terapi\u00ed.<\/li><li><strong>V\u0161eobecn\u00e1 Biologick\u00e1 Aktiv\u00e1cia:<\/strong> WBH indukuje tepeln\u00fa stresov\u00fa reakciu, ktor\u00e1 sp\u00fa\u0161\u0165a kask\u00e1du biologick\u00fdch procesov, vr\u00e1tane <strong>modul\u00e1cie hormon\u00e1lneho syst\u00e9mu<\/strong> a <strong>zr\u00fdchlenia metabolizmu<\/strong> [6, 4].<\/li><\/ol><p style=\"text-align: left;\">V\u010faka t\u00fdmto z\u00e1kladom funguje WBH ako <strong>syst\u00e9mov\u00fd imunomodul\u00e1tor<\/strong>, optimalizuj\u00faci <strong>n\u00e1dorov\u00e9 mikroprostredie (TME)<\/strong> a zosil\u0148uj\u00faci \u00fa\u010dinnos\u0165 \u0161pi\u010dkov\u00fdch onkologick\u00fdch lie\u010debn\u00fdch postupov [9].<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. K\u013e\u00fa\u010dov\u00e9 Mechanizmy \u00da\u010dinku (Molekul\u00e1rne, Fyziologick\u00e9 a Imunologick\u00e9)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>\u00a0<\/p><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">Terapeutick\u00e9 \u00fa\u010dinky WBH s\u00fa komplexn\u00e9, sprostredkovan\u00e9 zmenami na bunkovej, imunitnej a fyziologickej \u00farovni:<\/p><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Synergia s Chemoterapiou a R\u00e1dioterapiou (Chemo\/R\u00e1dio Senzibiliz\u00e1tor)<\/h3><ul><li style=\"text-align: left;\"><strong>Optimaliz\u00e1cia N\u00e1dorov\u00e9ho Mikroprostredia (TME):<\/strong> WBH zlep\u0161uje <strong>prekrvenie n\u00e1doru<\/strong> a <strong>okysli\u010denie<\/strong>, \u010d\u00edm zvr\u00e1ti n\u00e1dorov\u00fa hypoxiu. To je esenci\u00e1lne, preto\u017ee dobre okysli\u010den\u00e9 n\u00e1dorov\u00e9 bunky s\u00fa v\u00fdznamne n\u00e1chylnej\u0161ie na de\u0161trukciu <strong>Chemoterapiou<\/strong> (CT) a <strong>R\u00e1dioterapiou<\/strong> (RT) [9, 41].<\/li><li style=\"text-align: left;\"><strong>Chemo\/R\u00e1dio \u00da\u010dinnos\u0165:<\/strong> Hypertermia p\u00f4sob\u00ed ako <strong>chemo &amp; r\u00e1dio senzibiliz\u00e1tor<\/strong>, zlep\u0161uj\u00fac pr\u00edsun kysl\u00edka do n\u00e1doru (r\u00e1diosenzibilizuj\u00faci \u00fa\u010dinok) &amp; posil\u0148uj\u00fac \u00fa\u010dinnos\u0165 liekov ako Cisplatina, Gemcitab\u00edn a Karboplatina [12, 16, 36].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. Indukcia Silnej Protin\u00e1dorovej Imunitnej Odpovede (Imunomodul\u00e1cia)<\/h3><p style=\"text-align: left;\">WBH je siln\u00fd aktiv\u00e1tor obrann\u00e9ho syst\u00e9mu tela [11]:<\/p><ul><li style=\"text-align: left;\"><strong>Prote\u00edny Tepeln\u00e9ho \u0160oku (HSPs):<\/strong> Tepeln\u00fd stres stimuluje synt\u00e9zu a uvo\u013e\u0148ovanie <strong>HSP70<\/strong>. Tieto prote\u00edny p\u00f4sobia ako &#8218;sign\u00e1ly nebezpe\u010denstva&#8216;, ktor\u00e9 ozna\u010duj\u00fa rakovinov\u00e9 bunky pre zosilnen\u00fd \u00fatok imunitn\u00fdch <strong>Cytotoxick\u00fdch T Lymfocytov (CTLs)<\/strong> [9, 10, 29].<\/li><li style=\"text-align: left;\"><strong>Aktiv\u00e1cia K\u013e\u00fa\u010dov\u00fdch Imunitn\u00fdch Buniek:<\/strong> Teplotn\u00fd rozsah 39-43<strong>\u00b0<\/strong>C zvy\u0161uje aktivitu <strong>Prirodzen\u00fdch Zab\u00edja\u010dsk\u00fdch (NK) buniek<\/strong> a podporuje aktivitu <strong>pomocn\u00fdch a cytotoxick\u00fdch T buniek<\/strong>, <strong>dendritick\u00fdch buniek<\/strong>, a makrof\u00e1gov, pri\u010dom potenci\u00e1lne oslabuje imunosupres\u00edvne bunky [9, 10, 11, 25, 26].<\/li><li style=\"text-align: left;\"><strong>N\u00e1rast T-Lymfocytov:<\/strong> FR-WBH m\u00f4\u017ee <strong>v\u00fdznamne zv\u00fd\u0161i\u0165 (napr. 3-n\u00e1sobne) popul\u00e1ciu cytotoxick\u00fdch T lymfocytov<\/strong> v lymfatick\u00fdch org\u00e1noch, \u010d\u00edm zosil\u0148uje syst\u00e9mov\u00fd protin\u00e1dorov\u00fd imunitn\u00fd \u00fatok [10].<\/li><li style=\"text-align: left;\"><strong>Vakc\u00edny a APCs:<\/strong> WHT m\u00f4\u017ee regulova\u0165 funkciu buniek prezentuj\u00facich antig\u00e9n (APC) a zvy\u0161ova\u0165 \u00fa\u010dinnos\u0165 protirakovinov\u00fdch vakc\u00edn, vr\u00e1tane t\u00fdch, ktor\u00e9 s\u00fa zalo\u017een\u00e9 na HSP110 a GRP170 [37, 28].<\/li><\/ul><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Klinick\u00e9 D\u00f4kazy a Synergia v Multimod\u00e1lnej Terapii<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. Synergia s Imunoterapiou (Inhib\u00edtory Kontroln\u00fdch Bodov &#8211; ICI)<\/h3><p style=\"text-align: left;\">Retrospekt\u00edvna s\u00e9ria pr\u00edpadov 131 pacientov s pokro\u010dil\u00fdm (\u0161t\u00e1dium IV) rakovinov\u00fdm ochoren\u00edm sk\u00famala multimod\u00e1lny protokol zah\u0155\u0148aj\u00faci <strong>celotelov\u00fa hypertermiu<\/strong> spolu s inhib\u00edtormi kontroln\u00fdch bodov (Ipilimumab, Nivolumab) a IL-2 [18].