{"id":991,"date":"2025-10-13T09:59:16","date_gmt":"2025-10-13T09:59:16","guid":{"rendered":"https:\/\/ardenneiratherm.com\/clinical-trials-whole-body-hyperthermia-wira\/"},"modified":"2026-01-20T16:10:09","modified_gmt":"2026-01-20T16:10:09","slug":"klinik-calismalar-hipertermi-ir-a-fa-onkoloji","status":"publish","type":"page","link":"https:\/\/ardenneiratherm.com\/tr\/klinik-calismalar-hipertermi-ir-a-fa-onkoloji\/","title":{"rendered":"Klinik \u00c7al\u0131\u015fmalar"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"991\" class=\"elementor elementor-991 elementor-756\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea8f7b2 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"ea8f7b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInDown&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3c7e79 elementor-widget elementor-widget-heading\" data-id=\"f3c7e79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Onkoloji ve Di\u011fer Patolojilerde T\u00fcm V\u00fccut Hipertermi (TVH): G\u00fc\u00e7l\u00fc Sinerji, \u0130mm\u00fcnomod\u00fclasyon ve Klinik \u00c7al\u0131\u015fmalar<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02c88e animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c02c88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header><strong>Yay\u0131nlanma Tarihi: <time datetime=\"2025-10-13\">2025-10-13<\/time> | Son \u0130nceleme: <time datetime=\"2025-10-13\">2025-10-13<\/time><\/strong><\/header><p>Yazanlar:<br \/><a href=\"\/?p=139\">Veronica Iatan, MD<\/a>,<br \/><a href=\"\/?p=137\">Cristian Gologan, M.Sc.<\/a><\/p><section><p style=\"font-weight: bold; font-style: italic;\">T\u00fcm V\u00fccut Hipertermi (TVH), v\u00fccut \u00e7ekirdek s\u0131cakl\u0131\u011f\u0131n\u0131n kontroll\u00fc bir \u015fekilde \u0131s\u0131t\u0131lmas\u0131n\u0131 i\u00e7eren ve genellikle *suyla filtrelenmi\u015f K\u0131z\u0131l\u00f6tesi-A (wIRA)* teknolojisini kullanan sistemik bir onkolojik stratejidir. TVH, geleneksel tedavilerin etkinli\u011fini art\u0131rmak i\u00e7in t\u00fcm\u00f6r perf\u00fczyonunu ve oksijenlenmesini \u00f6nemli \u00f6l\u00e7\u00fcde *iyile\u015ftiren* temel bir *kemo\/radyo duyarl\u0131la\u015ft\u0131r\u0131c\u0131d\u0131r*. Daha da \u00f6nemlisi, Is\u0131 \u015eoku Proteinlerini (HSP&#8217;ler) ve T h\u00fccrelerini harekete ge\u00e7iren g\u00fc\u00e7l\u00fc bir *sistemik imm\u00fcnomod\u00fclat\u00f6r* olarak i\u015flev g\u00f6r\u00fcr, bu da en son *\u0130mm\u00fcnoterapi (ICI)* ile temel bir sinerji olu\u015fturur ve \u00e7e\u015fitli kanserlerde ve Fibromiyalji gibi kronik patolojilerde *dramatik, h\u0131zl\u0131 a\u011fr\u0131 giderme ve Ya\u015fam Kalitesinde iyile\u015fme* sunar.<\/p><\/section><section>* T\u0131bbi Feragatname: Bu makale yaln\u0131zca bilgilendirme ama\u00e7l\u0131d\u0131r ve lisansl\u0131 bir hekim taraf\u0131ndan sa\u011flanan bireysel t\u0131bbi kons\u00fcltasyon, te\u015fhis veya tedavinin yerine ge\u00e7mez.*<\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805e6aa e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"805e6aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67bd9be elementor-widget elementor-widget-heading\" data-id=\"67bd9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. T\u00fcm V\u00fccut Hipertermi (TVH) ve Terap\u00f6tik Teknolojinin Tan\u0131m\u0131<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67346b0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"67346b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h2>\u00a0<\/h2><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\"><strong>T\u00fcm V\u00fccut Hipertermi (TVH)<\/strong>, veya \u201csistemik hipertermi,\u201d terap\u00f6tik ama\u00e7larla v\u00fccut \u00e7ekirdek s\u0131cakl\u0131\u011f\u0131n\u0131n kontroll\u00fc bir \u015fekilde art\u0131r\u0131lmas\u0131 olarak tan\u0131mlan\u0131r. **Farkl\u0131 s\u0131cakl\u0131klardaki do\u011fal ate\u015fin etkileri** spektrumuna dayanarak, TVH prosed\u00fcrleri a\u015fa\u011f\u0131daki gibi farkl\u0131la\u015ft\u0131r\u0131l\u0131r:<\/p><ul style=\"text-align: left;\"><li><strong>Hafif TVH:<\/strong> &lt; 38.5<strong>\u00b0<\/strong>C<\/li><li><strong>Orta D\u00fczey TVH:<\/strong> 38.5<strong>\u00b0<\/strong>C- 40.5 <strong> \u00b0<\/strong>C<\/li><li><strong>A\u015f\u0131r\u0131 TVH:<\/strong> &gt; 40.5<strong>\u00b0<\/strong>C<\/li><\/ul><p style=\"text-align: left;\">\u00d6zellikle hafif ve orta d\u00fczey TVH **perf\u00fczyonu art\u0131r\u0131r,** metabolizmay\u0131 uyar\u0131r, kas tonusunu azalt\u0131r ve **ba\u011f\u0131\u015f\u0131kl\u0131k sistemini uyar\u0131r.**<\/p><p style=\"text-align: left;\"><a title=\"von Ardenne IRATHERM\u00ae 1000M TVH wIRA cihaz\u0131n\u0131n Teknik Detaylar\u0131\" href=\"https:\/\/ardenneiratherm.com\/tr\/hipertermi-cihazi-ardenne-iratherm\/\"><strong>von Ardenne IRATHERM<\/strong>\u00ae <strong>1000M TVH wIRA cihaz\u0131<\/strong><\/a>, bu ama\u00e7la sadece <strong>cilt dostu, derin doku, suyla filtrelenmi\u015f K\u0131z\u0131l\u00f6tesi-A (wIRA) \u0131s\u0131 radyasyonu<\/strong> (IR-B \/ IR-C olmaks\u0131z\u0131n) kullan\u0131r. Klostrofobik olmayan, a\u00e7\u0131k sistem tasar\u0131m\u0131, hastan\u0131n t\u00fcm (s\u0131rt) seviyesinde d\u00fczg\u00fcn bir \u0131\u015f\u0131nlama yo\u011funlu\u011fu sa\u011flar ve kullan\u0131c\u0131ya konum ve yo\u011funluk a\u00e7\u0131s\u0131ndan optimal, hastaya \u00f6zg\u00fc bir \u0131s\u0131 temini sunar.<\/p><p style=\"text-align: left;\">Suyla filtrelenmi\u015f k\u0131z\u0131l\u00f6tesi-A radyasyonu, g\u00fcne\u015fin do\u011fal termal radyasyonuna kar\u015f\u0131l\u0131k gelir ve d\u00fczg\u00fcn ve nazik \u0131s\u0131 uygulamas\u0131 i\u00e7in teknolojik temeli sa\u011flar [1, 5, 7, 8].<\/p><p style=\"text-align: left;\">30 y\u0131l\u0131 a\u015fk\u0131n s\u00fcredir geli\u015ftirilen ve kan\u0131tlanan von Ardenne IRATHERM<sup>\u00ae<\/sup> 1000 ilkesini kullanarak, <a title=\"Prof. Manfred von Ardenne - Katk\u0131lar\" href=\"\/?p=5\">Prof. Manfred von Ardenne<\/a> bu termal radyasyonu fiziksel ve teknik olarak yeniden \u00fcretmeyi ve t\u00fcm v\u00fccut hipertermisi yoluyla s\u00fcrd\u00fcr\u00fclebilir t\u0131bbi kullan\u0131m i\u00e7in end\u00fcstriyel olarak eri\u015filebilir k\u0131lmay\u0131 ba\u015farm\u0131\u015ft\u0131r<\/p><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c924fa elementor-invisible elementor-widget elementor-widget-image\" data-id=\"6c924fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-wIRA.