{"id":988,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2025-12-19T20:21:12","modified_gmt":"2025-12-19T20:21:12","slug":"klinicna-preskusanja-hipertermija-onkologija","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/sl\/klinicna-preskusanja-hipertermija-onkologija\/","title":{"rendered":"Klini\u010dna presku\u0161anja"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"988\" class=\"elementor elementor-988 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Hipertermija Celega Telesa (WBH) v Onkologiji in Drugih Patologijah: Utrjena Sinergija, Imunomodulacija in Klini\u010dni Dokazi<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>Objavljeno: <time datetime=\"2025-10-13\">2025-10-13<\/time> | Zadnja Revizija: <time datetime=\"2025-10-13\">2025-10-13<\/time> Avtorja: <a href=\"\/?p=139\">Veronica Iatan, MD<\/a>, <a href=\"\/?p=137\">Cristian Gologan, M.Sc.<\/a><\/p><section><p style=\"font-weight: bold; font-style: italic;\">Hipertermija Celega Telesa (WBH) je sistemska onkolo\u0161ka strategija, ki vklju\u010duje nadzorovano segrevanje telesne temperature, pogosto z uporabo tehnologije vodno filtriranega Infrarde\u010dega-A sevanja (wIRA). WBH je v osnovi kemo\/radio senzibilizator, ki <strong>bistveno izbolj\u0161a perfuzijo in oksigenacijo tumorja<\/strong>, da se okrepi u\u010dinkovitost tradicionalnih zdravljenj. Klju\u010dno deluje kot mo\u010dan <strong>sistemski imunomodulator<\/strong>, mobilizira Proteine Toplotnega \u0160oka (HSP) in T-celice, kar ustvarja bistveno sinergijo z najsodobnej\u0161o Imunoterapijo (ICI) in nudi <strong>dramati\u010dno, hitro laj\u0161anje bole\u010dine in izbolj\u0161anje Kakovosti \u017divljenja<\/strong> pri razli\u010dnih rakih in kroni\u010dnih patologijah, kot je Fibromialgija.<\/p><\/section><section>* Medicinsko opozorilo: Ta \u010dlanek je namenjen izklju\u010dno informativnim namenom in ni nadomestilo za individualno medicinsko posvetovanje, diagnozo ali zdravljenje, ki ga nudi poobla\u0161\u010deni zdravnik.*<\/section><section><h2>\u00a0<\/h2><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. Opredelitev Hipertermije Celega Telesa (WBH) in Terapevtske Tehnologije<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\"><strong>Hipertermija Celega Telesa (WBH)<\/strong>, ali &#8220;sistemska hipertermija&#8221;, je definirana kot nadzorovano pove\u010danje telesne temperature za terapevtske namene. Na podlagi spektra <strong>u\u010dinkov naravne vro\u010dine pri razli\u010dnih temperaturah<\/strong> se postopki WBH razlikujejo naslednje:<\/p><ul style=\"text-align: left;\"><li><strong>Blaga WBT:<\/strong> &lt; 38.5<strong>\u00b0<\/strong>C<\/li><li><strong>Zmerna WBT:<\/strong> 38.5<strong>\u00b0<\/strong>C \u2013 40.5 <strong>\u00b0<\/strong>C<\/li><li><strong>Ekstremna WBT:<\/strong> &gt; 40.5<strong>\u00b0<\/strong>C<\/li><\/ul><p style=\"text-align: left;\">Predvsem blaga in zmerna WBH <strong>pove\u010duje perfuzijo<\/strong>, spodbuja metabolizem, zmanj\u0161uje mi\u0161i\u010dni tonus in <strong>spodbuja imunski sistem.<\/strong><\/p><p style=\"text-align: left;\"><a href=\"https:\/\/ardenneiratherm.com\/sl\/naprava-za-hipertermijo-ardenne-iratherm\/\">Naprava von Ardenne IRATHERM\u00ae 1000M WBH wIRA<\/a> za ta namen uporablja izklju\u010dno <strong>ko\u017ei prijazno, globinsko, vodno filtrirano Infrarde\u010de-A (wIRA) toplotno sevanje<\/strong> (brez IR-B \/ IR-C). Njegova ne-klavstrofobi\u010dna, odprta sistemska zasnova zagotavlja enakomerno intenzivnost sevanja po celotni ravni pacienta (hrbta) in nudi uporabniku optimalno, pacientu specifi\u010dno oskrbo s toploto glede na lokacijo in intenzivnost.