<\/p><p style=\"text-align: left;\"><strong>K\u013e\u00fa\u010dov\u00fd Z\u00e1ver:<\/strong> wIRA Celotelov\u00e1 Hypertermia bola ur\u010den\u00e1 ako <strong>neoddelite\u013en\u00e1 a esenci\u00e1lna s\u00fa\u010das\u0165<\/strong>, ktor\u00e1 <strong>maximalizovala protin\u00e1dorov\u00fa imunitn\u00fa odpove\u010f<\/strong>. WBH aktivuje a mobilizuje T bunky (indukciou HSP70 a uvo\u013e\u0148ovan\u00edm n\u00e1dorov\u00fdch antig\u00e9nov); inhib\u00edtory kontroln\u00fdch bodov n\u00e1sledne &#8222;odstra\u0148uj\u00fa brzdu&#8220; z t\u00fdchto preaktivovan\u00fdch T buniek, \u010do vedie k neobvykle vysok\u00fdm mieram priaznivej klinickej odpovede pri pokro\u010dilom ochoren\u00ed [18].<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. Klinick\u00e9 Aplik\u00e1cie pri R\u00f4znych Typoch Rakoviny<\/h3><ul><li style=\"text-align: left;\"><strong>Rakovina Pankreasu:<\/strong> Protokoly F\u00e1zy I-II vyu\u017e\u00edvaj\u00face miernu WBH (FR-WBH) v kombin\u00e1cii s chemoterapiou a Interfer\u00f3nom-alfa preuk\u00e1zali aspo\u0148 50% regresiu n\u00e1doru u takmer poloviny pacientov rezistentn\u00fdch na terapiu [4, 22].<\/li><li style=\"text-align: left;\"><strong>Rakovina Prsn\u00edka (Recid\u00edva):<\/strong> WHT v kombin\u00e1cii s opakovan\u00fdm o\u017eiaren\u00edm alebo r\u00e1dioterapiou preuk\u00e1zala \u00fa\u010dinnos\u0165 pri lok\u00e1lne pokro\u010dilej rakovine prsn\u00edka a recid\u00edve hrudnej steny, potvrden\u00fa randomizovan\u00fdmi \u00fadajmi [39, 40].<\/li><li style=\"text-align: left;\"><strong>Rakovina Vaje\u010dn\u00edkov:<\/strong> WBH v kombin\u00e1cii s karboplatinou bola sk\u00faman\u00e1 v \u0161t\u00fadii F\u00e1zy II pre opakovan\u00fa rakovinu vaje\u010dn\u00edkov [16, 20].<\/li><li style=\"text-align: left;\"><strong>Kolorekt\u00e1lny Karcin\u00f3m:<\/strong> WBH wIRA bola pou\u017eit\u00e1 v kontexte Von Ardenneovej Syst\u00e9movej Viackrokovej Terapie Rakoviny (sCMT) v kombin\u00e1cii s chemoterapiou v \u0161t\u00fadii F\u00e1zy I\/II [15].<\/li><\/ul><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. R\u00fdchla \u00da\u013eava od Bolesti a V\u00fdznamn\u00e9 Zlep\u0161enie Kvality \u017divota (QoL)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">Pacienti m\u00f4\u017eu zaznamena\u0165 r\u00fdchlu \u00fa\u013eavu od bolesti a v\u0161eobecn\u00e9 zlep\u0161enie pohody, ako bolo pozorovan\u00e9 v \u0161t\u00fadii Dr. Bulla [12] a najm\u00e4 v nov\u0161ej klinickej \u0161t\u00fadii F\u00e1zy III vykonanej Sahinbasom a kol. [14].<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">Klinick\u00e1 \u0160t\u00fadia F\u00e1zy III (2024) pre Kostn\u00e9 Metast\u00e1zy<\/h3><section>In <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\">2024, Sahinbas a kolegovia zverejnili \u0161t\u00fadiu F\u00e1zy III<\/a> pre boles\u0165 kostn\u00fdch metast\u00e1z preva\u017ene z rakoviny prsn\u00edka a prostaty s pou\u017eit\u00edm WBH wIRA Iratherm hypertermick\u00fdch zariaden\u00ed ako doplnku k RT [14]. Na z\u00e1klade tejto \u0161t\u00fadie predstavovala skupina s monoterapiou r\u00e1dioterapiou (RT) najintenz\u00edvnej\u0161iu boles\u0165. \u0160t\u00fadia bola dokon\u010den\u00e1 po zaraden\u00ed celkovo 61 pacientov, 5 rokov po prvom zaraden\u00ed (apr\u00edl 2016 \u2013 febru\u00e1r 2021). Napokon miera Kompletnej Odpovede (CR) v skupine RT + WBH preuk\u00e1zala najv\u00fdraznej\u0161\u00ed rozdiel oproti samotnej RT, a to 47,4% vs. 5,3%, v priebehu 2 mesiacov po lie\u010dbe (P hodnota &lt; 0,05). <strong>\u010cas do kompletnej \u00fa\u013eavy od bolesti bol 10 dn\u00ed pre RT + WBH, zatia\u013e \u010do koncov\u00fd bod nebol v skupine so samotnou RT dosiahnut\u00fd.<\/strong> Progresia bolesti alebo stabilita ochorenia bola pozorovan\u00e1 u polovice pacientov v skupine RT v priebehu 4 t\u00fd\u017ed\u0148ov po lie\u010dbe. Av\u0161ak, <strong>toto sk\u00f3re bolo takmer nulov\u00e9 u pacientov RT + WBH v priebehu dvoch mesiacov po lie\u010dbe.<\/strong> <strong>Z\u00e1very:<\/strong> WBH plus RT preuk\u00e1zala v\u00fdznamn\u00e9 zv\u00fd\u0161enie \u00fa\u013eavy od bolesti a krat\u0161\u00ed \u010das odozvy v porovnan\u00ed so samotnou RT u pacientov s metastatick\u00fdmi kostn\u00fdmi l\u00e9ziami.