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-wIRA\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48fd6d3 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"48fd6d3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aafa804 elementor-widget elementor-widget-heading\" data-id=\"aafa804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. Bilimsel Temeller ve Sistemik Etkiler<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-672df30 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"672df30\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">TVH, sa\u011flam biyofiziksel ve fizyolojik ilkelere dayanan bir strateji olarak geli\u015fmi\u015ftir. Onkolojide odak noktas\u0131, birden fazla terap\u00f6tik endikasyona sahip tedaviler olarak kabul edilen <strong>Orta D\u00fczey<\/strong> ve <strong>Ate\u015f Aral\u0131\u011f\u0131 Hipertermisi (AA-TVH)<\/strong> \u00fczerindedir [1, 3].<\/p><p style=\"text-align: left;\">D\u00fczg\u00fcn ve nazik \u0131s\u0131 uygulamas\u0131n\u0131n teknolojik temeli, genellikle <strong>suyla filtrelenmi\u015f K\u0131z\u0131l\u00f6tesi-A (wIRA) radyasyonu<\/strong> kullanan cihazlar taraf\u0131ndan sa\u011flan\u0131r. Ayr\u0131nt\u0131l\u0131 biyofiziksel \u00e7al\u0131\u015fmalar, bu <strong>teknolojinin derin ve kontroll\u00fc \u0131s\u0131tma sa\u011flama yetene\u011fini<\/strong> do\u011frulam\u0131\u015f, cildin optik \u00f6zelliklerini ve dozimetri i\u00e7in fotobiyolojik temeli dikkate alm\u0131\u015ft\u0131r [5, 7, 8].<\/p><p style=\"text-align: left;\">Ayr\u0131nt\u0131l\u0131 biyofiziksel \u00e7al\u0131\u015fmalar, <strong>wIRA teknolojisinin<\/strong> <strong>derin ve kontroll\u00fc \u0131s\u0131tma<\/strong>\u00a0sa\u011flama yetene\u011fini do\u011frulam\u0131\u015ft\u0131r [5, 7, 8]. Fizyolojik d\u00fczeyde, TVH&#8217;nin temel sistemik etkileri vard\u0131r:<\/p><ol style=\"text-align: left;\"><li><strong>Geli\u015fmi\u015f Kan Reolojisi:<\/strong> IR-TVH&#8217;ye maruz kalma, <strong>kan ak\u0131\u015f \u00f6zelliklerini ve hemodinami\u011fi<\/strong> olumlu y\u00f6nde etkiler [2], <strong>t\u00fcm\u00f6r perf\u00fczyonunu iyile\u015ftirme<\/strong>\u00a0temel mekanizmas\u0131n\u0131 destekler\u2014bu da sistemik tedavilerin ba\u015far\u0131s\u0131 i\u00e7in kritik bir \u00f6n ko\u015fuldur.<\/li><li><strong>Genel Biyolojik Aktivasyon:<\/strong> TVH, <strong>hormonal sistemin mod\u00fclasyonu<\/strong> ve <strong>metabolizman\u0131n h\u0131zlanmas\u0131<\/strong>\u00a0[6, 4] dahil olmak \u00fczere bir dizi biyolojik s\u00fcreci tetikleyen termal stres yan\u0131t\u0131 olu\u015fturur.<\/li><\/ol><p style=\"text-align: left;\">Bu temeller nedeniyle, TVH bir <strong>sistemik imm\u00fcnomod\u00fclat\u00f6r<\/strong> olarak i\u015flev g\u00f6r\u00fcr, <strong>t\u00fcm\u00f6r mikro \u00e7evresini (TME)<\/strong> optimize eder ve <strong>en son onkolojik tedavilerin etkinli\u011fini art\u0131r\u0131r<\/strong>\u00a0[9].<\/p><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-73d38c1 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"73d38c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4061817 elementor-widget elementor-widget-heading\" data-id=\"4061817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. Temel Etki Mekanizmalar\u0131 (Molek\u00fcler, Fizyolojik ve \u0130mm\u00fcnolojik)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22327e2 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"22327e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">TVH&#8217;nin terap\u00f6tik etkileri, h\u00fccresel, ba\u011f\u0131\u015f\u0131kl\u0131k ve fizyolojik d\u00fczeylerdeki de\u011fi\u015fikliklerle arac\u0131l\u0131k edilen karma\u015f\u0131kt\u0131r:<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5638fef animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5638fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. Kemoterapi ve Radyoterapi ile Sinerji (Kemo\/Radyo Duyarl\u0131la\u015ft\u0131r\u0131c\u0131)<\/h3><ul><li style=\"text-align: left;\"><strong>T\u00fcm\u00f6r Mikro \u00c7evresinin (TME) Optimizasyonu:<\/strong> TVH, t\u00fcm\u00f6r hipoksisini tersine \u00e7evirerek **t\u00fcm\u00f6r kan perf\u00fczyonunu** ve **oksijenlenmesini** iyile\u015ftirir. Bu esast\u0131r, \u00e7\u00fcnk\u00fc iyi oksijenlenmi\u015f t\u00fcm\u00f6r h\u00fccreleri, **Kemoterapi** (KT) ve **Radyoterapi** (RT) ile yok edilmeye \u00f6nemli \u00f6l\u00e7\u00fcde daha duyarl\u0131d\u0131r [9, 41].<\/li><li style=\"text-align: left;\"><strong>Kemo\/Radyo Etkinli\u011fi:<\/strong> Hipertermi, **kemo &amp; radyo duyarl\u0131la\u015ft\u0131r\u0131c\u0131** olarak hareket eder, t\u00fcm\u00f6r oksijen tedarikini iyile\u015ftirir (<em>radyo duyarl\u0131la\u015ft\u0131r\u0131c\u0131 etki<\/em>) ve Cisplatin, Gemsitabin ve Carboplatin gibi ila\u00e7lar\u0131n etkinli\u011fini art\u0131r\u0131r [12, 16, 36].<\/li><\/ul><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3119e45 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3119e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. G\u00fc\u00e7l\u00fc Bir Anti-T\u00fcm\u00f6r Ba\u011f\u0131\u015f\u0131kl\u0131k Yan\u0131t\u0131n\u0131n \u0130nd\u00fcklenmesi (\u0130mm\u00fcnomod\u00fclasyon)<\/h3><p style=\"text-align: left;\">TVH, v\u00fccudun savunma sisteminin g\u00fc\u00e7l\u00fc bir aktivat\u00f6r\u00fcd\u00fcr [11]:<\/p><ul><li style=\"text-align: left;\"><strong>Is\u0131 \u015eoku Proteinleri (HSP&#8217;ler):<\/strong> Termal stres, **HSP70** sentezini ve sal\u0131n\u0131m\u0131n\u0131 uyar\u0131r. Bu proteinler, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin **Sitotoksik T Lenfositleri (STL&#8217;ler)** taraf\u0131ndan kanser h\u00fccrelerinin art\u0131r\u0131lm\u0131\u015f bir sald\u0131r\u0131 i\u00e7in i\u015faretlenmesini sa\u011flayan &#8216;tehlike sinyalleri&#8217; olarak i\u015flev g\u00f6r\u00fcr [9, 10, 29].<\/li><li style=\"text-align: left;\"><strong>Temel Ba\u011f\u0131\u015f\u0131kl\u0131k H\u00fccrelerinin Aktivasyonu:<\/strong> 39-43<strong>\u00b0<\/strong>C s\u0131cakl\u0131k aral\u0131\u011f\u0131, **Do\u011fal \u00d6ld\u00fcr\u00fcc\u00fc (NK) h\u00fccrelerin** aktivitesini art\u0131r\u0131r ve **yard\u0131mc\u0131 ve sitotoksik T h\u00fccrelerinin**, **dendritik h\u00fccrelerin** ve **makrofajlar\u0131n** aktivitesini te\u015fvik ederken, ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lay\u0131c\u0131 h\u00fccreleri potansiyel olarak tehlikeye atar [9, 10, 11, 25, 26].