<\/p><p style=\"text-align: left;\">Vodno filtrirano infrarde\u010de-A sevanje ustreza naravnemu toplotnemu sevanju sonca, kar zagotavlja tehnolo\u0161ko podlago za enakomerno in ne\u017eno uporabo toplote [1, 5, 7, 8].<\/p><p style=\"text-align: left;\">Z uporabo principa von Ardenne IRATHERM<sup>\u00ae<\/sup> 1000, ki je bil razvit in dokazan \u017ee ve\u010d kot 30 let, je [link: Prof. Manfred von Ardenne &#8211; Prispevki] Profesorju Manfreda von Ardenne uspelo toplotno sevanje fizi\u010dno in tehni\u010dno reproducirati in ga industrijsko omogo\u010diti za trajnostno medicinsko uporabo s pomo\u010djo hipertermije celega telesa.<\/p><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Znanstveni Temelji in Sistemski U\u010dinki<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">WBH se je razvila v strategijo, ki temelji na trdnih biofizikalnih in fiziolo\u0161kih na\u010delih. V onkologiji je poudarek na <strong>Zmerni<\/strong> in Hipertermiji v Razponu Vro\u010dine (FR-WBH), priznani kot zdravljenje z ve\u010d terapevtskimi indikacijami [1, 3].<\/p><p style=\"text-align: left;\">Tehnolo\u0161ko podlago za enakomerno in ne\u017eno uporabo toplote pogosto zagotavljajo naprave, ki uporabljajo <strong>vodno filtrirano Infrarde\u010de-A (wIRA) sevanje<\/strong>. Podrobne biofizikalne \u0161tudije so potrdile <strong>sposobnost te tehnologije za zagotavljanje globinskega in nadzorovanega segrevanja<\/strong>, ob upo\u0161tevanju opti\u010dnih lastnosti ko\u017ee in fotobiolo\u0161kih osnov za dozimetrijo [5, 7, 8].<\/p><p style=\"text-align: left;\">Podrobne biofizikalne \u0161tudije so potrdile sposobnost tehnologije wIRA za zagotavljanje <strong>globinskega in nadzorovanega segrevanja<\/strong> [5, 7, 8]. Na fiziolo\u0161ki ravni ima WBH temeljne sistemske u\u010dinke:<\/p><ol style=\"text-align: left;\"><li>Izbolj\u0161ana Reologija Krvi: Izpostavljenost IR-WBH ugodno vpliva na <strong>lastnosti pretoka krvi in hemodinamiko<\/strong> [2], s \u010dimer podpira bistven mehanizem <strong>izbolj\u0161anja perfuzije tumorja<\/strong>\u2014kriti\u010dnega predpogoja za uspeh sistemskih zdravljenj.<\/li><li>Splo\u0161na Biolo\u0161ka Aktivacija: WBH inducira termi\u010dni stresni odziv, ki spro\u017ei kaskado biolo\u0161kih procesov, vklju\u010dno z <strong>modulacijo hormonalnega sistema<\/strong> in <strong>pospe\u0161evanjem metabolizma<\/strong> [6, 4].<\/li><\/ol><p style=\"text-align: left;\">Zaradi teh temeljev WBH deluje kot <strong>sistemski imunomodulator<\/strong>, optimizira <strong>mikrookolje tumorja (TME)<\/strong> in <strong>okrepi u\u010dinkovitost najsodobnej\u0161ih onkolo\u0161kih zdravljenj<\/strong> [9].<\/p><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. Klju\u010dni Mehanizmi Delovanja (Molekularni, Fiziolo\u0161ki in Imunolo\u0161ki)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>\u00a0<\/p><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">Terapevtski u\u010dinki WBH so kompleksni, posredovani s spremembami na celi\u010dni, imunski in fiziolo\u0161ki ravni:<\/p><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. Sinergija s Kemoterapijo in Radioterapijo (Kemo\/Radio Senzibilizator)<\/h3><ul><li style=\"text-align: left;\"><strong>Optimizacija Mikrookolja Tumorja (TME):<\/strong> WBH izbolj\u0161a <strong>prekrvavitev tumorja<\/strong> in <strong>oksigenacijo<\/strong>, s \u010dimer odpravlja tumorsko hipoksijo. To je bistveno, saj so dobro oksigenirane tumorske celice bistveno bolj dovzetne za uni\u010denje s <strong>Kemoterapijo<\/strong> (CT) in <strong>Radioterapijo<\/strong> (RT) [9, 41].