<\/section><table border=\"1\"><thead><tr><th>Indik\u00e1tor QoL\/Zlep\u0161enie Bolesti<\/th><th>Monoterapia RT<\/th><th>RT + Hypertermia (WBH wIRA)<\/th><th>Dopad na QoL<\/th><\/tr><\/thead><tbody><tr><td><strong>Miera Kompletnej Odpovede (CR) po 2 mesiacoch<\/strong> (nulov\u00e9 sk\u00f3re bolesti)<\/td><td>5,3 %<\/td><td>47,4 %<\/td><td>* <strong>894% n\u00e1rast<\/strong> * v \u0161anci na \u00fapln\u00fa elimin\u00e1ciu bolesti.<\/td><\/tr><tr><td><strong>\u010cas do kompletnej \u00fa\u013eavy od bolesti<\/strong><\/td><td>nebol dosiahnut\u00fd<\/td><td>10 dn\u00ed<\/td><td><strong>\u201d v\u00fdznamn\u00fd a r\u00fdchly\u201d<\/strong> pr\u00ednos<\/td><\/tr><tr><td style=\"text-align: left;\"><strong>Trvanie \u00da\u013eavy od Bolesti <\/strong><\/td><td style=\"text-align: left;\">Medi\u00e1n: 28 dn\u00ed\/4 t\u00fd\u017edne u polovice pacientov<\/td><td style=\"text-align: left;\">Medi\u00e1n: Nebol zahrnut\u00fd pri 24 t\u00fd\u017ed\u0148och<\/td><td style=\"text-align: left;\">Trvanie \u00fa\u013eavy * <strong>sa \u0161es\u0165n\u00e1sobne zvy\u0161uje<\/strong> *, \u010do zni\u017euje z\u00e1vislos\u0165 na liekoch proti bolesti.<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">\u00a0<\/p><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">V porovnan\u00ed s podobnou [link: \u0160t\u00fadiou F\u00e1zy III Chi MS et al. 2017] (2017) s RF lokoregion\u00e1lnou hypertermiou, boli pr\u00ednosy (\u010do sa t\u00fdka QoL a zn\u00ed\u017eenia bolesti) dosiahnut\u00e9 pomocou WBH wIRA hypertermie \u010faleko lep\u0161ie \u2013 v\u00fdsledky \u0161t\u00fadie RF HT + RT:<\/p><table border=\"1\"><thead><tr><th>Indik\u00e1tor QoL\/Zlep\u0161enie Bolesti<\/th><th>Monoterapia RT<\/th><th>RT + Hypertermia (HT)<\/th><th>Dopad na QoL<\/th><\/tr><\/thead><tbody><tr><td><strong>Miera Kompletnej Odpovede (CR) po 3 Mesiacoch<\/strong> (nulov\u00e9 sk\u00f3re bolesti)<\/td><td>7,1 %<\/td><td>37,9 %<\/td><td>533% n\u00e1rast v \u0161anci na \u00fapln\u00fa \u00fa\u013eavu od bolesti.<\/td><\/tr><tr><td><strong>Trvanie \u00da\u013eavy od Bolesti<\/strong><\/td><td>Medi\u00e1n: 55 dn\u00ed\/7,9 t\u00fd\u017ed\u0148ov<\/td><td>Medi\u00e1n: Nebol zahrnut\u00fd pri 24 t\u00fd\u017ed\u0148och<\/td><td>Trvanie \u00fa\u013eavy sa strojn\u00e1sobuje, \u010do zni\u017euje z\u00e1vislos\u0165 na liekoch proti bolesti.<\/td><\/tr><\/tbody><\/table><p style=\"text-align: left;\">Zhrnutie: Konsolidovan\u00e9 vedeck\u00e9 d\u00f4kazy (od z\u00e1kladn\u00fdch \u0161t\u00fadi\u00ed o technol\u00f3gii wIRA po k\u013e\u00fa\u010dov\u00e9 klinick\u00e9 \u0161t\u00fadie F\u00e1zy III) potvrdzuj\u00fa \u00falohu WBH ako multi-impact adjuvantnej terapie v onkol\u00f3gii: posil\u0148uje \u00fa\u010dinnos\u0165 CT\/RT, aktivuje syst\u00e9mov\u00fd imunitn\u00fd syst\u00e9m (vr\u00e1tane synergie s imunoterapiou), a dramaticky zlep\u0161uje kontrolu bolesti a QoL u onkologick\u00fdch pacientov.<\/p><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Syst\u00e9mov\u00e9 Fyziologick\u00e9 V\u00fdhody a Terapeutick\u00fd Potenci\u00e1l pri In\u00fdch Patol\u00f3gi\u00e1ch<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header>Jemn\u00e9, kontrolovan\u00e9 teplo poskytovan\u00e9 WBH s wIRA \u017eiaren\u00edm sp\u00fa\u0161\u0165a komplexn\u00e9 termoregula\u010dn\u00e9 odpovede, ktor\u00e9 prin\u00e1\u0161aj\u00fa \u0161irok\u00e9 syst\u00e9mov\u00e9 v\u00fdhody, roz\u0161iruj\u00fac terapeutick\u00fd potenci\u00e1l aj mimo onkol\u00f3gie:<\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. Muskuloskelet\u00e1lne a Mana\u017ement Bolesti<\/h3><p style=\"text-align: left;\">WBH je \u00fa\u010dinn\u00e1 pri mana\u017emente syndr\u00f3mov chronickej bolesti, vyu\u017e\u00edvaj\u00fac jej fyziologick\u00e9 \u00fa\u010dinky na svalov\u00fd tonus a mikrocirkul\u00e1ciu:<\/p><ul><li style=\"text-align: left;\"><strong>Dorsalgia (Chronick\u00e1 Boles\u0165 Chrbta):<\/strong> \u0160t\u00fadie ukazuj\u00fa, \u017ee mierna WBH, v kombin\u00e1cii so stacion\u00e1rnou multimod\u00e1lnou lie\u010dbou bolesti, poskytuje v\u00fdznamn\u00fd pr\u00ednos pre pacientov s chronickou ne\u0161pecifickou boles\u0165ou dolnej \u010dasti chrbta (dorsalgia) [53, 54].<\/li><li style=\"text-align: left;\"><strong>Syndr\u00f3m Fibromyalgie (FMS):<\/strong> WBH je zdokumentovan\u00e1 doplnkov\u00e1 lie\u010dba FMS. Randomizovan\u00e9 kontrolovan\u00e9 \u0161t\u00fadie preuk\u00e1zali \u00fa\u010dinnos\u0165 miernej wIRA WBH v \u0161tandardnom multimod\u00e1lnom rehabilita\u010dnom prostred\u00ed, preukazuj\u00fac \u00fa\u010dinky na intenzitu bolesti a ment\u00e1lny stav [17, 56, 57]. Tento pr\u00ednos je \u010diasto\u010dne spojen\u00fd so zlep\u0161enou mikrocirkul\u00e1ciou, zn\u00e1mym probl\u00e9mom u pacientov s FMS [55].