<\/li><li style=\"text-align: left;\"><strong>T-Lenfosit Art\u0131\u015f\u0131:<\/strong> AA-TVH, lenfoid organlardaki **sitotoksik T lenfosit pop\u00fclasyonunu \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabilir (\u00f6rne\u011fin 3 kat)**, b\u00f6ylece **sistemik anti-t\u00fcm\u00f6r ba\u011f\u0131\u015f\u0131kl\u0131k sald\u0131r\u0131s\u0131n\u0131 g\u00fc\u00e7lendirir** [10].<\/li><li style=\"text-align: left;\"><strong>A\u015f\u0131lar ve APC&#8217;ler:<\/strong> TVH, Antijen Sunan H\u00fccrelerin (APC&#8217;ler) i\u015flevini d\u00fczenleyebilir ve HSP110 ve GRP170&#8217;e dayal\u0131 olanlar da dahil olmak \u00fczere kanser a\u015f\u0131lar\u0131n\u0131n etkinli\u011fini art\u0131rabilir [37, 28].<\/li><\/ul><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbbd880 animated-slow e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"bbbd880\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e99507b elementor-widget elementor-widget-heading\" data-id=\"e99507b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. Klinik Kan\u0131tlar ve Multimodal Terapide Sinerji<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a66ba animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e6a66ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">A. \u0130mm\u00fcnoterapi (Kontrol Noktas\u0131 \u0130nhibit\u00f6rleri &#8211; ICI) ile Sinerji<\/h3><p style=\"text-align: left;\">\u0130lerlemi\u015f (Evre IV) kanser hastas\u0131 olan 131 ki\u015filik retrospektif bir vaka serisi, kontrol noktas\u0131 inhibit\u00f6rleri (\u0130pilimumab, Nivolumab) ve IL-2 ile birlikte **t\u00fcm v\u00fccut hipertermisini** i\u00e7eren multimodal bir protokol\u00fc inceledi [18].<\/p><p style=\"text-align: left;\"><strong>Temel Sonu\u00e7:<\/strong> wIRA T\u00fcm V\u00fccut Hipertermi&#8217;nin **anti-t\u00fcm\u00f6r ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131n\u0131 maksimize eden** **ayr\u0131lmaz ve temel bir bile\u015fen** oldu\u011fu belirlendi. <strong>TVH, T h\u00fccrelerini aktive eder ve mobilize eder (HSP70&#8217;i ind\u00fckleyerek ve t\u00fcm\u00f6r antijenlerini salarak);<\/strong> kontrol noktas\u0131 inhibit\u00f6rleri daha sonra bu \u00f6nceden aktive edilmi\u015f T h\u00fccrelerinden &#8220;freni kald\u0131r\u0131r&#8221;, bu da ilerlemi\u015f hastal\u0131k i\u00e7in al\u0131\u015f\u0131lmad\u0131k derecede y\u00fcksek olumlu klinik yan\u0131t oranlar\u0131 ile sonu\u00e7lan\u0131r [18].<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-464662f animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"464662f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">B. \u00c7e\u015fitli Kanserlerde Klinik Uygulamalar<\/h3><ul><li style=\"text-align: left;\"><strong>Pankreas Kanseri:<\/strong> Kemoterapi ve \u0130nterferon-alfa ile birle\u015ftirilmi\u015f hafif TVH (AA-TVH) kullanan Faz I-II protokolleri, **tedaviye diren\u00e7li hastalar\u0131n neredeyse yar\u0131s\u0131nda en az %50 t\u00fcm\u00f6r gerilemesi** g\u00f6stermi\u015ftir [4, 22].<\/li><li style=\"text-align: left;\"><strong>Meme Kanseri (N\u00fcks):<\/strong> TVH&#8217;nin yeniden \u0131\u015f\u0131nlama veya radyoterapi ile birle\u015ftirilmesi, randomize verilerle do\u011frulanan lokal olarak ilerlemi\u015f meme kanseri ve g\u00f6\u011f\u00fcs duvar\u0131 n\u00fcks\u00fc i\u00e7in etkinlik g\u00f6stermi\u015ftir [39, 40].<\/li><li style=\"text-align: left;\"><strong>Yumurtal\u0131k Kanseri:<\/strong> N\u00fcks eden yumurtal\u0131k kanseri i\u00e7in bir Faz II \u00e7al\u0131\u015fmas\u0131nda **karboplatin** ile birle\u015ftirilmi\u015f TVH incelenmi\u015ftir [16, 20].<\/li><li style=\"text-align: left;\"><strong>Kolorektal Kanser:<\/strong> TVH wIRA, Von Ardenne&#8217;nin Sistemik Kanser \u00c7ok Ad\u0131ml\u0131 Tedavisi (s\u00c7AT) ba\u011flam\u0131nda bir Faz I\/II \u00e7al\u0131\u015fmas\u0131nda kemoterapi ile birle\u015ftirilmi\u015ftir [15].<\/li><\/ul><\/header><\/header><h2>\u00a0<\/h2><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4cb34f6 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"4cb34f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ca566 elementor-widget elementor-widget-heading\" data-id=\"c7ca566\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. H\u0131zl\u0131 A\u011fr\u0131 Giderme ve \u00d6nemli Ya\u015fam Kalitesi (YK) \u0130yile\u015fmesi<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec3c40 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8ec3c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">Hastalar, Dr. Bull&#8217;un \u00e7al\u0131\u015fmas\u0131nda g\u00f6zlemlendi\u011fi gibi [12] ve \u00f6zellikle Sahinbas ve arkada\u015flar\u0131 taraf\u0131ndan ger\u00e7ekle\u015ftirilen daha yeni Faz III klinik \u00e7al\u0131\u015fmas\u0131nda [14] h\u0131zl\u0131 a\u011fr\u0131 giderme ve genel bir iyi olu\u015f iyile\u015fmesi ya\u015fayabilir.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfebbf0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cfebbf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">Kemik Metastazlar\u0131 i\u00e7in Faz III Klinik \u00c7al\u0131\u015fmas\u0131 (2024)<\/h3><section><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0306456524000226\" target=\"_blank\" rel=\"noopener\">2024 y\u0131l\u0131nda, Sahinbas ve meslekta\u015flar\u0131<\/a>, RT&#8217;ye ek olarak TVH wIRA Iratherm hipertermi cihazlar\u0131 kullanarak esas olarak meme ve prostat kanserinden kaynaklanan kemik metastaz a\u011fr\u0131s\u0131 i\u00e7in bir Faz III \u00e7al\u0131\u015fmas\u0131 yay\u0131nlad\u0131lar [14].Bu \u00e7al\u0131\u015fmaya g\u00f6re, tek ba\u015f\u0131na radyoterapi (RT) grubu en \u015fiddetli a\u011fr\u0131y\u0131 sundu. \u00c7al\u0131\u015fma, ilk kay\u0131ttan 5 y\u0131l sonra (Nisan 2016 \u2013 \u015eubat 2021) toplam 61 hasta kaydedilerek tamamland\u0131. Sonu\u00e7 olarak, RT + TVH grubundaki Tam Yan\u0131t Oran\u0131 (TYO), tedavi sonras\u0131 2 ay i\u00e7inde tek ba\u015f\u0131na RT&#8217;ye g\u00f6re en \u00f6nemli fark\u0131 g\u00f6sterdi, s\u0131ras\u0131yla <strong>%47,4\\&#8217;e kar\u015f\u0131 %5,3<\/strong> (P de\u011feri &lt; 0.05). <strong>Tam a\u011fr\u0131 giderme s\u00fcresi RT + TVH i\u00e7in 10 g\u00fcn iken, tek ba\u015f\u0131na RT grubunda son noktaya ula\u015f\u0131lamad\u0131.