<\/li><li style=\"text-align: left;\"><strong>Kemo\/Radio U\u010dinkovitost:<\/strong> Hipertermija deluje kot <strong>kemo &amp; radio senzibilizator<\/strong>, izbolj\u0161uje oskrbo tumorja s kisikom (radio-senzibilizacijski u\u010dinek) in krepi u\u010dinkovitost zdravil kot so Cisplatina, Gemcitabin in Karboplatina [12, 16, 36].<\/li><\/ul><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. Spodbujanje Mo\u010dnega Protito Tumorskega Imunskega Odziva (Imunomodulacija)<\/h3><p style=\"text-align: left;\">WBH je mo\u010dan aktivator obrambnega sistema telesa [11]:<\/p><ul><li style=\"text-align: left;\"><strong>Proteini Toplotnega \u0160oka (HSPs):<\/strong> Termi\u010dni stres spodbuja sintezo in spro\u0161\u010danje <strong>HSP70<\/strong>. Ti proteini delujejo kot &#8216;signali nevarnosti&#8217;, ki ozna\u010dujejo rakave celice za okrepljen napad s strani imunskih <strong>Citotoksi\u010dnih T Limfocitov (CTLs)<\/strong> [9, 10, 29].<\/li><li style=\"text-align: left;\"><strong>Aktivacija Klju\u010dnih Imunskih Celic:<\/strong> Temperaturni razpon 39-43<strong>\u00b0<\/strong>C pove\u010da aktivnost Naravnih Celic Ubijalk (NK celice) in spodbuja aktivnost <strong>pomo\u017enih in citotoksi\u010dnih T celic<\/strong>, <strong>dendriti\u010dnih celic<\/strong> in <strong>makrofagov<\/strong>, hkrati pa potencialno oslabi imunosupresivne celice [9, 10, 11, 25, 26].<\/li><li style=\"text-align: left;\">Pove\u010danje T-Limfocitov: FR-WBH lahko <strong>bistveno pove\u010da (npr. 3-krat) populacijo citotoksi\u010dnih T limfocitov<\/strong> v limfoidnih organih, s \u010dimer <strong>okrepi sistemski protitumorski imunski napad<\/strong> [10].<\/li><li style=\"text-align: left;\">Cepiva in APCs: WHT lahko regulira funkcijo celic, ki predstavljajo antigen (APC), in pove\u010da u\u010dinkovitost rakavih cepiv, vklju\u010dno s tistimi, ki temeljijo na HSP110 in GRP170 [37, 28].<\/li><\/ul><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Klini\u010dni Dokazi in Sinergija v Multimodalni Terapiji<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. Sinergija z Imunoterapijo (Inhibitorji Kontrolnih To\u010dk &#8211; ICI)<\/h3><p style=\"text-align: left;\">Retrospektivna serija primerov 131 bolnikov z napredovalim (Faza IV) rakom je preiskovala multimodalni protokol, ki je vklju\u010deval <strong>hipertermijo celega telesa<\/strong> skupaj z inhibitorji kontrolnih to\u010dk (Ipilimumab, Nivolumab) in IL-2 [18].<\/p><p style=\"text-align: left;\"><strong>Klju\u010dni Zaklju\u010dek:<\/strong> wIRA Hipertermija Celega Telesa je bila dolo\u010dena kot <strong>sestavni in bistveni del<\/strong>, ki je <strong>maksimiziral protitumorski imunski odziv. WBH aktivira in mobilizira T celice (z indukcijo HSP70 in spro\u0161\u010danjem tumorskih antigenov);<\/strong> inhibitorji kontrolnih to\u010dk nato &#8220;odstranijo zavoro&#8221; s teh predhodno aktiviranih T celic, kar povzro\u010di nenavadno visoke stopnje ugodnega klini\u010dnega odziva pri napredovali bolezni [18].<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. Klini\u010dne Aplikacije pri Razli\u010dnih Rakih<\/h3><ul><li style=\"text-align: left;\">Rak Trebu\u0161ne Slivke: Protokoli Faze I-II z uporabo blage WBH (FR-WBH) v kombinaciji s kemoterapijo in Interferonom-alfa so pokazali <strong>vsaj 50% regresijo tumorja pri skoraj polovici bolnikov, odpornih na terapijo<\/strong> [4, 22].<\/li><li style=\"text-align: left;\">Rak Dojke (Ponovitev): WHT v kombinaciji s ponovnim obsevanjem ali radioterapijo je pokazala u\u010dinkovitost pri lokalno napredovalem raku dojke in ponovitvi na prsnem ko\u0161u, potrjeno z randomiziranimi podatki [39, 40].