<\/li><li style=\"text-align: left;\"><strong>Ankylozuj\u00faca Spondylit\u00edda (AS):<\/strong> WBH preuk\u00e1zala imunomodula\u010dn\u00e9 \u00fa\u010dinky u pacientov s AS, pri\u010dom \u0161t\u00fadie uv\u00e1dzaj\u00fa schopnos\u0165 WBH zv\u00fd\u0161i\u0165 protiz\u00e1palov\u00e9 medi\u00e1tory, ako je <strong>Interleuk\u00edn-10<\/strong> (IL-10), a modulova\u0165 proz\u00e1palov\u00e9 cytok\u00edny, ako je TNF-alfa, \u010do nazna\u010duje priazniv\u00fa \u00falohu pri mana\u017emente chronick\u00e9ho z\u00e1palu spojen\u00e9ho s t\u00fdmto ochoren\u00edm [58, 59, 52].<\/li><li style=\"text-align: left;\"><strong>Raynaudov Fenom\u00e9n pri Syst\u00e9movej Skler\u00f3ze:<\/strong> Hypertermia sprostredkovan\u00e1 infra\u010derven\u00fdm \u017eiaren\u00edm sa uk\u00e1zala ako \u00fa\u010dinn\u00e1 pri lie\u010dbe vazokonstrik\u010dn\u00fdch sympt\u00f3mov spojen\u00fdch s Raynaudov\u00fdm fenom\u00e9nom s\u00favisiacim so sklerodermiou, preukazuj\u00fac vaskul\u00e1rne v\u00fdhody [49].<\/li><\/ul><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. Kardiovaskul\u00e1rne a Obehov\u00e9 Zdravie \u2764\ufe0f<\/h3><p style=\"text-align: left;\">Okrem zlep\u0161enia perf\u00fazie n\u00e1doru m\u00e1 WBH \u0161pecifick\u00e9 \u00fa\u010dinky na obehov\u00fd syst\u00e9m:<\/p><ul><li style=\"text-align: left;\"><strong>Esenci\u00e1lna Hypertenzia:<\/strong> S\u00e9ria \u0161t\u00fadi\u00ed sk\u00famala pou\u017eitie miernej IR-A hypertermie u pacientov s arteri\u00e1lnou hypertenziou (WHO \u0160t\u00e1dium I a II). Zistenia nazna\u010duj\u00fa, \u017ee s\u00e9riov\u00e1 lie\u010dba m\u00f4\u017ee pozit\u00edvne ovplyvni\u0165 <strong>centr\u00e1lne a perif\u00e9rne pulzn\u00e9 vlny<\/strong>, krvn\u00fd tlak a <strong>viskozitu krvi<\/strong>, \u010do potvrdzuje \u00falohu WBH ako nefarmakologickej fyzik\u00e1lnej terapie [44, 47].<\/li><\/ul><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \" style=\"text-align: left;\"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">C. Neuro-Endokrinn\u00e9 a Psychologick\u00e9 \u00da\u010dinky<\/h3><p style=\"text-align: left;\">WBH zap\u00e1ja neuro-endokrinn\u00e9 syst\u00e9my tela, ovplyv\u0148uj\u00fac n\u00e1ladu a metabolizmus:<\/p><ul><li style=\"text-align: left;\"><strong>Hlavn\u00e1 Depres\u00edvna Porucha (MDD):<\/strong> Randomizovan\u00e1 klinick\u00e1 \u0161t\u00fadia preuk\u00e1zala, \u017ee jedin\u00e1 rel\u00e1cia WBH m\u00f4\u017ee p\u00f4sobi\u0165 ako r\u00fdchlo p\u00f4sobiace antidepres\u00edvum, \u010do vedie k zn\u00edzeniu depres\u00edvnych sympt\u00f3mov po dobu nieko\u013ek\u00fdch t\u00fd\u017ed\u0148ov. Tento \u00fa\u010dinok je spojen\u00fd s tepelne indukovanou aktiv\u00e1ciou imunitn\u00fdch a z\u00e1palov\u00fdch dr\u00e1h, ktor\u00e9 ovplyv\u0148uj\u00fa mozog [51].<\/li><li style=\"text-align: left;\"><strong>Hormon\u00e1lna Modul\u00e1cia (Endokrinol\u00f3gia):<\/strong> WBH stimuluje <strong>Hypotalamo-Hypof\u00fdzo-Adren\u00e1lnu (HPA) os<\/strong> a ovplyv\u0148uje hladiny horm\u00f3nov. \u0160t\u00fadie zdokumentovali odpovede <strong>Rastov\u00e9ho Horm\u00f3nu<\/strong> a <strong>Prolakt\u00ednu<\/strong> po\u010das celotelovej hypertermie, zd\u00f4raz\u0148uj\u00fac jej vplyv na endokrinn\u00fa regul\u00e1ciu [42, 43].<\/li><li style=\"text-align: left;\"><strong>Metabolizmus a Bunkov\u00e1 Reakcia:<\/strong> WBH ur\u00fdch\u013euje baz\u00e1lny metabolizmus. Na bunkovej \u00farovni teplo ovplyv\u0148uje kinetiku pO2 a je spojen\u00e9 so synt\u00e9zou ochrann\u00fdch prote\u00ednov, ako je <strong>ferit\u00edn<\/strong>, v ko\u017ei, podporuj\u00fac opravu tkan\u00edv [48; 46].<\/li><\/ul><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u010casto Kladen\u00e9 Ot\u00e1zky (FAQ) o Odpor\u00fa\u010dan\u00fdch WBH Seden\u00ed a Cie\u013eov\u00fdch Teplot\u00e1ch<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p><i>Lie\u010dba by sa mala vykon\u00e1va\u0165 iba po z\u00e1vere\u010dnej konzult\u00e1cii s lek\u00e1rom.<\/i><\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h4>Ak\u00fd je odpor\u00fa\u010dan\u00fd protokol Celotelovej Hypertermie (WBH) pre Esenci\u00e1lnu Hypertenziu?