<\/strong> Tedaviden sonraki 4 hafta i\u00e7inde RT grubundaki hastalar\u0131n yar\u0131s\u0131nda a\u011fr\u0131 ilerlemesi veya hastal\u0131k stabilitesi g\u00f6zlendi. Ancak,<strong> bu skor tedavi sonras\u0131 iki ay i\u00e7inde RT + TVH hastalar\u0131nda s\u0131f\u0131ra yak\u0131nd\u0131.<\/strong><strong>Sonu\u00e7lar: <\/strong> TVH art\u0131 RT, metastatik kemik lezyonlar\u0131 olan hastalarda tek ba\u015f\u0131na RT&#8217;ye k\u0131yasla a\u011fr\u0131 gidermede \u00f6nemli art\u0131\u015flar ve daha k\u0131sa yan\u0131t s\u00fcresi g\u00f6stermi\u015ftir.<\/section><table border=\"1\"><thead><tr><th>YK G\u00f6stergesi\/A\u011fr\u0131 \u0130yile\u015fmesi<\/th><th>Tek ba\u015f\u0131na RT<\/th><th>RT + Hipertermi (TVH wIRA)<\/th><th>YK Etkisi<\/th><\/tr><\/thead><tbody><tr><td><strong>2 Ayda Tam Yan\u0131t Oran\u0131 (TYO)<\/strong> (s\u0131f\u0131r a\u011fr\u0131 skoru)<\/td><td>%5,3<\/td><td>%47,4<\/td><td>* <strong>Toplam a\u011fr\u0131 eliminasyonu \u015fans\u0131nda %894 art\u0131\u015f<\/strong> *.<\/td><\/tr><tr><td><strong>Tam a\u011fr\u0131 giderme s\u00fcresi<\/strong><\/td><td>ula\u015f\u0131lamad\u0131<\/td><td>10 g\u00fcn<\/td><td><strong>\u201d\u00f6nemli ve h\u0131zl\u0131\u201d<\/strong> fayda<\/td><\/tr><tr><td style=\"text-align: left;\"><strong>A\u011fr\u0131 Giderme S\u00fcresi <\/strong><\/td><td style=\"text-align: left;\">Medyan: Hastalar\u0131n yar\u0131s\u0131nda 28 g\u00fcn\/4 hafta<\/td><td style=\"text-align: left;\">Medyan: 24 haftada dahil edilmedi<\/td><td style=\"text-align: left;\">Giderme s\u00fcresi * <strong>alt\u0131 kat artar<\/strong> *, a\u011fr\u0131 kesicilere ba\u011f\u0131ml\u0131l\u0131\u011f\u0131 azalt\u0131r.<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><p style=\"text-align: left;\">\u00a0<\/p><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e97cd55 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"e97cd55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p style=\"text-align: left;\">RF lokorejyonel hipertermi ile <a title=\"Faz III Chi MS et al. 2017 \u00c7al\u0131\u015fmas\u0131\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360-3016(17)33930-5\" target=\"_blank\" rel=\"noopener\">Chi MS ve arkada\u015flar\u0131 taraf\u0131ndan yay\u0131nlanan benzer Faz III \u00e7al\u0131\u015fmas\u0131 (2017)<\/a> ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, TVH wIRA hipertermi kullan\u0131larak elde edilen faydalar (<em>YK ve a\u011fr\u0131 azalmas\u0131 a\u00e7\u0131s\u0131ndan<\/em>) \u00e7ok daha \u00fcst\u00fcnd\u00fc \u2013 RF HT + RT \u00e7al\u0131\u015fma sonu\u00e7lar\u0131:<\/p><table border=\"1\"><thead><tr><th>YK G\u00f6stergesi\/A\u011fr\u0131 \u0130yile\u015fmesi<\/th><th>Tek ba\u015f\u0131na RT<\/th><th>RT + Hipertermi (HT)<\/th><th>YK Etkisi<\/th><\/tr><\/thead><tbody><tr><td><strong>3 Ayda Tam Yan\u0131t Oran\u0131 (TYO)<\/strong> (s\u0131f\u0131r a\u011fr\u0131 skoru)<\/td><td>%7,1<\/td><td>%37,9<\/td><td>Toplam a\u011fr\u0131 giderme \u015fans\u0131nda %533 art\u0131\u015f.<\/td><\/tr><tr><td><strong>A\u011fr\u0131 Giderme S\u00fcresi<\/strong><\/td><td>Medyan: 55 g\u00fcn\/7.9 hafta<\/td><td>Medyan: 24 haftada dahil edilmedi<\/td><td>Giderme s\u00fcresi \u00fc\u00e7e katlan\u0131r, a\u011fr\u0131 kesicilere ba\u011f\u0131ml\u0131l\u0131\u011f\u0131 azalt\u0131r.<\/td><\/tr><\/tbody><\/table><p style=\"text-align: left;\">\u00d6zetle, konsolide bilimsel kan\u0131tlar (<em>wIRA teknolojisi \u00fczerine yap\u0131lan temel \u00e7al\u0131\u015fmalardan kritik Faz III klinik deneylerine kadar<\/em>) TVH&#8217;nin onkolojide \u00e7ok etkili bir adjuvan terapi rol\u00fcn\u00fc do\u011frulamaktad\u0131r: <strong>KT\/RT etkinli\u011fini art\u0131r\u0131r, sistemik ba\u011f\u0131\u015f\u0131kl\u0131k sistemini aktive eder (imm\u00fcnoterapi ile sinerji dahil) ve kanser hastalar\u0131 i\u00e7in a\u011fr\u0131 kontrol\u00fcn\u00fc ve YK&#8217;yi \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015ftirir<\/strong>.<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b9b952 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b9b952\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9003cfd elementor-widget elementor-widget-heading\" data-id=\"9003cfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. Sistemik Fizyolojik Faydalar ve Di\u011fer Patolojilerde Terap\u00f6tik Potansiyel<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0307397 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0307397\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header>wIRA radyasyonu ile sa\u011flanan nazik, kontroll\u00fc \u0131s\u0131, onkolojinin \u00f6tesine uzanan geni\u015f sistemik faydalar sa\u011flayan karma\u015f\u0131k termoreg\u00fclat\u00f6r yan\u0131tlar\u0131 ba\u015flat\u0131r:<\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">\u00a0<\/h3><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8b16cd animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f8b16cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">A. Kas \u0130skelet Sistemi ve A\u011fr\u0131 Y\u00f6netimi<\/h3><p style=\"text-align: left;\">TVH, kas tonusu ve mikro sirk\u00fclasyon \u00fczerindeki fizyolojik etkilerini kullanarak kronik a\u011fr\u0131 sendromlar\u0131n\u0131n y\u00f6netiminde etkilidir:<\/p><ul><li style=\"text-align: left;\"><strong>Dorsalji (Kronik S\u0131rt A\u011fr\u0131s\u0131):<\/strong> \u00c7al\u0131\u015fmalar, hafif TVH&#8217;nin sabit multimodal a\u011fr\u0131 terapisi ile birle\u015ftirildi\u011finde kronik non-spesifik bel a\u011fr\u0131s\u0131 (dorsalji) olan hastalar i\u00e7in \u00f6nemli fayda sa\u011flad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir [53, 54].<\/li><li style=\"text-align: left;\"><strong>Fibromiyalji Sendromu (FMS):<\/strong> TVH, FMS i\u00e7in belgelenmi\u015f bir yard\u0131mc\u0131 tedavidir. Randomize kontroll\u00fc \u00e7al\u0131\u015fmalar, standart multimodal rehabilitasyon ortam\u0131nda hafif wIRA TVH&#8217;nin <strong>a\u011fr\u0131 yo\u011funlu\u011fu<\/strong> ve <strong>zihinsel durum<\/strong> \u00fczerindeki etkilerini g\u00f6stererek etkinli\u011fini kan\u0131tlam\u0131\u015ft\u0131r [17, 56, 57]. Bu fayda k\u0131smen FMS hastalar\u0131nda bilinen bir sorun olan geli\u015fmi\u015f mikro sirk\u00fclasyon ile ba\u011flant\u0131l\u0131d\u0131r [55].