<\/li><li style=\"text-align: left;\">Rak Jaj\u010dnikov: WBH v kombinaciji s karboplatino je bila preiskovana v \u0161tudiji Faze II za ponavljajo\u010di se rak jaj\u010dnikov [16, 20].<\/li><li style=\"text-align: left;\">Kolorektalni Karcinom: WBH wIRA je bila uporabljena v kontekstu Von Ardenneove Sistemske Ve\u010dstopenjske Terapije Raka (sCMT) v kombinaciji s kemoterapijo v \u0161tudiji Faze I\/II [15].<\/li><\/ul><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. Hitro Laj\u0161anje Bole\u010dine in Pomembno Izbolj\u0161anje Kakovosti \u017divljenja (QoL)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">Bolniki lahko do\u017eivijo hitro laj\u0161anje bole\u010dine in splo\u0161no izbolj\u0161anje po\u010dutja, kot je bilo opa\u017eeno v \u0161tudiji Dr. Bulla [12] in zlasti v novej\u0161i klini\u010dni \u0161tudiji Faze III, ki so jo izvedli Sahinbas et al. [14].<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">Klini\u010dno Presku\u0161anje Faze III (2024) za Kostne Metastaze<\/h3><section>V letu [link: 2024, Sahinbas in sodelavci so objavili \u0161tudijo Faze III] za bole\u010dino kostnih metastaz, predvsem raka dojke in prostate, z uporabo WBH wIRA Iratherm hipertermi\u010dnih naprav kot dodatka k RT [14]. Na podlagi te \u0161tudije je skupina s samo radioterapijo (RT) predstavljala najintenzivnej\u0161o bole\u010dino. \u0160tudija je bila zaklju\u010dena po vklju\u010ditvi skupno 61 bolnikov, 5 let po prvem vklju\u010devanju (april 2016 \u2013 februar 2021). Kon\u010dno je stopnja Popolnega Odziva (CR) v skupini RT + WBH pokazala najpomembnej\u0161o razliko s samo RT, in sicer 47,4% proti 5,3% v 2 mesecih po zdravljenju (P vrednost &lt; 0,05). <strong>\u010cas do popolnega laj\u0161anja bole\u010dine je bil 10 dni za RT + WBH, medtem ko kon\u010dni cilj v skupini s samo RT ni bil dose\u017een.<\/strong> Napredovanje bole\u010dine ali stabilnost bolezni so opazili pri polovici bolnikov v skupini RT v 4 tednih po zdravljenju. Vendar pa je bilo to \u0161tevilo blizu ni\u010d pri bolnikih RT + WBH v dveh mesecih po zdravljenju. Zaklju\u010dki: WBH plus RT je pokazala bistveno pove\u010danje laj\u0161anja bole\u010dine in kraj\u0161i \u010das odziva v primerjavi s samo RT pri bolnikih z metastatskimi kostnimi lezijami.<\/section><table border=\"1\"><thead><tr><th>Indikator QoL\/Izbolj\u0161anje Bole\u010dine<\/th><th>Monoterapija RT<\/th><th>RT + Hipertermija (WBH wIRA)<\/th><th>Vpliv QoL<\/th><\/tr><\/thead><tbody><tr><td><strong>Stopnja Popolnega Odziva (CR) po 2 mesecih<\/strong> (ni\u010delno \u0161tevilo bole\u010dine)<\/td><td>5,3 %<\/td><td>47,4 %<\/td><td>* <strong>894% pove\u010danje<\/strong> * mo\u017enosti popolnega odstranjevanja bole\u010dine.<\/td><\/tr><tr><td><strong>\u010cas do popolnega laj\u0161anja bole\u010dine<\/strong><\/td><td>ni bil dose\u017een<\/td><td>10 dni<\/td><td><strong>\u201d pomemben in hiter\u201d<\/strong>\u00a0prinos<\/td><\/tr><tr><td style=\"text-align: left;\"><strong>Trajanje Laj\u0161anja Bole\u010dine <\/strong><\/td><td style=\"text-align: left;\">Mediana: 28 dni\/4 tedne pri polovici bolnikov<\/td><td style=\"text-align: left;\">Mediana: Ni vklju\u010deno pri 24 tednih<\/td><td style=\"text-align: left;\">Trajanje laj\u0161anja * <strong>se pove\u010da za \u0161estkrat<\/strong> *, zmanj\u0161uje odvisnost od protibole\u010dinskih zdravil.