<\/h4><p>Protokol pre Esenci\u00e1lnu Hypertenziu odpor\u00fa\u010da 12 seden\u00ed pri cie\u013eovej teplote 38,3 \u00b0C. Ka\u017ed\u00e9 sedenie trv\u00e1 pribli\u017ene 45 min\u00fat, \u010do zah\u0155\u0148a 30-min\u00fatov\u00fa f\u00e1zu zvy\u0161ovania a 15-min\u00fatov\u00fa f\u00e1zu odpo\u010dinku (bez f\u00e1zy plat\u00f3).<\/p><h4>Ak\u00e9 s\u00fa odpor\u00fa\u010dan\u00e9 WBH parametre pre Chronick\u00fa Boles\u0165 Chrbta (Dorsalgia)?<\/h4><p>Pre Dorsalgiu sa zvy\u010dajne odpor\u00fa\u010da 6 seden\u00ed, s cie\u013eovou teplotou 38,4 \u00b0C. Celkov\u00e1 doba sedenia je pribli\u017ene 90 min\u00fat, so 45 min\u00fatami zvy\u0161ovania, 15-min\u00fatovou f\u00e1zou plat\u00f3 a 30-min\u00fatov\u00fdm odpo\u010dinkom.<\/p><h4>Ak\u00fd je WBH protokol pre Fibromyalgiu a Ankylozuj\u00facu Spondylit\u00eddu?<\/h4><p>Obidve, Fibromyalgia aj Ankylozuj\u00faca Spondylit\u00edda, zvy\u010dajne nasleduj\u00fa protokol 6 seden\u00ed, s cie\u013eovou teplotou 38,5 \u00b0C. Celkov\u00e1 doba sedenia je asi 90 min\u00fat, vr\u00e1tane 45 min\u00fat zvy\u0161ovania, 15-min\u00fatov\u00e9ho plat\u00f3 a 30-min\u00fatov\u00e9ho odpo\u010dinku.<\/p><h4>Ak\u00fd je odpor\u00fa\u010dan\u00fd protokol pre WBH ako Adit\u00edvnu Lie\u010dbu Rakoviny?<\/h4><p>Ako adit\u00edvna lie\u010dba rakoviny vy\u017eaduje protokol 2 alebo viac seden\u00ed, s cie\u013eovou baz\u00e1lnou teplotou medzi 39,0 \u00b0C a 40,0 \u00b0C. Celkov\u00e1 doba sedenia je najdlh\u0161ia, pohybuje sa od 3 do 4 hod\u00edn, \u010do zah\u0155\u0148a 60-90 min\u00fat pre f\u00e1zu zvy\u0161ovania, 60-90 min\u00fat pre f\u00e1zu plat\u00f3 a 60 min\u00fat pre f\u00e1zu odpo\u010dinku.<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header>.<\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\"><header><table width=\"1151\"><tbody><tr><td width=\"278\">Indik\u00e1cia<\/td><td width=\"99\">Po\u010det seden\u00ed<\/td><td width=\"135\">Cie\u013eov\u00e1 teplota<\/td><td colspan=\"2\" width=\"309\">\u010cas terapie F\u00e1za zvy\u0161ovania\u00a0 \u00a0 \u00a0 F\u00e1za plat\u00f3<\/td><td width=\"164\">\u010cas odpo\u010dinku F\u00e1za odpo\u010dinku<\/td><td width=\"164\"><strong>Celkov\u00e1<\/strong> <strong>doba WBH sedenia<\/strong><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Esenci\u00e1lna Hypertenzia<\/td><td rowspan=\"2\" width=\"99\">12<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>30 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 45 min<\/strong><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Dorsalgia<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,4 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>60 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 90 min<\/strong><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Fibromyalgia<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>60 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 90 min<\/strong><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Ankylozuj\u00faca Spondylit\u00edda<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>60 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 90 min<\/strong><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Syst\u00e9mov\u00e1 Skler\u00f3za<\/td><td rowspan=\"2\" width=\"99\">15<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>30 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 45 min<\/strong><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Hlavn\u00e1 Depres\u00edvna Porucha<\/td><td rowspan=\"2\" width=\"99\">1+<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>105 -170 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 2-3 hodiny<\/strong><\/td><\/tr><tr><td width=\"155\">45-110 min<\/td><td width=\"155\">60 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Adit\u00edvna Lie\u010dba Rakoviny<\/td><td rowspan=\"2\" width=\"99\">2+<\/td><td rowspan=\"2\" width=\"135\">39,0-40,0 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>120-180 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">60 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 3-4 hodiny<\/strong><\/td><\/tr><tr><td width=\"155\">60-90 min<\/td><td width=\"155\">60-90 min<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><\/header><\/header><p>\u00a0<\/p><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>POZN\u00c1MKA: tento \u010dl\u00e1nok nepredstavuje vy\u010derp\u00e1vaj\u00faci zoznam \u0161t\u00fadi\u00ed a \u00fa\u010dinkov WBH wIRA<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Referencie a Cit\u00e1cie<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><ol><li style=\"text-align: left;\">Ardenne M. von. Moderate Hyperthermie als Behandlungsmethode mit vielen Indikationen. \u00c4rztzeitschr Naturheilverf 1994; 5:356-61.