<\/li><li style=\"text-align: left;\"><strong>Ankilozan Spondilit (AS):<\/strong> TVH, AS hastalar\u0131nda imm\u00fcnomod\u00fclat\u00f6r etkiler g\u00f6stermi\u015ftir; \u00e7al\u0131\u015fmalar TVH&#8217;nin <strong>Interleukin-10<\/strong> (IL-10) gibi anti-enflamatuar medyat\u00f6rleri art\u0131rma ve TNF-alfa gibi pro-enflamatuar sitokinleri mod\u00fcle etme yetene\u011fini raporlam\u0131\u015f, durumla ili\u015fkili kronik enflamasyonun y\u00f6netiminde faydal\u0131 bir rol \u00f6nermi\u015ftir [58, 59, 52].<\/li><li style=\"text-align: left;\"><strong>Sistemik Sklerozda Raynaud Fenomeni:<\/strong> K\u0131z\u0131l\u00f6tesi arac\u0131l\u0131 hipertermi, Skleroderma ile \u0130li\u015fkili Raynaud Fenomeni ile ili\u015fkili vazokonstriktif semptomlar\u0131n tedavisinde etkili bulunmu\u015f, vask\u00fcler faydalar g\u00f6stermi\u015ftir [49].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c1b89 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b0c1b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><h3 style=\"text-align: left;\">B. Kardiyovask\u00fcler ve Dola\u015f\u0131m Sa\u011fl\u0131\u011f\u0131 \u2764\ufe0f<\/h3><p style=\"text-align: left;\">T\u00fcm\u00f6r perf\u00fczyonunu iyile\u015ftirmenin \u00f6tesinde, TVH&#8217;nin dola\u015f\u0131m sistemi \u00fczerinde spesifik etkileri vard\u0131r:<\/p><ul><li style=\"text-align: left;\"><strong>Esansiyel Hipertansiyon:<\/strong> Bir dizi \u00e7al\u0131\u015fma, arteriyel hipertansiyonu (WHO Evre I ve II) olan hastalarda hafif IR-A hipertermi kullan\u0131m\u0131n\u0131 ara\u015ft\u0131rm\u0131\u015ft\u0131r. Bulgular, seri tedavilerin <strong>merkezi ve periferik nab\u0131z dalgalar\u0131n\u0131<\/strong>, kan bas\u0131nc\u0131n\u0131 ve <strong>kan viskozitesini<\/strong> olumlu y\u00f6nde etkileyebilece\u011fini g\u00f6stererek, TVH&#8217;nin farmakolojik olmayan bir fizik tedavi se\u00e7ene\u011fi olarak rol\u00fcn\u00fc do\u011frulamaktad\u0131r [44, 47].<\/li><\/ul><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce4fdb9 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ce4fdb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \" style=\"text-align: left;\"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h3 style=\"text-align: left;\">C. N\u00f6ro-Endokrin ve Psikolojik Etkiler<\/h3><p style=\"text-align: left;\">TVH, v\u00fccudun n\u00f6ro-endokrin sistemlerini etkileyerek ruh halini ve metabolizmay\u0131 etkiler:<\/p><ul><li style=\"text-align: left;\"><strong>Maj\u00f6r Depresif Bozukluk (MDB):<\/strong> Randomize bir klinik \u00e7al\u0131\u015fma, tek bir TVH seans\u0131n\u0131n h\u0131zl\u0131 etkili bir antidepresan olarak hareket edebilece\u011fini ve depresif semptomlarda birka\u00e7 hafta boyunca azalmaya yol a\u00e7t\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Bu etki, \u0131s\u0131 kaynakl\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k ve enflamatuar yollar\u0131n beyne etki eden aktivasyonu ile ba\u011flant\u0131l\u0131d\u0131r [51].<\/li><li style=\"text-align: left;\"><strong>Hormonal Mod\u00fclasyon (Endokrinoloji):<\/strong> TVH, <strong>Hipotalamik-Hipofiz-Adrenal (HPA) aks\u0131n\u0131<\/strong> uyar\u0131r ve hormon seviyelerini etkiler. \u00c7al\u0131\u015fmalar, t\u00fcm v\u00fccut hipertermisi s\u0131ras\u0131nda <strong>B\u00fcy\u00fcme Hormonu<\/strong> ve <strong>Prolaktin<\/strong> yan\u0131tlar\u0131n\u0131 belgelemi\u015f, endokrin d\u00fczenleme \u00fczerindeki etkisini vurgulam\u0131\u015ft\u0131r [42, 43].<\/li><li style=\"text-align: left;\"><strong>Metabolizma ve H\u00fccre Reaksiyonu:<\/strong> TVH, bazal metabolik h\u0131z\u0131 h\u0131zland\u0131r\u0131r. H\u00fccresel d\u00fczeyde, \u0131s\u0131 pO2 kineti\u011fini etkiler ve ciltteki <strong>ferritin<\/strong> gibi koruyucu proteinlerin sentezi ile ba\u011flant\u0131l\u0131d\u0131r, doku onar\u0131m\u0131n\u0131 destekler [48; 46].<\/li><\/ul><\/header><\/header><p>\u00a0<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f7153 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"91f7153\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/ardenneiratherm.com\/wp-content\/uploads\/2025\/10\/von-Ardenne-Iratherm-10000-WBH-wIRA-hyperthermia-device-summary.jpg\" title=\"\" alt=\"von Ardenne Iratherm 10000 WBH wIRA hyperthermia-device-summary\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae37e3c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ae37e3c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7dda12 elementor-widget elementor-widget-heading\" data-id=\"a7dda12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u00d6nerilen TVH Seanslar\u0131 ve Hedef S\u0131cakl\u0131klar Hakk\u0131nda S\u0131k\u00e7a Sorulan Sorular (SSS)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa3b4f4 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"aa3b4f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><i>Tedaviler sadece bir t\u0131p doktoruyla yap\u0131lacak nihai kons\u00fcltasyondan sonra ger\u00e7ekle\u015ftirilmelidir.<\/i><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><h4>\u00a0<\/h4><\/header><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-968c093 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"968c093\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><header id=\"ut_header_68e7a7d03d95c\"><header><h4>Esansiyel Hipertansiyon i\u00e7in \u00f6nerilen T\u00fcm V\u00fccut Hipertermi (TVH) protokol\u00fc nedir?<\/h4><p>Esansiyel Hipertansiyon protokol\u00fc, 38.3 \u00b0C hedef s\u0131cakl\u0131kta 12 seans \u00f6nermektedir. Her seans yakla\u015f\u0131k 45 dakika s\u00fcrer; 30 dakikal\u0131k bir y\u00fckseltme faz\u0131 ve 15 dakikal\u0131k bir dinlenme faz\u0131 i\u00e7erir (plato faz\u0131 yoktur).<\/p><h4>Kronik S\u0131rt A\u011fr\u0131s\u0131 (Dorsalji) i\u00e7in \u00f6nerilen TVH parametreleri nelerdir?<\/h4><p>Dorsalji i\u00e7in tipik olarak 6 seans \u00f6nerilir ve 38.4 \u00b0C hedeflenir. Toplam seans s\u00fcresi yakla\u015f\u0131k 90 dakikad\u0131r; 45 dakikal\u0131k y\u00fckseltme, 15 dakikal\u0131k plato faz\u0131 ve 30 dakikal\u0131k dinlenme i\u00e7erir.<\/p><h4>Fibromiyalji ve Ankilozan Spondilit i\u00e7in TVH protokol\u00fc nedir?<\/h4><p>Hem Fibromiyalji hem de Ankilozan Spondilit tipik olarak 6 seansl\u0131k bir protokol\u00fc takip eder ve 38.5 \u00b0C hedeflenir. Toplam seans s\u00fcresi yakla\u015f\u0131k 90 dakikad\u0131r; 45 dakikal\u0131k y\u00fckseltme, 15 dakikal\u0131k plato ve 30 dakikal\u0131k dinlenme i\u00e7erir.<\/p><h4>Kansere Ek Tedavi olarak TVH i\u00e7in \u00f6nerilen protokol nedir?