<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">\u00a0<\/p><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">V primerjavi s podobno [link: \u0160tudijo Faze III Chi MS et al. 2017] (2017) z RF lokalno hipertermijo, so bili dose\u017eeni pr\u00ednosi (glede QoL in zmanj\u0161anja bole\u010dine) z uporabo WBH wIRA hipertermije <strong>dale\u010d bolj\u0161i<\/strong> \u2013 rezultati \u0161tudije RF HT + RT:<\/p><table border=\"1\"><thead><tr><th>Indikator QoL\/Izbolj\u0161anje Bole\u010dine<\/th><th>Monoterapija RT<\/th><th>RT + Hipertermija (HT)<\/th><th>Vpliv QoL<\/th><\/tr><\/thead><tbody><tr><td><strong>Stopnja Popolnega Odziva (CR) po 3 Mesecih<\/strong> (ni\u010delno \u0161tevilo bole\u010dine)<\/td><td>7,1 %<\/td><td>37,9 %<\/td><td>533% pove\u010danje mo\u017enosti popolnega laj\u0161anja bole\u010dine.<\/td><\/tr><tr><td><strong>Trajanje Laj\u0161anja Bole\u010dine<\/strong><\/td><td>Mediana: 55 dni\/7,9 tednov<\/td><td>Mediana: Ni vklju\u010deno pri 24 tednih<\/td><td>Trajanje laj\u0161anja se potroj\u00ed, zmanj\u0161uje odvisnost od protibole\u010dinskih zdravil.<\/td><\/tr><\/tbody><\/table><p style=\"text-align: left;\">\u010ce povzamemo, utrjeni znanstveni dokazi (od temeljnih \u0161tudij o tehnologiji wIRA do klju\u010dnih klini\u010dnih presku\u0161anj Faze III) potrjujejo vlogo WBH kot adjuvantne terapije z ve\u010d u\u010dinki v onkologiji: <strong>pove\u010da u\u010dinkovitost CT\/RT, aktivira sistemski imunski sistem (vklju\u010dno s sinergijo z imunoterapijo) in dramati\u010dno izbolj\u0161a nadzor bole\u010dine in QoL<\/strong> za onkolo\u0161ke bolnike.<\/p><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Sistemske Fiziolo\u0161ke Koristi in Terapevtski Potencial pri Drugih Patologijah<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>\u00a0<\/p><header id=\"ut_header_68e7a7d03d95c\"><header>Ne\u017ena, nadzorovana toplota, ki jo nudi WBH z wIRA sevanjem, spro\u017ei kompleksne termoregulacijske odzive, ki prina\u0161ajo \u0161iroke sistemske koristi, raz\u0161irjajo\u010d terapevtski potencial tudi izven onkologije:\u00a0<\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. Mi\u0161i\u010dno-Skeletno in Obvladovanje Bole\u010dine<\/h3><p style=\"text-align: left;\">WBH je u\u010dinkovita pri obvladovanju sindromov kroni\u010dne bole\u010dine, izkori\u0161\u010dajo\u010d njene fiziolo\u0161ke u\u010dinke na mi\u0161i\u010dni tonus in mikrocirkulacijo:<\/p><ul><li style=\"text-align: left;\">Dorsalgija (Kroni\u010dna Bole\u010dina v Hrbtu): \u0160tudije ka\u017eejo, da blaga WBH, v kombinaciji s stacionarno multimodalno terapijo bole\u010dine, nudi pomembno korist za bolnike s kroni\u010dno ne-specifi\u010dno bole\u010dino v spodnjem delu hrbta (dorsalgija) [53, 54].<\/li><li style=\"text-align: left;\">Sindrom Fibromialgije (FMS): WBH je dokumentirano dopolnilno zdravljenje za FMS. Randomizirana nadzorovana presku\u0161anja so dokazala u\u010dinkovitost blage wIRA WBH v standardnem multimodalnem rehabilitacijskem okolju, kar ka\u017ee na u\u010dinke na intenzivnost bole\u010dine in mentalno stanje [17, 56, 57]. Ta korist je deloma povezana z izbolj\u0161ano mikrocirkulacijo, znano te\u017eavo pri bolnikih z FMS [55].<\/li><li style=\"text-align: left;\">Ankylozivni Spondilitis (AS): WBH je pokazala imunomodulacijske u\u010dinke pri bolnikih z AS, pri \u010demer \u0161tudije poro\u010dajo o sposobnosti WBH pove\u010dati protivnetne mediatorje, kot je Interlevkin-10 (IL-10), in modulirati pro-vnetne citokine, kot je TNF-alfa, kar nakazuje na koristno vlogo pri obvladovanju kroni\u010dnega vnetja, povezanega s tem stanjem [58, 59, 52].<\/li><li style=\"text-align: left;\">Raynaudov Fenomen pri Sistemski Sklerozi: Infrarde\u010de posredovana hipertermija se je izkazala za u\u010dinkovito pri zdravljenju vazokonstriktivnih simptomov, povezanih s Raynaudovim fenomenom, povezanim s sklerodermijo, kar dokazuje vaskularne koristi [49].