<\/li><li style=\"text-align: left;\">B\u00e4umler H., Scherf H.P., Aurisch R., et al. Einflu\u00df einer Serie von Infrarot-Ganzk\u00f6rperbestrahlungen auf Flie\u00dfeigenschaften des Blutes und die H\u00e4modynamik. Perfusion 1990: 138-43.<\/li><li style=\"text-align: left;\">Heckel M. Ganzk\u00f6rper-Hyperthermie und Fiebertherapie, Grundlagen und Praxis. Stuttgart: Hippokrates Verlag, 1990.<\/li><li style=\"text-align: left;\">Kosaka M., Sugahara T., Schmidt K.L., Simon E. Thermotherapy: Principles and Practice. Heidelberg: Springer Verlag, 2000.<\/li><li style=\"text-align: left;\">Meffert H., Hecht H.C., G\u00fcnther H., et al. Biophysikalische Ergebnisse des klinischen Tests der IRA-Therm-Hyperthermietechnik der 2. Generation. ThermoMed 1990; 6:71-78.<\/li><li style=\"text-align: left;\">Schmidt K.L. Hyperthermie und Fieber, Wirkungen bei Mensch und Tier. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1987.<\/li><li style=\"text-align: left;\">Vaupel P., Kr\u00fcger W. W\u00e4rmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsm\u00f6glichkeiten. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1995.<\/li><li style=\"text-align: left;\">Piazena H., Meffert H. Optische Eigenschaften der Haut und die photobiologischen Grundlagen zur Dosierung von IR-Hautbestrahlungen in vivo und in vitro. 6. Symposium Licht und Gesundheit 2008 13.-14.03. Berlin, 2008:162-178.<\/li><li style=\"text-align: left;\">Zschaeck S. and Beck M. Chapter 8 Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?<\/li><li style=\"text-align: left;\">Zhang H, Wang W, Zhang S, Huang W. Comparison of the anti-tumor effects of various whole-body hyperthermia protocols&#8230; Immunol Invest. 2005;34(3):245-58.<\/li><li style=\"text-align: left;\">Abreu MM, Chocron AF, Smadja DM. From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. Front Immunol. 2025 Feb 28;16:1487296.<\/li><li style=\"text-align: left;\">Bull JMC. et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-\u03b1: A description of a phase I-II protocol. Journal of Hyperthermia. 2008; 24(8): 649-662.<\/li><li style=\"text-align: left;\">Weigelin B. Visualization of the immune effect of hyperthermia. ICHO 2021, Session: Hyperthermia and immunology.<\/li><li style=\"text-align: left;\">Faghihi Moghaddam F, Bakhshandeh M, Mofid B, et al. Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone&#8230; J Therm Biol. 2024 Feb;120:103804.<\/li><li style=\"text-align: left;\">Hildebrandt B, Dr\u00e4ger J, Kerner T. et al. Whole-body hyperthermia in the scope of von Ardenne\u2019s systemic cancer multistep therapy (sCMT)&#8230; International Journal of Hyperthermia. 2004;3:317\u2013333.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin in patients with recurrent ovarian cancer \u2013 a phase II study. Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Brockow T., Wagner A., Franke A., Offenb\u00e4cher M., Resch K.L. A Randomized Controlled Trial on the Effectiveness of Mild Water-filtered Near Infrared Whole-body Hyperthermia&#8230; Clin J Pain 2007; 1:67-75.<\/li><li style=\"text-align: left;\">Kleef R, Nagy R, Baierl A, et al. Low-dose Ipilimumab plus Nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series&#8230; Cancer Immunol Immunother. 2021;70:1393\u2013403.<\/li><li style=\"text-align: left;\">Adachi H., Katsuno M., Waza M., et al. Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications. Int J Hyperthermia 2009; 8:647-54.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin&#8230; Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Figueroa G., et al. An Update of a Phase II Clinical Trial Using Fever-Range Whole-Body Thermal Therapy (FR-WB-TT)&#8230; Soc for Thermal Med Joint Annual Meeting, 14.-17.5.2007.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Strebel F.R., et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine and daily interferon-\u03b1: A description of a phase I-II protocol. Int J Hyperthermia 2008; 8:649-62.<\/li><li style=\"text-align: left;\">Bull J.M., Nagle V.L., Scott G., et al. A phase-I-study of optimally-timed Gemcitabine + Cisplatin\/Interferon-a combined with long-duration, low-temperature whole-body hyperthermia. ESHO 2001, Verona\/ Italy, 30.05.-02.06.2001:67.<\/li><li style=\"text-align: left;\">Capitano M., Mace T., Nemeth M., et al. A novel strategy for improving neutrophil recovery following total body irradiation. Soc for Thermal Med Joint Annual Meeting, 24.