<\/h4><p>Kansere ek tedavi olarak protokol, 39.0 \u00b0C ile 40.0 \u00b0C aras\u0131nda bir \u00e7ekirdek s\u0131cakl\u0131\u011f\u0131 hedefleyen 2 veya daha fazla seans gerektirir. Toplam seans s\u00fcresi en uzundur ve 3 ila 4 saat aras\u0131nda de\u011fi\u015fir; buna 60-90 dakikal\u0131k y\u00fckseltme faz\u0131, 60-90 dakikal\u0131k plato faz\u0131 ve 60 dakikal\u0131k dinlenme faz\u0131 dahildir.<\/p><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><\/header><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3875720 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3875720\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\"><header><table width=\"1151\"><tbody><tr><td width=\"278\">Endikasyon<\/td><td width=\"99\">Seans Say\u0131s\u0131<\/td><td width=\"135\">Hedef S\u0131cakl\u0131k<\/td><td colspan=\"2\" width=\"309\">Terapi S\u00fcresi<br \/>Y\u00fckseltme faz\u0131 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Plato faz\u0131<\/td><td width=\"164\">Dinlenme S\u00fcresi<br \/>Dinlenme faz\u0131<\/td><td width=\"164\"><b>Toplam<\/b><br \/><b>TVH Seans\u0131 S\u00fcresi<\/b><\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Esansiyel Hipertansiyon<\/td><td rowspan=\"2\" width=\"99\">12<\/td><td rowspan=\"2\" width=\"135\">38.3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 dak<\/b><\/td><td rowspan=\"2\" width=\"164\">15 dak<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 dak<\/b><\/td><\/tr><tr><td width=\"155\">30 dak<\/td><td width=\"155\">0 dak<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Dorsalji<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.4 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 dak<\/b><\/td><td rowspan=\"2\" width=\"164\">30 dak<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 dak<\/b><\/td><\/tr><tr><td width=\"155\">45 dak<\/td><td width=\"155\">15 dak<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Fibromiyalji<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 dak<\/b><\/td><td rowspan=\"2\" width=\"164\">30 dak<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 dak<\/b><\/td><\/tr><tr><td width=\"155\">45 dak<\/td><td width=\"155\">15 dak<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Ankilozan Spondilit<\/td><td rowspan=\"2\" width=\"99\">6<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>60 dak<\/b><\/td><td rowspan=\"2\" width=\"164\">30 dak<\/td><td rowspan=\"2\" width=\"164\"><b>~ 90 dak<\/b><\/td><\/tr><tr><td width=\"155\">45 dak<\/td><td width=\"155\">15 dak<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Sistemik Skleroz<\/td><td rowspan=\"2\" width=\"99\">15<\/td><td rowspan=\"2\" width=\"135\">38.3 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>30 dak<\/b><\/td><td rowspan=\"2\" width=\"164\">15 dak<\/td><td rowspan=\"2\" width=\"164\"><b>~ 45 dak<\/b><\/td><\/tr><tr><td width=\"155\">30 dak<\/td><td width=\"155\">0 dak<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Maj\u00f6r Depresif Bozukluk<\/td><td rowspan=\"2\" width=\"99\">1+<\/td><td rowspan=\"2\" width=\"135\">38.5 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>105 -170 dak<\/b><\/td><td rowspan=\"2\" width=\"164\">30 dak<\/td><td rowspan=\"2\" width=\"164\"><b>~ 2-3 saat<\/b><\/td><\/tr><tr><td width=\"155\">45-110 dak<\/td><td width=\"155\">60 dak<\/td><\/tr><tr><td rowspan=\"2\" width=\"278\">Kansere Ek Tedavi<\/td><td rowspan=\"2\" width=\"99\">2+<\/td><td rowspan=\"2\" width=\"135\">39.0-40.0 \u00b0C<\/td><td colspan=\"2\" width=\"309\"><b>120-180 dak<\/b><\/td><td rowspan=\"2\" width=\"164\">60 dak<\/td><td rowspan=\"2\" width=\"164\"><b>~ 3-4 saat<\/b><\/td><\/tr><tr><td width=\"155\">60-90 dak<\/td><td width=\"155\">60-90 dak<\/td><\/tr><\/tbody><\/table><\/header><\/header><header id=\"ut_header_68e7a7d03d95c\"><header><\/header><\/header><\/div><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0149af animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d0149af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><p>NOT: Bu makale, TVH wIRA&#8217;n\u0131n \u00e7al\u0131\u015fmalar\u0131n\u0131n ve etkilerinin kapsaml\u0131 bir listesi de\u011fildir<\/p><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f3186c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0f3186c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-072e6e2 elementor-widget elementor-widget-heading\" data-id=\"072e6e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Referanslar ve Al\u0131nt\u0131lar<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13e67b animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d13e67b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><ol><li style=\"text-align: left;\">Ardenne M. von. Moderate Hyperthermie als Behandlungsmethode mit vielen Indikationen. \u00c4rztzeitschr Naturheilverf 1994; 5:356-61.<\/li><li style=\"text-align: left;\">B\u00e4umler H., Scherf H.P., Aurisch R., et al. Einflu\u00df einer Serie von Infrarot-Ganzk\u00f6rperbestrahlungen auf Flie\u00dfeigenschaften des Blutes und die H\u00e4modynamik. Perfusion 1990: 138-43.<\/li><li style=\"text-align: left;\">Heckel M. Ganzk\u00f6rper-Hyperthermie und Fiebertherapie, Grundlagen und Praxis. Stuttgart: Hippokrates Verlag, 1990.<\/li><li style=\"text-align: left;\">Kosaka M., Sugahara T., Schmidt K.L., Simon E. Thermotherapy: Principles and Practice. Heidelberg: Springer Verlag, 2000.<\/li><li style=\"text-align: left;\">Meffert H., Hecht H.C., G\u00fcnther H., et al. Biophysikalische Ergebnisse des klinischen Tests der IRA-Therm-Hyperthermietechnik der 2. Generation. ThermoMed 1990; 6:71-78.<\/li><li style=\"text-align: left;\">Schmidt K.L. Hyperthermie und Fieber, Wirkungen bei Mensch und Tier. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1987.<\/li><li style=\"text-align: left;\">Vaupel P., Kr\u00fcger W. W\u00e4rmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsm\u00f6glichkeiten. 2. \u00fcberarb Aufl. Stuttgart: Hippokrates Verlag, 1995.<\/li><li style=\"text-align: left;\">Piazena H., Meffert H. Optische Eigenschaften der Haut und die photobiologischen Grundlagen zur Dosierung von IR-Hautbestrahlungen in vivo und in vitro. 6. Symposium Licht und Gesundheit 2008 13.-14.03. Berlin, 2008:162-178.<\/li><li style=\"text-align: left;\">Zschaeck S. and Beck M. Chapter 8 Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?