<\/li><\/ul><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. Kardiovaskularno in O\u017eilno Zdravje \u2764\ufe0f<\/h3><p style=\"text-align: left;\">Poleg izbolj\u0161anja perfuzije tumorja ima WBH specifi\u010dne u\u010dinke na obto\u010dni sistem:<\/p><ul><li style=\"text-align: left;\">Esencialna Hipertenzija: Serija \u0161tudij je preiskovala uporabo blage IR-A hipertermije pri bolnikih z arterijsko hipertenzijo (WHO Faze I in II). Ugotovitve ka\u017eejo, da lahko serijska zdravljenja pozitivno vplivajo na <strong>centralne in periferne pulzne valove<\/strong>, krvni tlak in <strong>viskoznost krvi<\/strong>, kar potrjuje vlogo WBH kot ne-farmakolo\u0161ke mo\u017enosti fizikalne terapije [44, 47].<\/li><\/ul><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \" style=\"text-align: left;\"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">C. Nevro-Endokrini in Psiholo\u0161ki U\u010dinki<\/h3><p style=\"text-align: left;\">WBH vklju\u010duje nevro-endokrine sisteme telesa, ki vplivajo na razpolo\u017eenje in metabolizem:<\/p><ul><li style=\"text-align: left;\">Velika Depresivna Motnja (MDD): Randomizirano klini\u010dno presku\u0161anje je pokazalo, da lahko posamezno sedenje WBH deluje kot hitro delujo\u010di antidepresiv, kar povzro\u010di zmanj\u0161anje depresivnih simptomov za ve\u010d tednov. Ta u\u010dinek je povezan s toplotno inducirano aktivacijo imunskih in vnetnih poti, ki vplivajo na mo\u017egane [51].<\/li><li style=\"text-align: left;\">Hormonska Modulacija (Endokrinologija): WBH spodbuja <strong>Hipotalami\u010dno-Hipofizno-Nadledvi\u010dno (HPA) os<\/strong> in vpliva na ravni hormonov. \u0160tudije so dokumentirale odzive <strong>Rastnega Hormona<\/strong> in <strong>Prolaktina<\/strong> med hipertermijo celega telesa, kar poudarja njen vpliv na endokrino regulacijo [42, 43].<\/li><li style=\"text-align: left;\">Metabolizem in Celi\u010dna Reakcija: WBH pospe\u0161i bazalni metabolizem. Na celi\u010dni ravni toplota vpliva na pO2 kinetiko in je povezana s sintezo za\u0161\u010ditnih proteinov, kot je <strong>feritin<\/strong>, v ko\u017ei, kar podpira popravilo tkiva [48; 46].<\/li><\/ul><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pogosta Vpra\u0161anja (FAQ) o Priporo\u010denih WBH Sedenjih in Ciljnih Temperaturah<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header>Zdravljenje se sme izvajati le po kon\u010dnem posvetovanju z zdravnikom.<\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h4>\u00a0<\/h4><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h4>Kak\u0161en je priporo\u010deni protokol Hipertermije Celega Telesa (WBH) za Esencialno Hipertenzijo?<\/h4><p>Protokol za Esencialno Hipertenzijo priporo\u010da 12 sedenj pri ciljni temperaturi 38,3 \u00b0C. Vsako sedenje traja pribli\u017eno 45 minut, kar vklju\u010duje 30-minutno fazo pove\u010danja in 15-minutno fazo po\u010ditka (brez faze platoja).<\/p><h4>Kak\u0161ni so priporo\u010deni WBH parametri za Kroni\u010dno Bole\u010dino v Hrbtu (Dorsalgija)?<\/h4><p>Za Dorsalgijo se obi\u010dajno priporo\u010da 6 sedenj, z ciljno temperaturo 38,4 \u00b0C. Celoten \u010das sedenja je pribli\u017eno 90 minut, s 45 minutami pove\u010danja, 15-minutno fazo platoja in 30-minutnim po\u010ditkom.<\/p><h4>Kak\u0161en je WBH protokol za Fibromialgijo in Ankylozivni Spondilitis?<\/h4><p>Obe, Fibromialgija in Ankylozivni Spondilitis, obi\u010dajno sledita protokolu 6 sedenj, z ciljno temperaturo 38,5 \u00b0C. Celoten \u010das sedenja je pribli\u017eno 90 minut, vklju\u010dno s 45 minutami pove\u010danja, 15-minutnim platojem in 30-minutnim po\u010ditkom.<\/p><h4>Kak\u0161en je priporo\u010deni protokol za WBH kot Aditivno Zdravljenje Raka?