-26.4.2010.<\/li><li style=\"text-align: left;\">Dayanc B.E., Ostberg J.R., Repasky E.A. Enhancement of NK Cell Cytotoxic Activity by Mild Thermal Stress. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Hajto T., Hostanska K. Effect of in vivo hyperthermia on human natural killer cells. Clin Trials J 1985; 6:514-20.<\/li><li style=\"text-align: left;\">Hattori T., Kokura S., Okuda T., et al. Antitumor effect of whole body hyperthermia with \u03b1-galactosylceramide in a subcutaneous tumor model of colon cancer. Int J Hyperthermia 2007; 7:591-98.<\/li><li style=\"text-align: left;\">Kisailus A., Pritchard M., Li Y., Ostberg J., Repasky E.A. Thermal Regulation of Antigen Presenting Cells: Use of Hyperthermia as an Adjuvant for Cancer Vaccines. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Multhoff G. Letter to Editor, Hyperthermia classic commentary: Activation of natural killer (NK) cells by heat shock protein 70&#8230; Int J Hyperthermia 2009; 3:176-79.<\/li><li style=\"text-align: left;\">Peer A.J., Grimm M.J., Zynda E.R., Repasky E.A. Diverse immune mechanisms may contribute to the survival benefit seen in cancer patients receiving hyperthermia. Immunol Res 2010; 1-3:137-154.<\/li><li style=\"text-align: left;\">Rowe R.W., Stebel F.R., Proett J.M., et al. Fever-range whole body thermotherapy combined with oxaliplatin: A curative regimen in a pre-clinical breast cancer model. Int J Hyperthermia 2010; 6:565-76.<\/li><li style=\"text-align: left;\">Schencking M., Frese T., Sandholzer H. Behandlung einer Radikulopathie bei oss\u00e4rer Metastasierung der Lendenwirbels\u00e4ule durch Infrarot-A-Ganzk\u00f6rperhyperthermie. Forsch Komplementmed 2008; 15:273-76.<\/li><li style=\"text-align: left;\">Scott G.L., Bull J.M.C., Kochn M. Management of Conscious Sedation&#8230; 9th Int Congress on Hyperthermic Oncology, 20.-24.4.2004.<\/li><li style=\"text-align: left;\">Shecterle L.M., Cyr J.A.S. Hyperthermia Aids Patients with Advanced Lung Cancer. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Skitzki J.J., Repasky E.A., Evans S.S. Hyperthermia as an immunotherapy strategy for cancer. Current Opnion in Investigational Drugs 2009; 6: 550-58.<\/li><li style=\"text-align: left;\">Toyota N., Strebel F.R., Stephens L.C., et al. Long-duration, mild whole body hyperthermia with cisplatin: tumour response and kinetics of apoptosis and necrosis&#8230; Int. J. Hyperthermia 1997; 5:497-506.<\/li><li style=\"text-align: left;\">Wang X.Y., Kazim L., Repasky E.A., Subjeck J.R. Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines&#8230; J of Immunology 2001; 165:490-97.<\/li><li style=\"text-align: left;\">VanderZee J., DeBruijne M., Mens J.W.M., et al. Reirradiation combined with hyperthermia in breast cancer recurrences&#8230; Int J Hyperthermia 2010; 7:638-48.<\/li><li style=\"text-align: left;\">Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia for locally advanced breast cancer. Int J Hyperthermia 2010; 7:618-24.<\/li><li style=\"text-align: left;\">Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence&#8230; Int J Hyperthermia 2010; 7: 612\u201317.<\/li><li style=\"text-align: left;\">Sen A., Capitano M., Dommer M., et al. Thermoregulatory responses to mild systemic thermal stress increase tumor perfusion&#8230; Cancer Res. 2011; 71(11):3872-3880.<\/li><li style=\"text-align: left;\">Koska J., Rovensky J., Zimanova T., Vigas M. Growth hormone and prolactin responses during partial and whole body warm-water immersions. Acta Physiol Scand. 2003 May;178(1):19-23.<\/li><li style=\"text-align: left;\">Vigas M., Rovensky J., Zimanova T., Koska J. Responses of growth hormone and prolactin to local and whole-body application of Piestany mud. Acta Rheumatol et Balneol Pistiniana 2002:31-38.<\/li><li style=\"text-align: left;\">Meffert B., Hochmuth O., Steiner M. Effects of a multiple mild infrared a induced hyperthermia on central and peripheral pulse waves in hypertensive patients. North Sea Conference on Biomedical Engineering 1990.<\/li><li style=\"text-align: left;\">Meffert H., Scherf HP., Meffert B. Milde Infrarot-A-Hyperthermie. Auswirkungen von Serienbestrahlungen mit wassergefilterter Infrarotstrahlung&#8230; Akt Dermatol 1993; 19:142-48.<\/li><li style=\"text-align: left;\">Applegate L.A., Scaletta C., Panizzon R., et al. Induction of the putative protein ferritin by infrared radiation: Implications in skin repair. Int J of Molecular Med 2000; 5:247-51.