<\/li><li style=\"text-align: left;\">Zhang H, Wang W, Zhang S, Huang W. Comparison of the anti-tumor effects of various whole-body hyperthermia protocols&#8230; Immunol Invest. 2005;34(3):245-58.<\/li><li style=\"text-align: left;\">Abreu MM, Chocron AF, Smadja DM. From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy. Front Immunol. 2025 Feb 28;16:1487296.<\/li><li style=\"text-align: left;\">Bull JMC. et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-\u03b1: A description of a phase I-II protocol. Journal of Hyperthermia. 2008; 24(8): 649-662.<\/li><li style=\"text-align: left;\">Weigelin B. Visualization of the immune effect of hyperthermia. ICHO 2021, Session: Hyperthermia and immunology.<\/li><li style=\"text-align: left;\">Faghihi Moghaddam F, Bakhshandeh M, Mofid B, et al. Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone&#8230; J Therm Biol. 2024 Feb;120:103804.<\/li><li style=\"text-align: left;\">Hildebrandt B, Dr\u00e4ger J, Kerner T. et al. Whole-body hyperthermia in the scope of von Ardenne\u2019s systemic cancer multistep therapy (sCMT)&#8230; International Journal of Hyperthermia. 2004;3:317\u2013333.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin in patients with recurrent ovarian cancer \u2013 a phase II study. Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Brockow T., Wagner A., Franke A., Offenb\u00e4cher M., Resch K.L. A Randomized Controlled Trial on the Effectiveness of Mild Water-filtered Near Infrared Whole-body Hyperthermia&#8230; Clin J Pain 2007; 1:67-75.<\/li><li style=\"text-align: left;\">Kleef R, Nagy R, Baierl A, et al. Low-dose Ipilimumab plus Nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series&#8230; Cancer Immunol Immunother. 2021;70:1393\u2013403.<\/li><li style=\"text-align: left;\">Adachi H., Katsuno M., Waza M., et al. Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications. Int J Hyperthermia 2009; 8:647-54.<\/li><li style=\"text-align: left;\">Atmaca A., Al-Batran S.E., Neumann A., et al. Whole-body hyperthermia (WBH) in combination with carboplatin&#8230; Gynecol Oncol 2009; 2:384-88.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Figueroa G., et al. An Update of a Phase II Clinical Trial Using Fever-Range Whole-Body Thermal Therapy (FR-WB-TT)&#8230; Soc for Thermal Med Joint Annual Meeting, 14.-17.5.2007.<\/li><li style=\"text-align: left;\">Bull J.M., Scott G.L., Strebel F.R., et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine and daily interferon-\u03b1: A description of a phase I-II protocol. Int J Hyperthermia 2008; 8:649-62.<\/li><li style=\"text-align: left;\">Bull J.M., Nagle V.L., Scott G., et al. A phase-I-study of optimally-timed Gemcitabine + Cisplatin\/Interferon-a combined with long-duration, low-temperature whole-body hyperthermia. ESHO 2001, Verona\/ Italy, 30.05.-02.06.2001:67.<\/li><li style=\"text-align: left;\">Capitano M., Mace T., Nemeth M., et al. A novel strategy for improving neutrophil recovery following total body irradiation. Soc for Thermal Med Joint Annual Meeting, 24.-26.4.2010.<\/li><li style=\"text-align: left;\">Dayanc B.E., Ostberg J.R., Repasky E.A. Enhancement of NK Cell Cytotoxic Activity by Mild Thermal Stress. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Hajto T., Hostanska K. Effect of in vivo hyperthermia on human natural killer cells. Clin Trials J 1985; 6:514-20.<\/li><li style=\"text-align: left;\">Hattori T., Kokura S., Okuda T., et al. Antitumor effect of whole body hyperthermia with \u03b1-galactosylceramide in a subcutaneous tumor model of colon cancer. Int J Hyperthermia 2007; 7:591-98.<\/li><li style=\"text-align: left;\">Kisailus A., Pritchard M., Li Y., Ostberg J., Repasky E.A. Thermal Regulation of Antigen Presenting Cells: Use of Hyperthermia as an Adjuvant for Cancer Vaccines. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Multhoff G. Letter to Editor, Hyperthermia classic commentary: Activation of natural killer (NK) cells by heat shock protein 70&#8230; Int J Hyperthermia 2009; 3:176-79.<\/li><li style=\"text-align: left;\">Peer A.J., Grimm M.J., Zynda E.R., Repasky E.A. Diverse immune mechanisms may contribute to the survival benefit seen in cancer patients receiving hyperthermia. Immunol Res 2010; 1-3:137-154.<\/li><li style=\"text-align: left;\">Rowe R.W., Stebel F.R., Proett J.M., et al. Fever-range whole body thermotherapy combined with oxaliplatin: A curative regimen in a pre-clinical breast cancer model. Int J Hyperthermia 2010; 6:565-76.<\/li><li style=\"text-align: left;\">Schencking M., Frese T., Sandholzer H. Behandlung einer Radikulopathie bei oss\u00e4rer Metastasierung der Lendenwirbels\u00e4ule durch Infrarot-A-Ganzk\u00f6rperhyperthermie. Forsch Komplementmed 2008; 15:273-76.<\/li><li style=\"text-align: left;\">Scott G.L., Bull J.M.C., Kochn M. Management of Conscious Sedation&#8230; 9th Int Congress on Hyperthermic Oncology, 20.-24.4.2004.<\/li><li style=\"text-align: left;\">Shecterle L.M., Cyr J.A.S. Hyperthermia Aids Patients with Advanced Lung Cancer. Soc of Thermal Med Annual Meeting, 6.-8.4.2006.<\/li><li style=\"text-align: left;\">Skitzki J.J., Repasky E.A., Evans S.S. Hyperthermia as an immunotherapy strategy for cancer. Current Opnion in Investigational Drugs 2009; 6: 550-58.<\/li><li style=\"text-align: left;\">Toyota N., Strebel F.R., Stephens L.C., et al. Long-duration, mild whole body hyperthermia with cisplatin: tumour response and kinetics of apoptosis and necrosis&#8230; Int. J. Hyperthermia 1997; 5:497-506.<\/li><li style=\"text-align: left;\">Wang X.Y., Kazim L., Repasky E.A., Subjeck J.R. Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines&#8230; J of Immunology 2001; 165:490-97.<\/li><li style=\"text-align: left;\">VanderZee J., DeBruijne M., Mens J.W.M., et al. Reirradiation combined with hyperthermia in breast cancer recurrences&#8230; Int J Hyperthermia 2010; 7:638-48.<\/li><li style=\"text-align: left;\">Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia for locally advanced breast cancer. Int J Hyperthermia 2010; 7:618-24.<\/li><li style=\"text-align: left;\">Zagar T.M., Oleson J.R., Vujaskovic Z., et al. Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence&#8230; Int J Hyperthermia 2010; 7: 612\u201317.<\/li><li style=\"text-align: left;\">Sen A., Capitano M., Dommer M., et al. Thermoregulatory responses to mild systemic thermal stress increase tumor perfusion&#8230; Cancer Res. 2011; 71(11):3872-3880.