<\/h4><p>Kot aditivno zdravljenje raka protokol zahteva 2 ali ve\u010d sedenj, z ciljno bazalno temperaturo med 39,0 \u00b0C in 40,0 \u00b0C. Celoten \u010das sedenja je najdalj\u0161i, se giblje od 3 do 4 ure, kar vklju\u010duje 60-90 minut za fazo pove\u010danja, 60-90 minut za fazo platoja in 60 minut za fazo po\u010ditka.<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header>.<table width=\"1151\"><tbody><tr><td width=\"278\">\u00a0<\/td><\/tr><\/tbody><\/table><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div><div class=\"wpb_content_element \"><div><div><header id=\"ut_header_68e7a7d03d95c\"><header><table width=\"1151\"><tbody><tr><td width=\"278\">Indikacija<\/td><td width=\"99\">\u0160t. sedenj<\/td><td width=\"135\">Ciljna temperatura<\/td><td colspan=\"2\" width=\"309\">\u010cas terapije Faza pove\u010danja\u00a0 \u00a0 \u00a0 Faza platoja<\/td><td width=\"164\">\u010cas po\u010ditka Faza po\u010ditka<\/td><td width=\"164\"><strong>Skupni<\/strong> <strong>\u010das WBH sedenja<\/strong><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Esencialna Hipertenzija<\/td><td rowspan=\"2\" width=\"99\">12<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>30 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 45 min<\/strong><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Dorsalgija<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,4 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>60 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 90 min<\/strong><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Fibromialgija<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>60 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 90 min<\/strong><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Ankylozivni Spondilitis<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>60 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 90 min<\/strong><\/td><\/tr><tr><td width=\"155\">45 min<\/td><td width=\"155\">15 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Sistemska Skleroza<\/td><td rowspan=\"2\" width=\"99\">15<\/td><td rowspan=\"2\" width=\"135\">38,3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>30 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">15 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 45 min<\/strong><\/td><\/tr><tr><td width=\"155\">30 min<\/td><td width=\"155\">0 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Velika Depresivna Motnja<\/td><td rowspan=\"2\" width=\"99\">1+<\/td><td rowspan=\"2\" width=\"135\">38,5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>105 -170 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">30 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 2-3 ure<\/strong><\/td><\/tr><tr><td width=\"155\">45-110 min<\/td><td width=\"155\">60 min<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Aditivno Zdravljenje Raka<\/td><td rowspan=\"2\" width=\"99\">2+<\/td><td rowspan=\"2\" width=\"135\">39,0-40,0 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><strong>120-180 min<\/strong><\/td><td rowspan=\"2\" width=\"164\">60 min<\/td><td rowspan=\"2\" width=\"164\"><strong>~ 3-4 ure<\/strong><\/td><\/tr><tr><td width=\"155\">60-90 min<\/td><td width=\"155\">60-90 min<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><\/header><p>\u00a0<\/p><\/div><\/div><\/div><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header>OPOMBA: ta \u010dlanek ni iz\u010drpen seznam \u0161tudij in u\u010dinkov WBH wIRA<\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Referencie a Cit\u00e1cie<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><ol><li style=\"text-align: left;\">Ardenne M. von. Moderate Hyperthermie als Behandlungsmethode mit vielen Indikationen. \u00c4rztzeitschr Naturheilverf 1994; 5:356-61.