<\/li><li style=\"text-align: left;\">Scherf H.P., Meffert H., B\u00e4umler H., et al. Wirkung einer einmaligen milden Infrarot-A-Hyperthermie auf K\u00f6rpertemperatur, Herzfrequenz, Blutdruck und Blutviskosit\u00e4t&#8230; Dermatol Monatsschr 1989; 175:733-40.<\/li><li style=\"text-align: left;\">Streffer C. Metabolic changes during and after hyperthermia. Int J Hyperthermia 1985; 4:305-319.<\/li><li style=\"text-align: left;\">F\u00f6rster J., Fleischanderl S., Wittstock S., et al. Infrared-Mediated Hyperthermia is Effective in the Treatment of Scleroderma-Associated Raynaud\u2019s Phenomenon. J of Investigative Dermatology 2005; 6:1313-16.<\/li><li style=\"text-align: left;\">Koska J., Rovensky J., Zimanova T., et al. Sympathoadrenal regulation of circulatory responses to whole-body hyperthermia&#8230; Acta Rheumatol et Balneol Pistiniana 2002:23-30.<\/li><li style=\"text-align: left;\">Janssen C.W., Lowry C.A., Mehl M.R., et al. Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder \u2013 A Randomized Clinical Trial. JAMA Psychiatry. 2016 May 12.<\/li><li style=\"text-align: left;\">Tarner I.H., Ladner U.M., Uhlemann C., Lange U. The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1 beta and IL-6 in patients with ankylosing spondylitis. Clin Rheumatol 2009; 4:397-402.<\/li><li style=\"text-align: left;\">Ettrich U., Konrad B., Prate K., et al. Milde Ganzk\u00f6rperhyperthermie in Kombination mit station\u00e4rer multimodal orientierter Schmerztherapie&#8230; Orthop\u00e4de 2014; 2:165-74.<\/li><li style=\"text-align: left;\">Weller E., Ullrich D. Infrarot-A-Hyperthermie-Anwendung bei Patienten mit Analgetica-Abusus wegen chronischer R\u00fcckenschmerzen. Vortrag auf dem 95. Kongre\u00df der Gesellschaft f\u00fcr Phys Med und Rehab 5.10.1990.<\/li><li style=\"text-align: left;\">Morf S., Vesti B.A., Forster A., et al. Microcirculation abnormalities in patients with fibromyalgia \u2013 measured by capillary and laser fluxmetry. Arthritis Res Ther 2005; 7:R209-16.<\/li><li style=\"text-align: left;\">Walz J., Hinzmann J., Haase I., Witte T. Ganzk\u00f6rperhyperthermie in der Schmerztherapie \u2013 eine kontrollierte Studie an Patienten mit Fibromyalgiesyndrom. Schmerz 2013; 27:38-45.<\/li><li style=\"text-align: left;\">Romeyke T., Stummer H. Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic whole-body hyperthermia&#8230; J Musculoskel Pain 2014; 4:341-55.<\/li><li style=\"text-align: left;\">Zauner D., Quehenberger F., Hermann J., et al. Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study. Int J Hyperthermia 2014; 6:393-401.<\/li><li style=\"text-align: left;\">Lange U., M\u00fcller-Ladner U., Dischereit G. Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis&#8230; Akt Rheumatol 2017; 2:122-128.<\/li><\/ol><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>\u00a0<\/p><\/section><footer>\u00a9 <time>2025<\/time> Romanian Society Oncologic Hyperthermia All rights reserved. Source: Analysis based on scientific literature.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Celotelov\u00e1 Hypertermia (WBH) v Onkol\u00f3gii a In\u00fdch Patol\u00f3gi\u00e1ch: Konsolidovan\u00e1 Synergia, Imunomodul\u00e1cia a Klinick\u00e9 \u0161t\u00fadie Zverejnen\u00e9:\u00a02025-10-13\u00a0| Posledn\u00e1 \u00daprava:\u00a02025-10-13 Autori: Veronica Iatan, M.D., Cristian Gologan, M.Sc. Celotelov\u00e1 Hypertermia (WBH) je syst\u00e9mov\u00e1 onkologick\u00e1 strat\u00e9gia zah\u0155\u0148aj\u00faca kontrolovan\u00e9 zv\u00fd\u0161enie telesnej teploty, \u010dasto s vyu\u017eit\u00edm technol\u00f3gie vody-filtrovan\u00e9ho infra\u010derven\u00e9ho \u017eiarenia A (wIRA). WBH je prim\u00e1rne Chemo\/R\u00e1dio-senzibiliz\u00e1tor, ktor\u00fd v\u00fdznamne zlep\u0161uje perf\u00faziu a okysli\u010denie<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/sk\/klinicke-studie-hypertermia-wira-onkologia\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-987","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/sk\/wp-json\/wp\/v2\/pages\/987","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/sk\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/sk\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/sk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/sk\/wp-json\/wp\/v2\/comments?post=987"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/sk\/wp-json\/wp\/v2\/pages\/987\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/sk\/wp-json\/wp\/v2\/media?parent=987"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}