<\/li><li style=\"text-align: left;\">Koska J., Rovensky J., Zimanova T., Vigas M. Growth hormone and prolactin responses during partial and whole body warm-water immersions. Acta Physiol Scand. 2003 May;178(1):19-23.<\/li><li style=\"text-align: left;\">Vigas M., Rovensky J., Zimanova T., Koska J. Responses of growth hormone and prolactin to local and whole-body application of Piestany mud. Acta Rheumatol et Balneol Pistiniana 2002:31-38.<\/li><li style=\"text-align: left;\">Meffert B., Hochmuth O., Steiner M. Effects of a multiple mild infrared a induced hyperthermia on central and peripheral pulse waves in hypertensive patients. North Sea Conference on Biomedical Engineering 1990.<\/li><li style=\"text-align: left;\">Meffert H., Scherf HP., Meffert B. Milde Infrarot-A-Hyperthermie. Auswirkungen von Serienbestrahlungen mit wassergefilterter Infrarotstrahlung&#8230; Akt Dermatol 1993; 19:142-48.<\/li><li style=\"text-align: left;\">Applegate L.A., Scaletta C., Panizzon R., et al. Induction of the putative protein ferritin by infrared radiation: Implications in skin repair. Int J of Molecular Med 2000; 5:247-51.<\/li><li style=\"text-align: left;\">Scherf H.P., Meffert H., B\u00e4umler H., et al. Wirkung einer einmaligen milden Infrarot-A-Hyperthermie auf K\u00f6rpertemperatur, Herzfrequenz, Blutdruck und Blutviskosit\u00e4t&#8230; Dermatol Monatsschr 1989; 175:733-40.<\/li><li style=\"text-align: left;\">Streffer C. Metabolic changes during and after hyperthermia. Int J Hyperthermia 1985; 4:305-319.<\/li><li style=\"text-align: left;\">F\u00f6rster J., Fleischanderl S., Wittstock S., et al. Infrared-Mediated Hyperthermia is Effective in the Treatment of Scleroderma-Associated Raynaud\u2019s Phenomenon. J of Investigative Dermatology 2005; 6:1313-16.<\/li><li style=\"text-align: left;\">Koska J., Rovensky J., Zimanova T., et al. Sympathoadrenal regulation of circulatory responses to whole-body hyperthermia&#8230; Acta Rheumatol et Balneol Pistiniana 2002:23-30.<\/li><li style=\"text-align: left;\">Janssen C.W., Lowry C.A., Mehl M.R., et al. Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder \u2013 A Randomized Clinical Trial. JAMA Psychiatry. 2016 May 12.<\/li><li style=\"text-align: left;\">Tarner I.H., Ladner U.M., Uhlemann C., Lange U. The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1 beta and IL-6 in patients with ankylosing spondylitis. Clin Rheumatol 2009; 4:397-402.<\/li><li style=\"text-align: left;\">Ettrich U., Konrad B., Prate K., et al. Milde Ganzk\u00f6rperhyperthermie in Kombination mit station\u00e4rer multimodal orientierter Schmerztherapie&#8230; Orthop\u00e4de 2014; 2:165-74.<\/li><li style=\"text-align: left;\">Weller E., Ullrich D. Infrarot-A-Hyperthermie-Anwendung bei Patienten mit Analgetica-Abusus wegen chronischer R\u00fcckenschmerzen. Vortrag auf dem 95. Kongre\u00df der Gesellschaft f\u00fcr Phys Med und Rehab 5.10.1990.<\/li><li style=\"text-align: left;\">Morf S., Vesti B.A., Forster A., et al. Microcirculation abnormalities in patients with fibromyalgia \u2013 measured by capillary and laser fluxmetry. Arthritis Res Ther 2005; 7:R209-16.<\/li><li style=\"text-align: left;\">Walz J., Hinzmann J., Haase I., Witte T. Ganzk\u00f6rperhyperthermie in der Schmerztherapie \u2013 eine kontrollierte Studie an Patienten mit Fibromyalgiesyndrom. Schmerz 2013; 27:38-45.<\/li><li style=\"text-align: left;\">Romeyke T., Stummer H. Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic whole-body hyperthermia&#8230; J Musculoskel Pain 2014; 4:341-55.<\/li><li style=\"text-align: left;\">Zauner D., Quehenberger F., Hermann J., et al. Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study. Int J Hyperthermia 2014; 6:393-401.<\/li><li style=\"text-align: left;\">Lange U., M\u00fcller-Ladner U., Dischereit G. Wirkung iterativer Ganzk\u00f6rperhyperthermie mit wassergefilterter Infrarot-A-Strahlung bei ankylosierender Spondylitis&#8230; Akt Rheumatol 2017; 2:122-128.<\/li><\/ol><\/section><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97dc368 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"97dc368\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"wpb_column vc_column_container vc_col-sm-4\" style=\"text-align: center;\"><div id=\"ut-column-inner-68e7a7d03c96a\" class=\"vc_column-inner vc_column-inner-nested \"><div class=\"wpb_wrapper\"><div class=\"section\"><div class=\"wpb_content_element \"><header id=\"ut_header_68e7a7d03d95c\" class=\"section-header ut-no-title-linebreak-mobile pt-style-2 header-center header-tablet-center header-mobile-center\"><div class=\"lead \" style=\"text-align: center;\" data-delay=\"0\"><header><section><p>\u00a0<\/p><\/section><footer>\u00a9 <time>2025<\/time> Romanian Society Oncologic Hyperthermia All rights reserved. Source: Analysis based on scientific literature.<\/footer><\/header><\/div><\/header><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Onkoloji ve Di\u011fer Patolojilerde T\u00fcm V\u00fccut Hipertermi (TVH): G\u00fc\u00e7l\u00fc Sinerji, \u0130mm\u00fcnomod\u00fclasyon ve Klinik \u00c7al\u0131\u015fmalar Yay\u0131nlanma Tarihi: 2025-10-13 | Son \u0130nceleme: 2025-10-13 Yazanlar:Veronica Iatan, MD,Cristian Gologan, M.Sc. T\u00fcm V\u00fccut Hipertermi (TVH), v\u00fccut \u00e7ekirdek s\u0131cakl\u0131\u011f\u0131n\u0131n kontroll\u00fc bir \u015fekilde \u0131s\u0131t\u0131lmas\u0131n\u0131 i\u00e7eren ve genellikle *suyla filtrelenmi\u015f K\u0131z\u0131l\u00f6tesi-A (wIRA)* teknolojisini kullanan sistemik bir onkolojik stratejidir. TVH, geleneksel tedavilerin etkinli\u011fini art\u0131rmak<br \/><a class=\"moretag\" href=\"https:\/\/ardenneiratherm.com\/tr\/klinik-calismalar-hipertermi-ir-a-fa-onkoloji\/\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-fullwidth_template.php","meta":{"footnotes":""},"class_list":["post-991","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ardenneiratherm.com\/tr\/wp-json\/wp\/v2\/pages\/991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ardenneiratherm.com\/tr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ardenneiratherm.com\/tr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ardenneiratherm.com\/tr\/wp-json\/wp\/v2\/comments?post=991"}],"version-history":[{"count":0,"href":"https:\/\/ardenneiratherm.com\/tr\/wp-json\/wp\/v2\/pages\/991\/revisions"}],"wp:attachment":[{"href":"https:\/\/ardenneiratherm.com\/tr\/wp-json\/wp\/v2\/media?parent=991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}