<\/li><li style=\"text-align: left;\">B\u00e4umler H., Scherf H.P., Aurisch R., et al. Einflu\u00df einer Serie von Infrarot-Ganzk\u00f6rperbestrahlungen auf Flie\u00dfeigenschaften des Blutes und die H\u00e4modynamik. Perfusion 1990: 138-43.<\/li><li style=\"text-align: left;\">Heckel M. Ganzk\u00f6rper-Hyperthermie und Fiebertherapie, Grundlagen und Praxis. Stuttgart: Hippokrates Verlag, 1990.<\/li><li style=\"text-align: left;\">Kosaka M., Sugahara T., Schmidt K.L., Simon E. Thermotherapy: Principles and Practice. Heidelberg: Springer Verlag, 2000.<\/li><li style=\"text-align: left;\">Meffert H., Hecht H.C., G\u00fcnther H., et al. Biophysikalische Ergebnisse des klinischen Tests der IRA-Therm-Hyperthermietechnik der 2. Generation. ThermoMed 1990; 6:71-78.<\/li><li style=\"text-align: left;\">Schmidt K.L. Hyperthermie und Fieber, Wirkungen bei Mensch und Tier. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1987.<\/li><li style=\"text-align: left;\">Vaupel P., Kr\u00fcger W. W\u00e4rmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsm\u00f6glichkeiten. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1995.<\/li><li style=\"text-align: left;\">Piazena H., Meffert H. Optische Eigenschaften der Haut und die photobiologischen Grundlagen zur Dosierung von IR-Hautbestrahlungen in vivo und in vitro. 6. Symposium Licht und Gesundheit 2008 13.-14.03. Berlin, 2008:162-178.<\/li><li style=\"text-align: left;\">Zschaeck S. and Beck M. Chapter 8 Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?<\/li><li style=\"text-align: left;\">Zhang H, Wang W, Zhang S, Huang W. 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Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic whole-body hyperthermia&#8230; J Musculoskel Pain 2014; 4:341-55.<\/li><li style=\"text-align: left;\">Zauner D., Quehenberger F., Hermann J., et al. Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study. Int J Hyperthermia 2014; 6:393-401.<\/li><li style=\"text-align: left;\">Lange U., M\u00fcller-Ladner U., Dischereit G. Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis&#8230; Akt Rheumatol 2017; 2:122-128.<\/li><\/ol><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>\u00a0<\/p><\/section><footer>\u00a9 <time>2025<\/time> Romanian Society Oncologic Hyperthermia All rights reserved. Source: Analysis based on scientific literature.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Hipertermija Celega Telesa (WBH) v Onkologiji in Drugih Patologijah: Utrjena Sinergija, Imunomodulacija in Klini\u010dni Dokazi Objavljeno: 2025-10-13 | Zadnja Revizija: 2025-10-13 Avtorja: Veronica Iatan, MD, Cristian Gologan, M.Sc. Hipertermija Celega Telesa (WBH) je sistemska onkolo\u0161ka strategija, ki vklju\u010duje nadzorovano segrevanje telesne temperature, pogosto z uporabo tehnologije vodno filtriranega Infrarde\u010dega-A sevanja (wIRA). WBH je v osnovi<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/sl\/klinicna-preskusanja-hipertermija-onkologija\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-988","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/sl\/wp-json\/wp\/v2\/pages\/988","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/sl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/sl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/sl\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/sl\/wp-json\/wp\/v2\/comments?post=988"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/sl\/wp-json\/wp\/v2\/pages\/988\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/sl\/wp-json\/wp\/v2\/media?parent=988"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}